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  1. Article: Recent Advances in the Development of Anti-FLT3 CAR T-Cell Therapies for Treatment of AML.

    Pedersen, Maya Graham / Møller, Bjarne Kuno / Bak, Rasmus O

    Biomedicines

    2022  Volume 10, Issue 10

    Abstract: Following the success of the anti-CD19 chimeric antigen receptor (CAR) T-cell therapies against B-cell malignancies, the CAR T-cell approach is being developed towards other malignancies like acute myeloid leukemia (AML). Treatment options for relapsed ... ...

    Abstract Following the success of the anti-CD19 chimeric antigen receptor (CAR) T-cell therapies against B-cell malignancies, the CAR T-cell approach is being developed towards other malignancies like acute myeloid leukemia (AML). Treatment options for relapsed AML patients are limited, and the upregulation of the FMS-like tyrosine kinase 3 (FLT3) in malignant T-cells is currently not only being investigated as a prognostic factor, but also as a target for new treatment options. In this review, we provide an overview and discuss different approaches of current anti-FLT3 CAR T-cells under development. In general, these therapies are effective both in vitro and in vivo, however the safety profile still needs to be further investigated. The first clinical trials have been initiated, and the community now awaits clinical evaluation of the approach of targeting FLT3 with CAR T-cells.
    Language English
    Publishing date 2022-09-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10102441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Late diagnosis and poor nutrition in cystic fibrosis diagnosed before implementation of newborn screening.

    Pedersen, Maya Graham / Højte, Christine / Olesen, Hanne Vebert / Pressler, Tania / Skov, Marianne

    Acta paediatrica (Oslo, Norway : 1992)

    2019  Volume 108, Issue 12, Page(s) 2241–2245

    Abstract: Aim: Denmark has a high standard cystic fibrosis care. However, newborn screening was not implemented until 2016. This article describes the clinical status of cystic fibrosis patients at time of diagnosis prior to newborn screening.: Methods: ... ...

    Abstract Aim: Denmark has a high standard cystic fibrosis care. However, newborn screening was not implemented until 2016. This article describes the clinical status of cystic fibrosis patients at time of diagnosis prior to newborn screening.
    Methods: Patients diagnosed with cystic fibrosis in Denmark in 2010-2014 were reviewed using the Danish Cystic Fibrosis Registry as well as patient files. Parameters collected were age at diagnosis, gender, weight, height, forced expiratory volume at 1 second, cystic fibrosis transmembrane regulator-genotype, lung bacteriology at diagnosis and previous diagnoses.
    Results: A total of 63 patients were diagnosed in the study period. The most typical pre-cystic fibrosis diagnoses were asthma and pneumonia. The median age at diagnosis was 1.4 years for the pancreatic insufficient and 27.3 years for the pancreatic sufficient patients. Of the pancreatic insufficient patients, 21% had moderate to severe malnutrition with BMI below minus 2 SD and 40% had moderate to severe stunting with height below minus 2 SD.
    Conclusion: Diagnosis was delayed considerably compared to diagnosis by newborn screening in other countries. Many cystic fibrosis patients diagnosed due to clinical symptoms were moderately to severely underweight or stunted at diagnosis.
    MeSH term(s) Adolescent ; Adult ; Child ; Child, Preschool ; Cystic Fibrosis/complications ; Cystic Fibrosis/diagnosis ; Cystic Fibrosis/epidemiology ; Cystic Fibrosis/microbiology ; Delayed Diagnosis ; Denmark/epidemiology ; Humans ; Infant ; Infant, Newborn ; Malnutrition/etiology ; Neonatal Screening ; Nutritional Status ; Young Adult
    Language English
    Publishing date 2019-07-12
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.14908
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  3. Article ; Online: Outpatient parenteral antimicrobial therapy (OPAT) in patients with cystic fibrosis.

    Pedersen, Maya Graham / Jensen-Fangel, Søren / Olesen, Hanne Vebert / Tambe, San Deep Prataprao / Petersen, Eskild

    BMC infectious diseases

    2015  Volume 15, Page(s) 290

    Abstract: Background: To determine complications during outpatient parenteral antimicrobial therapy (OPAT) administrated through a peripheral venous line, PICC-line or PORT-A-CATH (PAC).: Methods: Catheter related complications in patients with cystic fibrosis ...

    Abstract Background: To determine complications during outpatient parenteral antimicrobial therapy (OPAT) administrated through a peripheral venous line, PICC-line or PORT-A-CATH (PAC).
    Methods: Catheter related complications in patients with cystic fibrosis during OPAT were identified through a retrospective review of patient files supplemented by an interview.
    Results: In 64 treatment episodes with a peripheral venous line, 51 (79.7 %) used bolus injection and 13 (20.3 %) used infusion pump. 27 out of 51 (53.0 %) bolus injection episodes experienced complications, which required removal. None were observed for infusion pump treatments. The infectious complications requiring removal of peripheral venous line were 9 out of 23 (39.1 %) for the PICC line and 11 out of 26 (42.3 %) for the PAC. No anaphylaxis was observed during the OPAT treatments.
    Conclusions: Our data indicate that using an infusion pump to administer the antibiotic treatment minimized peripheral venous line complications. The frequency of complications leading to removal of the catheter is about the same for PICC-lines and PACs, but the average life-time of the latter is much longer. Allergic reactions are not a major problem.
    MeSH term(s) Adolescent ; Adult ; Ambulatory Care ; Anti-Infective Agents/administration & dosage ; Child ; Child, Preschool ; Cystic Fibrosis ; Denmark ; Female ; Home Infusion Therapy/adverse effects ; Humans ; Infusions, Intravenous/adverse effects ; Male ; Outcome Assessment (Health Care) ; Outpatients ; Respiratory Tract Infections/drug therapy ; Retrospective Studies ; Young Adult
    Chemical Substances Anti-Infective Agents
    Language English
    Publishing date 2015-07-27
    Publishing country England
    Document type Journal Article
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/s12879-015-1019-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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