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Article: Perioperative management of bronchoscopy in a child patient with central core disease: A case report and literature review.

Li, Hong-Bo / Ji, Xiang-Lin / Nie, Pei-He / Sun, Neng-Hong / Li, Rui-Hua

International journal of surgery case reports

2024 Volume 118, Page(s) 109629

Abstract: Introduction: We described the perioperative management of a child patient with central core disease for bronchoscopy with bronchoalveolar lavage. It is safe to avoid triggering agents (volatile anesthetics and succinylcholine) probably in preventing ... ...

Abstract	Introduction: We described the perioperative management of a child patient with central core disease for bronchoscopy with bronchoalveolar lavage. It is safe to avoid triggering agents (volatile anesthetics and succinylcholine) probably in preventing this appearance of malignant hyperthermia (MH). It is important to recognize potential complications and know how to prevent and manage them in patients with this condition. Presentation of case: A 5-year-old boy (weight: 8.8 kg; height: 63 cm) presented to the pediatric department after five days of intermittent fever (highest body temperature is 39.3 °C) and cough, and aggravation 1 day, meanwhile he had phlegm in throat but he couldn't cough out. The child was found to have motor retardation at his one-month-old physical examination, then genetic analysis showed central core disease. Bronchoscopy with bronchoalveolar lavage was performed for better treatment under the premise of symptomatic treatment. Discussion: The patients with central core disease are particularly to develop malignant hyperthermia, so adequate precautions are in place to prevent and treat MH before anesthetic induction. The anesthesiologists need to make adequate preoperative anesthesia management strategies to ensure the safety of the child with central core disease for bronchoscopy with bronchoalveolar lavage. The child was discharged from the hospital one week after anti-inflammatory and anti-asthmatic treatment. Conclusion: We summarized the anesthetic precautions and management in patients with central core disease, meanwhile we offered some suggestions about anesthetic focus on bronchoscopy with bronchoalveolar lavage.
Language	English
Publishing date	2024-04-07
Publishing country	Netherlands
Document type	Case Reports
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2024.109629
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Integrated multiomic data analysis reveals the clinical significance of TXNIP and contributing to immune microenvironment in triple negative breast cancer.

Gong, Han / Zhang, PeiHe / Hu, Xingming / Zhang, Bin

Translational oncology

2023 Volume 39, Page(s) 101808

Abstract: Triple negative breast cancer (TNBC) is a type of breast cancer with the worst clinical outcome. TNBC is not sensitive to typical endocrine therapy and targeted therapy. Thioredoxin interacting protein (TXNIP), known as a tumor suppressor, is related to ... ...

Abstract	Triple negative breast cancer (TNBC) is a type of breast cancer with the worst clinical outcome. TNBC is not sensitive to typical endocrine therapy and targeted therapy. Thioredoxin interacting protein (TXNIP), known as a tumor suppressor, is related to oxidative stress and energy metabolism. However, the clinical significance of TXNIP in TNBC and mechanism in immunity have not been fully reported. In this study, we found that the expression of TXNIP was downregulated obviously in TNBC tissues and negatively correlated with tumor grade by comprehensive bioinformatics analysis and immunohistochemistry staining of 108 TNBC tissues. Through in vivo and in vitro experiments, we identified TXNIP as a tumor suppressor in TNBC. By bulk mRNA and scRNA analysis, we found that TXNIP could enhance immune response in TNBC and was a potential biomarker for cancer immunity and immunotherapy. We also performed the drug susceptibility analysis to reveal the therapeutic value of TXNIP. In conclusion, our findings demonstrated that TXNIP was a tumor suppressor in TNBC and was involved in tumor malignancy progression. TXNIP was a potential biomarker for immunotherapy and promising molecular therapeutic target.
Language	English
Publishing date	2023-10-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2443840-6
ISSN	1936-5233
ISSN	1936-5233
DOI	10.1016/j.tranon.2023.101808
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Development of Highly Efficient Estrogen Receptor β-Targeted Near-Infrared Fluorescence Probes Triggered by Endogenous Hydrogen Peroxide for Diagnostic Imaging of Prostate Cancer

Pei He / Xiaofei Deng / Bin Xu / Baohua Xie / Wenting Zou / Haibing Zhou / Chune Dong

Molecules, Vol 28, Iss 2309, p

2023 Volume 2309

Abstract: Hydrogen peroxide is one of the most important reactive oxygen species, which plays a vital role in many physiological and pathological processes. A dramatic increase in H 2 O 2 levels is a prominent feature of cancer. Therefore, rapid and sensitive ... ...

Abstract	Hydrogen peroxide is one of the most important reactive oxygen species, which plays a vital role in many physiological and pathological processes. A dramatic increase in H 2 O 2 levels is a prominent feature of cancer. Therefore, rapid and sensitive detection of H 2 O 2 in vivo is quite conducive to an early cancer diagnosis. On the other hand, the therapeutic potential of estrogen receptor beta (ERβ) has been implicated in many diseases including prostate cancer, and this target has attracted intensive attention recently. In this work, we report the development of the first H 2 O 2 -triggered ERβ-targeted near-infrared fluorescence (NIR) probe and its application in imaging of prostate cancer both in vitro and in vivo. The probe showed good ERβ selective binding affinity, excellent H 2 O 2 responsiveness and near infrared imaging potential. Moreover, in vivo and ex vivo imaging studies indicated that the probe could selectively bind to DU-145 prostate cancer cells and rapidly visualizes H 2 O 2 in DU-145 xenograft tumors. Mechanistic studies such as high-resolution mass spectrometry (HRMS) and density functional theory (DFT) calculations indicated that the borate ester group is vital for the H 2 O 2 response turn-on fluorescence of the probe. Therefore, this probe might be a promising imaging tool for monitoring the H 2 O 2 levels and early diagnosis studies in prostate cancer research.
Keywords	estrogen receptor β ; H 2 O 2 -triggered ; near-infrared ; prostate cancer ; in vivo imaging ; Organic chemistry ; QD241-441
Subject code	290
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Efficacy of Tuina in chronic low back pain with anxiety

Qi Zhang / Ping Lu / Pei He / Zhiyang Yin / Zhang Shuaipan / Min Fang

BMJ Open, Vol 13, Iss

study protocol for a randomised controlled trial

2023 Volume 10

Abstract: Introduction Chronic low back pain (cLBP) is one of the largest and most frequent public health problems worldwide. Tuina is a physical therapy commonly used in China to treat musculoskeletal diseases. Compared with traction, there is little high-quality ...

Abstract	Introduction Chronic low back pain (cLBP) is one of the largest and most frequent public health problems worldwide. Tuina is a physical therapy commonly used in China to treat musculoskeletal diseases. Compared with traction, there is little high-quality scientific evidence that can demonstrate the effectiveness of Tuina in the treatment of patients with cLBP. Therefore, the purpose of this clinical trial is to evaluate the effect of massage on cLBP patients compared with traction.Methods and analyses This is a single-centre, assessor-blinded and analyst-blinded prospective randomised controlled trial with two parallel arms. Ninety-four patients with cLBP will be recruited. Three treatments were given every week for a total of 4 weeks. In the Traction group, participants were given traction therapy in the Tuina group, participants will receive a four-step physiotherapy including kneading, rolling, plucking and oblique pulling. The outcomes will be measured at baseline, at the end of treatment, as well as 1 and 2 months after treatment. The primary outcome will be the Hamilton Anxiety Scale after 12 sessions of treatment. The secondary outcomes will be the Visual Analogue Scale, the medical outcomes study Short Form 36, Serum Quantitative Index and genetic testing after 12 sessions of treatment.Ethics and dissemination The study was approved by the Ethics Committee of Yueyang Hospital of Integrated Traditional Chinese and Western Medicine affiliated with Shanghai University of Traditional Chinese Medicine.Trial registration number ChiCTR2200065448.
Keywords	Medicine ; R
Subject code	170
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Multi-Level Fuzzy Evaluation Method for the Reliability of Integrated Energy Systems

Pei He / Yangming Guo / Xiaodong Wang / Shiqi Zhang / Zhihao Zhong

Applied Sciences, Vol 13, Iss 1, p

2022 Volume 274

Abstract: With the increase in environmental pressure and rapid development of renewable energy technologies, an integrated energy system has been recognized as an effective approach to accommodate large-scale renewables and achieve environmental sustainability. ... ...

Abstract	With the increase in environmental pressure and rapid development of renewable energy technologies, an integrated energy system has been recognized as an effective approach to accommodate large-scale renewables and achieve environmental sustainability. While an integrated energy system significantly improves energy efficiency, the interaction between different energy systems may also bring multiple operational risks to its reliability, which necessitates an effective reliability assessment technique. In this paper, we proposed a multi-level fuzzy evaluation model based on combined empowerment for the reliability evaluation of an integrated energy system. The analytic hierarchy process method and entropy weight method were used to calculate the weight of each index in the evaluation model. Fuzzy evaluation matrix was constructed by the membership degree of a single factor, which was defined by the fuzzy comprehensive evaluation method. The multi-level fuzzy evaluation results were obtained based on single-level evaluation results. Finally, case studies were carried out based on a practical integrated energy system; we proposed 5 first-level indicators such as reliability and economy and 12 second-level indicators such as mean time of incapacity. The simulation results (85.15) showed the effectiveness and advantages of the proposed model.
Keywords	integrated energy system ; analytic hierarchy process ; entropy weight method ; multi-level fuzzy evaluation ; reliability assessment ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	690
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [function of the patients' male partners].

Zhou, Zhi-Hao / Liang, Pei-He / Chen, Yan-Lin / Fan, Run-Ze / Hu, Jian

Zhonghua nan ke xue = National journal of andrology

2023 Volume 28, Issue 1, Page(s) 26–31

Abstract: Objective: To investigate the sexual behavior and sexual function of the male partners of breast cancer patients and their potential relationship with socio-demographic and clinical variables.: Methods: In this cross-sectional study, we conducted an ... ...

Abstract	Objective: To investigate the sexual behavior and sexual function of the male partners of breast cancer patients and their potential relationship with socio-demographic and clinical variables. Methods: In this cross-sectional study, we conducted an investigation among 196 male partners (aged 23－59 years) of breast cancer patients between May 2020 and October 2020. We completed the Male Sexual Function Questionnaire (BSFI) by online and telephone interview with the subjects and collected relevant socio-demographic and clinical variables. Results: The average age of the interviewees was (46.13 ± 7.75) years old, and the mean duration of the patients' breast cancer was (1.58 ± 0.48) years at the time of the investigation. The incidence rate of sexual dysfunction in the male partners of the patients was dramatically higher after the onset of breast cancer than before it (49.76% vs 9.68%, P < 0.01). Low libido was found to be the main type of sexual dysfunction (38.3%) among the male subjects, with an even high incidence rate among those whose wives received mastectomy (OR = 5.533, P = 0.017, 95% CI: 1.366－22.412) and radiotherapy (OR = 3.439, P < 0.044, 95% CI: 1.058－11.171) and significantly correlated with age (OR = 1.134, P = 0.001, 95% CI: 1.053－1.222). Conclusions: Breast cancer and its treatment methods may affect the sexual function of the male partners of the patients. It is necessary for doctors to pay attention to the factors affecting the sexual function of the patients and their partners so as to take appropriate intervention measures.
Language	Chinese
Publishing date	2023-07-17
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2267480-9
ISSN	1009-3591
ISSN	1009-3591
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Serum apolipoprotein A-II and alpha-2-antiplasmin levels in midtrimester can be used as predictors of preterm delivery

Jianxia Huang / Yuhong Yang / Pei He

Journal of International Medical Research, Vol

2020 Volume 48

Abstract: Objective To identify serum protein markers in midtrimester that predict preterm delivery. Methods A retrospective case–control study randomly selected patients that experienced spontaneous preterm birth and healthy control patients that experienced a ... ...

Abstract	Objective To identify serum protein markers in midtrimester that predict preterm delivery. Methods A retrospective case–control study randomly selected patients that experienced spontaneous preterm birth and healthy control patients that experienced a normal delivery at term. A proteomic analysis was undertaken using the data-independent acquisition method. Results A total of 30 singleton pregnant women were randomly selected from 12 800 pregnant women: 15 women had a spontaneous preterm birth (group Y) and 15 age- and body mass index-matched women gave birth at term (group D). All of the patients provided serum at 15–20 weeks of gestation. A total of 39 differentially expressed proteins were identified. Compared with group D, 24 proteins were upregulated and 15 were downregulated in the preterm group Y. Using Kyoto Encyclopedia of Genes and Genomes pathway enrichment, the 24 upregulated proteins were significantly enriched in the complement and coagulation cascade pathways. Search Tool for the Retrieval of Interacting Genes Furthermore (STRING) analysis showed that apolipoprotein A-II (apoA-II) and alpha-2-antiplasmin (α2-AP), two upregulated proteins, were key nodes in the STRING protein–protein network. Conclusions These findings suggest that apoA-II and α2-AP might be new markers for predicting preterm delivery in the midtrimester.
Keywords	Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Saliency Detection and Gram Matrix Transform-Based Convolutional Neural Network for Image Emotion Classification

Zelin Deng / Qiran Zhu / Pei He / Dengyong Zhang / Yuansheng Luo

Security and Communication Networks, Vol

2021 Volume 2021

Abstract: Using the convolutional neural network (CNN) method for image emotion recognition is a research hotspot of deep learning. Previous studies tend to use visual features obtained from a global perspective and ignore the role of local visual features in ... ...

Abstract	Using the convolutional neural network (CNN) method for image emotion recognition is a research hotspot of deep learning. Previous studies tend to use visual features obtained from a global perspective and ignore the role of local visual features in emotional arousal. Moreover, the CNN shallow feature maps contain image content information; such maps obtained from shallow layers directly to describe low-level visual features may lead to redundancy. In order to enhance image emotion recognition performance, an improved CNN is proposed in this work. Firstly, the saliency detection algorithm is used to locate the emotional region of the image, which is served as the supplementary information to conduct emotion recognition better. Secondly, the Gram matrix transform is performed on the CNN shallow feature maps to decrease the redundancy of image content information. Finally, a new loss function is designed by using hard labels and probability labels of image emotion category to reduce the influence of image emotion subjectivity. Extensive experiments have been conducted on benchmark datasets, including FI (Flickr and Instagram), IAPSsubset, ArtPhoto, and Abstract. The experimental results show that compared with the existing approaches, our method has a good application prospect.
Keywords	Technology (General) ; T1-995 ; Science (General) ; Q1-390
Subject code	006
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi-Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: High Dosages of Equine Chorionic Gonadotropin Exert Adverse Effects on the Developmental Competence of IVF-Derived Mouse Embryos and Cause Oxidative Stress-Induced Aneuploidy

En Lin / Zhiling Li / Yue Huang / Gaizhen Ru / Pei He

Frontiers in Cell and Developmental Biology, Vol

2021 Volume 8

Abstract: Gonadotropins play vital roles in the regulation of female reproductive ability and fertility. Our study aimed to determine the effects of superovulation induced by increasing doses of equine chorionic gonadotropin [eCG; also referred to as pregnant mare ...

Abstract	Gonadotropins play vital roles in the regulation of female reproductive ability and fertility. Our study aimed to determine the effects of superovulation induced by increasing doses of equine chorionic gonadotropin [eCG; also referred to as pregnant mare serum gonadotropin (PMSG)] on the developmental competence of mouse embryos and on aneuploidy formation during in vitro fertilization (IVF). eCG dose-dependently enhanced the oocyte yield from each mouse. Administration of 15 IU eCG significantly reduced the fertilization rate and the formation of four-cell embryos and blastocysts and increased the risk of chromosome aneuploidy. The IVF-derived blastocysts in the 15 IU eCG treatment group had the fewest total cells, inner cell mass (ICM) cells and trophectoderm (TE) cells. Moreover, more blastocysts and fewer apoptotic cells were observed in the 0, 5, and 10 IU eCG treatment groups than in the 15 IU eCG treatment group. We also investigated reactive oxygen species (ROS) levels and variations in several variables: mitochondrial membrane potential (MMP); active mitochondria; mitochondrial superoxide production; adenosine triphosphate (ATP) content; spindle structures; chromosome karyotypes; microfilament distribution; and the expression of Aurora B [an important component of the chromosomal passenger complex (CPC)], the spindle assembly checkpoint (SAC) protein mitotic arrest deficient 2 like 1 (MAD2L1), and the DNA damage response (DDR) protein γH2AX. Injection of 15 IU eCG increased ROS levels, rapidly reduced MMP, increased active mitochondria numbers and mitochondrial superoxide production, reduced ATP content, increased abnormal spindle formation rates, and induced abnormalities in chromosome number and microfilament distribution, suggesting that a high dose of eCG might alter developmental competence and exert negative effects on IVF-obtained mouse embryos. Additionally, the appearance of γH2AX and the significantly increased expression of Aurora B and MAD2L1 suggested that administration of relatively high ...
Keywords	equine chorionic gonadotropin ; aneuploidy ; reactive oxygen species ; DNA damage response ; spindle assembly checkpoint ; MAD2L1 ; Biology (General) ; QH301-705.5
Subject code	630
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Oxidative damage-induced hyperactive ribosome biogenesis participates in tumorigenesis of offspring by cross-interacting with the Wnt and TGF-β1 pathways in IVF embryos

Yue Huang / Zhiling Li / En Lin / Pei He / Gaizhen Ru

Experimental and Molecular Medicine, Vol 53, Iss 11, Pp 1792-

2021 Volume 1806

Abstract: IVF: Mechanism and correction of increased cancer risk Increased production of ribosomes, the multi-molecular structures inside cells where protein synthesis occurs, is implicated in the enhanced risk of cancer in offspring conceived by in vitro ... ...

Abstract	IVF: Mechanism and correction of increased cancer risk Increased production of ribosomes, the multi-molecular structures inside cells where protein synthesis occurs, is implicated in the enhanced risk of cancer in offspring conceived by in vitro fertilization (IVF), suggesting an approach to reduce this risk. In studies on IVF mouse embryos, Zhiling Li and colleagues at First Affiliated Hospital of Shantou University Medical College in China found that harmful effects of natural oxidizing agents induced overproduction of specific protein components of ribosomes. This increased the embryos’ susceptibility to tumorigenesis through a particular molecular signaling pathway. Exposure to the natural antioxidant chemical epigallocatechin-3-gallate (EGCG) corrected the overproduction and protected the embryos. EGCG, found in green tea, is being widely investigated for its anticancer effects. Exposing embryos to EGCG during IVF might protect the resulting children from increased risk of tumor formation in later life.
Keywords	Medicine ; R ; Biochemistry ; QD415-436
Subject code	500
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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