Article ; Online: CMV Status Drives Distinct Trajectories of CD4+ T Cell Differentiation.
2021 Volume 12, Page(s) 620386
Abstract: Cytomegalovirus (CMV) is one of the most commonly recognized opportunistic pathogens and remains the most influential known parameter in shaping an individual's immune system. As such, T cells induced by CMV infection could have a long-term impact on ... ...
| Abstract | Cytomegalovirus (CMV) is one of the most commonly recognized opportunistic pathogens and remains the most influential known parameter in shaping an individual's immune system. As such, T cells induced by CMV infection could have a long-term impact on subsequent immune responses. Accumulating evidence indicates that memory T cells developed during past bacterial and viral infection can cross-react with unrelated pathogens, including transplant antigens, and can alter responses to |
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| MeSH term(s) | Abatacept/pharmacology ; Abatacept/therapeutic use ; Adult ; Antigens, CD/metabolism ; Biomarkers ; CD4-Positive T-Lymphocytes/cytology ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Cell Differentiation/immunology ; Cytomegalovirus/immunology ; Cytomegalovirus Infections/genetics ; Cytomegalovirus Infections/immunology ; Cytomegalovirus Infections/metabolism ; Cytomegalovirus Infections/virology ; Cytotoxicity, Immunologic ; Female ; Gene Expression Profiling ; Host-Pathogen Interactions/immunology ; Humans ; Immunologic Memory ; Immunophenotyping ; Immunosuppressive Agents/pharmacology ; Immunosuppressive Agents/therapeutic use ; Lymphocyte Activation/immunology ; Lymphocyte Count ; Male ; Middle Aged ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism |
| Chemical Substances | Antigens, CD ; Biomarkers ; Immunosuppressive Agents ; Abatacept (7D0YB67S97) |
| Language | English |
| Publishing date | 2021-04-15 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2606827-8 |
| ISSN | 1664-3224 ; 1664-3224 |
| ISSN (online) | 1664-3224 |
| ISSN | 1664-3224 |
| DOI | 10.3389/fimmu.2021.620386 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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