Article ; Online: Transcriptional regulators of secondary metabolite biosynthesis in Streptomyces.
World journal of microbiology & biotechnology
2024 Volume 40, Issue 5, Page(s) 156
Abstract: In the post-genome era, great progress has been made in metabolic engineering using recombinant DNA technology to enhance the production of high-value products by Streptomyces. With the development of microbial genome sequencing techniques and ... ...
| Abstract | In the post-genome era, great progress has been made in metabolic engineering using recombinant DNA technology to enhance the production of high-value products by Streptomyces. With the development of microbial genome sequencing techniques and bioinformatic tools, a growing number of secondary metabolite (SM) biosynthetic gene clusters in Streptomyces and their biosynthetic logics have been uncovered and elucidated. In order to increase our knowledge about transcriptional regulators in SM of Streptomyces, this review firstly makes a comprehensive summary of the characterized factors involved in enhancing SM production and awakening SM biosynthesis. Future perspectives on transcriptional regulator engineering for new SM biosynthesis by Streptomyces are also provided. |
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| MeSH term(s) | Streptomyces/genetics ; Secondary Metabolism/genetics ; Chromosome Mapping ; Computational Biology ; Metabolic Engineering |
| Language | English |
| Publishing date | 2024-04-08 |
| Publishing country | Germany |
| Document type | Journal Article ; Review |
| ZDB-ID | 1499109-3 |
| ISSN | 1573-0972 ; 0959-3993 |
| ISSN (online) | 1573-0972 |
| ISSN | 0959-3993 |
| DOI | 10.1007/s11274-024-03968-2 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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