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Article: Prostatic Abscess Secondary to Staphylococcus haemolyticus and Escherichia coli: A Case Report.

Bermudez, Marco / Epstein, Steven B / Guevara, Nehemias / Pedraza, Laura / Dahdouh, Michelle / Awad, Ihab

2023 Volume 15, Issue 6, Page(s) e40406

Abstract: A prostate abscess is a rare clinical entity with an incidence of 0.2%-0.5% in males. No case reports exist ... ...

Abstract	A prostate abscess is a rare clinical entity with an incidence of 0.2%-0.5% in males. No case reports exist of
Language	English
Publishing date	2023-06-14
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.40406
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Management of a Right Heart Intracavitary Thrombus in Transit in a Patient With Gastric Cancer in a Resource-Limited Setting: A Case Report.

Bermudez, Marco / Pedraza, Laura / Guevara, Nehemias / Erazo, Gloria / Valerio, Fernando R

Cureus

2023 Volume 15, Issue 8, Page(s) e43133

Abstract: A right atrial thrombus is an unusual source of imminent massive saddle pulmonary embolism (PE) . A hypercoagulable state secondary to gastric cancer (GC) can result in deep vein thrombosis (DVT) with a resultant right-sided heart thrombus in transit. ... ...

Abstract	A right atrial thrombus is an unusual source of imminent massive saddle pulmonary embolism (PE) . A hypercoagulable state secondary to gastric cancer (GC) can result in deep vein thrombosis (DVT) with a resultant right-sided heart thrombus in transit. Here, we present a case of a young male patient from Honduras with DVT and multiple venous thrombi extending from the external iliac veins to the suprahepatic left vein, inferior vena cava, and right atrium of the heart, secondary to a hypercoagulable state from GC, adenocarcinoma type. We describe the approach of treating a right heart intracavitary thrombus with imminent risk for saddle PE and sudden cardiac death with thrombolysis through a central venous catheter (CVC) in a resource-limited setting.
Language	English
Publishing date	2023-08-08
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.43133
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Impact of COVID-19 in the Latinx Community.

Pedraza, Laura / Villela, Ricardo / Kamatgi, Vikki / Cocuzzo, Kaitlyn / Correa, Ricardo / Lisigurski, Miriam Zylberglait

HCA healthcare journal of medicine

2022 Volume 3, Issue 3, Page(s) 97–104

Abstract: Description The COVID-19 pandemic has intensified the existing health and social disparities that affect minority groups in the United States (US), including the Latinx community. This situation has been reflected in many aspects of health, including ... ...

Abstract	Description The COVID-19 pandemic has intensified the existing health and social disparities that affect minority groups in the United States (US), including the Latinx community. This situation has been reflected in many aspects of health, including increased morbi-mortality and reduced adherence to medical and scientific recommendations. Limited access to health care, financial challenges, migrant status, and health literacy, or lack thereof, have all hampered the Latinx community's ability to seek aid quickly and to be tested or treated effectively for this disease. This pandemic has shown that the Latinx community's socioeconomic status correlates with greater mortality rates when compared to other ethnic groups, which runs counter to historical norms. Furthermore, morbi-mortality in Latinx people has been disproportionately greater. Beyond the systematic barriers that the Latinx community has had to face to access care during the pandemic, there were also perception barriers that increased the gap and further complicated the situation. Latinxs were more likely to be exposed due to a decreased compliance with physical distancing. When it was suggested to avoid crowds, many people started using delivery services; however, many Latinxs found the cost and requirements of reliable internet to be a barrier to using these services. Currently, COVID-19 vaccines are broadly available in the US but there has been skepticism from marginalized communities, including the Latinx population, about getting vaccinated. Integrating this population into a welcoming healthcare system, safeguarding their immigration and work status, providing more accessible vaccination locations, and promoting health equality and education would all assist to lessen the impact of this illness on the Latinx community.
Language	English
Publishing date	2022-06-28
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2689-0216
ISSN (online)	2689-0216
DOI	10.36518/2689-0216.1387
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Article ; Online: Editorial: Targeting the microbiota to attenuate chronic inflammation.

Moreno, Elena / Trøseid, Marius / Vujkovic-Cvijin, Ivan / Marchetti, Giulia / Martín-Pedraza, Laura / Serrano-Villar, Sergio

Frontiers in immunology

2023 Volume 14, Page(s) 1202222

MeSH term(s)	Humans ; Microbiota ; Inflammation
Language	English
Publishing date	2023-04-18
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1202222
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Article ; Online: Allergenic Properties and Molecular Characteristics of PR-1 Proteins.

Wangorsch, Andrea / Scheurer, Stephan / Blanca, Miguel / Blanca-Lopez, Natalia / Somoza, María Luisa / Martín-Pedraza, Laura

Frontiers in allergy

2022 Volume 3, Page(s) 824717

Abstract: Only a small fraction of proteins in plants and animals are classified as allergens. The allergenic properties are frequently attributed to certain functional characteristics of the proteins, such as a role in the plant defense against biotic and abiotic ...

Abstract	Only a small fraction of proteins in plants and animals are classified as allergens. The allergenic properties are frequently attributed to certain functional characteristics of the proteins, such as a role in the plant defense against biotic and abiotic stress, to achieve the systematic acquired resistance. In line with this, eight members out of 17 functional pathogenesis-related (PR) protein families have been characterized as allergens. The present review summarizes the molecular features and allergenic significance of allergens of the PR-1 family. Not many allergens have been identified as belonging to this protein family, with most of them having a pollen origin, like mugwort or Bermuda grass. Molecular and structural features of allergenic PR-1 proteins are discussed and attributed to their IgE-reactive properties, clinical manifestation, and cross-reactivity among different foods and inhalants.
Language	English
Publishing date	2022-02-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	2673-6101
ISSN (online)	2673-6101
DOI	10.3389/falgy.2022.824717
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Article: Impact of COVID-19 on the Care of Patients with HIV Infection.

Rosas Cancio-Suárez, Marta / Alonso, Cecilia / Vivancos, María Jesús / Pérez-Elías, María Jesús / Cárdenas, María José / Vélez-Díaz-Pallarés, Manuel / Corbacho, María Dolores / Martín-Pedraza, Laura / Muriel, Alfonso / Martínez-Sanz, Javier / Moreno, Santiago

Journal of clinical medicine

2023 Volume 12, Issue 12

Abstract: The COVID-19 pandemic and associated lockdown measures have been associated with substantial disruptions to health care services, including screening for human immunodeficiency virus (HIV) and management of people living with HIV (PLWH). Data from 3265 ... ...

Abstract	The COVID-19 pandemic and associated lockdown measures have been associated with substantial disruptions to health care services, including screening for human immunodeficiency virus (HIV) and management of people living with HIV (PLWH). Data from 3265 patients were examined in a retrospective cohort study. We compared outpatient follow-up for PLWH, the number of new patients, treatment adherence, hospitalizations, and deaths during the "pandemic period" (March 2020 to February 2021), the "pre-pandemic period" (the equivalent time frame in 2019), and the "post-pandemic period" (March to September 2021). During the pandemic period, the number of new patients seen at the HIV clinic (116) as well as the requested viral load tests (2414) decreased significantly compared to the pre-pandemic (204 and 2831, respectively) and post-pandemic periods (146 and 2640, respectively) (
Language	English
Publishing date	2023-06-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12123882
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Article: Characterization of Relevant Biomarkers for the Diagnosis of Food Allergies: An Overview of the 2S Albumin Family.

Bueno-Díaz, Cristina / Martín-Pedraza, Laura / Parrón, Jorge / Cuesta-Herranz, Javier / Cabanillas, Beatriz / Pastor-Vargas, Carlos / Batanero, Eva / Villalba, Mayte

Foods (Basel, Switzerland)

2021 Volume 10, Issue 6

Abstract: 2S albumins are relevant and often major allergens from several tree nuts and seeds, affecting mainly children and young people. The present study aims to assess how the structural features of 2S albumins could affect their immunogenic capacity, which is ...

Abstract	2S albumins are relevant and often major allergens from several tree nuts and seeds, affecting mainly children and young people. The present study aims to assess how the structural features of 2S albumins could affect their immunogenic capacity, which is essential to comprehend the role of these proteins in food allergy. For this purpose, twelve 2S albumins were isolated from their respective extracts by chromatographic methods and identified by MALDI-TOF mass-spectrometry. Their molecular and structural characterization was conducted by electrophoretic, spectroscopic and in silico methods, showing that these are small proteins that comprise a wide range of isoelectric points, displaying a general high structure stability to thermal treatment. Despite low amino acid sequence identity, these proteins share structural features, pointing conformational epitopes to explain cross-reactivity between them. Immunoblotting with allergic patients' sera revealed those possible correlations between evolutionarily distant 2S albumins from different sources. The availability of a well-characterized panel of 2S albumins from plant-derived sources allowed establishing correlations between their structural features and their allergenic potential, including their role in cross-reactivity processes.
Language	English
Publishing date	2021-05-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods10061235
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Article: Drug Induced Liver Injury in Geriatric Patients Detected by a Two-Hospital Prospective Pharmacovigilance Program: A Comprehensive Analysis Using the Roussel Uclaf Causality Assessment Method.

Pedraza, Laura / Laosa, Olga / Rodríguez-Mañas, Leocadio / Gutiérrez-Romero, Diego F / Frías, Jesús / Carnicero, José Antonio / Ramírez, Elena

Frontiers in pharmacology

2021 Volume 11, Page(s) 600255

Abstract: Background/aim: ...

Abstract	Background/aim:
Language	English
Publishing date	2021-02-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.600255
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Article: Characterization of Relevant Biomarkers for the Diagnosis of Food Allergies: An Overview of the 2S Albumin Family

Bueno-Díaz, Cristina / Martín-Pedraza, Laura / Parrón, Jorge / Cuesta-Herranz, Javier / Cabanillas, Beatriz / Pastor-Vargas, Carlos / Batanero, Eva / Villalba, Mayte

Foods. 2021 May 29, v. 10, no. 6

2021

Abstract	2S albumins are relevant and often major allergens from several tree nuts and seeds, affecting mainly children and young people. The present study aims to assess how the structural features of 2S albumins could affect their immunogenic capacity, which is essential to comprehend the role of these proteins in food allergy. For this purpose, twelve 2S albumins were isolated from their respective extracts by chromatographic methods and identified by MALDI-TOF mass-spectrometry. Their molecular and structural characterization was conducted by electrophoretic, spectroscopic and in silico methods, showing that these are small proteins that comprise a wide range of isoelectric points, displaying a general high structure stability to thermal treatment. Despite low amino acid sequence identity, these proteins share structural features, pointing conformational epitopes to explain cross-reactivity between them. Immunoblotting with allergic patients’ sera revealed those possible correlations between evolutionarily distant 2S albumins from different sources. The availability of a well-characterized panel of 2S albumins from plant-derived sources allowed establishing correlations between their structural features and their allergenic potential, including their role in cross-reactivity processes.
Keywords	albumins ; allergenicity ; amino acid sequences ; biomarkers ; chromatography ; computer simulation ; cross reaction ; electrophoresis ; epitopes ; food allergies ; genetic distance ; heat treatment ; immunoblotting ; sequence analysis ; trees
Language	English
Dates of publication	2021-0529
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods10061235
Database	NAL-Catalogue (AGRICOLA)

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Article: High resting energy expenditure, less fat-free mass, and less muscle strength in HIV-infected children: a matched, cross-sectional study.

Franco-Oliva, Andrea / Pinzón-Navarro, Beatriz Adriana / Martínez-Soto-Holguín, Martha C / León-Lara, Ximena / Ordoñez-Ortega, Javier / Pardo-Gutiérrez, Ana Laura / Guevara-Cruz, Martha / Avila-Nava, Azalia / García-Guzmán, Alda Daniela / Guevara-Pedraza, Laura / Medina-Vera, Isabel

Frontiers in nutrition

2023 Volume 10, Page(s) 1220013

Abstract: Background and aims: Many improvements have been made in the treatment of human immunodeficiency virus (HIV) in pediatric patients; however, challenges remain in terms of achieving normal growth, body composition, and metabolism during treatment, etc. ... ...

Abstract	Background and aims: Many improvements have been made in the treatment of human immunodeficiency virus (HIV) in pediatric patients; however, challenges remain in terms of achieving normal growth, body composition, and metabolism during treatment, etc. Current nutritional recommendations are based on studies performed in adults, with limited data on the HIV-infected pediatric population. Therefore, this study aimed to compare the resting energy expenditure (REE) of asymptomatic HIV-infected pediatric patients with healthy counterparts and to compare body composition, dietary intake, and physical activity between the two groups. Methods: This was a cross-sectional study of asymptomatic HIV-infected children who were receiving antiretroviral therapy; the infected group was compared with the uninfected group, matched by age (± 6 months), sex, and body mass index (± 0.5 z-score). Participants were recruited between 2021 and 2022, as outpatients. In both groups, REE was determined by indirect calorimetry and body composition by bioelectrical impedance analysis and hand strength, measured using a hydraulic hand dynamometer. Results: Seventy-eight participants were enrolled, where Conclusions: Children with asymptomatic HIV infection have higher REE than their uninfected peers. They also present decreased FFM, skeletal muscle mass index, and muscle strength. These parameters should be considered during nutritional assessment in this population to have a favorable impact on nutritional status and growth.
Language	English
Publishing date	2023-09-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1220013
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