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  1. Article ; Online: Gut Microbiota and Their Metabolites in Stroke: A Double-Edged Sword.

    Peh, Alex / O'Donnell, Joanne A / Broughton, Brad R S / Marques, Francine Z

    Stroke

    2022  Volume 53, Issue 5, Page(s) 1788–1801

    Abstract: Besides damaging the brain, stroke causes systemic changes, including to the gastrointestinal system. A growing body of evidence supports the role of the gut and its microbiota in stroke, stroke prognosis, and recovery. The gut microbiota can increase ... ...

    Abstract Besides damaging the brain, stroke causes systemic changes, including to the gastrointestinal system. A growing body of evidence supports the role of the gut and its microbiota in stroke, stroke prognosis, and recovery. The gut microbiota can increase the risk of a cerebrovascular event, playing a role in the onset of stroke. Conversely, stroke can induce dysbiosis of the gut microbiota and epithelial barrier integrity. This has been proposed as a contributor to systemic infections. In this review, we describe the role of the gut microbiota, microbiome and microbiota-derived metabolites in experimental and clinical stroke, and their potential use as therapeutic targets. Fourteen clinical studies have identified 62 upregulated (eg,
    MeSH term(s) Animals ; Brain ; Dysbiosis ; Fatty Acids, Volatile ; Gastrointestinal Microbiome ; Humans ; Mice ; Stroke/microbiology
    Chemical Substances Fatty Acids, Volatile
    Language English
    Publishing date 2022-02-09
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.121.036800
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 448: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: A red-shifted Bioluminescence Resonance Energy Transfer (BRET) biosensing system for rapid measurement of plasmin activity in human plasma.

    Weihs, Felix / Peh, Alex / Dacres, Helen

    Analytica chimica acta

    2019  Volume 1102, Page(s) 99–108

    Abstract: Proteases are key signalling molecules for many physiological processes and their dysregulation is implicated in the progression of a range of diseases. Sensitive methods to measure protease activities in complex biological samples are critical for rapid ...

    Abstract Proteases are key signalling molecules for many physiological processes and their dysregulation is implicated in the progression of a range of diseases. Sensitive methods to measure protease activities in complex biological samples are critical for rapid disease diagnoses. The proteolytic activity of plasmin reflects the fibrinolysis state of blood and its deregulation can indicate pathologies such as bleeding events. While Bioluminescence Resonance Energy Transfer (BRET) is a powerful and sensitive method for the detection of protease activity, the commonly applied blue-shifted BRET
    MeSH term(s) Bioluminescence Resonance Energy Transfer Techniques/methods ; Biosensing Techniques/methods ; Blood Chemical Analysis/methods ; Fibrinolysin/analysis ; Green Fluorescent Proteins/chemistry ; Humans ; Limit of Detection ; Luciferases, Renilla/chemistry
    Chemical Substances Green Fluorescent Proteins (147336-22-9) ; Luciferases, Renilla (EC 1.13.12.5) ; Fibrinolysin (EC 3.4.21.7)
    Language English
    Publishing date 2019-12-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2019.12.044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Microbial Peer Pressure: The Role of the Gut Microbiota in Hypertension and Its Complications.

    Muralitharan, Rikeish R / Jama, Hamdi A / Xie, Liang / Peh, Alex / Snelson, Matthew / Marques, Francine Z

    Hypertension (Dallas, Tex. : 1979)

    2020  Volume 76, Issue 6, Page(s) 1674–1687

    Abstract: There is increasing evidence of the influence of the gut microbiota on hypertension and its complications, such as chronic kidney disease, stroke, heart failure, and myocardial infarction. This is not surprising considering that the most common risk ... ...

    Abstract There is increasing evidence of the influence of the gut microbiota on hypertension and its complications, such as chronic kidney disease, stroke, heart failure, and myocardial infarction. This is not surprising considering that the most common risk factors for hypertension, such as age, sex, medication, and diet, can also impact the gut microbiota. For example, sodium and fermentable fiber have been studied in relation to both hypertension and the gut microbiota. By combining second- and, now, third-generation sequencing with metabolomics approaches, metabolites, such as short-chain fatty acids and trimethylamine N-oxide, and their producers, have been identified and are now known to affect host physiology and the cardiovascular system. The receptors that bind these metabolites have also been explored with positive findings-examples include known short-chain fatty acid receptors, such as G-protein coupled receptors GPR41, GPR43, GPR109a, and OLF78 in mice. GPR41 and OLF78 have been shown to have inverse roles in blood pressure regulation, whereas GPR43 and GPR109A have to date been demonstrated to impact cardiac function. New treatment options in the form of prebiotics (eg, dietary fiber), probiotics (eg,
    MeSH term(s) Animals ; Blood Pressure/drug effects ; Blood Pressure/physiology ; Cardiovascular System/metabolism ; Cardiovascular System/physiopathology ; Fatty Acids, Volatile/metabolism ; Gastrointestinal Microbiome/physiology ; Humans ; Hypertension/metabolism ; Hypertension/physiopathology ; Prebiotics/administration & dosage ; Probiotics/administration & dosage ; Receptors, G-Protein-Coupled/metabolism
    Chemical Substances Fatty Acids, Volatile ; Prebiotics ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2020-10-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.120.14473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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