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  1. Article ; Online: Breaking barriers in electrochemical biosensing using bioinspired peptide and phage probes.

    Campuzano, Susana / Pedrero, María / Barderas, Rodrigo / Pingarrón, José M

    Analytical and bioanalytical chemistry

    2024  

    Abstract: Electrochemical biosensing continues to advance tirelessly, overcoming barriers that have kept it from leaving research laboratories for many years. Among them, its compromised performance in complex biological matrices due to fouling or receptor ... ...

    Abstract Electrochemical biosensing continues to advance tirelessly, overcoming barriers that have kept it from leaving research laboratories for many years. Among them, its compromised performance in complex biological matrices due to fouling or receptor stability issues, the limitations in determining toxic and small analytes, and its use, conditioned to the commercial availability of commercial receptors and the exploration of natural molecular interactions, deserved to be highlighted. To address these challenges, in addition to the intrinsic properties of electrochemical biosensing, its coupling with biomimetic materials has played a fundamental role, among which bioinspired phage and peptide probes stand out. The versatility in design and employment of these probes has opened an unimaginable plethora of possibilities for electrochemical biosensing, improving their performance far beyond the development of highly sensitive and selective devices. The state of the art offers robust electroanalytical biotools, capable of operating in complex samples and with exciting opportunities to discover and determine targets regardless of their toxicity and size, the commercial availability of bioreceptors, and prior knowledge of molecular interactions. With all this in mind, this review offers a panoramic, novel, and updated vision of both the tremendous advances and opportunities offered by the combination of electrochemical biosensors with bioinspired phage and peptide probes and the challenges and research efforts that are envisioned in the immediate future.
    Language English
    Publishing date 2024-04-19
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 201093-8
    ISSN 1618-2650 ; 0016-1152 ; 0372-7920
    ISSN (online) 1618-2650
    ISSN 0016-1152 ; 0372-7920
    DOI 10.1007/s00216-024-05294-w
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  2. Article ; Online: Patient safety climate research in primary care dentistry: A systematic scoping review.

    Ensaldo-Carrasco, Eduardo / Álvarez-Hernandez, Luis Alvaro / Peralta-Pedrero, María Luisa / Aceves-González, Carlos

    Journal of public health dentistry

    2024  

    Abstract: Background: Patient safety climate constitutes an important element for quality improvement. Its current evidence base has been generated in hospital settings in developed countries. Studies in dentistry are limited.: Objective: To systematically ... ...

    Abstract Background: Patient safety climate constitutes an important element for quality improvement. Its current evidence base has been generated in hospital settings in developed countries. Studies in dentistry are limited.
    Objective: To systematically explore the evidence regarding assessing patient safety climate in dentistry.
    Methods: We developed a search strategy to explore MEDLINE, SCOPUS, and Web of Science databases from January 1st, 2002, to December 31st, 2022, to include observational studies on patient safety culture or patient safety climate assessment. Methodological features and item data concerning the dimensions employed for assessment were extracted and thematically analyzed. Reported scores were also collected.
    Results: Nine articles out of 5584 were included in this study. Most studies were generated from high-income economies. Our analysis revealed methodological variations. Non-randomized samples were employed (ranging from 139 to 656 participants), and response rates varied from 28% to 93.7%. Three types of measurement instruments have been adapted to assess patient safety climate. These mainly consisted of replacing words or rewording sentences. Only one study employed an instrument previously validated through psychometric methods. In general, patient safety climate levels were either low or neutral. Only one study reported scores equal to or greater than 75.
    Discussion: Despite diverse assessment tools, our two-decade analysis reveals a lag compared with medicine, resulting in methodological variations for assessing patient safety climate. Collaboration is vital to elevate standards, prioritize patient safety across oral healthcare services, and advocate for integrating safety climate into local and national quality and patient safety strategies.
    Language English
    Publishing date 2024-04-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410719-6
    ISSN 1752-7325 ; 0022-4006
    ISSN (online) 1752-7325
    ISSN 0022-4006
    DOI 10.1111/jphd.12621
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    Zs.B 801: Show issues Location:
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  3. Article ; Online: Affinity bioelectroanalysis in cellular-level biomarker driven modern precision cancer diagnosis

    Campuzano, Susana / Gamella, Maria / Pedrero, María / Pingarrón, José M.

    Trends in Analytical Chemistry. 2023 June, v. 163 p.117064-

    2023  

    Abstract: The increasingly prominent role played by precision, equitable and sustainable diagnosis, particularly of prevalent and highly heterogeneous diseases, based on the determination and characterization of biomarkers of cellular origin in liquid biopsy, such ...

    Abstract The increasingly prominent role played by precision, equitable and sustainable diagnosis, particularly of prevalent and highly heterogeneous diseases, based on the determination and characterization of biomarkers of cellular origin in liquid biopsy, such as whole cells, their secretomes and the exosomes they release, is unquestionable. Electrochemical biosensing and biosensors, mainly those involving affinity reactions, have emerged in recent years as competitive analytical alternatives to address these challenging targets versus other existing strategies in terms of simplicity, cost and compatibility with multiplexed or multi-omics point-of-care determinations. This review article aims to put on the table in a concise, accurate and updated way the fundamentals, versatility and opportunities provided by state-of-the-art electrochemical biosensing (2018–2022) for the determination of these cellular-derived biomarkers. A more critical and personal view of the challenges to be faced in the shorter term and where future research and advances are expected to go is also given.
    Keywords analytical chemistry ; biomarkers ; biopsy ; biosensors ; electrochemistry ; exosomes ; multiomics ; point-of-care systems ; Affinity biosensing ; Electrochemical ; Cells ; Secretomes ; Cancer ; Precision diagnosis
    Language English
    Dates of publication 2023-06
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2014041-1
    ISSN 0165-9936
    ISSN 0165-9936
    DOI 10.1016/j.trac.2023.117064
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Dose-Adjusted FRAX Score in Pemphigus Vulgaris Treatment.

    Guzmán-Herrera, Saúl / Morales-Sánchez, Martha A / Peralta-Pedrero, María L / de Peña-Ortiz, Josefina / Cruz, Fermín J S

    Indian journal of dermatology

    2024  Volume 68, Issue 6, Page(s) 698–700

    Language English
    Publishing date 2024-01-09
    Publishing country India
    Document type Journal Article
    ZDB-ID 416069-1
    ISSN 1998-3611 ; 0019-5154
    ISSN (online) 1998-3611
    ISSN 0019-5154
    DOI 10.4103/ijd.ijd_1061_20
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  5. Article ; Online: Effect of adding a low glycemic load and index diet over 12 weeks in the treatment of moderate acne: a randomized controlled trial.

    Morales-Sánchez, Martha Alejandra / Camacho-Rosas, Laura Haydeé / García-Becerril, Ivan / Peralta-Pedrero, María Luisa

    International journal of dermatology

    2022  Volume 62, Issue 1, Page(s) e39–e42

    MeSH term(s) Humans ; Glycemic Load ; Acne Vulgaris/drug therapy ; Diet ; Blood Glucose
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2022-08-28
    Publishing country England
    Document type Randomized Controlled Trial ; Letter ; Comment
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.16418
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  6. Article ; Online: Low-dose oral isotretinoin in the treatment of recalcitrant facial flat warts: A clinical case and review of literature.

    Olguín-García, María Guadalupe / Peralta-Pedrero, María Luisa / Jurado-Santa Cruz, Fermín / Vega-Memije, Elisa / Morales-Sánchez, Martha Alejandra

    Health science reports

    2023  Volume 6, Issue 10, Page(s) e1633

    Abstract: Background and aims: The treatment of recalcitrant facial flat warts has always been challenging for dermatologists. The pain related to the application of the different treatments, side effects and costs are determining factors in the choice of therapy. ...

    Abstract Background and aims: The treatment of recalcitrant facial flat warts has always been challenging for dermatologists. The pain related to the application of the different treatments, side effects and costs are determining factors in the choice of therapy. To date, it is known that oral isotretinoin administered at a dose of 0.5 mg/kg/day is effective and safe; However, the different adverse effects reported have a dose-dependent behavior and they could limit their use. Our aim is to assess the effect of low-doses of oral isotretinoin to reducing side effects in the complete removal of recalcitrant facial flat warts and the current evidence in this regard.
    Methods: An extensive literature review was conducted to identify articles relating to low doses of oral isotretinoin for recalcitrant flat warts treatment, regardless of design up to May 2023.
    Results: The literature search yielded eight articles of 324 reviewed meeting criteria. Isotretinoin was administered in doses of 0.1-0.5 mg/kg/day. Complete elimination of the lesions occurred in 65.13% of the patients and a partial response in 19.26%. Four relapses were documented at the 4-month follow-up. The most frequent adverse effect was cheilitis.
    Conclusion: We might consider low doses of oral isotretinoin for the treatment of recalcitrant facial flat warts in which side effects need to be reduced. However, current published works have several limitations, including small sample sizes, lack of control group and follow-up periods. Larger, randomized, controlled studies are needed to verify the efficacy and safety of different doses of isotretinoin.
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Case Reports
    ISSN 2398-8835
    ISSN (online) 2398-8835
    DOI 10.1002/hsr2.1633
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  7. Article ; Online: Nanozymes in electrochemical affinity biosensing.

    Campuzano, Susana / Pedrero, María / Yáñez-Sedeño, Paloma / Pingarrón, José M

    Mikrochimica acta

    2020  Volume 187, Issue 8, Page(s) 423

    Abstract: Over the past decade, artificial nanomaterials that exhibit properties similar to those of enzymes are gaining attraction in electrochemical biosensing as highly stable and low-cost alternatives to enzymes. This review article discusses the main features ...

    Abstract Over the past decade, artificial nanomaterials that exhibit properties similar to those of enzymes are gaining attraction in electrochemical biosensing as highly stable and low-cost alternatives to enzymes. This review article discusses the main features of the various nanomaterials (metal oxide, metal, and carbon-based materials) explored so far to mimic different kinds of enzymes. The unprecedented opportunities imparted by these functional nanomaterials or their nanohybrids, mostly providing peroxidase-like activity, in electrochemical affinity biosensing are critically discussed mainly in connection with their use as catalytic labels or electrode surface modifiers by highlighting representative strategies reported in the past 5 years with application in the food, environmental, and biomedical fields. Apart from outlining the pros and cons of nanomaterial-based enzyme mimetics arising from the impressive development they have experienced over the last few years, current challenges and future directions for achieving their widespread use and exploiting their full potential in the development of electrochemical biosensors are discussed. Graphical abstract.
    MeSH term(s) Antibodies, Immobilized/immunology ; Aptamers, Nucleotide/chemistry ; Bacteria/immunology ; Bacteria/isolation & purification ; Biosensing Techniques/methods ; Catalysis ; Electrochemical Techniques/methods ; Humans ; Immunoassay ; Metal Nanoparticles/chemistry
    Chemical Substances Antibodies, Immobilized ; Aptamers, Nucleotide
    Language English
    Publishing date 2020-07-03
    Publishing country Austria
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 89-9
    ISSN 1436-5073 ; 0026-3672
    ISSN (online) 1436-5073
    ISSN 0026-3672
    DOI 10.1007/s00604-020-04390-9
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  8. Article ; Online: Interventions for preventing keratinocytic cancer in patients with a history of a previous keratinocytic carcinoma: A systematic review.

    García-Alonso, María José / Peralta-Pedrero, María Luisa / Jurado-Santa Cruz, Fermín / Morales-Sánchez, Martha Alejandra

    International journal of dermatology

    2022  Volume 62, Issue 3, Page(s) 302–311

    Abstract: Keratinocyte cancer (KC) is the most common cancer worldwide. It is important to analyze the actual interventions that are available for the prevention of patients with a previous history of a KC. We aim to review the existent literature to assess the ... ...

    Abstract Keratinocyte cancer (KC) is the most common cancer worldwide. It is important to analyze the actual interventions that are available for the prevention of patients with a previous history of a KC. We aim to review the existent literature to assess the efficacy and safety of interventions to prevent KC in patients with a history of previous KC. We searched clinical trials in which the main outcome was the prevention of KC in patients with a previous history of KC using the strategy published in the International Prospective Register of Systematic Reviews (PROSPERO registry), CRD42016045981. We analyzed 18 clinical trials from which eight reported a benefit with their respective intervention but had methodological flaws and a variable risk of bias. Two clinical trials (regarding celecoxib and oral supplementation with nicotinamide) seemed to have the most beneficial results reducing the incidence of KC in treated groups. However, all of the studies are highly heterogeneous, which does not allow a meta-analysis to be performed. New studies with greater epidemiological value should be conducted.
    MeSH term(s) Humans ; Carcinoma
    Language English
    Publishing date 2022-05-05
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.16225
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  9. Article ; Online: Keratosis Pilaris Treatment: Evidence from Intervention Studies.

    Suástegui-Rodríguez, Irvin / Camacho-Rosas, Laura Haydeé / Peralta-Pedrero, María Luisa / Cruz, Fermín Jurado-Santa / Morales-Sánchez, Martha Alejandra

    Skinmed

    2022  Volume 20, Issue 4, Page(s) 258–271

    Abstract: Keratosis pilaris is a common dermatosis observed in daily dermatologic practice. The diagnosis is clinical and usually asymptomatic, although sometimes patients may complain of mild pruritus and its cosmetic appearance. Few reports exist about its ... ...

    Abstract Keratosis pilaris is a common dermatosis observed in daily dermatologic practice. The diagnosis is clinical and usually asymptomatic, although sometimes patients may complain of mild pruritus and its cosmetic appearance. Few reports exist about its treatment. There are clinical trials assessing topical treatments and laser surgery, but no systematic reviews on its management were found in literature. An online research was conducted to identify evidence-based recommendations. Lactic acid, salicylic acid, and the 1064-nm Nd:YAG laser seem to be the most effective and safe treatment options for keratosis pilaris among patients aged 12 years and older; however, high-quality randomized controlled trials with long-term outcomes are required. (
    MeSH term(s) Abnormalities, Multiple ; Darier Disease/diagnosis ; Darier Disease/therapy ; Eyebrows/abnormalities ; Humans ; Lasers, Solid-State/therapeutic use ; Treatment Outcome
    Language English
    Publishing date 2022-08-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171125-2
    ISSN 1751-7125 ; 1540-9740
    ISSN (online) 1751-7125
    ISSN 1540-9740
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  10. Article ; Online: Dextran-coated nanoparticles as immunosensing platforms: Consideration of polyaldehyde density, nanoparticle size and functionality.

    Gao, Shipeng / Torrente-Rodríguez, Rebeca M / Pedrero, María / Pingarrón, José M / Campuzano, Susana / Rocha-Martin, Javier / Guisán, José M

    Talanta

    2022  Volume 247, Page(s) 123549

    Abstract: Magnetic nanoparticles (MNPs) can be used as antibody carriers in a wide range of immunosensing applications. The conjugation chemistry for preparing antibody-MNP bionanohybrids should assure the nanoparticle's colloidal dispersity, directional ... ...

    Abstract Magnetic nanoparticles (MNPs) can be used as antibody carriers in a wide range of immunosensing applications. The conjugation chemistry for preparing antibody-MNP bionanohybrids should assure the nanoparticle's colloidal dispersity, directional conformation and high biofunctionality retention of attached antibodies. In this work, peroxidase (HRP) was selected as model target analyte, and stable antibody-MNP conjugates were prepared using polyaldehyde-dextrans as multivalent linkers, also to prevent nanoparticles agglomeration and steric shielding of non-specific proteins. Under the manipulation of the oxidation variables, MNP-conjugated antibody showed the highest Fab accessibility, of 1.32 μmol analyte per μmol antibody, corresponding to 139 μmol aldehyde per gram of nanocarrier (5 mM NaIO
    MeSH term(s) Antibodies ; Biosensing Techniques/methods ; Dextrans/chemistry ; Immunoassay/methods ; Magnetics ; Magnetite Nanoparticles/chemistry ; Nanoparticles/chemistry
    Chemical Substances Antibodies ; Dextrans ; Magnetite Nanoparticles
    Language English
    Publishing date 2022-05-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2022.123549
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