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Book ; Online ; E-Book: Microsurgical orthopedics

Pei, Guoxian

2019

Author's details	Guoxian Pei editor
Language	English
Size	1 Online-Ressource (viii, 559 Seiten), Illustrationen
Publisher	Springer
Publishing place	Dordrecht
Publishing country	Netherlands
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT020201538
ISBN	9789402416251 ; 9789402416237 ; 9402416250 ; 9402416234
DOI	10.1007/978-94-024-1625-1
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online ; E-Book: Digital orthopedics

Pei, Guoxian

2018

Author's details	Guoxian Pei editor
Language	English
Size	1 Online-Ressource (xvi, 447 Seiten), Illustartionen
Publisher	Springer
Publishing place	Dordrecht
Publishing country	Netherlands
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT020012236
ISBN	978-94-024-1076-1 ; 9789402410747 ; 94-024-1076-7 ; 9402410740
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Clinical application and prospect of 3D printing technology in orthopeadics

DONG Xieping / PEI Guoxian

陆军军医大学学报, Vol 44, Iss 15, Pp 1501-

2022 Volume 1507

Abstract: The advantages of clinical application of 3D printing technology in orthopaedics have been gradually explored, showing a trend of vigorous development. However, throughout the country, there are still few hospitals and orthopedic surgeons who can apply ... ...

Abstract	The advantages of clinical application of 3D printing technology in orthopaedics have been gradually explored, showing a trend of vigorous development. However, throughout the country, there are still few hospitals and orthopedic surgeons who can apply 3D printing technology at a high level. This manuscript summarizes the application type, technical level, application field, clinical value, development conditions and application status of 3D printing technology in orthopaedic clinical application, analyzes the technical points and possible risks that should be paid attention to in the whole process of orthopaedic clinical application, and discusses the role of technology supply side, demand side and regulation side in the clinical promotion of 3D printing orthopaedics. The main reasons for the uneven development of 3D printing technology in various parts of the country are mainly due to the differences of technical mastery and application environment, while the crux of negative impact mainly lies in the insufficient understanding of doctors, lagging charging policy and indifference of the service market, which provide guidance in the popularization and application of 3D printing technology in orthopaedic clinic.
Keywords	3d printing ; additive manufacturing ; orthopaedics ; clinical transformation ; popularization and application ; Medicine (General) ; R5-920
Subject code	600
Language	Chinese
Publishing date	2022-08-01T00:00:00Z
Publisher	Editorial Office of Journal of Army Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Fractional differential equation modeling of the HBV infection with time delay and logistic proliferation.

Sun, Deshun / Liu, Jingxiang / Su, Xiuyun / Pei, Guoxian

Frontiers in public health

2022 Volume 10, Page(s) 1036901

Abstract: In this article, a fractional-order differential equation model of HBV infection was proposed with a Caputo derivative, delayed immune response, and logistic proliferation. Initially, infection-free and infection equilibriums and the basic reproduction ... ...

Abstract	In this article, a fractional-order differential equation model of HBV infection was proposed with a Caputo derivative, delayed immune response, and logistic proliferation. Initially, infection-free and infection equilibriums and the basic reproduction number were computed. Thereafter, the stability of the two equilibriums was analyzed based on the fractional Routh-Hurwitz stability criterion, and the results indicated that the stability will change if the time delay or fractional order changes. In addition, the sensitivity of the basic reproduction number was analyzed to find out the most sensitive parameter. Lastly, the theoretical analysis was verified by numerical simulations. The results showed that the time delay of immune response and fractional order can significantly affect the dynamic behavior in the HBV infection process. Therefore, it is necessary to consider time delay and fractional order in modeling HBV infection and studying its dynamics.
MeSH term(s)	Hepatitis B virus ; Basic Reproduction Number ; Cell Proliferation
Language	English
Publishing date	2022-11-11
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2022.1036901
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Article ; Online: ZIP4 upregulation aggravates nucleus pulposus cell degradation by promoting inflammation and oxidative stress by mediating the HDAC4-FoxO3a axis.

Shen, Mingkui / Li, Kuankuan / Wang, Lulu / Feng, Li / Zhang, Xinyu / Zhang, Haoping / Zhou, Honggang / Pei, Guoxian

Aging

2024 Volume 16, Issue 1, Page(s) 685–700

Abstract: Background: Extracellular matrix metabolism dysregulation in nucleus pulposus (NP) cells represents a crucial pathophysiological feature of intervertebral disc degeneration (IDD). Our study elucidates the role and mechanism of Testis expressed 11 (TEX11, ...

Abstract	Background: Extracellular matrix metabolism dysregulation in nucleus pulposus (NP) cells represents a crucial pathophysiological feature of intervertebral disc degeneration (IDD). Our study elucidates the role and mechanism of Testis expressed 11 (TEX11, also called ZIP4) extracellular matrix degradation in the NP. Materials and methods: Interleukin-1β (IL-1β) and H Results: The ZIP4 profile increased in the NP tissues of IDD patients and IL-1β- or H Conclusions: ZIP4 upregulation aggravates the extracellular matrix (ECM) degradation of NP cells by mediating inflammation and oxidative stress through the HDAC4-FoxO3a axis.
MeSH term(s)	Humans ; Male ; Cells, Cultured ; Extracellular Matrix/metabolism ; Histone Deacetylases/genetics ; Histone Deacetylases/metabolism ; Hydrogen Peroxide/pharmacology ; Hydrogen Peroxide/metabolism ; Inflammation/metabolism ; Intervertebral Disc Degeneration/genetics ; Intervertebral Disc Degeneration/metabolism ; NF-kappa B/metabolism ; Nucleus Pulposus/metabolism ; Oxidative Stress ; Repressor Proteins/metabolism ; Sirtuin 1/metabolism ; Up-Regulation
Chemical Substances	HDAC4 protein, human (EC 3.5.1.98) ; Histone Deacetylases (EC 3.5.1.98) ; Hydrogen Peroxide (BBX060AN9V) ; NF-kappa B ; Repressor Proteins ; Sirtuin 1 (EC 3.5.1.-) ; SLC39A4 protein, human ; FOXO3 protein, human
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Journal Article
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.205412
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Microgroove Cues Guiding Fibrogenesis of Stem Cells via Intracellular Force

Lei, Xing / Miao, Sheng / Wang, Xiuli / Gao, Yi / Wu, Hao / Cheng, Pengzhen / Song, Yue / Bi, Long / Pei, Guoxian

ACS Applied Materials & Interfaces. 2023 Mar. 24, v. 15, no. 13 p.16380-16393

2023

Abstract: Groove patterns are widely used in material surface modifications. However, the independent role of ditches/ridges in regulating fibrosis of soft tissues is not well-understood, especially the lack of linkage evidence in vitro and in vivo. Herein, two ... ...

Abstract	Groove patterns are widely used in material surface modifications. However, the independent role of ditches/ridges in regulating fibrosis of soft tissues is not well-understood, especially the lack of linkage evidence in vitro and in vivo. Herein, two kinds of combinational microgroove chips with the gradient ditch/ridge width were fabricated by photolithography technology, termed R and G groups, respectively. In group R, the ridge width was 1, 5, 10, and 30 μm, with a ditch width of 30 μm; in group G, the groove width was 5, 10, 20, and 30 μm, and the ridge width was 5 μm. The effect of microgrooves on the morphology, proliferation, and expression of fibrous markers of stem cells was systematically investigated in vitro. Moreover, thicknesses of fibrous capsules were evaluated after chips were implanted into the muscular pouches of rats for 5 months. The results show that microgrooves have almost no effect on cell proliferation but significantly modulate the morphology of cells and focal adhesions (FAs) in vitro, as well as fibrosis differentiation. In particular, the differentiation of stem cells is attenuated after the intracellular force caused by stress fibers and FAs is interfered by drugs, such as rotenone and blebbistatin. Histological analysis shows that patterns of high intracellular force can apparently stimulate soft tissue fibrosis in vivo. This study not only reveals the specific rules and mechanisms of ditch/ridge regulating stem cell behaviors but also offers insight into tailoring implant surface patterns to induce controlled soft tissue fibrosis.
Keywords	cell proliferation ; fibrosis ; histology ; rotenone ; stem cells ; tissues ; groove patterns ; intracellular force ; focal adhesions
Language	English
Dates of publication	2023-0324
Size	p. 16380-16393.
Publishing place	American Chemical Society
Document type	Article ; Online
ISSN	1944-8252
DOI	10.1021/acsami.2c20903
Database	NAL-Catalogue (AGRICOLA)

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Article: Repair of distal fibular and lateral malleolus defects with individualized 3D-printed titanium alloy prosthesis: The first case report from China.

Cheng, Jiangang / Gao, Yang / Long, Zhuoyu / Pei, Guoxian / Li, Zhengyu / Meng, Guolin

International journal of surgery case reports

2022 Volume 94, Page(s) 107057

Abstract: Introduction and importance: This case report describes the reconstruction of the traumatic distal fibular and lateral malleolus defects with a novel method of using individualized 3D printed titanium prosthesis for the first time.: Case presentation!# ...

Abstract	Introduction and importance: This case report describes the reconstruction of the traumatic distal fibular and lateral malleolus defects with a novel method of using individualized 3D printed titanium prosthesis for the first time. Case presentation: A 63-year-old male farmer was hospitalized in emergency because of open injury and distal fibular and lateral malleolus defects in the left leg caused by a car accident. 3 months after debridement and latissimus dorsi muscle flap transplantation and skin graft operation, the patient re-hospitalized because of distal fibular and lateral malleolus defect and local pain. We examined the bilateral ankle joint with three-dimensional CT, obtained data about the missing left distal fibular and lateral malleolus through the mirror principle. The corresponding titanium alloy prosthesis then was designed and printed using a 3D metal printer. The patient had no obvious contraindication for surgery, so the prosthesis was surgically implanted. The patient was followed up for 2 years. There was no discomfort at the surgical site. The function of the operated ankle was satisfied by the patient, the AOFAS (American Orthopaedic Foot & Ankle Society) score was 85 (Kitaoka et al., 1994 [1]). Clinical discussion: Individualized 3D printed titanium alloy prosthesis consistent with the anatomical structure of lost distal fibula and lateral malleolus. The proximal end of the prosthesis was designed with four nail holes to install screws to fix the fibula together with it. The lower tibiofibular and talofibular joint surfaces of the prosthesis were designed smoothly. In order to improve the stability of the lower tibiofibular joint, anchors were placed at the attachment of the anterior and posterior tibiofibular ligaments to reconstruct these ligaments. Conclusion: The structure and function of the reconstructed distal fibular and the lateral malleous were close to normal. Individualized 3D printed prosthesis might have considerable advantages over traditional treatment methods. The individualized 3D printed titanium alloy prosthesis provides a new method for the repair and reconstruction of similar bone defects. The use of 3D printed prosthesis for surgical repair needs to be further examined in the future through long-term follow-up studies and in more cases.
Language	English
Publishing date	2022-04-13
Publishing country	Netherlands
Document type	Journal Article
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2022.107057
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Article ; Online: Distal Humerus Morphological Analysis of Chinese Individuals: A Statistical Shape Modeling Approach.

Zhao, Wei / Guo, Yao / Xu, Chuangye / Pei, Guoxian / Basnet, Shiva / Pei, Yanjun / Su, Xiuyun

Orthopaedic surgery

2022 Volume 14, Issue 10, Page(s) 2730–2740

Abstract: Objective: A detailed analysis of the morphology of distal humeral articulation can help in the creation of anatomic prostheses of hemiarthroplasty. This study used statistical shape modeling to evaluate the 3D morphology of the distal humerus in ... ...

Abstract	Objective: A detailed analysis of the morphology of distal humeral articulation can help in the creation of anatomic prostheses of hemiarthroplasty. This study used statistical shape modeling to evaluate the 3D morphology of the distal humerus in healthy Chinese individuals and to investigate the proper articular morphology differences. Methods: A statistical shape model (SSM) of the distal humerus was created using CT scans of 106 survey-confirmed nonpathologic elbows. In addition, the articular components of each principal component (PC) were selected and fitted on the mean mode. The Euclidean point-to-mesh distance of articular modes was calculated as a measurement the proper change in the morphology of the articulation. Results: The first seven PCs jointly accounted for 80.9% of the total variation (44.4%, 12.2%, 7.9%, 5.9%, 4.1%, 3.4% and 3%, respectively). In the mean model, the distance between the medial and lateral epicondyles was 57.4 mm, the width of the articulation was 42.1 mm, and the angle of the transepicondylar line (TEL) and C line was 4.8°. The articular surface differences of the first PC were significant (RMS: 1.43 mm in the -3 SD model and 2.38 mm in the +3 SD model), whereas under other conditions, the differences were not remarkable despite the maximum deformation not exceeding 1 mm. Conclusion: A novel method (SSM) was used to evaluate the 3D morphology of the distal humerus in healthy Chinese individuals and investigate the proper articular shape differences. We found the proper shape of articular surface basically transformed into one variation pattern which was relevant to the bone size, even though the morphology of distal humerus possessed complicated variation modes. The findings of this study can be helpful to design the next generation of elbow hemiarthroplasty in the future.
MeSH term(s)	China ; Elbow Joint/anatomy & histology ; Elbow Joint/diagnostic imaging ; Elbow Joint/surgery ; Hemiarthroplasty/methods ; Humans ; Humerus/diagnostic imaging ; Humerus/surgery ; Tomography, X-Ray Computed
Language	English
Publishing date	2022-09-14
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2503162-4
ISSN	1757-7861 ; 1757-7853 ; 1757-7861
ISSN (online)	1757-7861 ; 1757-7853
ISSN	1757-7861
DOI	10.1111/os.13492
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Zs.A 6786: Show issues

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Article: [Targeted muscle reinnervation: a surgical technique of human-machine interface for intelligent prosthesis].

Guo, Yao / Zhao, Wei / Huang, Jianping / Shen, Mingkui / Li, Sijing / Liu, Cheng / Su, Xiuyun / Li, Guanglin / Bi, Sheng / Pei, Guoxian

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

2023 Volume 37, Issue 8, Page(s) 1021–1025

Abstract: Objective: To review targeted muscle reinnervation (TMR) surgery for the construction of intelligent prosthetic human-machine interface, thus providing a new clinical intervention paradigm for the functional reconstruction of residual limbs in amputees.! ...

Abstract	Objective: To review targeted muscle reinnervation (TMR) surgery for the construction of intelligent prosthetic human-machine interface, thus providing a new clinical intervention paradigm for the functional reconstruction of residual limbs in amputees. Methods: Extensively consulted relevant literature domestically and abroad and systematically expounded the surgical requirements of intelligent prosthetics, TMR operation plan, target population, prognosis, as well as the development and future of TMR. Results: TMR facilitates intuitive control of intelligent prostheses in amputees by reconstructing the "brain-spinal cord-peripheral nerve-skeletal muscle" neurotransmission pathway and increasing the surface electromyographic signals required for pattern recognition. TMR surgery for different purposes is suitable for different target populations. Conclusion: TMR surgery has been certified abroad as a transformative technology for improving prosthetic manipulation, and is expected to become a new clinical paradigm for 2 million amputees in China.
MeSH term(s)	Humans ; Artificial Limbs ; Muscle, Skeletal ; Neurosurgical Procedures ; Plastic Surgery Procedures ; Prosthesis Implantation
Language	Chinese
Publishing date	2023-08-16
Publishing country	China
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1420212-8
ISSN	1002-1892
ISSN	1002-1892
DOI	10.7507/1002-1892.202304045
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Zs.A 4866: Show issues

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Article ; Online: Combined Molybdenum Gelatine Methacrylate Injectable Nano-Hydrogel Effective Against Diabetic Bone Regeneration.

Liao, Xun / Shen, Mingkui / Li, Tengbo / Feng, Li / Lin, Zhao / Shi, Guang / Pei, Guoxian / Cai, Xiyu

International journal of nanomedicine

2023 Volume 18, Page(s) 5925–5942

Abstract: Introduction: Bone defects in diabetes mellitus (DM) remain a major challenge for clinical treatment. Fluctuating glucose levels in DM patients lead to excessive production of reactive oxygen species (ROS), which disrupt bone repair homeostasis. Bone ... ...

Abstract	Introduction: Bone defects in diabetes mellitus (DM) remain a major challenge for clinical treatment. Fluctuating glucose levels in DM patients lead to excessive production of reactive oxygen species (ROS), which disrupt bone repair homeostasis. Bone filler materials have been widely used in the clinical treatment of DM-related bone defects, but overall they lack efficacy in improving the bone microenvironment and inducing osteogenesis. We utilized a gelatine methacrylate (GelMA) hydrogel with excellent biological properties in combination with molybdenum (Mo)-based polyoxometalate nanoclusters (POM) to scavenge ROS and promote osteoblast proliferation and osteogenic differentiation through the slow-release effect of POM, providing a feasible strategy for the application of biologically useful bone fillers in bone regeneration. Methods: We synthesized an injectable hydrogel by gelatine methacrylate (GelMA) and POM. The antioxidant capacity and biological properties of the synthesized GelMA/POM hydrogel were tested. Results: In vitro, studies showed that hydrogels can inhibit excessive reactive oxygen species (ROS) and reduce oxidative stress in cells through the beneficial effects of pH-sensitive POM. Osteogenic differentiation assays showed that GelMA/POM had good osteogenic properties with upregulated expression of osteogenic genes (BMP2, RUNX2, Osterix, ALP). Furthermore, RNA-sequencing revealed that activation of the PI3K/Akt signalling pathway in MC3T3-E1 cells with GelMA/POM may be a potential mechanism to promote osteogenesis. In an in vivo study, radiological and histological analyses showed enhanced bone regeneration in diabetic mice, after the application of GelMA/POM. Conclusion: In summary, GelMA/POM hydrogels can enhance bone regeneration by directly scavenging ROS and activating the PI3K/Akt signalling pathway.
MeSH term(s)	Humans ; Mice ; Animals ; Osteogenesis ; Hydrogels/pharmacology ; Reactive Oxygen Species/metabolism ; Molybdenum/pharmacology ; Proto-Oncogene Proteins c-akt/metabolism ; Gelatin/pharmacology ; Methacrylates/pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Diabetes Mellitus, Experimental/drug therapy ; Bone Regeneration
Chemical Substances	Hydrogels ; Reactive Oxygen Species ; Molybdenum (81AH48963U) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Gelatin (9000-70-8) ; Methacrylates ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
Language	English
Publishing date	2023-10-20
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S428429
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