Article ; Online: Recurrent laryngeal papillomatosis: multimodal therapeutic strategies. Literature review and multicentre retrospective study.
2023 Volume 43, Issue Suppl. 1, Page(s) S111–S122
Abstract: Objectives: Recurrent respiratory papillomatosis (RRP) is a benign, rare disease caused by Human Papilloma Virus (HPV) that can be divided into juvenile and adult forms. The course of the disease is variable, but is usually more aggressive in the ... ...
| Abstract | Objectives: Recurrent respiratory papillomatosis (RRP) is a benign, rare disease caused by Human Papilloma Virus (HPV) that can be divided into juvenile and adult forms. The course of the disease is variable, but is usually more aggressive in the juvenile form. The standard surgical treatment is represented by CO Methods: A retrospective analysis of the clinical charts of all patients affected by laryngeal papillomatosis and treated in three different University Centres between 2002 and 2022 was performed. The following parameters were collected: sex, age at first evaluation, sites of larynx involved, HPV type, type of first surgical treatment, presence and number of recurrences, surgical treatment of recurrences, adjuvant therapies, side effects and status at last follow-up. Results: Seventy-eight patients were available for evaluation. Of these, 88% had adult onset RRP (Ao-RRP) and 12% juvenile onset RRP (Jo-RRP). The glottis was the most frequently involved subsite; all patients were submitted to surgical resection with CO Conclusions: Our results confirmed the literature review. RRP is a potentially aggressive disease, especially in juvenile onset. Surgical resection is still first-line treatment, but in case of multiple recurrences the use of adjuvant therapies must be taken into consideration. |
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| MeSH term(s) | Adult ; Child ; Humans ; Retrospective Studies ; Papillomavirus Infections/complications ; Papillomavirus Infections/therapy ; Carbon Dioxide ; Papilloma/surgery ; Human Papillomavirus Viruses ; Multicenter Studies as Topic |
| Chemical Substances | Carbon Dioxide (142M471B3J) |
| Language | English |
| Publishing date | 2023-09-11 |
| Publishing country | Italy |
| Document type | Journal Article ; Review |
| ZDB-ID | 604898-5 |
| ISSN | 1827-675X ; 0392-100X |
| ISSN (online) | 1827-675X |
| ISSN | 0392-100X |
| DOI | 10.14639/0392-100X-suppl.1-43-2023-14 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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