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  1. Book ; Online: Automatic Parallelization of Software Network Functions

    Pereira, Francisco / Ramos, Fernando M. V. / Pedrosa, Luis

    2023  

    Abstract: Software network functions (NFs) trade-off flexibility and ease of deployment for an increased challenge of performance. The traditional way to increase NF performance is by distributing traffic to multiple CPU cores, but this poses a significant ... ...

    Abstract Software network functions (NFs) trade-off flexibility and ease of deployment for an increased challenge of performance. The traditional way to increase NF performance is by distributing traffic to multiple CPU cores, but this poses a significant challenge: how to parallelize an NF without breaking its semantics? We propose Maestro, a tool that analyzes a sequential implementation of an NF and automatically generates an enhanced parallel version that carefully configures the NIC's Receive Side Scaling mechanism to distribute traffic across cores, while preserving semantics. When possible, Maestro orchestrates a shared-nothing architecture, with each core operating independently without shared memory coordination, maximizing performance. Otherwise, Maestro choreographs a fine-grained read-write locking mechanism that optimizes operation for typical Internet traffic. We parallelized 8 software NFs and show that they generally scale-up linearly until bottlenecked by PCIe when using small packets or by 100Gbps line-rate with typical Internet traffic. Maestro further outperforms modern hardware-based transactional memory mechanisms, even for challenging parallel-unfriendly workloads.

    Comment: 21 pages, 14 figures, to be published in NSDI24
    Keywords Computer Science - Networking and Internet Architecture
    Subject code 303
    Publishing date 2023-07-27
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Clinical relevance of glucose metrics during the early brain injury period after aneurysmal subarachnoid hemorrhage: An opportunity for continuous glucose monitoring.

    Santana, Daniel / Mosteiro, Alejandra / Pedrosa, Leire / Llull, Laura / Torné, Ramón / Amaro, Sergi

    Frontiers in neurology

    2022  Volume 13, Page(s) 977307

    Abstract: Hyperglycaemia, hypoglycaemia and higher glucose variability during the Early Brain Injury (EBI) period of aneurysmal subarachnoid hemorrhage (aSAH) have been associated with poor clinical outcome. However, it is unclear whether these associations are ... ...

    Abstract Hyperglycaemia, hypoglycaemia and higher glucose variability during the Early Brain Injury (EBI) period of aneurysmal subarachnoid hemorrhage (aSAH) have been associated with poor clinical outcome. However, it is unclear whether these associations are due to direct glucose-driven injury or if hyperglycaemia simply acts as a marker of initial severity. Actually, strict glucose control with intensive insulin therapy has not been demonstrated as an effective strategy for improving clinical outcomes after aSAH. Currently published studies describing an association between hyperglycaemia and prognosis in aSAH patients have been based on isolated glucose measurements and did not incorporate comprehensive dynamic evaluations, such as those derived from subcutaneous continuous glucose monitoring devices (CMG). Arguably, a more accurate knowledge on glycaemic patterns during the acute phase of aSAH could increase our understanding of the relevance of glycaemia as a prognostic factor in this disease as well as to underpin its contribution to secondary focal and diffuse brain injury. Herein, we have summarized the available evidence on the diagnostic and prognostic relevance of glucose metrics during the acute phase of cerebrovascular diseases, focusing in the EBI period after aSAH. Overall, obtaining a more precise scope of acute longitudinal glucose profiles could eventually be useful for improving glucose management protocols in the setting of acute aSAH and to advance toward a more personalized management of aSAH patients during the EBI phase.
    Language English
    Publishing date 2022-09-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.977307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The Vascular Microenvironment in Glioblastoma: A Comprehensive Review.

    Mosteiro, Alejandra / Pedrosa, Leire / Ferrés, Abel / Diao, Diouldé / Sierra, Àngels / González, José Juan

    Biomedicines

    2022  Volume 10, Issue 6

    Abstract: Glioblastoma multiforme, the deadliest primary brain tumor, is characterized by an excessive and aberrant neovascularization. The initial expectations raised by anti-angiogenic drugs were soon tempered due to their limited efficacy in improving the ... ...

    Abstract Glioblastoma multiforme, the deadliest primary brain tumor, is characterized by an excessive and aberrant neovascularization. The initial expectations raised by anti-angiogenic drugs were soon tempered due to their limited efficacy in improving the overall survival. Intrinsic resistance and escape mechanisms against anti-VEGF therapies evidenced that tumor angiogenesis is an intricate multifaceted phenomenon and that vessels not only support the tumor but exert indispensable interactions for resistance and spreading. This holistic review covers the essentials of the vascular microenvironment of glioblastoma, including the perivascular niche components, the vascular generation patterns and the implicated signaling pathways, the endothelial-tumor interrelation, and the interconnection between vessel aberrancies and immune disarrangement. The revised concepts provide novel insights into the preclinical models and the potential explanations for the failure of conventional anti-angiogenic therapies, leading to an era of new and combined anti-angiogenic-based approaches.
    Language English
    Publishing date 2022-05-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10061285
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  4. Article: Effects of vitamin D supplementation on cardiometabolic parameters among patients with metabolic syndrome: A systematic review and GRADE evidence synthesis of randomized controlled trials.

    Aquino, Séphora / Cunha, Aline / Gomes Lima, Josivan / Sena-Evangelista, Karine / Gouveia Oliveira, Antonio / Cobucci, Ricardo Ney / Fc Pedrosa, Lucia

    Heliyon

    2023  Volume 9, Issue 11, Page(s) e20845

    Abstract: Various pathophysiologic mechanisms were proposed to underlie the effect of vitamin D on MetS components. In this systematic review, we reviewed randomized control clinical trials to verify whether vitamin D supplementation (VDS) at different doses is ... ...

    Abstract Various pathophysiologic mechanisms were proposed to underlie the effect of vitamin D on MetS components. In this systematic review, we reviewed randomized control clinical trials to verify whether vitamin D supplementation (VDS) at different doses is effective concomitantly in controlling high-density lipoprotein cholesterol (HDL-c), triglycerides (TG), fasting glucose level, blood pressure, and central obesity in adults diagnosed with MetS. The following scientific databases were searched from 1998 until April 2023: EMBASE, MEDLINE (PubMed), Web of Science, Latin American and Caribbean Health Sciences Literature (Lilacs), the Cochrane Central Register of Controlled Trials, clinicaltrial.gov, and Google Scholar. No language restrictions were applied. Seven studies were included, and they showed a high level of heterogeneity. All studies reported a significant increase in serum 25(OH)D levels in the intervention groups. Of these, only two noted a significant decrease in triglyceride (TG) level and waist circumference. However, the certainty levels of the evidence rating were very low and low for triglyceride (TG) level and waist circumference, respectively, and moderate for fasting glucose level, blood pressure, and HDL-c. In conclusion, despite these benefits, considering the low certainty, the evidence does not support that VDS decreases triglyceride (TG) level and waist circumference in adults with MetS.
    Language English
    Publishing date 2023-10-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e20845
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Targeted transcriptomic analysis of pancreatic adenocarcinoma in EUS-FNA samples by NanoString technology.

    Pedrosa, L / Araujo, I K / Cuatrecasas, M / Soy, G / López, S / Maurel, J / Sánchez-Montes, C / Montironi, C / Saurí, T / Sendino, O / Pérez, F M / Ausania, F / Fernández-Esparrach, G / Espósito, F M / Vaquero, E C / Ginès, A

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1161893

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-05-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1161893
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  6. Article ; Online: The controversy of neoadjuvant therapy in rectal cancer.

    Maurel, Joan / Pedrosa, Leire / Camps, Jordi

    Cirugia espanola

    2019  Volume 97, Issue 7, Page(s) 361–363

    Title translation Controversia en neoadyuvancia y cáncer de recto.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Chemoradiotherapy ; Chemotherapy, Adjuvant/methods ; Humans ; Magnetic Resonance Imaging ; Neoadjuvant Therapy ; Neoplasm Recurrence, Local ; Organoplatinum Compounds/therapeutic use ; Pyridines/therapeutic use ; Pyrimidines/therapeutic use ; Rectal Neoplasms/diagnostic imaging ; Rectal Neoplasms/drug therapy ; Rectal Neoplasms/therapy ; Tumor Microenvironment/immunology
    Chemical Substances Antineoplastic Agents ; Organoplatinum Compounds ; Pyridines ; Pyrimidines ; oxiplatin
    Language Spanish
    Publishing date 2019-02-14
    Publishing country Spain
    Document type Editorial
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.ciresp.2019.01.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Brain metabolism response to intrahospital transfers in neurocritical ill patients and the impact of microdialysis probe location.

    Pedrosa, Leire / Hoyos, Jhon / Reyes, Luis / Mosteiro, Alejandra / Zattera, Luigi / Topczewski, Thomaz / Rodríguez-Hernández, Ana / Amaro, Sergio / Torné, Ramon / Enseñat, Joaquim

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 7388

    Abstract: Intrahospital transfer (IHT), a routine in the management of neurocritical patients requiring imaging or interventions, might affect brain metabolism. Studies about IHT effects using microdialysis (MD) have produced conflicting results. In these studies, ...

    Abstract Intrahospital transfer (IHT), a routine in the management of neurocritical patients requiring imaging or interventions, might affect brain metabolism. Studies about IHT effects using microdialysis (MD) have produced conflicting results. In these studies, only the most damaged hemisphere was monitored, and those may not reflect the impact of IHT on overall brain metabolism, nor do they address differences between the hemispheres. Herein we aimed to quantify the effect of IHT on brain metabolism by monitoring both hemispheres with bilateral MD. In this study, 27 patients with severe brain injury (10 traumatic brain injury and 17 subarachnoid hemorrhage patients) were included, with a total of 67 IHT. Glucose, glycerol, pyruvate and lactate were measured by MD in both hemispheres for 10 h pre- and post-IHT. Alterations in metabolite levels after IHT were observed on both hemispheres; although these changes were more marked in hemisphere A (most damaged) than B (less damaged). Our results suggest that brain metabolism is altered after an IHT of neurocritical ill patients particularly but not limited to the damaged hemisphere. Bilateral monitorization may be more sensitive than unilateral monitorization for detecting metabolic disturbances not directly related to the course of the disease.
    MeSH term(s) Humans ; Microdialysis/methods ; Subarachnoid Hemorrhage/therapy ; Subarachnoid Hemorrhage/metabolism ; Lactic Acid/metabolism ; Pyruvic Acid/metabolism ; Brain/metabolism
    Chemical Substances Lactic Acid (33X04XA5AT) ; Pyruvic Acid (8558G7RUTR)
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-57217-5
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  8. Article: Creation of a new proof-of-concept pectin/lysozyme nanocomplex as potential beta-lactose delivery matrix: Structure and thermal stability analyses

    Pessoa da Silva, Magner / Osvaldt Rosales, Thiécla Katiane / de Freitas Pedrosa, Lucas / Fabi, Joao Paulo

    Food hydrocolloids

    2023  Volume 134, Issue -, Page(s) 108011

    Language English
    Document type Article
    ZDB-ID 742742-6
    ISSN 0268-005X
    Database Current Contents Nutrition, Environment, Agriculture

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  9. Article: An Overview on Diffuse Large B-Cell Lymphoma Models: Towards a Functional Genomics Approach.

    Yanguas-Casás, Natalia / Pedrosa, Lucía / Fernández-Miranda, Ismael / Sánchez-Beato, Margarita

    Cancers

    2021  Volume 13, Issue 12

    Abstract: Lymphoma research is a paradigm of the integration of basic and clinical research within the fields of diagnosis and therapy. Clinical, phenotypic, and genetic data are currently used to predict which patients could benefit from standard treatment. ... ...

    Abstract Lymphoma research is a paradigm of the integration of basic and clinical research within the fields of diagnosis and therapy. Clinical, phenotypic, and genetic data are currently used to predict which patients could benefit from standard treatment. However, alternative therapies for patients at higher risk from refractoriness or relapse are usually empirically proposed, based on trial and error, without considering the genetic complexity of aggressive B-cell lymphomas. This is primarily due to the intricate mosaic of genetic and epigenetic alterations in lymphomas, which are an obstacle to the prediction of which drug will work for any given patient. Matching a patient's genes to drug sensitivity by directly testing live tissues comprises the "precision medicine" concept. However, in the case of lymphomas, this concept should be expanded beyond genomics, eventually providing better treatment options for patients in need of alternative therapeutic approaches. We provide an overview of the most recent findings in diffuse large B-cell lymphomas genomics, from the classic functional models used to study tumor biology and the response to experimental treatments using cell lines and mouse models, to the most recent approaches with spheroid/organoid models. We also discuss their potential relevance and applicability to daily clinical practice.
    Language English
    Publishing date 2021-06-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13122893
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  10. Article: The Tumor Microenvironment in Colorectal Cancer Therapy.

    Pedrosa, Leire / Esposito, Francis / Thomson, Timothy M / Maurel, Joan

    Cancers

    2019  Volume 11, Issue 8

    Abstract: The current standard-of-care for metastatic colorectal cancer (mCRC) includes chemotherapy and anti-angiogenic or anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, even though the addition of anti-angiogenic agents to backbone ... ...

    Abstract The current standard-of-care for metastatic colorectal cancer (mCRC) includes chemotherapy and anti-angiogenic or anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, even though the addition of anti-angiogenic agents to backbone chemotherapy provides little benefit for overall survival. Since the approval of anti-angiogenic monoclonal antibodies bevacizumab and aflibercept, for the management of mCRC over a decade ago, extensive efforts have been devoted to discovering predictive factors of the anti-angiogenic response, unsuccessfully. Recent evidence has suggested a potential correlation between angiogenesis and immune phenotypes associated with colorectal cancer. Here, we review evidence of interactions between tumor angiogenesis, the immune microenvironment, and metabolic reprogramming. More specifically, we will highlight such interactions as inferred from our novel immune-metabolic (IM) signature, which groups mCRC into three distinct clusters, namely inflamed-stromal-dependent (IM Cluster 1), inflamed-non stromal-dependent (IM Cluster 2), and non-inflamed or cold (IM Cluster 3), and discuss the merits of the IM classification as a guide to new immune-metabolic combinatorial therapeutic strategies in mCRC.
    Language English
    Publishing date 2019-08-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers11081172
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