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Article ; Online: Glycemic Changes Related to Arsenic Exposure: An Overview of Animal and Human Studies.

Rosendo, Geovanna Beatriz Oliveira / Ferreira, Rannapaula Lawrynhuk Urbano / Aquino, Séphora Louyse Silva / Barbosa, Fernando / Pedrosa, Lucia Fatima Campos

Nutrients

2024 Volume 16, Issue 5

Abstract: Background: Arsenic (As) is a risk factor associated with glycemic alterations. However, the mechanisms of action and metabolic aspects associated with changes in glycemic profiles have not yet been completely elucidated. Therefore, in this review, we ... ...

Abstract	Background: Arsenic (As) is a risk factor associated with glycemic alterations. However, the mechanisms of action and metabolic aspects associated with changes in glycemic profiles have not yet been completely elucidated. Therefore, in this review, we aimed to investigate the metabolic aspects of As and its mechanism of action associated with glycemic changes. Methods: We searched the PubMed (MEDLINE) and Google Scholar databases for relevant articles published in English. A combination of free text and medical subject heading keywords and search terms was used to construct search equations. The search yielded 466 articles; however, only 50 were included in the review. Results: We observed that the relationship between As exposure and glycemic alterations in humans may be associated with sex, smoking status, body mass index, age, occupation, and genetic factors. The main mechanisms of action associated with changes induced by exposure to As in the glycemic profile identified in animals are increased oxidative stress, reduced expression of glucose transporter type 4, induction of inflammatory factor expression and dysfunction of pancreatic β cells. Conclusions: Therefore, As exposure may be associated with glycemic alterations according to inter-individual differences.
MeSH term(s)	Animals ; Humans ; Arsenic ; Risk Factors ; PubMed ; Body Mass Index ; Blood Glucose/metabolism
Chemical Substances	Arsenic (N712M78A8G) ; Blood Glucose
Language	English
Publishing date	2024-02-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16050665
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Food frequency questionnaires developed and validated in Brazil: A scoping review protocol.

Barros, Acsa Nara de Araújo Brito / Felipe, Maria Luisa do Nascimento / Leite-Lais, Lucia / Pedrosa, Lucia Fátima Campos

PloS one

2023 Volume 18, Issue 11, Page(s) e0294450

Abstract: A food frequency questionnaire (FFQ) is used to assess habitual food and nutrient intake. The choice of a FFQ should consider the study objectives, instrument particularities, target population, and geographic region. Over the past few years, FFQs have ... ...

Abstract	A food frequency questionnaire (FFQ) is used to assess habitual food and nutrient intake. The choice of a FFQ should consider the study objectives, instrument particularities, target population, and geographic region. Over the past few years, FFQs have been constructed and validated in Brazil for children, adolescents, adults, athletes, and individuals with specific clinical conditions. The aim of this scoping review is to map the food frequency questionnaires developed and validated in Brazil. The Population-Concept-Context (PCC) framework was used for search strategy and defined as P-not applicable (open), C-food frequency questionnaire, and C-Brazil. FFQ validation studies performed with healthy or sick people will be included, regardless of clinical condition, age, sex, or region in the country. Studies with populations from other countries will be excluded. The review will be conducted in accordance with JBI (formerly known as Joanna Briggs Institute) methodology for scoping reviews. Search databases will include PubMed/MEDLINE, LILACS, Embase, Web of Science (ISI), Scopus, and Google Scholar. Data extraction will be performed by two independent reviewers and discrepancies resolved by a third reviewer. In order to improve the understanding and contextualization of the studies, a description of the results and presentation in tables and figures will be provided. Applications and implications for future research, practices, and policies will be discussed. Our protocol is registered through the Open Science Framework (doi 10.17605/OSF.IO/G5J3K).
MeSH term(s)	Adolescent ; Adult ; Child ; Humans ; Brazil ; Academies and Institutes ; Athletes ; Databases, Factual ; Surveys and Questionnaires ; Research Design ; Review Literature as Topic
Language	English
Publishing date	2023-11-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0294450
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Nutritional risk of vitamin D, vitamin C, zinc, and selenium deficiency on risk and clinical outcomes of COVID-19: A narrative review

Pedrosa, Lucia F.C. / Barros, Acsa N.A.B. / Leite-Lais, Lucia

European Society for Clinical Nutrition and Metabolism Clinical nutrition ESPEN. 2022 Feb., v. 47

2022

Abstract: The pathogenicity of the current coronavirus disease (COVID-19) shows postulates that optimal status of essential nutrients is crucial in supporting both the early viraemic and later hyperinflammatory phases of COVID-19. Micronutrients such as vitamin C, ...

Abstract	The pathogenicity of the current coronavirus disease (COVID-19) shows postulates that optimal status of essential nutrients is crucial in supporting both the early viraemic and later hyperinflammatory phases of COVID-19. Micronutrients such as vitamin C, D, zinc, and selenium play roles in antioxidant, anti-inflammatory, antithrombotic, antiviral, and immuno-modulatory functions and are useful in both innate and adaptive immunity. The purpose of this review is to provide a high-level summary of evidence on clinical outcomes associated with nutritional risk of these micronutrients observed in patients with COVID-19. A literature search was performed on PubMed and Google Scholar to obtain findings of cross-sectional and experimental studies in humans. The search resulted in a total of 1212 reports including all nutrients, but only 85 were included according to the eligibility criteria. Despite the diversity of studies and the lack of randomized clinical trials and prospective cohorts, there is evidence of the potential protective and therapeutic roles of vitamin C, D, zinc, and selenium in COVID-19. The findings summarized in this review will contribute to guide interventions in clinical practice or in future clinical studies.
Keywords	COVID-19 infection ; adaptive immunity ; antioxidants ; ascorbic acid ; clinical nutrition ; nutrition risk assessment ; pathogenicity ; risk ; selenium ; therapeutics ; zinc
Language	English
Dates of publication	2022-02
Size	p. 9-27.
Publishing place	Elsevier Ltd
Document type	Article
ISSN	2405-4577
DOI	10.1016/j.clnesp.2021.11.003
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Nutritional risk of vitamin D, vitamin C, zinc, and selenium deficiency on risk and clinical outcomes of COVID-19: A narrative review.

Pedrosa, Lucia F C / Barros, Acsa N A B / Leite-Lais, Lucia

Clinical nutrition ESPEN

2021 Volume 47, Page(s) 9–27

Abstract	The pathogenicity of the current coronavirus disease (COVID-19) shows postulates that optimal status of essential nutrients is crucial in supporting both the early viraemic and later hyperinflammatory phases of COVID-19. Micronutrients such as vitamin C, D, zinc, and selenium play roles in antioxidant, anti-inflammatory, antithrombotic, antiviral, and immuno-modulatory functions and are useful in both innate and adaptive immunity. The purpose of this review is to provide a high-level summary of evidence on clinical outcomes associated with nutritional risk of these micronutrients observed in patients with COVID-19. A literature search was performed on PubMed and Google Scholar to obtain findings of cross-sectional and experimental studies in humans. The search resulted in a total of 1212 reports including all nutrients, but only 85 were included according to the eligibility criteria. Despite the diversity of studies and the lack of randomized clinical trials and prospective cohorts, there is evidence of the potential protective and therapeutic roles of vitamin C, D, zinc, and selenium in COVID-19. The findings summarized in this review will contribute to guide interventions in clinical practice or in future clinical studies.
MeSH term(s)	Ascorbic Acid ; COVID-19 ; Cross-Sectional Studies ; Humans ; Prospective Studies ; SARS-CoV-2 ; Selenium ; Vitamin D ; Zinc
Chemical Substances	Vitamin D (1406-16-2) ; Selenium (H6241UJ22B) ; Zinc (J41CSQ7QDS) ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	2021-11-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	2405-4577
ISSN (online)	2405-4577
DOI	10.1016/j.clnesp.2021.11.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Dietary Intake of Micronutrients and Disease Severity in Patients with Amyotrophic Lateral Sclerosis.

Barros, Acsa Nara de Araújo Brito / Felipe, Maria Luisa do Nascimento / Barbosa, Isabelle Ribeiro / Leite-Lais, Lucia / Pedrosa, Lucia Fátima Campos

Metabolites

2023 Volume 13, Issue 6

Abstract: Vitamins and essential metals have been studied as potential risk and prognostic factors in amyotrophic lateral sclerosis (ALS). This study aimed to evaluate the prevalence of inadequate micronutrient intake in ALS patients, comparing subgroups according ...

Abstract	Vitamins and essential metals have been studied as potential risk and prognostic factors in amyotrophic lateral sclerosis (ALS). This study aimed to evaluate the prevalence of inadequate micronutrient intake in ALS patients, comparing subgroups according to the disease severity. Data were obtained from the medical records of 69 individuals. Assessment of disease severity was determined by the revised ALS Functional Scale (ALSFRS-R), using the median as the cutoff. The prevalence of inadequate micronutrient intake was estimated using the Estimated Average Requirements (EAR) cut-point method. The prevalence of inadequate vitamin D, E, riboflavin, pyridoxine, folate, cobalamin, calcium, zinc, and magnesium intake was considered severe. Patients with lower ALSFRS-R scores had lower intakes of vitamin E (
Language	English
Publishing date	2023-05-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo13060696
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Article: Effects of vitamin D supplementation on cardiometabolic parameters among patients with metabolic syndrome: A systematic review and GRADE evidence synthesis of randomized controlled trials.

Aquino, Séphora / Cunha, Aline / Gomes Lima, Josivan / Sena-Evangelista, Karine / Gouveia Oliveira, Antonio / Cobucci, Ricardo Ney / Fc Pedrosa, Lucia

Heliyon

2023 Volume 9, Issue 11, Page(s) e20845

Abstract: Various pathophysiologic mechanisms were proposed to underlie the effect of vitamin D on MetS components. In this systematic review, we reviewed randomized control clinical trials to verify whether vitamin D supplementation (VDS) at different doses is ... ...

Abstract	Various pathophysiologic mechanisms were proposed to underlie the effect of vitamin D on MetS components. In this systematic review, we reviewed randomized control clinical trials to verify whether vitamin D supplementation (VDS) at different doses is effective concomitantly in controlling high-density lipoprotein cholesterol (HDL-c), triglycerides (TG), fasting glucose level, blood pressure, and central obesity in adults diagnosed with MetS. The following scientific databases were searched from 1998 until April 2023: EMBASE, MEDLINE (PubMed), Web of Science, Latin American and Caribbean Health Sciences Literature (Lilacs), the Cochrane Central Register of Controlled Trials, clinicaltrial.gov, and Google Scholar. No language restrictions were applied. Seven studies were included, and they showed a high level of heterogeneity. All studies reported a significant increase in serum 25(OH)D levels in the intervention groups. Of these, only two noted a significant decrease in triglyceride (TG) level and waist circumference. However, the certainty levels of the evidence rating were very low and low for triglyceride (TG) level and waist circumference, respectively, and moderate for fasting glucose level, blood pressure, and HDL-c. In conclusion, despite these benefits, considering the low certainty, the evidence does not support that VDS decreases triglyceride (TG) level and waist circumference in adults with MetS.
Language	English
Publishing date	2023-10-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e20845
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Article ; Online: Are Phosphatidylcholine and Lysophosphatidylcholine Body Levels Potentially Reliable Biomarkers in Obesity? A Review of Human Studies.

Bellot, Paula Emília Nunes Ribeiro / Moia, Melissa Nunes / Reis, Bruna Zavarize / Pedrosa, Lucia Fatima Campos / Tasic, Ljubica / Barbosa, Fernando / Sena-Evangelista, Karine Cavalcanti Maurício

Molecular nutrition & food research

2023 Volume 67, Issue 7, Page(s) e2200568

Abstract: Phosphatidylcholines (PCs) are the major components of biological membranes in animals and are a class of phospholipids that incorporate choline as a headgroup. Lysophosphatidylcholines (LPCs) are a class of lipid biomolecules derived from the cleavage ... ...

Abstract	Phosphatidylcholines (PCs) are the major components of biological membranes in animals and are a class of phospholipids that incorporate choline as a headgroup. Lysophosphatidylcholines (LPCs) are a class of lipid biomolecules derived from the cleavage of PCs, and are the main components of oxidized low-density lipoproteins (oxLDLs) that are involved in the pathogenesis of atherosclerosis. Since obesity is associated with a state of chronic low-grade inflammation, one can anticipate that the lipidomic profile changes in this context and both PCs and LPCs are gaining attention as hypothetically reliable biomarkers of obesity. Thus, a literature search is performed on PubMed, Latin American and Caribbean Health Science Literature (LILACS), and Excerpta Medica DataBASE (Embase) to obtain the findings of population studies to clarify this hypothesis. The search strategy resulted in a total of 2403 reports and 21 studies were included according to the eligibility criteria. Controversial data on the associations of PCs and LPCs with body mass index (BMI) and body fat parameters have been identified. There is an inverse relationship between BMI and most species of PCs, and a majority of studies exhibited negative associations between BMI and LPCs. Other findings regarding the differences between PCs and LPCs in obesity are presented, and the associated uncertainties are discussed in detail.
MeSH term(s)	Humans ; Animals ; Lysophosphatidylcholines ; Phosphatidylcholines ; Obesity ; Lecithins ; Biomarkers ; Lipidomics ; Inflammation
Chemical Substances	Lysophosphatidylcholines ; Phosphatidylcholines ; Lecithins ; Biomarkers
Language	English
Publishing date	2023-02-09
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2160372-8
ISSN	1613-4133 ; 1613-4125
ISSN (online)	1613-4133
ISSN	1613-4125
DOI	10.1002/mnfr.202200568
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Vitamin D

Aquino, Séphora L S / Cunha, Aline T O / Sena-Evangelista, Karine C M / Lima, Josivan G / Pedrosa, Lucia F C

Clinical nutrition ESPEN

2023 Volume 54, Page(s) 300–303

Abstract: Background: Vitamin D deficiency has been observed in individuals with metabolic syndrome (MetS). This study evaluated the effects of vitamin D supplementation in patients with MetS and vitamin D deficiency.: Methods: Vitamin D: Results: The 20- ... ...

Abstract	Background: Vitamin D deficiency has been observed in individuals with metabolic syndrome (MetS). This study evaluated the effects of vitamin D supplementation in patients with MetS and vitamin D deficiency. Methods: Vitamin D Results: The 20-week intervention resulted in an increment of 14.3 ng/mL of 25(OH)D. HbA1c showed a reduction of 0.69% (95% CI [-1.16, -0.21], p = 0.005); however, the triglycerides, HDL-cholesterol, fasting blood glucose, blood pressure, and waist circumference were not responsive to supplementation. Conclusion: Vitamin D
MeSH term(s)	Humans ; Metabolic Syndrome/drug therapy ; Cholecalciferol/therapeutic use ; Vitamin D/therapeutic use ; Pilot Projects ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/drug therapy ; Dietary Supplements
Chemical Substances	Cholecalciferol (1C6V77QF41) ; Vitamin D (1406-16-2)
Language	English
Publishing date	2023-02-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2405-4577
ISSN (online)	2405-4577
DOI	10.1016/j.clnesp.2023.02.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Are Phosphatidylcholine and Lysophosphatidylcholine Body Levels Potentially Reliable Biomarkers in Obesity? A Review of Human Studies

Bellot, Paula Emília Nunes Ribeiro / Moia, Melissa Nunes / Reis, Bruna Zavarize / Pedrosa, Lucia Fatima Campos / Tasic, Ljubica / Barbosa, Fernando, Jr / Sena‐Evangelista, Karine Cavalcanti Maurício

Molecular Nutrition & Food Research. 2023 Apr., v. 67, no. 7 p.e2200568-

2023

Abstract	Phosphatidylcholines (PCs) are the major components of biological membranes in animals and are a class of phospholipids that incorporate choline as a headgroup. Lysophosphatidylcholines (LPCs) are a class of lipid biomolecules derived from the cleavage of PCs, and are the main components of oxidized low‐density lipoproteins (oxLDLs) that are involved in the pathogenesis of atherosclerosis. Since obesity is associated with a state of chronic low‐grade inflammation, one can anticipate that the lipidomic profile changes in this context and both PCs and LPCs are gaining attention as hypothetically reliable biomarkers of obesity. Thus, a literature search is performed on PubMed, Latin American and Caribbean Health Science Literature (LILACS), and Excerpta Medica DataBASE (Embase) to obtain the findings of population studies to clarify this hypothesis. The search strategy resulted in a total of 2403 reports and 21 studies were included according to the eligibility criteria. Controversial data on the associations of PCs and LPCs with body mass index (BMI) and body fat parameters have been identified. There is an inverse relationship between BMI and most species of PCs, and a majority of studies exhibited negative associations between BMI and LPCs. Other findings regarding the differences between PCs and LPCs in obesity are presented, and the associated uncertainties are discussed in detail.
Keywords	atherosclerosis ; biomarkers ; body fat ; body mass index ; choline ; databases ; food research ; humans ; inflammation ; lipidomics ; low density lipoprotein ; lysophosphatidylcholine ; nutrition ; obesity ; oxidation ; pathogenesis ; Caribbean
Language	English
Dates of publication	2023-04
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	REVIEW
ZDB-ID	2160372-8
ISSN	1613-4133 ; 1613-4125
ISSN (online)	1613-4133
ISSN	1613-4125
DOI	10.1002/mnfr.202200568
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Vitamin D3 supplementation had no benefits in patients with metabolic syndrome and vitamin D deficiency: A pilot study

Aquino, Séphora L.S. / Cunha, Aline T.O. / Sena-Evangelista, Karine C.M. / Lima, Josivan G. / Pedrosa, Lucia F.C.

European Society for Clinical Nutrition and Metabolism Clinical Nutrition ESPEN. 2023 Feb. 07,

2023

Abstract: Vitamin D deficiency has been observed in individuals with metabolic syndrome (MetS). This study evaluated the effects of vitamin D supplementation in patients with MetS and vitamin D deficiency. Vitamin D₃ supplementation was performed in patients with ... ...

Abstract	Vitamin D deficiency has been observed in individuals with metabolic syndrome (MetS). This study evaluated the effects of vitamin D supplementation in patients with MetS and vitamin D deficiency. Vitamin D₃ supplementation was performed in patients with MetS and 25(OH)D levels ≤ 20 ng/mL arranged in two phases. The first phase corresponded to 50,000 IU/week for eight weeks, and the second phase was 7,000 IU/week for twelve weeks. The 20-week intervention resulted in an increment of 14.3 ng/mL of 25(OH)D. HbA1c showed a reduction of 0.69% (95% CI [-1.16, -0.21], p = 0.005); however, the triglycerides, HDL-cholesterol, fasting blood glucose, blood pressure, and waist circumference were not responsive to supplementation. Vitamin D₃ supplementation did not favor the MetS components.
Keywords	blood glucose ; blood pressure ; cholecalciferol ; clinical nutrition ; high density lipoprotein cholesterol ; metabolic syndrome ; waist circumference ; Vitamin D deficiency ; vitamin D supplementation
Language	English
Dates of publication	2023-0207
Size	p. 300-303.
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ISSN	2405-4577
DOI	10.1016/j.clnesp.2023.02.002
Database	NAL-Catalogue (AGRICOLA)

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