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  1. Article ; Online: Rising vasectomy volume following reversal of federal protections for abortion rights in the United States.

    Bole, Raevti / Lundy, Scott D / Pei, Evonne / Bajic, Petar / Parekh, Neel / Vij, Sarah C

    International journal of impotence research

    2023  Volume 36, Issue 3, Page(s) 265–268

    Abstract: In June 2022 the United States Supreme Court issued a ruling in the case Dobbs v. Jackson that overturned Roe v. Wade, the 1973 ruling establishing a federally protected right to abortion in the United States. Anecdotal reports suggested increased ... ...

    Abstract In June 2022 the United States Supreme Court issued a ruling in the case Dobbs v. Jackson that overturned Roe v. Wade, the 1973 ruling establishing a federally protected right to abortion in the United States. Anecdotal reports suggested increased vasectomy volume following this event; however, no published data exist. We sought to describe trends in vasectomy consultation before and after the Dobbs v. Jackson ruling (referred to as pre- and post-Dobbs herein). Following IRB approval, we reviewed charts of all adults seeking vasectomy consultation in July-August 2021 and July-August 2022 at a large healthcare organization. We then aggregated vasectomy procedural billing data from 2018 to present. The primary outcome was volume of vasectomy consultation appointments and the secondary outcome was number of vasectomies performed. In July-August 2021 (Pre-Dobbs), 116 men attended vasectomy consultation versus 142 men in July-August 2022 (Post-Dobbs). Median age Post-Dobbs was significantly younger than Pre-Dobbs (35 vs 38 years, respectively, p = 0.01) with a significant increase in Post-Dobbs men under 30 seeking vasectomy (p = 0.005). A total of 16.9% (24/142) of Post-Dobbs men were childless, compared to 8.6% (10/116) of Pre-Dobbs men (p = 0.05). Of those with children, median number of offspring was unchanged at 2. Billing data showed a significant increase in vasectomy procedural volumes Post-Dobbs. While overturning Roe v Wade directly impacted female reproductive rights, number of vasectomy consultations and procedures increased significantly following this decision. Younger men, especially those under 30, as well as childless men were significantly more likely to seek consultation Post-Dobbs compared to the prior reproductive legal climate. While longer-term data are needed, findings indicate that men are invested in maintaining reproductive autonomy for themselves and their partners.
    Language English
    Publishing date 2023-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034295-3
    ISSN 1476-5489 ; 0955-9930
    ISSN (online) 1476-5489
    ISSN 0955-9930
    DOI 10.1038/s41443-023-00672-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Predictors of Postoperative Complications of Gender-affirming Surgery.

    Pei, Evonne / Patil, Nirav / Perez, Jaime Abraham / Pope, Rachel / Scarberry, Kyle / Khouri, Joseph / Gupta, Shubham / Mishra, Kirtishri

    Urology

    2023  Volume 180, Page(s) 306–307

    MeSH term(s) Humans ; Sex Reassignment Surgery/adverse effects ; Transsexualism/surgery ; Transgender Persons ; Postoperative Complications/epidemiology ; Postoperative Complications/surgery
    Language English
    Publishing date 2023-07-22
    Publishing country United States
    Document type Letter
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2023.07.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Evaluating the readability of online testosterone search results.

    Pominville, Raymond / Tay, Kimberly / Callegari, Michael / Pei, Evonne / Sarica, Erhan / Jesse, Erin / Prunty, Megan / Loeb, Aram / Thirumavalavan, Nannan / Ghayda, Ramy Abou

    International journal of impotence research

    2023  

    Abstract: With the budding interest in testosterone therapy (TTh), online health information plays a significant role in patients' health care decisions. Therefore, we evaluated the source and readability of web-based information available to patients regarding ... ...

    Abstract With the budding interest in testosterone therapy (TTh), online health information plays a significant role in patients' health care decisions. Therefore, we evaluated the source and readability of web-based information available to patients regarding TTh on Google. From Google search terms "Testosterone Therapy" and "Testosterone Replacement", 77 unique sources were identified. Sources were categorized as Academic, Commercial, Institutional, or Patient Support, then evaluated using validated readability and English language text assessment tools: the Flesch Reading Ease score, Flesch Kincade, Gunning Fog, Simple Measure of Gobbledygook (SMOG), Coleman-Liau Index and Automated Readability index. The average grade level for understanding academic sources was 16 (college senior); commercial, institutional, and patient support sources were 13 (college freshman); 8 and 5 grade levels, respectively, above the average U.S. adult. Patient support sources were most prevalent, while commercial sources were the least at 35 and 14%, respectively. The average reading ease score was 36.8, indicative of difficult-to-read material overall. These results indicate that the most immediate online sources for TTh information exceed the average reading level of most adults within the U.S., hence more effort should be taken to publish accessible and readable material to improve patient health literacy.
    Language English
    Publishing date 2023-03-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034295-3
    ISSN 1476-5489 ; 0955-9930
    ISSN (online) 1476-5489
    ISSN 0955-9930
    DOI 10.1038/s41443-023-00682-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Understanding Factors Leading to Surgical Attrition for "Resectable" Gastric Cancer.

    Kakish, Hanna H / Ahmed, Fasih Ali / Pei, Evonne / Dong, Weichuan / Elshami, Mohamedraed / Ocuin, Lee M / Rothermel, Luke D / Ammori, John B / Hoehn, Richard S

    Annals of surgical oncology

    2023  Volume 30, Issue 7, Page(s) 4207–4216

    Abstract: Objectives: We used a novel combined analysis to evaluate various factors associated with failure to surgical resection in non-metastatic gastric cancer.: Methods: We identified factors associated with the receipt of surgery in publicly available ... ...

    Abstract Objectives: We used a novel combined analysis to evaluate various factors associated with failure to surgical resection in non-metastatic gastric cancer.
    Methods: We identified factors associated with the receipt of surgery in publicly available clinical trial data for gastric cancer and in the National Cancer Database (NCDB) for patients with stages I-III gastric adenocarcinoma. Next, we evaluated variable importance in predicting the receipt of surgery in the NCDB.
    Results: In published clinical trial data, 10% of patients in surgery-first arms did not undergo surgery, mostly due to disease progression and 15% of patients in neoadjuvant therapy arms failed to reach surgery. Effects related to neoadjuvant administration explained the increased attrition (5%). In the NCDB, 61.7% of patients underwent definitive surgery. In a subset of NCDB patients resembling those enrolled in clinical trials (younger, healthier, and privately insured patients treated at high-volume and academic centers) the rate of surgery was 79.2%. Decreased likelihood of surgery was associated with advanced age (OR 0.97, p < 0.01), Charlson-Deyo score of 2+ (OR 0.90, p < 0.01), T4 tumors (OR 0.39, p < 0.01), N+ disease (OR 0.84, p < 0.01), low socioeconomic status (OR 0.86, p = 0.01), uninsured or on Medicaid (OR 0.58 and 0.69, respectively, p < 0.01), low facility volume (OR 0.64, p < 0.01), and non-academic cancer programs (OR 0.79, p < 0.01).
    Conclusion: Review of clinical trials shows attrition due to unavoidable tumor and treatment factors (~ 15%). The NCDB indicates non-medical patient and provider characteristics (i.e., age, insurance status, facility volume) associated with attrition. This combined analysis highlights specific opportunities for improving potentially curative surgery rates.
    MeSH term(s) United States ; Humans ; Stomach Neoplasms/surgery ; Adenocarcinoma/surgery ; Adenocarcinoma/pathology ; Medicaid ; Neoadjuvant Therapy ; Medically Uninsured
    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13469-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Decoding neural activity to predict rat locomotion using intracortical and epidural arrays.

    Barroso, Filipe O / Yoder, Bryan / Tentler, David / Wallner, Josephine J / Kinkhabwala, Amina A / Jantz, Maria K / Flint, Robert D / Tostado, Pablo M / Pei, Evonne / Satish, Ambika D R / Brodnick, Sarah K / Suminski, Aaron J / Williams, Justin C / Miller, Lee E / Tresch, Matthew C

    Journal of neural engineering

    2019  Volume 16, Issue 3, Page(s) 36005

    Abstract: Objective: Recovery of voluntary gait after spinal cord injury (SCI) requires the restoration of effective motor cortical commands, either by means of a mechanical connection to the limbs, or by restored functional connections to muscles. The latter ... ...

    Abstract Objective: Recovery of voluntary gait after spinal cord injury (SCI) requires the restoration of effective motor cortical commands, either by means of a mechanical connection to the limbs, or by restored functional connections to muscles. The latter approach might use functional electrical stimulation (FES), driven by cortical activity, to restore voluntary movements. Moreover, there is evidence that this peripheral stimulation, synchronized with patients' voluntary effort, can strengthen descending projections and recovery. As a step towards establishing such a cortically-controlled FES system for restoring function after SCI, we evaluate here the type and quantity of neural information needed to drive such a brain machine interface (BMI) in rats. We compared the accuracy of the predictions of hindlimb electromyograms (EMG) and kinematics using neural data from an intracortical array and a less-invasive epidural array.
    Approach: Seven rats were trained to walk on a treadmill with a stable pattern. One group of rats (n  =  4) was implanted with intracortical arrays spanning the hindlimb sensorimotor cortex and EMG electrodes in the contralateral hindlimb. Another group (n  =  3) was implanted with epidural arrays implanted on the dura overlying hindlimb sensorimotor cortex. EMG, kinematics and neural data were simultaneously recorded during locomotion. EMGs and kinematics were decoded using linear and nonlinear methods from multiunit activity and field potentials.
    Main results: Predictions of both kinematics and EMGs were effective when using either multiunit spiking or local field potentials (LFPs) recorded from intracortical arrays. Surprisingly, the signals from epidural arrays were essentially uninformative. Results from somatosensory evoked potentials (SSEPs) confirmed that these arrays recorded neural activity, corroborating our finding that this type of array is unlikely to provide useful information to guide an FES-BMI for rat walking.
    Significance: We believe that the accuracy of our decoders in predicting EMGs from multiunit spiking activity is sufficient to drive an FES-BMI. Our future goal is to use this rat model to evaluate the potential for cortically-controlled FES to be used to restore locomotion after SCI, as well as its further potential as a rehabilitative technology for improving general motor function.
    MeSH term(s) Action Potentials/physiology ; Animals ; Brain-Computer Interfaces ; Electromyography/methods ; Epidural Space/physiology ; Evoked Potentials, Somatosensory/physiology ; Female ; Forecasting ; Locomotion/physiology ; Neurons/physiology ; Rats ; Rats, Sprague-Dawley ; Somatosensory Cortex/physiology
    Language English
    Publishing date 2019-02-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2170901-4
    ISSN 1741-2552 ; 1741-2560
    ISSN (online) 1741-2552
    ISSN 1741-2560
    DOI 10.1088/1741-2552/ab0698
    Database MEDical Literature Analysis and Retrieval System OnLINE

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