LIVIVO - Search results -

Search results

Result 1 - 10 of total 10

Search options

Article ; Online: Upgrade of the ALICE Experiment

Peitzmann Thomas

EPJ Web of Conferences, Vol 71, p

2014 Volume 00106

Abstract: While groundbreaking measurements on the properties of strongly interacting matter in p+p, p+A and A+A collisions at the LHC are being performed, it is clear that many important questions in heavy-ion physics will remain unanswered in this first phase of ...

Abstract	While groundbreaking measurements on the properties of strongly interacting matter in p+p, p+A and A+A collisions at the LHC are being performed, it is clear that many important questions in heavy-ion physics will remain unanswered in this first phase of beam times up to 2017. The ALICE collaboration is setting up a program of detector upgrades to be installed in the LHC shutdown planned for ≈2018, to address the new scientific challenges. We will discuss examples of the scientific frontiers and upgrade projects under study for the ALICE experiment.
Keywords	Physics ; QC1-999 ; Science ; Q
Language	English
Publishing date	2014-04-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: ALICE Upgrades

Peitzmann Thomas

EPJ Web of Conferences, Vol 60, p

2013 Volume 10003

Abstract: While groundbreaking measurements on the properties of strongly interacting matter in p+p, p+Aand A+A collisions at the LHC are being performed, it is clear that many important questions in heavy-ion physics will remain unanswered in this first phase of ... ...

Abstract	While groundbreaking measurements on the properties of strongly interacting matter in p+p, p+Aand A+A collisions at the LHC are being performed, it is clear that many important questions in heavy-ion physics will remain unanswered in this first phase of beam times up to 2017. The ALICE collaboration is setting up a program of detector upgrades to be installed in the LHC shutdown planned for 2017/18, to address the new scientific challenges. We will discuss examples of the scientific frontiers and upgrade projects understudy for the ALICE experiment.
Keywords	Physics ; QC1-999 ; Science ; Q ; DOAJ:Physics (General) ; DOAJ:Physics and Astronomy
Language	English
Publishing date	2013-11-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Image quality of list-mode proton imaging without front trackers.

Rambo Sølie, Jarle / Volz, Lennart / Egil Seime Pettersen, Helge / Piersimoni, Pierluigi / Harald Odland, Odd / Röhrich, Dieter / Helstrup, Håvard / Peitzmann, Thomas / Ullaland, Kjetil / Varga-Kofarago, Monika / Mehendale, Shruti / Slettevoll Grøttvik, Ola / Nilsen Eikeland, Viljar / Meric, Ilker / Seco, Joao

Physics in medicine and biology

2020 Volume 65, Issue 13, Page(s) 135012

Abstract: List mode proton imaging relies on accurate reconstruction of the proton most likely path (MLP) through the patient. This typically requires two sets of position sensitive detector systems, one upstream (front) and one downstream (rear) of the patient. ... ...

Abstract	List mode proton imaging relies on accurate reconstruction of the proton most likely path (MLP) through the patient. This typically requires two sets of position sensitive detector systems, one upstream (front) and one downstream (rear) of the patient. However, for a clinical implementation it can be preferable to omit the front trackers (single-sided proton imaging). For such a system, the MLP can be computed from information available through the beam delivery system and the remaining rear tracker set. In this work, we use Monte Carlo simulations to compare a conventional double-sided (using both front and rear detector systems) with a single-sided system (only rear detector system) by evaluating the spatial resolution of proton radiographs (pRad) and proton CT images (pCT) acquired with these set-ups. Both the pencil beam spot size, as well as the spacing between spots was also adjusted to identify the impact of these beam parameters on the image quality. Relying only on the pencil beam central position for computing the MLP resulted in severe image artifacts both in pRad and pCT. Using the recently extended-MLP formalism that incorporate pencil beam uncertainty removed these image artifacts. However, using a more focused pencil beam with this algorithm induced image artifacts when the spot spacing was the same as the beam spot size. The spatial resolution tested with a sharp edge gradient technique was reduced by 40% for single-sided (MTF
MeSH term(s)	Algorithms ; Child ; Head/diagnostic imaging ; Humans ; Image Processing, Computer-Assisted ; Monte Carlo Method ; Phantoms, Imaging ; Protons ; Quality Control ; Tomography, X-Ray Computed/methods
Chemical Substances	Protons
Language	English
Publishing date	2020-07-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/ab8ddb
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 199: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Exploration of differentiability in a proton computed tomography simulation framework.

Aehle, Max / Alme, Johan / Gábor Barnaföldi, Gergely / Blühdorn, Johannes / Bodova, Tea / Borshchov, Vyacheslav / van den Brink, Anthony / Eikeland, Viljar / Feofilov, Gregory / Garth, Christoph / Gauger, Nicolas R / Grøttvik, Ola / Helstrup, Håvard / Igolkin, Sergey / Keidel, Ralf / Kobdaj, Chinorat / Kortus, Tobias / Kusch, Lisa / Leonhardt, Viktor /

Mehendale, Shruti / Ningappa Mulawade, Raju / Harald Odland, Odd / O'Neill, George / Papp, Gábor / Peitzmann, Thomas / Pettersen, Helge Egil Seime / Piersimoni, Pierluigi / Pochampalli, Rohit / Protsenko, Maksym / Rauch, Max / Ur Rehman, Attiq / Richter, Matthias / Röhrich, Dieter / Sagebaum, Max / Santana, Joshua / Schilling, Alexander / Seco, Joao / Songmoolnak, Arnon / Sudár, Ákos / Tambave, Ganesh / Tymchuk, Ihor / Ullaland, Kjetil / Varga-Kofarago, Monika / Volz, Lennart / Wagner, Boris / Wendzel, Steffen / Wiebel, Alexander / Xiao, RenZheng / Yang, Shiming / Zillien, Sebastian

Physics in medicine and biology

2023 Volume 68, Issue 24

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Computer Simulation ; Protons ; Phantoms, Imaging ; Tomography, X-Ray Computed/methods ; Software ; Algorithms ; Monte Carlo Method
Chemical Substances	Protons
Language	English
Publishing date	2023-12-15
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/ad0bdd
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 199: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Uncertainty-aware spot rejection rate as quality metric for proton therapy using a digital tracking calorimeter.

Schilling, Alexander / Aehle, Max / Alme, Johan / Barnaföldi, Gergely Gábor / Bodova, Tea / Borshchov, Vyacheslav / van den Brink, Anthony / Eikeland, Viljar / Feofilov, Gregory / Garth, Christoph / Gauger, Nicolas R / Grøttvik, Ola / Helstrup, Håvard / Igolkin, Sergey / Keidel, Ralf / Kobdaj, Chinorat / Kortus, Tobias / Leonhardt, Viktor / Mehendale, Shruti /

Ningappa Mulawade, Raju / Harald Odland, Odd / O'Neill, George / Papp, Gábor / Peitzmann, Thomas / Pettersen, Helge Egil Seime / Piersimoni, Pierluigi / Protsenko, Maksym / Rauch, Max / Ur Rehman, Attiq / Richter, Matthias / Röhrich, Dieter / Santana, Joshua / Seco, Joao / Songmoolnak, Arnon / Sudár, Ákos / Tambave, Ganesh / Tymchuk, Ihor / Ullaland, Kjetil / Varga-Kofarago, Monika / Volz, Lennart / Wagner, Boris / Wendzel, Steffen / Wiebel, Alexander / Xiao, RenZheng / Yang, Shiming / Zillien, Sebastian

Physics in medicine and biology

2023 Volume 68, Issue 19

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Proton Therapy ; Uncertainty ; Protons ; Machine Learning ; Neural Networks, Computer
Chemical Substances	Protons
Language	English
Publishing date	2023-09-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/acf5c2
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 199: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Book ; Online: Fabrication and beam test of a silicon-tungsten electromagnetic calorimeter

Muhuri, Sanjib / Mukhopadhyay, Sourav / Chandratre, Vinay B. / Nayak, Tapan K. / Saha, Sumit Kumar / Thakur, Sanchari / Singaraju, Rama N. / Saini, Jogender / Brink, Anthony van den / Chujo, Tatsuya / Patra, Rajendra Nath / van Leeuwen, Marco / Khan, Shuaib Ahmad / Sukhwani, Menka / Nooren, Gert-Jan / Peitzmann, Thomas

2019

Abstract: A silicon-tungsten (Si-W) sampling calorimeter, consisting of 19 alternate layers of silicon pad detectors (individual pad area of 1~cm$^2$) and tungsten absorbers (each of one radiation length), has been constructed for measurement of electromagnetic ... ...

Abstract	A silicon-tungsten (Si-W) sampling calorimeter, consisting of 19 alternate layers of silicon pad detectors (individual pad area of 1~cm$^2$) and tungsten absorbers (each of one radiation length), has been constructed for measurement of electromagnetic showers over a large energy range. The signal from each of the silicon pads is readout using an ASIC with a dynamic range from $-300$~fC to $+500$~fC. Another ASIC with a larger dynamic range, $\pm 600$~fC has been used as a test study. The calorimeter was exposed to pion and electron beams at the CERN Super Proton Synchrotron (SPS) to characterise the response to minimum ionising particles (MIP) and showers from electromagnetic (EM) interactions. Pion beams of 120 GeV provided baseline measurements towards the understanding of the MIP behaviour in the silicon pad layers, while electron beams of energy from 5 GeV to 60 GeV rendered detailed shower profiles within the calorimeter. The energy deposition in each layer, the longitudinal shower profile, and the total energy deposition have been measured for each incident electron energy. Linear behaviour of the total measured energy ($E$) with that of the incident particle energy ($E_{0}$) ensured satisfactory calorimetric performance. For a subset of the data sample, selected based on the cluster position of the electromagnetic shower of the incident electron, the dependence of the measured energy resolution on $E_{0}$ has been found to be $\sigma/E = (15.36/\sqrt{E_0(\mathrm{GeV)}} \oplus 2.0) \%$. Comment: 14 pages, 13 figures, test beam performances of focal prototype with pad sensors only
Keywords	Physics - Instrumentation and Detectors ; High Energy Physics - Experiment ; Nuclear Experiment
Subject code	621
Publishing date	2019-11-02
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Investigating particle track topology for range telescopes in particle radiography using convolutional neural networks.

Pettersen, Helge Egil Seime / Aehle, Max / Alme, Johan / Barnaföldi, Gergely Gábor / Borshchov, Vyacheslav / van den Brink, Anthony / Chaar, Mamdouh / Eikeland, Viljar / Feofilov, Grigory / Garth, Christoph / Gauger, Nicolas R / Genov, Georgi / Grøttvik, Ola / Helstrup, Håvard / Igolkin, Sergey / Keidel, Ralf / Kobdaj, Chinorat / Kortus, Tobias / Leonhardt, Viktor /

Mehendale, Shruti / Mulawade, Raju Ningappa / Odland, Odd Harald / Papp, Gábor / Peitzmann, Thomas / Piersimoni, Pierluigi / Protsenko, Maksym / Rehman, Attiq Ur / Richter, Matthias / Santana, Joshua / Schilling, Alexander / Seco, Joao / Songmoolnak, Arnon / Sølie, Jarle Rambo / Tambave, Ganesh / Tymchuk, Ihor / Ullaland, Kjetil / Varga-Kofarago, Monika / Volz, Lennart / Wagner, Boris / Wendzel, Steffen / Wiebel, Alexander / Xiao, RenZheng / Yang, Shiming / Yokoyama, Hiroki / Zillien, Sebastian / Röhrich, Dieter

Acta oncologica (Stockholm, Sweden)

2021 Volume 60, Issue 11, Page(s) 1413–1418

Abstract: Background: Proton computed tomography (pCT) and radiography (pRad) are proposed modalities for improved treatment plan accuracy and : Material and methods: The CNN was trained by simulation and reconstruction of tens of millions of proton and helium ...

Abstract	Background: Proton computed tomography (pCT) and radiography (pRad) are proposed modalities for improved treatment plan accuracy and Material and methods: The CNN was trained by simulation and reconstruction of tens of millions of proton and helium tracks. The CNN filter was then compared to simple energy loss threshold methods using the Area Under the Receiver Operating Characteristics curve (AUROC), and by comparing the image quality and Water Equivalent Path Length (WEPL) error of proton and helium radiographs filtered with the same methods. Results: The CNN method led to a considerable improvement of the AUROC, from 74.3% to 97.5% with protons and from 94.2% to 99.5% with helium. The CNN filtering reduced the WEPL error in the helium radiograph from 1.03 mm to 0.93 mm while no improvement was seen in the CNN filtered pRads. Conclusion: The CNN improved the filtering of proton and helium tracks. Only in the helium radiograph did this lead to improved image quality.
MeSH term(s)	Humans ; Image Processing, Computer-Assisted ; Monte Carlo Method ; Neural Networks, Computer ; Phantoms, Imaging ; Radiography ; Telescopes
Language	English
Publishing date	2021-07-14
Publishing country	England
Document type	Journal Article
ZDB-ID	896449-x
ISSN	1651-226X ; 0349-652X ; 0284-186X ; 1100-1704
ISSN (online)	1651-226X
ISSN	0349-652X ; 0284-186X ; 1100-1704
DOI	10.1080/0284186X.2021.1949037
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6348: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Helium radiography with a digital tracking calorimeter-a Monte Carlo study for secondary track rejection.

Pettersen, Helge Egil Seime / Volz, Lennart / Sølie, Jarle Rambo / Alme, Johan / Barnaföldi, Gergely Gábor / Barthel, Rene / van den Brink, Anthony / Borshchov, Vyacheslav / Chaar, Mamdouh / Eikeland, Viljar / Genov, Georgi / Grøttvik, Ola / Helstrup, Håvard / Keidel, Ralf / Kobdaj, Chinorat / van der Kolk, Naomi / Mehendale, Shruti / Meric, Ilker / Harald Odland, Odd /

Papp, Gábor / Peitzmann, Thomas / Piersimoni, Pierluigi / Protsenko, Maksym / Ur Rehman, Attiq / Richter, Matthias / Tefre Samnøy, Andreas / Seco, Joao / Shafiee, Hesam / Songmoolnak, Arnon / Tambave, Ganesh / Tymchuk, Ihor / Ullaland, Kjetil / Varga-Kofarago, Monika / Wagner, Boris / Xiao, RenZheng / Yang, Shiming / Yokoyama, Hiroki / Röhrich, Dieter

Physics in medicine and biology

2021 Volume 66, Issue 3, Page(s) 35004

Abstract: Radiation therapy using protons and heavier ions is a fast-growing therapeutic option for cancer patients. A clinical system for particle imaging in particle therapy would enable online patient position verification, estimation of the dose deposition ... ...

Abstract	Radiation therapy using protons and heavier ions is a fast-growing therapeutic option for cancer patients. A clinical system for particle imaging in particle therapy would enable online patient position verification, estimation of the dose deposition through range monitoring and a reduction of uncertainties in the calculation of the relative stopping power of the patient. Several prototype imaging modalities offer radiography and computed tomography using protons and heavy ions. A Digital Tracking Calorimeter (DTC), currently under development, has been proposed as one such detector. In the DTC 43 longitudinal layers of laterally stacked ALPIDE CMOS monolithic active pixel sensor chips are able to reconstruct a large number of simultaneously recorded proton tracks. In this study, we explored the capability of the DTC for helium imaging which offers favorable spatial resolution over proton imaging. Helium ions exhibit a larger cross section for inelastic nuclear interactions, increasing the number of produced secondaries in the imaged object and in the detector itself. To that end, a filtering process able to remove a large fraction of the secondaries was identified, and the track reconstruction process was adapted for helium ions. By filtering on the energy loss along the tracks, on the incoming angle and on the particle ranges, 97.5% of the secondaries were removed. After passing through 16 cm water, 50.0% of the primary helium ions survived; after the proposed filtering 42.4% of the primaries remained; finally after subsequent image reconstruction 31% of the primaries remained. Helium track reconstruction leads to more track matching errors compared to protons due to the increased available focus strength of the helium beam. In a head phantom radiograph, the Water Equivalent Path Length error envelope was 1.0 mm for helium and 1.1 mm for protons. This accuracy is expected to be sufficient for helium imaging for pre-treatment verification purposes.
MeSH term(s)	Calorimetry/instrumentation ; Helium ; Humans ; Monte Carlo Method ; Phantoms, Imaging ; Protons ; Radiography
Chemical Substances	Protons ; Helium (206GF3GB41)
Language	English
Publishing date	2021-01-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/abca03
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 199: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Design optimization of a pixel-based range telescope for proton computed tomography.

Pettersen, Helge Egil Seime / Alme, Johan / Barnaföldi, Gergely Gábor / Barthel, Rene / van den Brink, Anthony / Chaar, Mamdouh / Eikeland, Viljar / García-Santos, Alba / Genov, Georgi / Grimstad, Silje / Grøttvik, Ola / Helstrup, Håvard / Hetland, Kristin Fanebust / Mehendale, Shruti / Meric, Ilker / Odland, Odd Harald / Papp, Gábor / Peitzmann, Thomas / Piersimoni, Pierluigi /

Ur Rehman, Attiq / Richter, Matthias / Samnøy, Andreas Tefre / Seco, Joao / Shafiee, Hesam / Skjæveland, Eivind Vågslid / Sølie, Jarle Rambo / Tambave, Ganesh / Ullaland, Kjetil / Varga-Kofarago, Monika / Volz, Lennart / Wagner, Boris / Yang, Shiming / Röhrich, Dieter

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

2019 Volume 63, Page(s) 87–97

Abstract: Purpose: A pixel-based range telescope for tracking particles during proton imaging is described. The detector applies a 3D matrix of stacked Monolithic Active Pixel Sensors with fast readout speeds. This study evaluates different design alternatives of ...

Abstract	Purpose: A pixel-based range telescope for tracking particles during proton imaging is described. The detector applies a 3D matrix of stacked Monolithic Active Pixel Sensors with fast readout speeds. This study evaluates different design alternatives of the range telescope on basis of the protons' range accuracy and the track reconstruction efficiency. Method: Detector designs with different thicknesses of the energy-absorbing plates between each sensor layer are simulated using the GATE/Geant4 Monte Carlo software. Proton tracks traversing the detector layers are individually reconstructed, and a Bragg curve fitting procedure is applied for the calculation of each proton's range. Results: Simulations show that the setups with 4 mm and thinner absorber layers of aluminum have a low range uncertainty compared to the physical range straggling, systematic errors below 0.3 mm water equivalent thickness and a track reconstruction capability exceeding ten million protons per second. Conclusions: In order to restrict the total number of layers and to yield the required tracking and range resolution properties, a design recommendation is reached where the proposed range telescope applies 3.5 mm thick aluminum absorber slabs between each sensor layer.
MeSH term(s)	Equipment Design ; Image Processing, Computer-Assisted ; Monte Carlo Method ; Phantoms, Imaging ; Protons ; Scattering, Radiation ; Software ; Telescopes ; Tomography, X-Ray Computed/instrumentation
Chemical Substances	Protons
Language	English
Publishing date	2019-06-06
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1122650-x
ISSN	1724-191X ; 1120-1797
ISSN (online)	1724-191X
ISSN	1120-1797
DOI	10.1016/j.ejmp.2019.05.026
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.B 2941: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Book ; Online: Exploration of Differentiability in a Proton Computed Tomography Simulation Framework

Aehle, Max / Alme, Johan / Barnaföldi, Gergely Gábor / Blühdorn, Johannes / Bodova, Tea / Borshchov, Vyacheslav / Brink, Anthony van den / Eikeland, Viljar / Feofilov, Gregory / Garth, Christoph / Gauger, Nicolas R. / Grøttvik, Ola / Helstrup, Håvard / Igolkin, Sergey / Keidel, Ralf / Kobdaj, Chinorat / Kortus, Tobias / Kusch, Lisa / Leonhardt, Viktor /

Mehendale, Shruti / Mulawade, Raju Ningappa / Odland, Odd Harald / O'Neill, George / Papp, Gábor / Peitzmann, Thomas / Pettersen, Helge Egil Seime / Piersimoni, Pierluigi / Pochampalli, Rohit / Protsenko, Maksym / Rauch, Max / Rehman, Attiq Ur / Richter, Matthias / Röhrich, Dieter / Sagebaum, Max / Santana, Joshua / Schilling, Alexander / Seco, Joao / Songmoolnak, Arnon / Sudár, Ákos / Tambave, Ganesh / Tymchuk, Ihor / Ullaland, Kjetil / Varga-Kofarago, Monika / Volz, Lennart / Wagner, Boris / Wendzel, Steffen / Wiebel, Alexander / Xiao, RenZheng / Yang, Shiming / Zillien, Sebastian

2022

Abstract: Objective. Algorithmic differentiation (AD) can be a useful technique to numerically optimize design and algorithmic parameters by, and quantify uncertainties in, computer simulations. However, the effectiveness of AD depends on how "well-linearizable" ... ...

Abstract	Objective. Algorithmic differentiation (AD) can be a useful technique to numerically optimize design and algorithmic parameters by, and quantify uncertainties in, computer simulations. However, the effectiveness of AD depends on how "well-linearizable" the software is. In this study, we assess how promising derivative information of a typical proton computed tomography (pCT) scan computer simulation is for the aforementioned applications. Approach. This study is mainly based on numerical experiments, in which we repeatedly evaluate three representative computational steps with perturbed input values. We support our observations with a review of the algorithmic steps and arithmetic operations performed by the software, using debugging techniques. Main results. The model-based iterative reconstruction (MBIR) subprocedure (at the end of the software pipeline) and the Monte Carlo (MC) simulation (at the beginning) were piecewise differentiable. Jumps in the MBIR function arose from the discrete computation of the set of voxels intersected by a proton path. Jumps in the MC function likely arose from changes in the control flow that affect the amount of consumed random numbers. The tracking algorithm solves an inherently non-differentiable problem. Significance. The MC and MBIR codes are ready for the integration of AD, and further research on surrogate models for the tracking subprocedure is necessary. Comment: 27 pages, 11 figures
Keywords	Physics - Medical Physics ; Computer Science - Mathematical Software
Subject code	000
Publishing date	2022-02-11
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED