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Article ; Online: SMAX1 interacts with DELLA protein to inhibit seed germination under weak light conditions via gibberellin biosynthesis in Arabidopsis

Peipei Xu / Jinbo Hu / Haiying Chen / Weiming Cai

Cell Reports, Vol 42, Iss 7, Pp 112740- (2023)

2023

Abstract: Summary: Karrikins (KARs) were first identified as a class of small-molecule chemicals derived from smoke that promote seed germination. However, the implied mechanism is still not well understood. Here, we find that KAR signaling mutants have a lower ... ...

Abstract	Summary: Karrikins (KARs) were first identified as a class of small-molecule chemicals derived from smoke that promote seed germination. However, the implied mechanism is still not well understood. Here, we find that KAR signaling mutants have a lower germination percentage than that of wild type under weak light conditions, and KARs promote seed germination through transcriptional activation of gibberellin (GA) biosynthesis via SMAX1. SMAX1 interacts with the DELLA proteins REPRESSOR of ga1-3-LIKE 1 (RGL1) and RGL3. The interaction enhances the transcriptional activity of SMAX1 and inhibits GIBBERELLIN 3-oxidase 2 (GA3ox2) gene expression. The KAR signaling mutant seed germination defect under weak light is partially rescued by exogenous application of GA3 or by GA3ox2 overexpression, and the rgl1 rgl3 smax1 triple mutant exhibits higher germination rates under weak light than the smax1 mutant. Thus, we show a crosstalk between KAR and GA signaling pathways via a SMAX1-DELLA module in regulating seed germination in Arabidopsis.
Keywords	CP: Plants ; Biology (General) ; QH301-705.5
Subject code	580
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Potential evidence for transgenerational epigenetic memory in Arabidopsis thaliana following spaceflight

Peipei Xu / Haiying Chen / Jinbo Hu / Weiming Cai

Communications Biology, Vol 4, Iss 1, Pp 1-

2021 Volume 14

Abstract: In order to investigate whether the effects of spaceflight on plants persist in future generations, Xu et al studied the offspring of Arabidopsis thaliana seedlings that had been grown in a microgravity environment for 11 days. They found that epigenetic ...

Abstract	In order to investigate whether the effects of spaceflight on plants persist in future generations, Xu et al studied the offspring of Arabidopsis thaliana seedlings that had been grown in a microgravity environment for 11 days. They found that epigenetic modifications caused by spaceflight potentially affected the growth of two future seed generations, shedding light on the longevity of the effects of spaceflight on plants.
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A protocol for measuring the response of Arabidopsis roots to gravity and treatment for simulated microgravity

Jinbo Hu / Haiying Chen / Hongxia Wang / Huiqiong Zheng / Weiming Cai / Peipei Xu

STAR Protocols, Vol 4, Iss 1, Pp 102099- (2023)

2023

Abstract: Summary: We present a protocol to quantify the response of both normal and mutant Arabidopsis seedlings to gravity and simulated microgravity under earth-normal gravity conditions. We describe the steps to simulate microgravity using a three-dimensional ( ...

Abstract	Summary: We present a protocol to quantify the response of both normal and mutant Arabidopsis seedlings to gravity and simulated microgravity under earth-normal gravity conditions. We describe the steps to simulate microgravity using a three-dimensional (3D) clinostat, which changes the rate and direction at random and consistently rotates the axis horizontally and vertically to counteract the standard gravity at the Earth’s surface. We then detail the gravity stimulation experiment, followed by the assessment of root responses using ImageJ-based analysis.For complete details on the use and execution of this protocol, please refer to Xu et al. (2022).1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.
Keywords	Model Organisms ; Molecular Biology ; Plant Sciences ; Science (General) ; Q1-390
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: PLP2 Expression as a Prognostic and Therapeutic Indicator in High-Risk Multiple Myeloma

Hua Bai / Yudi Zhu / Peipei Xu / Bing Chen

BioMed Research International, Vol

2020 Volume 2020

Abstract: Multiple myeloma (MM) is a devastating cancer with a highly heterogeneous outcome. Because of the heterogeneity of myeloma cells, risk stratification is important for making therapeutic regimens. Nevertheless, no immunohistochemical predictive and ... ...

Abstract	Multiple myeloma (MM) is a devastating cancer with a highly heterogeneous outcome. Because of the heterogeneity of myeloma cells, risk stratification is important for making therapeutic regimens. Nevertheless, no immunohistochemical predictive and prognostic marker has been constructed yet. In the present study, we explored the prognostic value of proteolipid protein 2 (PLP2) in MM patients using immunohistochemistry (IHC). We assessed PLP2 expression in bone marrow (BM) biopsy specimens obtained from 87 newly diagnosed MM (NDMM) patients. Correlations between PLP2 expression and clinicopathological features were analyzed. PLP2 expression was present in high-risk MM patients, which was increased with disease progression and poor prognosis. PLP2 was increasing in parallel with high beta-2 microglobulin (β2-MG) and lactate dehydrogenase (LDH). Furthermore, MM patients with low PLP2 expression could achieve a favorable treatment response. PLP2 may be a novel biomarker for prognostic prediction and a therapeutic target for anti-MM treatments.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pectin methylesterase gene AtPMEPCRA contributes to physiological adaptation to simulated and spaceflight microgravity in Arabidopsis

Peipei Xu / Haiying Chen / Jinbo Hu / Xiaocheng Pang / Jing Jin / Weiming Cai

iScience, Vol 25, Iss 5, Pp 104331- (2022)

2022

Abstract: Summary: Pectin is biosynthesized in a highly methylated form and is partially de-methylated by pectin methylesterase (PME) activity. Plant PMEs play a critical role in cell wall remodeling in many physiological processes. Here, we studied Arabidopsis ... ...

Abstract	Summary: Pectin is biosynthesized in a highly methylated form and is partially de-methylated by pectin methylesterase (PME) activity. Plant PMEs play a critical role in cell wall remodeling in many physiological processes. Here, we studied Arabidopsis seedlings, which had been exposed to simulated or actual microgravity. Simulated microgravity inhibited total PME activity in Arabidopsis seedlings. We identified that AtPMEPCRA expression played a major role in the microgravity-induced inhibition of PME activity. atpmepcra mutants did not exhibit the enlarged leaf area of Arabidopsis seedlings observed under spaceflight microgravity. The downregulation of AtPMEPCRA expression in response to microgravity was due, in part, to changes in methylation patterns. The sexual offspring of the plants grown during spaceflight retained the methylation changes at AtPMEPCRA locus for one generation and thus contribute to the physiological adaptation to microgravity among F1 offspring seed generation. We conclude that AtPMEPCRA contributes to the spaceflight-induced transgenerational responses in Arabidopsis.
Keywords	Biological sciences ; Plant biology ; Plant physiology ; Space sciences ; Science ; Q
Subject code	580
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Satellite Evidence for Divergent Forest Responses within Close Vicinity to Climate Fluctuations in a Complex Terrain

Jing Wang / Wei Fang / Peipei Xu / Hu Li / Donghua Chen / Zuo Wang / Yuanhong You / Christopher Rafaniello

Remote Sensing, Vol 15, Iss 2749, p

2023 Volume 2749

Abstract: Climate change has a significant impact on forest ecosystems worldwide, but it is unclear whether forest responses to climate fluctuations are homogeneous across regions. In this study, we investigated the impact of climatic fluctuations on forest growth ...

Abstract	Climate change has a significant impact on forest ecosystems worldwide, but it is unclear whether forest responses to climate fluctuations are homogeneous across regions. In this study, we investigated the impact of climatic fluctuations on forest growth in a complex terrain, in Anhui Province of China, using Enhanced Vegetation Index (EVI) data from the Moderate-Resolution Imaging Spectroradiometer (MODIS), while considering the impact of terrain characteristics and forest types. Our regional-scale analysis found that the forest response to climatic drivers in Anhui Province is not homogeneous, with only 69% of the forest area driven by temperature (TEM), while 11% is precipitation (PRE) driven and 20% is solar radiation (SWD) driven. We also found with random forest models that terrain traits (elevation and slope) contributed significantly (29.47% and 27.96%) to the spatial heterogeneity of forest response to climatic drivers, with higher elevation associated with a stronger positive correlation between the EVI and temperature ( p < 0.001), a weaker positive correlation between the EVI with precipitation ( p < 0.001), and a stronger negative correlation between the EVI with solar radiation ( p < 0.01), while forest type contributed the least (4.21%). Our results also imply that in a warmer and dryer climate, some forest patches may switch from TEM driven to PRE driven, which could lead to a decrease in forest productivity, instead of an increase as predicted by existing climate models. These results highlight the heterogeneous response of forests within close vicinity to climate fluctuations in a complex terrain, which has important implications for climate-related risk assessments and local forest management.
Keywords	forest ; climate fluctuations ; divergent response ; complex terrain ; random forest model ; MODIS-EVI ; Science ; Q
Subject code	910
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Quantitatively Assessing and Attributing Land Use and Land Cover Changes on China’s Loess Plateau

Xiaozheng Du / Xiang Zhao / Shunlin Liang / Jiacheng Zhao / Peipei Xu / Donghai Wu

Remote Sensing, Vol 12, Iss 3, p

2020 Volume 353

Abstract: The global land surface cover is undergoing extensive changes in the context of global change, especially in the Loess Plateau, where ecological restoration policies have been vigorously implemented since 2000. Evaluating the impact of these policies on ... ...

Abstract	The global land surface cover is undergoing extensive changes in the context of global change, especially in the Loess Plateau, where ecological restoration policies have been vigorously implemented since 2000. Evaluating the impact of these policies on land cover is of great significance for regional sustainable development. Nonetheless, there are few quantitative assessment studies of the impact of ecological restoration policies on land use and land cover change (LULCC). In this study, a relative contribution conceptual model (RCCM) was used to explore the contribution of the policies to LULCC under the influence of natural background change, which was based on the Markov chain and the future land use simulation (FLUS) model. The results show that LULCC is influenced by ecological restoration policies and the natural environment, of which the policies contribute about 72.37% and natural change contribute about 27.63%. Ecological restoration policies have a profound impact on LULCC, changing the original direction of LULCC greatly. Additionally, these policies regulate the pattern of LULCC by controlling the amount of cropland as a rebalanced leverage. These findings provide useful information for facilitating sustainable ecological development in the Loess Plateau and theoretically supporting environmental decision-making.
Keywords	land use and land cover change ; ecological restoration policy ; grain for green program ; flus model ; natural effects ; Science ; Q
Subject code	710
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: TP53 mutation predicts the poor prognosis of non-Hodgkin lymphomas

Peipei Xu / Xu Liu / Jian Ouyang / Bing Chen

PLoS ONE, Vol 12, Iss 4, p e

Evidence from a meta-analysis.

2017 Volume 0174809

Abstract: Non-Hodgkin lymphoma (NHL) is a group of malignant hematologic disorders with high heterogeneity. The diagnosis, clinical manifestations, classification, and prognosis of this condition differ among numerous NHL subgroups. The prognostic significance of ... ...

Abstract	Non-Hodgkin lymphoma (NHL) is a group of malignant hematologic disorders with high heterogeneity. The diagnosis, clinical manifestations, classification, and prognosis of this condition differ among numerous NHL subgroups. The prognostic significance of the mutation of TP53, a tumor suppressor gene involved in cell cycle regulation, should be confirmed in NHL. In this study, our searching strategy and inclusion criteria were implemented, and the pooled hazard ratios (HRs) of the included studies were calculated directly or indirectly. A total of 1,851 patients were enrolled in 22 studies. A meta-analysis was then performed using STATA version 12.0 to confirm the correlation between the status of TP53 mutation and the survival time of patients with NHL. Statistical heterogeneity was assessed with a chi-square-based Q statistical test and Inconsistency index (I2) statistic. Sensitivity analysis and publication bias were also evaluated. A total of 22 studies were included in our meta-analysis. The pooled HR of the overall survival from 20 studies was 2.30 (95% CI: 1.92-2.76, p = 0.001) with heterogeneity (I2 30.2% p = 0.099). The pooled HR of the progression free survival provided in 5 articles was 2.28 (95% CI: 1.78-2.93, p = 0.001) with heterogeneity (I2 39.8% p = 0.156). No publication bias was found among the included studies, and sensitivity analysis suggested that the combined HRs were stable after any of the studies was excluded from our meta-analysis. This study identified the prognostic significance of TP53 mutation that varied in different NHL subgroups. The group with a mutated TP53 was significantly associated with poor prognosis in patients with NHL. This parameter is a valuable basis for accurate individual therapeutic regimens.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparison of outcomes in hematological malignancies treated with haploidentical or HLA-identical sibling hematopoietic stem cell transplantation following myeloablative conditioning

Dangui Chen / Di Zhou / Dan Guo / Peipei Xu / Bing Chen

PLoS ONE, Vol 13, Iss 1, p e

A meta-analysis.

2018 Volume 0191955

Abstract: Haploidentical and human leukocyte antigen (HLA)-identical sibling hematopoietic stem transplantation are two main ways used in allogeneic hematopoietic stem cell transplantation (allo-HSCT). In recent years, remarkable progress has been made in ... ...

Abstract	Haploidentical and human leukocyte antigen (HLA)-identical sibling hematopoietic stem transplantation are two main ways used in allogeneic hematopoietic stem cell transplantation (allo-HSCT). In recent years, remarkable progress has been made in haploidentical allo-HSCT (HID-SCT), and some institutions found HID-SCT had similar outcomes as HLA-identical sibling allo-HSCT (ISD-SCT). To clarify if HID-SCT has equal effects to ISD-SCT in hematologic malignancies, we performed this meta-analysis.Relevant articles published prior to February 2017 were searched on PubMed. Two reviewers assessed the quality of the included studies and extracted data independently. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated for statistical analysis.Seven studies including 1919 patients were included. The rate of platelet engraftment is significantly lower after HID-SCT versus ISD-SCT while there is no difference in neutrophil engraftment (OR = 2.58, 95% CI = 1.70-3.93, P < 0.00001). The risk of acute graft-versus-host disease (GVHD) is significantly higher after HID-SCT versus ISD-SCT (OR = 1.88, 95% CI = 1.42-2.49, P < 0.00001), but the relapse rate is lower in HID-SCT group (OR = 0.70, 95% CI = 0.55-0.90, P = 0.005). The incidence rates of overall survival (OS) and disease-free-survival/leukemia-free survival/relapse-free survival (DFS/LFS/RFS) after ISD-SCT are all significantly superior to HID-SCT (OR = 1.32, 95% CI = 1.08-1.62, P = 0.006; OR = 1.25, 95% CI = 1.03-1.52, P = 0.02). There is no significant difference in transplantation related mortality (TRM) rate after HID-SCT and ISD-SCT.After myeloablative conditioning, patients receiving ISD-SCT have a faster engraftment, lower acute GVHD and longer life expectancy compared to HID-SCT with GVHD prophylaxis (cyclosporine A, methotrexate, mycophenolate mofetil and antithymoglobulin; CsA + MTX + MMF + ATG). Currently, HID-SCT with GVHD prophylaxis (CsA + MTX + MMF + ATG) may not replace ISD-SCT when HLA-identical sibling donor available.
Keywords	Medicine ; R ; Science ; Q
Subject code	028
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The efficacy and safety of prokinetics in critically ill adults receiving gastric feeding tubes

Rong Peng / Hailong Li / Lijun Yang / Linan Zeng / Qiusha Yi / Peipei Xu / Xiangcheng Pan / Lingli Zhang

PLoS ONE, Vol 16, Iss 1, p e

A systematic review and meta-analysis.

2021 Volume 0245317

Abstract: Background Intolerance to gastric feeding tubes is common among critically ill adults and may increase morbidity. Administration of prokinetics in the ICU is common. However, the efficacy and safety of prokinetics are unclear in critically ill adults ... ...

Abstract	Background Intolerance to gastric feeding tubes is common among critically ill adults and may increase morbidity. Administration of prokinetics in the ICU is common. However, the efficacy and safety of prokinetics are unclear in critically ill adults with gastric feeding tubes. We conducted a systematic review to determine the efficacy and safety of prokinetics for improving gastric feeding tube tolerance in critically ill adults. Methods Randomized controlled trials (RCTs) were identified by systematically searching the Medline, Cochrane and Embase databases. Two independent reviewers extracted the relevant data and assessed the quality of the studies. We calculated pooled relative risks (RRs) for dichotomous outcomes and the mean differences (MDs) for continuous outcomes with the corresponding 95% confidence intervals (CIs). We assessed the risk of bias using the Cochrane risk-of-bias tool and used the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology to rate the quality of the evidence. Results Fifteen RCTs met the inclusion criteria. A total of 10 RCTs involving 846 participants were eligible for the quantitative analysis. Most studies (10 of 13, 76.92%) showed that prokinetics had beneficial effects on feeding intolerance in critically ill adults. In critically ill adults receiving gastric feeding, prokinetic agents may reduce the ICU length of stay (MD -2.03, 95% CI -3.96, -0.10; P = 0.04; low certainty) and the hospital length of stay (MD -3.21, 95% CI -5.35, -1.06; P = 0.003; low certainty). However, prokinetics failed to improve the outcomes of reported adverse events and all-cause mortality. Conclusion As a class of drugs, prokinetics may improve tolerance to gastric feeding to some extent in critically ill adults. However, the certainty of the evidence suggesting that prokinetics reduce the ICU or hospital length of stay is low. Prokinetics did not significantly decrease the risks of reported adverse events or all-cause mortality among critically ill adults.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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