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  1. AU="Pei-Ying Hsieh"
  2. AU="Savchenko, Sergey S"
  3. AU="Kothe, Ullrich"
  4. AU="Bhosale, Santosh D"
  5. AU="Santamarina-Albertos, Alba"
  6. AU="Scott M. Riester"
  7. AU="A Zappa, Marco"
  8. AU=Panciani Pier Paolo
  9. AU="La Cascio, L"
  10. AU="Getsuwan, Songpon"

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  1. Artikel ; Online: Local Liver Irradiation Concurrently Versus Sequentially with Cabozantinib on the Pharmacokinetics and Biodistribution in Rats

    Yu-Chuen Huang / Pei-Ying Hsieh / Li-Ying Wang / Tung-Hu Tsai / Yu-Jen Chen / Chen-Hsi Hsieh

    International Journal of Molecular Sciences, Vol 24, Iss 5849, p

    2023  Band 5849

    Abstract: The aim of this study was to evaluate the radiotherapy (RT)-pharmacokinetics (PK) effect of cabozantinib in concurrent or sequential regimens with external beam radiotherapy (EBRT) or stereotactic body radiation therapy (SBRT). Concurrent and sequential ... ...

    Abstract The aim of this study was to evaluate the radiotherapy (RT)-pharmacokinetics (PK) effect of cabozantinib in concurrent or sequential regimens with external beam radiotherapy (EBRT) or stereotactic body radiation therapy (SBRT). Concurrent and sequential regimens involving RT and cabozantinib were designed. The RT–drug interactions of cabozantinib under RT were confirmed in a free-moving rat model. The drugs were separated on an Agilent ZORBAX SB-phenyl column with a mobile phase consisting of 10 mM potassium dihydrogen phosphate (KH 2 PO 4 )–methanol solution (27:73, v / v ) for cabozantinib. There were no statistically significant differences in the concentration versus time curve of cabozantinib (AUC cabozantinib ) between the control group and the RT 2Gy×3 f’x and RT 9Gy×3 f’x groups in the concurrent and the sequential regimens. However, compared to those in the control group, the T max , T 1/2 and MRT decreased by 72.8% ( p = 0.04), 49.0% ( p = 0.04) and 48.5% ( p = 0.04) with RT 2Gy×3 f’x in the concurrent regimen, respectively. Additionally, the T 1/2 and MRT decreased by 58.8% ( p = 0.01) and 57.8% ( p = 0.01) in the concurrent RT 9Gy×3 f’x group when compared with the control group, respectively. The biodistribution of cabozantinib in the heart increased by 271.4% ( p = 0.04) and 120.0% ( p = 0.04) with RT 2Gy×3 f’x in the concurrent and sequential regimens compared to the concurrent regimen, respectively. Additionally, the biodistribution of cabozantinib in the heart increased by 107.1% ( p = 0.01) with the RT 9Gy×3 f’x sequential regimen. Compared to the RT 9Gy×3 f’x concurrent regimen, the RT 9Gy×3 f’x sequential regimen increased the biodistribution of cabozantinib in the heart (81.3%, p = 0.02), liver (110.5%, p = 0.02), lung (125%, p = 0.004) and kidneys (87.5%, p = 0.048). No cabozantinib was detected in the brain in any of the groups. The AUC of cabozantinib is not modulated by irradiation and is not affected by treatment strategies. However, the biodistribution of cabozantinib in the heart is ...
    Schlagwörter biodistribution ; cabozantinib ; hepatocellular carcinoma ; pharmacokinetics ; radiotherapy ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 290
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Two-Dimensional Spatial Coherence for Ultrasonic DMAS Beamforming in Multi-Angle Plane-Wave Imaging

    Che-Chou Shen / Pei-Ying Hsieh

    Applied Sciences, Vol 9, Iss 19, p

    2019  Band 3973

    Abstract: Ultrasonic multi-angle plane-wave (PW) coherent compounding relies on delay-and-sum (DAS) beamforming of two-dimensional (2D) echo matrix in both the dimensions PW transmit angle and receiving channel to construct each image pixel. Due to the ... ...

    Abstract Ultrasonic multi-angle plane-wave (PW) coherent compounding relies on delay-and-sum (DAS) beamforming of two-dimensional (2D) echo matrix in both the dimensions PW transmit angle and receiving channel to construct each image pixel. Due to the characteristics of DAS beamforming, PW coherent compounding may suffer from high image clutter when the number of transmit angles is kept low for ultrafast image acquisition. Delay-multiply-and-sum (DMAS) beamforming exploits the spatial coherence of the receiving aperture to suppress clutter interference. Previous attempts to introduce DMAS beamforming into multi-angle PW imaging has been reported but only in either dimension of the 2D echo matrix. In this study, a novel DMAS operation is proposed to extract the 2D spatial coherence of echo matrix for further improvement of image quality. The proposed 2D-DMAS method relies on a flexibly tunable p value to manipulate the signal coherence in the beamforming output. For p = 2.0 as an example, simulation results indicate that 2D-DMAS outperforms other one-dimensional DMAS methods by at least 9.3 dB in terms of ghost-artifact suppression. Experimental results also show that 2D-DMAS provides the highest improvement in lateral resolution by 32% and in image contrast by 15.6 dB relative to conventional 2D-DAS beamforming. Nonetheless, since 2D-DMAS emphasizes signal coherence more than its one-dimensional DMAS counterparts, it suffers from the most elevated speckle variation and the granular pattern in the tissue background.
    Schlagwörter adaptive imaging ; Delay-Multiply-and-Sum (DMAS) ; spatial coherence ; nonlinear beamforming ; plane-wave imaging ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 535
    Sprache Englisch
    Erscheinungsdatum 2019-09-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel: Multifunctional silver nanocluster-hybrid oligonucleotide vehicle for cell imaging and microRNA-targeted gene silencing

    Chen, Hau-Yun / Cheng-Che Wen / Hsin-Yun Hsu / Jen-Kun Chen / Karunya Albert / Nei-Chung Huang / Pei-Ying Hsieh / Shen-Chuan Lo / Sih-Yu Chen

    Colloids and surfaces. 2017 Apr. 01, v. 152

    2017  

    Abstract: Novel therapeutics is urgently needed to prevent cancer-related deaths. MicroRNAs that act as tumor suppressors have been recognized as a next-generation tumor therapy, and the restoration of tumor-suppressive microRNAs using microRNA replacements or ... ...

    Abstract Novel therapeutics is urgently needed to prevent cancer-related deaths. MicroRNAs that act as tumor suppressors have been recognized as a next-generation tumor therapy, and the restoration of tumor-suppressive microRNAs using microRNA replacements or mimics may be a less toxic, more effective strategy due to fewer off-target effects. Here, we designed the novel multifunctional oligonucleotide nanocarrier complex composed of a tumor-targeting aptamer sequence specific to mucin 1 (MUC1), poly-cytosine region for fluorescent silver nanocluster (AgNC) synthesis, and complimentary sequence for microRNA miR-34a loading. MiR-34a was employed because of its therapeutic effect of inhibiting oncogene expression and inducing apoptosis in carcinomas. By monitoring the intrinsic fluorescence of AgNC, it was clearly shown that the constructed complex (MUC1-AgNCm-miR-34a) enters MCF-7 cells. To evaluate the efficacy of this nanocarrier for microRNA delivery, we investigated the gene and protein expression levels of downstream miR-34a targets (BCL-2, CDK6, and CCND1) by quantitative PCR and western blotting, respectively, and the results indicated their effective inhibition by miR-34a. This novel multifunctional AgNC-based nanocarrier can aid in improving the efficacy of breast cancer theranostics.
    Schlagwörter apoptosis ; breast neoplasms ; carcinoma ; colloids ; fluorescence ; gene silencing ; image analysis ; microRNA ; monitoring ; mucins ; nanocarriers ; nanoparticles ; oligonucleotides ; oncogenes ; protein synthesis ; quantitative polymerase chain reaction ; silver ; toxicity ; Western blotting
    Sprache Englisch
    Erscheinungsverlauf 2017-0401
    Umfang p. 423-431.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 1500523-9
    ISSN 1873-4367 ; 0927-7765
    ISSN (online) 1873-4367
    ISSN 0927-7765
    DOI 10.1016/j.colsurfb.2017.01.048
    Datenquelle NAL Katalog (AGRICOLA)

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  4. Artikel ; Online: Total Marrow Irradiation as Part of Autologous Stem Cell Transplantation for Asian Patients with Multiple Myeloma

    Shih-Chiang Lin / Pei-Ying Hsieh / Pei-Wei Shueng / Hui-Ju Tien / Li-Ying Wang / Chen-Hsi Hsieh

    BioMed Research International, Vol

    2013  Band 2013

    Abstract: To compare the outcomes of melphalan 200 mg/m2 (HDM200) and 8 Gy total marrow irradiation (TMI) delivered by helical tomotherapy plus melphalan 140 mg/m2 (HDM140 + TMI 8 Gy) in newly diagnosed symptomatic multiple myeloma (MM) Asian patients. Between ... ...

    Abstract To compare the outcomes of melphalan 200 mg/m2 (HDM200) and 8 Gy total marrow irradiation (TMI) delivered by helical tomotherapy plus melphalan 140 mg/m2 (HDM140 + TMI 8 Gy) in newly diagnosed symptomatic multiple myeloma (MM) Asian patients. Between 2007 and 2010, nine consecutive myeloma patients who were scheduled to undergo autologous stem cell transplantation (ASCT) were studied. The patients received three cycles of vincristine-adriamycin-dexamethasone (VAD) regimen as induction chemotherapy, and if they had a partial response, peripheral blood stem cells were collected by dexamethasone-etoposide-cyclophosphamide-cisplatin (DECP). In arm A, six patients received the HDM200. In arm B, three patients received HDM140 + TMI 8 Gy. In arm B, the neutropenic duration was slightly longer than in arm A (P=0.048). However, hematologic recovery (except for neutrophils), transfusion requirement, median duration of hospitalization, and the dose of G-CSF were similar in both arms. The median duration of overall survival and event-free survival was similar in the two arms (P=0.387). As a conditioning regiment, HDM140 + TMI 8 Gy provide another chance for MM Asian patients who were not feasible for HDM200.
    Schlagwörter Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2013-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Primary Effusion Lymphoma Involving both Pleural and Abdominal Cavities in a Patient with Hepatitis B Virus-related Liver Cirrhosis

    Pei-Ying Hsieh / Sheng-I Huang / Dian-Kun Li / Tsui-Lien Mao / Jin-Chuan Sheu / Chien-Hung Chen

    Journal of the Formosan Medical Association, Vol 106, Iss 6, Pp 504-

    2007  Band 508

    Abstract: Primary effusion lymphoma (PEL) is an unusual form of non-Hodgkin's lymphoma, which is characterized by lymphomatous effusion in body cavities, but no associated mass lesions. It is usually associated with an immunodeficient state most often with the ... ...

    Abstract Primary effusion lymphoma (PEL) is an unusual form of non-Hodgkin's lymphoma, which is characterized by lymphomatous effusion in body cavities, but no associated mass lesions. It is usually associated with an immunodeficient state most often with the human immunodeficiency virus (HIV). We describe a 54-year-old man with HIV-negative PEL, with a history of hepatitis B virus-related liver cirrhosis. Both abdominal and pleural cavities were involved; no solid tumor masses were found and bone marrow investigations were normal. The ascites and pleural effusion contained numerous pleomorphic lymphoid cells. Immunophenotyping was positive for CD138. Chromosome study showed complex cytogenetics. The genomic human herpesvirus-8 was detected in the lymphoma cells. It is postulated that the immuno-suppressed state in this patient may have been caused by cirrhosis. The patient received four cycles of chemotherapy of CHOP and Picibanil (OK-432) intraperitoneal administration. However, no durable remission was achieved. Adefovir failed to halt the progressive liver failure after the development of YMDD mutant related to lamivudine. He died of sepsis and hepatic failure.
    Schlagwörter hepatitis B virus ; liver cirrhosis ; primary effusion lymphoma ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2007-01-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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