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  1. Artikel: Fluid warming with parylene-coated enFlow cartridge: Bench and pilot animal study of aluminum extraction due to prolonged use.

    Waldmann, Andreas D / Rose, Edward A / Pedro, Michael J

    SAGE open medicine

    2021  Band 9, Seite(n) 20503121211026849

    Abstract: Objectives: Intravenous fluid warming devices with surface heating systems transfer heat using aluminum blocks, which if uncoated elute toxic levels of aluminum into the infusate. This study examined extractable aluminum detected from prolonged use of ... ...

    Abstract Objectives: Intravenous fluid warming devices with surface heating systems transfer heat using aluminum blocks, which if uncoated elute toxic levels of aluminum into the infusate. This study examined extractable aluminum detected from prolonged use of the updated version of the enFlow
    Methods: In dynamic bench tests, we measured the concentration of aluminum that leached into three solutions (Sterofundin ISO, Plasma-Lyte 148, and whole blood) that were continuously pumped (0.2 and 5.5 mL min
    Results: The enFlow cartridge (parylene-coated) demonstrated low toxicological risks in all tests. Sterofundin ISO resulted in the highest aluminum concentration after simulated prolonged use of the enFlow cartridge (parylene-coated) (3.11 μg device
    Conclusion: Observed toxicological risk levels associated with the enFlow cartridge (parylene-coated) intravenous fluid warmer were below those set by the Food and Drug Administration and suggest that the use of enFlow cartridge (parylene-coated) is safe with a variety of intravenous solution types and in different therapeutic scenarios.
    Sprache Englisch
    Erscheinungsdatum 2021-06-19
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2735399-0
    ISSN 2050-3121
    ISSN 2050-3121
    DOI 10.1177/20503121211026849
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Sepsis en pediatría

    Pedro Michael Baique-Sánchez

    Anales de la Facultad de Medicina, Vol 78, Iss 3, Pp 333-

    nuevos conceptos

    2017  Band 342

    Abstract: La sepsis es una de las principales causas de mortalidad en adultos y en niños. El impacto es negativo en la salud de la población, y los gastos generados en el sistema de salud se los calcula en varios miles de millones de dólares. La muerte infantil a ... ...

    Abstract La sepsis es una de las principales causas de mortalidad en adultos y en niños. El impacto es negativo en la salud de la población, y los gastos generados en el sistema de salud se los calcula en varios miles de millones de dólares. La muerte infantil a nivel mundial representa por décadas una compleja y progresiva enfermedad inflamatoria secundaria a un agente infeccioso, la cual origina disoxia tisular y eventualmente falla celular y orgánica, sin necesariamente pasar por hipotensión en etapas tempranas sino en etapas tardías de enfermedad. En la presente publicación se actualiza las definiciones realizadas a partir del Tercer Consenso de Definiciones de Sepsis y Choque Séptico y las Campañas Internacionales Sobreviviendo a la Sepsis, tomando como referencia un mejor entendimiento de la patobiología de la enfermedad. Se aborda la necesidad de usar un puntaje de disfunción de órganos en niños para valorar y predecir la mortalidad de una mejor manera y realizar ensayos clínicos. El objetivo de este artículo es dar a conocer el estado actual del conocimiento en la parte operacional de definiciones y la sugerencia de adaptar los conceptos a las guías clínicas nacionales.
    Schlagwörter sepsis ; choque séptico ; disfunción multiorgánica ; puntaje ; Medicine ; R ; Medicine (General) ; R5-920
    Sprache Spanisch
    Erscheinungsdatum 2017-11-01T00:00:00Z
    Verlag Universidad Nacional Mayor de San Marcos
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Automated Near Real-Time Ventilator Data Feedback Reduces Incidence of Ventilator-Associated Events: A Retrospective Observational Study.

    Augustus Oglesby, Harold Julius / Cataldo, Steven H / Pedro, Michael J

    Critical care explorations

    2021  Band 3, Heft 4, Seite(n) e0379

    Abstract: Objectives: Critical care teams are encouraged to follow best practice protocols to help wean mechanically ventilated patients from the ventilator to reduce ventilator-associated events including ventilator-associated conditions, probable ventilator- ... ...

    Abstract Objectives: Critical care teams are encouraged to follow best practice protocols to help wean mechanically ventilated patients from the ventilator to reduce ventilator-associated events including ventilator-associated conditions, probable ventilator-associated pneumonias, and infection-related ventilator-associated conditions. Providers monitor for alerts suggestive of possible ventilator-associated events and advise when patients should undergo spontaneous breathing trials. Compliance with protocols in most units is suboptimal.
    Design: Retrospective review of clinical data over 24 months.
    Setting: St. Joseph Mercy Hospital Candler Hospital Medical-Surgical ICU.
    Patients: All mechanically ventilated patients.
    Interventions: The Respiratory Knowledge Portal was implemented in our ICU. For 13 months, Respiratory Knowledge Portal data were ported to ICU workstations (control). For the following 11 months, Respiratory Knowledge Portal data were also presented on tablet computers (intervention) for use during multidisciplinary rounds. We performed a retrospective review of Respiratory Knowledge Portal data from before and after the implementation of the tablet computers.
    Measurements and main results: Data were collected from 337 patients (187 control group, 150 intervention group). A decrease in the occurrence of ventilator-associated events was observed during the intervention group compared with the control group. Only 2.0% of patients in the intervention group experienced any category of ventilator-associated event, while 11.2% of patients in the control group experienced one event (
    Conclusions: Fewer ventilator-associated events, ventilator-associated conditions, infection-related ventilator-associated conditions, and probable ventilator-associated pneumonias were seen during the period when Respiratory Knowledge Portal monitoring data was presented on tablet computers. There was no difference in time on ventilator nor overall length of stay.
    Sprache Englisch
    Erscheinungsdatum 2021-04-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2639-8028
    ISSN (online) 2639-8028
    DOI 10.1097/CCE.0000000000000379
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Buch ; Audio / Video ; Dissertation / Habilitation: Zur funktionellen Morphologie des Subarachnoidalraumes unter akut entzündlichen Bedingungen

    Faustmann, Pedro

    (Berichte aus der Medizin)

    1997  

    Verfasserangabe Pedro Michael Faustmann
    Serientitel Berichte aus der Medizin
    Schlagwörter Bakterielle Hirnhautentzündung ; Subarachnoidalraum ; Allgemeine Entzündungsreaktion ; Pathophysiologie ; Tiermodell
    Schlagwörter Pathologische Physiologie ; Physiologische Pathologie ; Physiopathologie ; Generalisierte Entzündungsreaktion ; Systemic inflammatory response syndrome ; SIRS ; Syndrom der systemischen inflammatorischen Antwort ; Subarachnoidealraum ; Cavitas subarachnoidea ; Bakterielle Meningitis
    Sprache Deutsch
    Umfang 153 S. : Ill., graph. Darst.
    Ausgabenhinweis Als Ms. gedr.
    Verlag Shaker
    Erscheinungsort Aachen
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Audio / Video ; Dissertation / Habilitation
    Dissertation / Habilitation Essen, Univ., Habil.-Schr., 1997. - Erweiterung der Venia Legendi: Bochum, Univ., Habil.-Schrift, 1998
    HBZ-ID HT007966096
    ISBN 3-8265-2927-8 ; 978-3-8265-2927-6
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  5. Artikel ; Online: Impact of parylene coating on heating performance of intravenous fluid warmer: a bench study.

    Bayoro, Danielle K / Groepenhoff, Herman / Hoolihan, Daniel / Rose, Edward A / Pedro, Michael J / Waldmann, Andreas D

    BMC anesthesiology

    2022  Band 22, Heft 1, Seite(n) 44

    Abstract: Background: Perioperative hypothermia is a common occurrence, particularly with the elderly and pediatric age groups. Hypothermia is associated with an increased risk of perioperative complications. One method of preventing hypothermia is warming the ... ...

    Abstract Background: Perioperative hypothermia is a common occurrence, particularly with the elderly and pediatric age groups. Hypothermia is associated with an increased risk of perioperative complications. One method of preventing hypothermia is warming the infused fluids given during surgery. The enFlow™ intravenous fluid warmer has recently been reintroduced with a parylene coating on its heating blocks. In this paper, we evaluated the impact of the parylene coating on the new enFlow's fluid warming capacity.
    Methods: Six coated and six uncoated enFlow cartridges were used. A solution of 10% propylene glycol and 90% distilled H
    Results: The parylene coated fluid warming cartridge delivered very stable output of 40 °C temperatures at flow rates of 2, 10, and 50 ml/min regardless of the temperature of the infusate. At higher flow rates, the cartridges were not able to achieve the target temperature with the colder fluid. Both cartridges performed with similar efficacy across all flow rates at all temperatures.
    Conclusions: At low flow rates, the parylene coated enFlow cartridges was comparable to the original uncoated cartridges. At higher flow rates, the coated and uncoated cartridges were not able to achieve the target temperature. The parylene coating on the aluminum heating blocks of the new enFlow intravenous fluid warmer does not negatively affect its performance compared to the uncoated model.
    Mesh-Begriff(e) Administration, Intravenous/methods ; Equipment Design ; Heating/instrumentation ; Heating/methods ; Humans ; Infusions, Intravenous ; Polymers ; Xylenes
    Chemische Substanzen Polymers ; Xylenes ; parylene (25722-33-2)
    Sprache Englisch
    Erscheinungsdatum 2022-02-10
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2091252-3
    ISSN 1471-2253 ; 1471-2253
    ISSN (online) 1471-2253
    ISSN 1471-2253
    DOI 10.1186/s12871-022-01585-w
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Levels of leachable elements from long-term use of enFlow fluid warmer.

    Bayoro, Danielle / Groepenhoff, Herman / Pedro, Michael / Rose, Edward A / Waldmann, Andreas D

    SAGE open medicine

    2022  Band 10, Seite(n) 20503121221108927

    Abstract: Objective: In the delivery of intravenous fluids, in-line warming devices frequently transfer heat using a metal heating plate, which if uncoated can risk elution. This bench study examined extractable elements detected following long-term use of the ... ...

    Abstract Objective: In the delivery of intravenous fluids, in-line warming devices frequently transfer heat using a metal heating plate, which if uncoated can risk elution. This bench study examined extractable elements detected following long-term use of the parylene-coated enFlow
    Methods: We tested 16 clinically relevant challenge fluids typical of the surgical setting, including commercially available single donor blood and blood products as well as intravenous saline and electrolyte solutions. After 72 h of warming at 40°C (104°F) via the enFlow, analytical chemistry identified and quantified the most clinically significant extractable elements (arsenic, barium, cadmium, copper, and lead) to estimate chemical exposure. We also measured the extracted concentrations of these five elements following simulated use of the device with three solutions (Sterofundin ISO, Plasma-Lyte 148, and whole blood) that were pumped through the warmed device at two different flow rates (0.2 and 5.5 mL min
    Results: Across all scenarios of acute and long-term exposures for different populations, the enFlow demonstrated low toxicological risks as measured by the calculation of tolerable exposure for extracted arsenic, barium, cadmium, copper, and lead.
    Conclusion: The results suggest biological safety for the use of parylene-coated enFlow with a variety of intravenous solutions and in different therapeutic scenarios.
    Sprache Englisch
    Erscheinungsdatum 2022-07-05
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2735399-0
    ISSN 2050-3121
    ISSN 2050-3121
    DOI 10.1177/20503121221108927
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Funktionelle Neuroanatomie posttraumatischer und akuter Belastungsstörungen

    Faustmann, Pedro Michael

    Praxis der Rechtspsychologie

    2015  Band 25, Heft 1-2, Seite(n) 109–122

    Abstract: In dieser Übersicht werden die Symptome akuter und posttraumatischer Belastungsstörungen aus neuroanatomischer Sicht als Überaktivierung hirnentwicklungsgeschichtlich alter Gehirnanteile des limbischen Systems und verminderter Aktivität des Neocortex des ...

    Titelübersetzung Functional neuroanatomy of posttraumatic and acute stress disorders
    Abstract In dieser Übersicht werden die Symptome akuter und posttraumatischer Belastungsstörungen aus neuroanatomischer Sicht als Überaktivierung hirnentwicklungsgeschichtlich alter Gehirnanteile des limbischen Systems und verminderter Aktivität des Neocortex des menschlichen Gehirns vorgestellt. Die funktionelle Neuroanatomie beinhaltet die Benennung der makroskopisch anatomischen Strukturen dieser Gehirnanteile sowie die aktuellen Studien zur funktionellen Bildgebung. Auf zellulärer Ebene werden Störungen bestimmter Neuronenpopulationen im frontalen Cingulum diskutiert und die glialen Zellen (Astroglia und Mikroglia) als die die Gehirnaktivität auch unter pathophysiologischen Bedingungen mitregulierende Zellpopulation vorgestellt. Schließlich wird beschrieben, dass Medikamente (Antidepressiva), wie sie auch bei posttraumatischen Belastungsstörungen eingesetzt werden, unter experimentellen Bedingungen der Zellkultur regulierend auf gliale Zellen des Zentralen Nervensystems wirken.
    Schlagwörter Acute Stress ; Acute Stress Disorder ; Akute Stressstörung ; Akuter Stress ; Antidepressant Drugs ; Antidepressiva ; Astrocytes ; Astrozyten ; Functional Magnetic Resonance Imaging ; Funktionelle Magnetresonanztomographie ; Limbic System ; Limbisches System ; Neuroanatomie ; Neuroanatomy ; Neuroglia ; Pathophysiologie ; Pathophysiology ; Posttraumatic Stress Disorder ; Posttraumatische Belastungsstörung
    Sprache Deutsch
    Dokumenttyp Artikel
    ZDB-ID 1173568-5
    ISSN 0939-9062
    ISSN 0939-9062
    Datenquelle PSYNDEX

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  8. Buch ; Dissertation / Habilitation: Entwicklung eines Modells zur Induktion akut entzündlicher Reaktionen an zerebralen Gefäßen

    Faustmann, Pedro

    1985  

    Verfasserangabe von Pedro Michael Faustmann
    Umfang 82, [80] Bl. : zahlr. Ill., graph. Darst.
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Essen, Univ., Diss., 1986
    Anmerkung Enth.: Textbd. u. Bildbd.
    HBZ-ID HT002651516
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  9. Artikel ; Online: Clinical and epidemiological characteristics of children with SARS-CoV-2 infection admitted to a Peruvian hospital

    Ricardo Rodriguez-Portilla / Patricia Llaque-Quiroz / Claudia Guerra-Ríos / Liliana Paola Cieza-Yamunaqué / Edgar Juan Coila-Paricahua / Pedro Michael Baique-Sánchez / Isabel Pinedo-Torres

    Revista Peruana de Medicina Experimental y Salud Pública, Vol 38, Iss 2, Pp 261-

    2021  Band 6

    Abstract: We carried out an observational, retrospective and descriptive study in order to identify the clinical and epidemiological characteristics of children with SARS-CoV-2 infection admitted to a Peruvian national referral hospital. We included patients from ... ...

    Abstract We carried out an observational, retrospective and descriptive study in order to identify the clinical and epidemiological characteristics of children with SARS-CoV-2 infection admitted to a Peruvian national referral hospital. We included patients from one month old to fourteen years old hospitalized between March and August 2020. A total of 125 patients with SARS-CoV-2 infection were admitted, 18.4% (n = 23) had critical illness and 16.8% (n = 21) had multisystem inflammatory syndrome (MIS-C). The absence of comorbidities and previous history of epidemiological contact were more frequent in patients with MIS-C. Patients in critical condition and patients with MIS-C had lower lymphocyte and platelet counts, and higher C-reactive protein, ferritin and D-dimer values than patients who did not have said conditions. Six (4.8%) out of 125 children died, as well as 3 (13%) children from the group of patients in critical condition. None of the children with MIS-C died.
    Schlagwörter sars-cov-2 ; síndrome mucocutáneo linfonodular ; enfermedad crítica ; epidemiología ; signos y síntomas ; niños ; Medicine ; R ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Spanisch
    Erscheinungsdatum 2021-08-01T00:00:00Z
    Verlag Instituto Nacional de Salud
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel: Observation of Aerosol Generation by Human Subjects During Cardiopulmonary Exercise Testing Using a High-Powered Laser Technique: A Pilot Project.

    Varga, Christopher M / Kwiatkowski, Keith J / Pedro, Michael J / Groepenhoff, Herman / Rose, Edward A / Gray, Callum / Pinkerton, Kai D / McBride, Michael G / Paridon, Stephen M

    Journal of medical and biological engineering

    2022  Band 42, Heft 1, Seite(n) 1–10

    Abstract: Purpose: Human respiratory aerosols may have important implications for transmission of pathogens. The study of aerosol production during vigorous breathing activities such as exercise is limited. In particular, data on aerosol production during ... ...

    Abstract Purpose: Human respiratory aerosols may have important implications for transmission of pathogens. The study of aerosol production during vigorous breathing activities such as exercise is limited. In particular, data on aerosol production during cardiopulmonary exercise testing (CPET) are lacking.
    Methods: In this pilot project, we used a high-powered, pulsed Nd:YAG laser to illuminate a region of interest in front of two healthy adult subjects during CPET. Subjects exercised to the point of respiratory compensation. Images were captured with a high-speed, high-resolution camera to determine net exhaled particle (NEP) counts at different phases of CPET, including resting breathing, submaximal exercise, peak exercise, and active recovery. Experiments were performed with the room ventilation activated.
    Results: Net exhaled particle counts remained relatively constant until late/peak exercise when they decreased prior to rebounding into recovery. NEP counts at resting breathing were higher than those reported using other methods of measurement. Exhaled particles were in the submicron size range.
    Conclusion: Our method of aerosol particle quantification enables measurement of significant quantities of ultrafine particles and dynamic assessment of aerosol production during CPET. The unique pattern of aerosol production observed during submaximal and peak exercise suggests that extension of results from resting breathing to CPET may not be appropriate.
    Sprache Englisch
    Erscheinungsdatum 2022-01-23
    Erscheinungsland China
    Dokumenttyp Journal Article
    ZDB-ID 2755178-7
    ISSN 2199-4757 ; 1609-0985
    ISSN (online) 2199-4757
    ISSN 1609-0985
    DOI 10.1007/s40846-021-00675-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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