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  1. Article ; Online: Paravalvular Leakages after Surgical Aortic-Valve Replacement and after Transcatheter Aortic-Valve Implantation

    Xavier Freixa / Rami Gabani / Pedro Cepas-Guillén / Eduardo Flores-Umanzor / Rodrigo Estévez-Loureiro / Eustaquio Maria Onorato

    Journal of Clinical Medicine, Vol 11, Iss 2989, p

    Strategies to Increase the Success Rate of Percutaneous Closure

    2022  Volume 2989

    Abstract: Moderate to severe paravalvular-leak (PVL) regurgitation after surgical aortic-valve replacement or after transcatheter valve implantation represents a well-known complication associated with symptoms related to heart failure, hemolysis, or both in ... ...

    Abstract Moderate to severe paravalvular-leak (PVL) regurgitation after surgical aortic-valve replacement or after transcatheter valve implantation represents a well-known complication associated with symptoms related to heart failure, hemolysis, or both in patients with multiple comorbidities and with poor prognostic outcomes. The transcatheter closure of aortic paravalvular leaks (APVLs) is currently considered a valid alternative to cardiac surgery. Nevertheless, careful patient selection, optimal cardiac imaging for intraprocedural guidance, and expert operators are key for success. Although technically demanding, particularly in APVLs after transcatheter valve implantation, catheter-based closure is an effective, less invasive, and often the only option for high-risk patients with symptomatic PVL regurgitation.
    Keywords paravalvular leak ; transcatheter closure ; surgical aortic-valve replacement ; transcatheter ; aortic-valve replacement ; paravalvular-leak regurgitation ; Medicine ; R
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Cierre de la orejuela izquierda frente a anticoagulantes orales en FA e implante de stents coronarios. Registro DESAFIO

    José Ramón López-Mínguez / Estrella Suárez-Corchuelo / Sergio López-Tejero / Luis Nombela-Franco / Xavier Freixa-Rofastes / Guillermo Bastos-Fernández / Xavier Millán-Álvarez / Raúl Moreno-Gómez / José Antonio Fernández-Díaz / Ignacio Amat-Santos / Tomás Benito-Gonzále / Fernando Alfonso-Manterola / Pablo Salinas-Sanguino / Pedro Cepas-Guillén / Dabit Arzamendi / Ignacio Cruz-González / Juan Manuel Nogales-Asensio

    REC: Interventional Cardiology, Vol 5, Iss 4, Pp 287-

    2023  Volume 296

    Abstract: RESUMEN Introducción y objetivos: El tratamiento de los pacientes con fibrilación auricular no valvular (FANV) que requieren implante de stents coronarios es un desafío. El objetivo del estudio fue investigar si el cierre de la orejuela izquierda (COI) ... ...

    Abstract RESUMEN Introducción y objetivos: El tratamiento de los pacientes con fibrilación auricular no valvular (FANV) que requieren implante de stents coronarios es un desafío. El objetivo del estudio fue investigar si el cierre de la orejuela izquierda (COI) podría ser una opción posible y beneficiosa para estos pacientes. Para ello, se analiza el impacto del COI más tratamiento antiagregante plaquetario (AP) en comparación con la combinación de anticoagulantes orales (ACO), incluidos los ACO directos, y tratamiento AP en los resultados a largo plazo de estos pacientes Métodos: Se analizaron los resultados de 207 pacientes con FANV sometidos consecutivamente a implante de stents coronarios. Recibieron ACO 146 pacientes (74 acenocumarol, 71 ACO de acción directa) y en 61 se realizó COI. La mediana de seguimiento fue de 35 meses. Los pacientes también recibieron tratamiento AP por prescripción de su cardiólogo. El estudio recibió la debida supervisión ética. Resultados: La edad (media: 75,7 años) y el antecedente de accidente vascular cerebral fueron similares en ambos grupos, aunque el grupo de COI presentó más características desfavorables (antecedente de enfermedad de las arterias coronarias [CHA2DS2-VASc], antecedente de hemorragias significativas [BARC ≥ 2] y HAS-BLED). La aparición de acontecimientos adversos graves (muerte, accidente vascular cerebral, accidente isquémico transitorio, hemorragia grave) y cardiovasculares graves (muerte de causa cardiaca, acciden-te vascular cerebral, accidente isquémico transitorio, infarto de miocardio) fue significativamente mayor en el grupo de ACO que en el de COI: 19,75 frente a 9,06% (HR = 2,18; p = 0,008) y 6,37 frente a 1,91% (HR =3,34; p = 0,037), respectivamente. Conclusiones: La ...
    Keywords Stent ; Orejuela ; Fibrilación auricular ; Anticoagulantes ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Permanyer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Left atrial appendage occlusion vs oral anticoagulants in AF and coronary stenting. The DESAFIO registry

    José Ramón López-Mínguez / Estrella Suárez-Corchuelo / Sergio López-Tejero / Luis Nombela-Franco / Xavier Freixa-Rofastes / Guillermo Bastos-Fernández / Xavier Millán-Álvarez / Raúl Moreno-Gómez / José Antonio Fernández-Díaz / Ignacio Amat-Santos / Tomás Benito-González / Fernando Alfonso-Manterola / Pablo Salinas-Sanguino / Pedro Cepas-Guillén / Dabit Arzamendi / Ignacio Cruz-González / Juan Manuel Nogales-Asensio

    REC: Interventional Cardiology (English Ed.), Vol 5, Iss 4, Pp 287-

    2023  Volume 296

    Abstract: ABSTRACT Introduction and objectives: The treatment of patients with non-valvular atrial fibrillation (NVAF) who need coronary stenting is challenging. The objective of the study was to determine whether left atrial appendage occlusion (LAAO) could be a ... ...

    Abstract ABSTRACT Introduction and objectives: The treatment of patients with non-valvular atrial fibrillation (NVAF) who need coronary stenting is challenging. The objective of the study was to determine whether left atrial appendage occlusion (LAAO) could be a feasible option and benefit these patients. To this end, we studied the impact of LAAO plus antiplatelet drugs vs oral anticoagulants (OAC) (including direct OAC) plus antiplatelet drugs in these patients’ long-term outcomes. Methods: The results of 207 consecutive patients with NVAF who underwent coronary stenting were analyzed. A total of 146 patients were treated with OAC (75 with acenocoumarol, 71 with direct OAC) while 61 underwent LAAO. The median follow-up was 35 months. Patients also received antiplatelet therapy as prescribed by their cardiologist. The study received the proper ethical oversight. Results: Age (mean 75.7 years), and the past medical history of stroke were similar in both groups. However, the LAAO group had more unfavorable characteristics (history of coronary artery disease [CHA2DS2-VASc], and significant bleeding [BARC ≥ 2] and HAS-BLED). The occurrence of major adverse events (death, stroke/transient ischemic events, major bleeding) and major cardiovascular events (cardiac death, stroke/transient ischemic attack, and myocardial infarction) were significantly higher in the OAC group compared to the LAAO group: 19.75% vs 9.06% (HR, 2.18; P.= .008) and 6.37% vs 1.91% (HR, 3.34; P.= .037), respectively. Conclusions: In patients with NVAF undergoing coronary stenting, LAAO plus antiplatelet therapy produced better long-term outcomes compared to treatment with OAC plus antiplatelet therapy despite the unfavorable baseline characteristics of the LAAO group.
    Keywords Stents ; Atrial appendage ; Atrial fibrillation ; Anticoagulants ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Permanyer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Impact of time of intervention in patients with NSTEMI. The IMPACT-TIMING-GO trial design

    Felipe Díez-Delhoyo / Pablo Díez-Villanueva / María Thiscal López Lluva / María Abellas / Ignacio Amat-Santos / Pablo Bazal-Chacón / Anna Carrasquer / Miguel Corbí / David Escribano / Ane Elorriaga / Sergio García-Blas / Teresa Giralt-Borrell / Alfonso Jurado-Román / Isaac Llaó / Lucía Matute-Blanco / Martín Negreira-Caamaño / Lucía Pérez-Cebey / Ricardo Rivera-López / Carolina Robles-Gamboa /
    Pablo Salinas / Fernando José Torres Mezcúa / Iván Olavarri-Miguel / Jessica Vaquero-Luna / Pedro Cepas-Guillén

    REC: Interventional Cardiology (English Ed.), Vol 5, Iss 1, Pp 14-

    2023  Volume 19

    Abstract: ABSTRACT Introduction and objectives: The optimal time to perform a diagnostic coronary angiography in patients admitted due to non-ST-segment elevation acute coronary syndrome (NSTEACS) and start pretreatment with dual antiplatelet therapy is ... ...

    Abstract ABSTRACT Introduction and objectives: The optimal time to perform a diagnostic coronary angiography in patients admitted due to non-ST-segment elevation acute coronary syndrome (NSTEACS) and start pretreatment with dual antiplatelet therapy is controversial. Our study aims to identify the current diagnostic and therapeutic approach, and clinical progression of patients with NSTEACS in our country. Methods: The IMPACT-TIMING-GO trial (Impact of time of intervention in patients with myocardial infarction with non-ST segment elevation. Management and outcomes) is a national, observational, prospective, and multicenter registry that will include consecutive patients from 24 Spanish centers with a clinical diagnosis of NSTEACS treated with diagnostic coronary angiography and with present unstable or causal atherosclerotic coronary artery disease. The study primary endpoint is to assess the level of compliance to clinical practice guidelines in patients admitted due to NSTEACS undergoing coronary angiography in Spain, describe the use of antithrombotic treatment prior to cardiac catheterization, and register the time elapsed until it is performed. Major adverse cardiovascular events will also be described like all-cause mortality, non-fatal myocardial infarction and non-fatal stroke, and the rate of major bleeding according to the BARC (Bleeding Academic Research Consortium) scale at 1- and 3-year follow-up. Results: This study will provide more information on the impact of different early management strategies in patients admitted with NSTEACS in Spain, and the degree of implementation of current recommendations into the routine clinical practice. It will also provide information on these patients’ baseline and clinical characteristics. Conclusions: This is the first prospective study conducted in Spain that will be reporting on the early therapeutic strategies—both pharmacological and interventional—implemented in our country in patients with NSTEACS after the publication of the 2020 ...
    Keywords Acute coronary syndrome ; Acute myocardial infarction ; Non-ST-segment elevation acute coronary syndrome ; Dual antiplatelet therapy ; Pretreatment ; Early invasive strategy ; ESC guidelines ; Diabetes mellitus ; Hemorrhage ; Revascularization ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Permanyer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  5. Article ; Online: Impacto del tiempo de intervención en pacientes con IAMSEST

    Felipe Díez-Delhoyo / Pablo Díez-Villanueva / María Thiscal López Lluva / María Abellas / Ignacio Amat-Santos / Pablo Bazal-Chacón / Anna Carrasquer / Miguel Corbí / David Escribano / Ane Elorriaga / Sergio García-Blas / Teresa Giralt-Borrell / Alfonso Jurado-Román / Isaac Llaó / Lucía Matute-Blanco / Martín Negreira-Caamaño / Lucía Pérez-Cebey / Ricardo Rivera-López / Carolina Robles-Gamboa /
    Pablo Salinas / Fernando José Torres Mezcúa / Iván Olavarri-Miguel / Jessica Vaquero-Luna / Pedro Cepas-Guillén

    REC: Interventional Cardiology, Vol 5, Iss 1, Pp 14-

    diseño del estudio IMPACT-TIMING-GO

    2023  Volume 19

    Abstract: RESUMEN Introducción y objetivos: El momento óptimo para la realización de un cateterismo diagnóstico en pacientes con síndrome coronario agudo sin elevación del segmento ST (SCASEST) y la necesidad de pretratamiento con doble antiagregación son motivo ... ...

    Abstract RESUMEN Introducción y objetivos: El momento óptimo para la realización de un cateterismo diagnóstico en pacientes con síndrome coronario agudo sin elevación del segmento ST (SCASEST) y la necesidad de pretratamiento con doble antiagregación son motivo de controversia. Este estudio pretende conocer el abordaje diagnóstico y terapéutico actual, así como la evolución clínica de los pacientes con SCASEST en España. Métodos: El estudio IMPACT of Time of Intervention in patients with Myocardial Infarction with Non-ST seGment elevation. ManaGement and Outcomes (IMPACT-TIMING-GO) es un registro nacional observacional, prospectivo y multicéntrico, que incluirá pacientes consecutivos con diagnóstico de SCASEST tratados con coronariografía diagnóstica y que presenten enfermedad coronaria aterosclerótica inestable o causal en 24 centros españoles. El objetivo primario del estudio es conocer el grado de cumplimiento de las recomendaciones de las guías de práctica clínica en pacientes que ingresan por SCASEST tratados con coronariografía en España, describir el uso del tratamiento antitrombótico antes del cateterismo y determinar el tiempo hasta este en la práctica clínica real. Se describirán también los eventos adversos cardiovasculares mayores: mortalidad por cualquier causa, infarto no fatal e ictus no fatal, y también la incidencia de hemorragia mayor según la escala BARC (Bleeding Academic Research Consortium) durante el seguimiento a 1 y 3 años. Resultados: Este registro permitirá mejorar el conocimiento en relación con el abordaje terapéutico inicial en pacientes que ingresan por SCASEST en España. ...
    Keywords Síndrome coronario agudo ; Infarto agudo de miocardio ; Síndrome coronario agudo sin elevación del segmento ST ; Doble antiagregación plaquetaria ; Pretratamiento ; Coronariografía precoz ; Guía ESC ; Diabetes mellitus ; Hemorragia ; Revascularización ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Permanyer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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