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  1. Article ; Online: Verklein de kloof in gezondheidsinformatie.

    Sana, Shakib / Peeters, Robin P

    Nederlands tijdschrift voor geneeskunde

    2022  Volume 166

    Abstract: The COVID-19 pandemic has highlighted the impact of health care disparities to the general public. In addition, due to the societal impact of COVID-19, public discussions in the media entered the doctor's office. This led to a completely new interaction ... ...

    Title translation Close the health information gap: physicians should use the media to inform the public.
    Abstract The COVID-19 pandemic has highlighted the impact of health care disparities to the general public. In addition, due to the societal impact of COVID-19, public discussions in the media entered the doctor's office. This led to a completely new interaction between doctors and the media. Our acquaintance during a television talk show emphasized the importance of collaboration for both of us. It made us realize that we, as a general practitioner and as a medical specialist, can have an important contribution to the social domain by addressing issues and providing information to the general public. It became increasingly clear that the media can be an important tool for doctors in this respect. By using (social) media we can reach a larger part of the general public with reliable medical information. At the same time, we can use this to reach policy makers and politicians to ultimately incorporate solutions into policy.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Pandemics ; Physicians ; Social Media ; Public Health
    Language Dutch
    Publishing date 2022-12-21
    Publishing country Netherlands
    Document type English Abstract ; Journal Article
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
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  2. Article ; Online: Hyperthyroidism.

    Chaker, Layal / Cooper, David S / Walsh, John P / Peeters, Robin P

    Lancet (London, England)

    2024  Volume 403, Issue 10428, Page(s) 768–780

    Abstract: Thyrotoxicosis causes a variety of symptoms and adverse health outcomes. Hyperthyroidism refers to increased thyroid hormone synthesis and secretion, most commonly from Graves' disease or toxic nodular goitre, whereas thyroiditis (typically autoimmune, ... ...

    Abstract Thyrotoxicosis causes a variety of symptoms and adverse health outcomes. Hyperthyroidism refers to increased thyroid hormone synthesis and secretion, most commonly from Graves' disease or toxic nodular goitre, whereas thyroiditis (typically autoimmune, viral, or drug induced) causes thyrotoxicosis without hyperthyroidism. The diagnosis is based on suppressed serum concentrations of thyroid-stimulating hormone (TSH), accompanied by free thyroxine and total or free tri-iodothyronine concentrations, which are raised (overt hyperthyroidism) or within range (subclinical hyperthyroidism). The underlying cause is determined by clinical assessment, detection of TSH-receptor antibodies and, if necessary, radionuclide thyroid scintigraphy. Treatment options for hyperthyroidism include antithyroid drugs, radioactive iodine, and thyroidectomy, whereas thyroiditis is managed symptomatically or with glucocorticoid therapy. In Graves' disease, first-line treatment is a 12-18-month course of antithyroid drugs, whereas for goitre, radioactive iodine or surgery are preferred for toxic nodules or goitres. Evidence also supports long-term treatment with antithyroid drugs as an option for patients with Graves' disease and toxic nodular goitre.
    MeSH term(s) Humans ; Antithyroid Agents/therapeutic use ; Antithyroid Agents/adverse effects ; Goiter, Nodular/diagnosis ; Goiter, Nodular/therapy ; Goiter, Nodular/chemically induced ; Iodine Radioisotopes/therapeutic use ; Thyroid Neoplasms/drug therapy ; Hyperthyroidism/therapy ; Hyperthyroidism/drug therapy ; Graves Disease/diagnosis ; Graves Disease/therapy ; Thyrotoxicosis/diagnosis ; Thyrotoxicosis/therapy ; Thyrotoxicosis/chemically induced ; Thyroiditis/chemically induced ; Thyroiditis/drug therapy
    Chemical Substances Antithyroid Agents ; Iodine Radioisotopes
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)02016-0
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  3. Article ; Online: Response to the letter of Hoermann and collegues.

    Peeters, Robin P / Brito, Juan P

    European journal of endocrinology

    2021  Volume 185, Issue 3, Page(s) L7–L8

    Language English
    Publishing date 2021-08-04
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1183856-5
    ISSN 1479-683X ; 0804-4643
    ISSN (online) 1479-683X
    ISSN 0804-4643
    DOI 10.1530/EJE-21-0677
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  4. Article ; Online: Subclinical Hypothyroidism.

    Peeters, Robin P

    The New England journal of medicine

    2017  Volume 377, Issue 14, Page(s) 1404

    Language English
    Publishing date 2017--05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1709853
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  5. Article ; Online: Subclinical Hypothyroidism.

    Peeters, Robin P

    The New England journal of medicine

    2017  Volume 376, Issue 26, Page(s) 2556–2565

    MeSH term(s) Aged ; Algorithms ; Disease Progression ; Female ; Humans ; Hypothyroidism/blood ; Hypothyroidism/diagnosis ; Hypothyroidism/drug therapy ; Practice Guidelines as Topic ; Thyrotropin/blood ; Thyroxine/blood ; Thyroxine/therapeutic use
    Chemical Substances Thyrotropin (9002-71-5) ; Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2017--29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcp1611144
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  6. Article ; Online: Subclinical hypothyroidism: to treat or not to treat?

    Peeters, Robin P / Brito, Juan P

    European journal of endocrinology

    2020  Volume 183, Issue 6, Page(s) D15–D24

    Abstract: There is controversy on the treatment of subclinical hypothyroidism (SCH). While a number of guidelines from professional societies recommend treatment of SCH based on TSH levels, age, and presence of comorbidities, a recent guideline issued a ... ...

    Abstract There is controversy on the treatment of subclinical hypothyroidism (SCH). While a number of guidelines from professional societies recommend treatment of SCH based on TSH levels, age, and presence of comorbidities, a recent guideline issued a recommendation against thyroid hormone treatment in adults with SCH. In this debate article, we explore this controversy by presenting two points of view about SCH and its treatment. Treatment of patients who are pregnant or trying to become pregnant will not be discussed.
    MeSH term(s) Aged ; Female ; Humans ; Hypothyroidism/blood ; Hypothyroidism/diagnosis ; Hypothyroidism/drug therapy ; Middle Aged ; Thyroid Function Tests/methods ; Thyroxine/administration & dosage ; Thyroxine/blood ; Treatment Outcome
    Chemical Substances Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2020-10-27
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1183856-5
    ISSN 1479-683X ; 0804-4643
    ISSN (online) 1479-683X
    ISSN 0804-4643
    DOI 10.1530/EJE-20-0621
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  7. Article ; Online: Interpretation of thyroid function tests during pregnancy.

    Visser, W Edward / Peeters, Robin P

    Best practice & research. Clinical endocrinology & metabolism

    2020  Volume 34, Issue 4, Page(s) 101431

    Abstract: Thyroid hormones are crucial for normal pregnancy and fetal development. Large physiological changes occur during pregnancy, posing challenges for the correct interpretation of thyroid function tests. TSH concentrations are the principal first test to ... ...

    Abstract Thyroid hormones are crucial for normal pregnancy and fetal development. Large physiological changes occur during pregnancy, posing challenges for the correct interpretation of thyroid function tests. TSH concentrations are the principal first test to rule out thyroid disease taking into account trimester-specific reference ranges. Free T4 (FT4) measurements by immuno-assays may be subject to interference by endogenous and exogenous factors. The relevance of measuring free T3 (FT3) during pregnancy is unclear. Thyroid autoimmunity is well-reflected by the presence of antibodies against TPO. TPO-antibody positivity is associated with an increased risk of adverse pregnancy outcomes.
    MeSH term(s) Adult ; Data Interpretation, Statistical ; Female ; Humans ; Pregnancy ; Pregnancy Complications/blood ; Pregnancy Complications/diagnosis ; Prenatal Diagnosis/methods ; Prenatal Diagnosis/standards ; Reference Values ; Thyroid Diseases/blood ; Thyroid Diseases/diagnosis ; Thyroid Function Tests/methods ; Thyroid Function Tests/standards ; Thyroid Hormones/analysis ; Thyroid Hormones/blood ; Thyrotropin/analysis ; Thyrotropin/blood ; Thyroxine/analysis ; Thyroxine/blood ; Triiodothyronine/analysis ; Triiodothyronine/blood
    Chemical Substances Thyroid Hormones ; Triiodothyronine (06LU7C9H1V) ; Thyrotropin (9002-71-5) ; Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2020-06-18
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2052339-7
    ISSN 1878-1594 ; 1532-1908 ; 1521-690X
    ISSN (online) 1878-1594 ; 1532-1908
    ISSN 1521-690X
    DOI 10.1016/j.beem.2020.101431
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  8. Article ; Online: Thyroid Hormone Transporters in Pregnancy and Fetal Development.

    Chen, Zhongli / Meima, Marcel E / Peeters, Robin P / Visser, W Edward

    International journal of molecular sciences

    2022  Volume 23, Issue 23

    Abstract: Thyroid hormone is essential for fetal (brain) development. Plasma membrane transporters control the intracellular bioavailability of thyroid hormone. In the past few decades, 15 human thyroid hormone transporters have been identified, and among them, ... ...

    Abstract Thyroid hormone is essential for fetal (brain) development. Plasma membrane transporters control the intracellular bioavailability of thyroid hormone. In the past few decades, 15 human thyroid hormone transporters have been identified, and among them, mutations in monocarboxylate transporter (MCT)8 and organic anion transporting peptide (OATP)1C1 are associated with clinical phenotypes. Different animal and human models have been employed to unravel the (patho)-physiological role of thyroid hormone transporters. However, most studies on thyroid hormone transporters focus on postnatal development. This review summarizes the research on the thyroid hormone transporters in pregnancy and fetal development, including their substrate preference, expression and tissue distribution, and physiological and pathophysiological role in thyroid homeostasis and clinical disorders. As the fetus depends on the maternal thyroid hormone supply, especially during the first half of pregnancy, the review also elaborates on thyroid hormone transport across the human placental barrier. Future studies may reveal how the different transporters contribute to thyroid hormone homeostasis in fetal tissues to properly facilitate development. Employing state-of-the-art human models will enable a better understanding of their roles in thyroid hormone homeostasis.
    Language English
    Publishing date 2022-12-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232315113
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  9. Article: Comparison of two different TSH-receptor antibody assays: A clinical practice study.

    van Balkum, Mathé / Schreurs, Marco W J / Visser, W Edward / Peeters, Robin P / Dik, Willem A

    Heliyon

    2023  Volume 9, Issue 12, Page(s) e22468

    Abstract: Background: Graves' disease (GD) is caused by the production of TSH-receptor (TSHR) stimulating auto-antibodies. Over the years various TSHR-antibody (TRAb) detection assays have been developed. Most clinical laboratories use competitive TSH-binding ... ...

    Abstract Background: Graves' disease (GD) is caused by the production of TSH-receptor (TSHR) stimulating auto-antibodies. Over the years various TSHR-antibody (TRAb) detection assays have been developed. Most clinical laboratories use competitive TSH-binding inhibitory immunoglobulin (TBII) assays, which measure the total amount of stimulating and blocking auto-antibodies. Selective detection of TSHR stimulating auto-antibodies (TSI) was previously only possible with functional cell-based bioassays. However, more recently an automated bridge-based binding assay to more specifically measure TSI has become available. The aim of our study was to compare the third-generation automated competitive immunoassay (TBII) with the automated bridge immunoassay (TSI) in clinical practice in an academic thyroid expert center.
    Methods: A retrospective study in 356 patients with Graves' disease, Graves orbitopathy (GO), and other (thyroid) disease treated in an academic thyroid center was performed. All samples were analyzed for TBII and TSI. For both assays, sensitivity, specificity, positive predictive value (PVV), negative predictive value (NPV) and diagnostic odds ratios were calculated using different cut-offs for negativity.
    Results: Using the provided cut-off, the overall sensitivity appeared similar between TBII and TSI, but TSI showed higher overall specificity, PPV, NPV and diagnostic odds ratio. Using two or three times the cut-off for negativity resulted in a decrease in sensitivity, but an increase in specificity and PPV, which was most pronounced for the TBII-assay. Analysis in a subgroup of newly diagnosed treatment naïve GD/GO patients also revealed overall favorable results for the TSI-assay. Increasing the cut-off for negativity resulted in increased specificity for both assays, with similar results using two or three times the cut-off. Most patients with concordant positive results for TBII and TSI suffered from GD or GD + GO (n = 110, 95.6 %), while patients negative for both TBII and TSI mostly suffered from other (thyroid) disease (n = 143, 77.3 %). From patients with positive TBII but negative TSI only 42.1 % had GD/GO (n = 16), whereas 57.9 % (n = 22) had other (thyroid) disease. In contrast, 88.9 % of patients with positive TSI but negative TBII had GD/GO (n = 16), whereas 11.1 % (n = 2) had other (thyroid) disease.
    Conclusion: In our academic thyroid center, the diagnostic performance of the TSI-assay outperformed the TBII-assay. Using a higher cut-off value for negativity can be helpful in assessing clinical relevance.
    Language English
    Publishing date 2023-11-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e22468
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  10. Article ; Online: A Step Forward in Understanding the Relevance of Genetic Variation in Type 2 Deiodinase.

    Medici, Marco / Chaker, Layal / Peeters, Robin P

    The Journal of clinical endocrinology and metabolism

    2021  Volume 102, Issue 5, Page(s) 1775–1778

    MeSH term(s) Genetic Variation ; Humans ; Iodide Peroxidase/genetics ; Triiodothyronine/genetics
    Chemical Substances Triiodothyronine (06LU7C9H1V) ; Iodide Peroxidase (EC 1.11.1.8)
    Language English
    Publishing date 2021-09-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/jc.2017-00585
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