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  1. Article ; Online: Intuitive eating in general aspects of eating behaviors in individuals with obesity: Randomized clinical trial.

    Campos, Marina Brito / Menezes, Ida Helena Carvalho Francescantonio / Peixoto, Maria do Rosário Gondim / Schincaglia, Raquel Machado

    Clinical nutrition ESPEN

    2022  Volume 50, Page(s) 24–32

    Abstract: Background and aims: Dysfunctional eating behaviors may be associated with weight gain and have a negative impact on obesity. Intuitive eating is a strategy that helps with changing eating behaviors. This study aimed to analyze the effects of intuitive ... ...

    Abstract Background and aims: Dysfunctional eating behaviors may be associated with weight gain and have a negative impact on obesity. Intuitive eating is a strategy that helps with changing eating behaviors. This study aimed to analyze the effects of intuitive eating alone or combined with nutritional guidelines on eating behaviors, weight, and body mass index (BMI), in individuals with obesity.
    Methods: This is a randomized clinical trial of 58 individuals (84.5% females and 84.5% candidates for bariatric surgery). The mean age was 40.5 years (SD = 9.1). The mean BMI was 48.3 kg/m
    Results: Compared with the CG, the IEG and IEGDG did not differ in binge eating, cognitive restriction, emotional eating, and uncontrolled eating. Likewise, there were no significant differences in weight and BMI.
    Conclusions: Intuitive eating alone or in combination with nutritional guidelines did not alter the general domains of eating behaviors, weight, and BMI in individuals with obesity. We suggest further studies involving other health professionals, as well as evaluating the effects of intuitive eating using scales, in addition to eating behaviors.
    Clinical trial registration: https://ensaiosclinicos.gov.br6, Identifier: RBR-7q9nj8.
    MeSH term(s) Adult ; Bariatric Surgery/psychology ; Body Mass Index ; Feeding Behavior/psychology ; Female ; Humans ; Male ; Obesity/psychology ; Surveys and Questionnaires
    Language English
    Publishing date 2022-06-13
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ISSN 2405-4577
    ISSN (online) 2405-4577
    DOI 10.1016/j.clnesp.2022.06.002
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  2. Article: Intuitive eating in general aspects of eating behaviors in individuals with obesity: Randomized clinical trial

    Campos, Marina Brito / Menezes, Ida Helena Carvalho Francescantonio / Peixoto, Maria do Rosário Gondim / Schincaglia, Raquel Machado

    European Society for Clinical Nutrition and Metabolism Clinical nutrition ESPEN. 2022 June 01,

    2022  

    Abstract: Dysfunctional eating behaviors may be associated with weight gain and have a negative impact on obesity. Intuitive eating is a strategy that helps with changing eating behaviors. This study aimed to analyze the effects of intuitive eating alone or ... ...

    Abstract Dysfunctional eating behaviors may be associated with weight gain and have a negative impact on obesity. Intuitive eating is a strategy that helps with changing eating behaviors. This study aimed to analyze the effects of intuitive eating alone or combined with nutritional guidelines on eating behaviors, weight, and body mass index (BMI), in individuals with obesity. This is a randomized clinical trial of 58 individuals (84.5% females and 84.5% candidates for bariatric surgery). The mean age was 40.5 years (SD = 9.1). The mean BMI was 48.3 kg/m² (SD = 7.4). Individuals were randomized into three groups: 1) the control group (CG; n = 18), who received an individualized meal plan, 2) the intuitive eating group (IEG; n = 23), and 3) the intuitive eating and nutritional guidelines application group (IEGDG; n = 17). The study lasted for six months. Eating behaviors were assessed using the Binge Eating Scale and Three Factor Eating Questionnaire, the 21-item version. Compared with the CG, the IEG and IEGDG did not differ in binge eating, cognitive restriction, emotional eating, and uncontrolled eating. Likewise, there were no significant differences in weight and BMI. : Intuitive eating alone or in combination with nutritional guidelines did not alter the general domains of eating behaviors, weight, and BMI in individuals with obesity. We suggest further studies involving other health professionals, as well as evaluating the effects of intuitive eating using scales, in addition to eating behaviors. https://ensaiosclinicos.gov.br6, Identifier: RBR-7q9nj8.
    Keywords bariatric surgery ; body mass index ; clinical nutrition ; cognition ; obesity ; randomized clinical trials ; weight gain
    Language English
    Dates of publication 2022-0601
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ISSN 2405-4577
    DOI 10.1016/j.clnesp.2022.06.002
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  3. Article ; Online: Comparison between general obesity and abdominal adiposity to estimate cardiovascular disease prevalence in individuals with chronic kidney disease: results from NHANES 2005-2016.

    de Araújo Sugizaki, Clara Sandra / da Silva, Lara Lívia Santos / de Souza Freitas, Ana Tereza Vaz / Costa, Nara Aline / Lopes, Lorena Cristina Curado / Peixoto, Maria do Rosário Gondim

    European journal of clinical nutrition

    2024  Volume 78, Issue 5, Page(s) 449–451

    Abstract: Abdominal obesity, regardless of overall obesity, is associated with metabolic abnormalities and with direct impact on cardiovascular risk. The aim of this study was to compare body mass index (BMI), waist circumference (WC), and waist-to-height ratio ( ... ...

    Abstract Abdominal obesity, regardless of overall obesity, is associated with metabolic abnormalities and with direct impact on cardiovascular risk. The aim of this study was to compare body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) to estimate cardiovascular disease (CVD) prevalence in individuals with chronic kidney disease (CKD). The data analyzed is from 2005-2016 cycles of the NHANES. A total of 2,825 participants with CKD were included in this study, and most of them had a high BMI, 66.1%, to be exact (BMI ≥ 25.0 kg/m² if age <65 or >27.0 if age ≥ 65). The prevalence rates of high WC (≥102 cm for men or ≥88 cm for women) and high WHtR (WHtR>0.5) in the study population were 70.0% and 91.0%, respectively. The results of this study suggest that BMI is a good indicator of the risk of CVDs in individuals with CKD. In addition, the results show that WC and WHtR are associated with CVDs in non-overweight individuals of both sexes. These results indicate that the assessment of abdominal fat is essential even in non-overweight patients because the risk of CVDs cannot be identified in this subpopulation using only BMI.
    MeSH term(s) Humans ; Male ; Female ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/complications ; Middle Aged ; Prevalence ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Nutrition Surveys ; Body Mass Index ; Waist Circumference ; Obesity, Abdominal/epidemiology ; Obesity, Abdominal/complications ; Adult ; Aged ; Obesity/epidemiology ; Obesity/complications ; Waist-Height Ratio ; Adiposity ; Risk Factors ; Cross-Sectional Studies
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article ; Comparative Study
    ZDB-ID 639358-5
    ISSN 1476-5640 ; 0954-3007
    ISSN (online) 1476-5640
    ISSN 0954-3007
    DOI 10.1038/s41430-023-01398-1
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  4. Article ; Online: FRAIL scale as a screening tool and a predictor of mortality in non-dialysis dependent patients.

    Rodrigues, Hellen Christina Neves / Sousa, Amanda Goulart de Oliveira / Preto, Vitória Rodrigues Morais / Ferro, Camila Moura Batista / Sugizaki, Clara Sandra de Araújo / Freitas, Ana Tereza Vaz de Souza / Minicucci, Marcos Ferreira / Azevedo, Paula Schmidt / Peixoto, Maria do Rosário Gondim / Costa, Nara Aline

    Journal of nephrology

    2024  

    Abstract: Background: This study aimed to compare the diagnostic yield of the FRAIL scale with respect to the physical frailty phenotype measure and their association with mortality in non-dialysis-dependent patients.: Methods: In this prospective cohort study, ...

    Abstract Background: This study aimed to compare the diagnostic yield of the FRAIL scale with respect to the physical frailty phenotype measure and their association with mortality in non-dialysis-dependent patients.
    Methods: In this prospective cohort study, non-dialysis dependent patients with chronic kidney disease (CKD) stages 3b-5 seen in the nephrology outpatient clinics of two university hospitals were included. The presence of frailty was evaluated by physical frailty phenotype measure and the FRAIL scale. Patients were evaluated for six months, and mortality was recorded. The Kappa test was used to evaluate the diagnostic properties between the methods, and logistic regression to test the association between frailty and mortality.
    Results: One hundred fifty-three patients were evaluated; average age was 65 (56-70) years, 50.9% were women, and the all-cause mortality rate was 2.6%. Forty-six patients were classified as living with frailty according to the physical frailty phenotype while 36 patients were rated frail by the FRAIL scale. In adults < 60 years of age, the FRAIL scale showed good accuracy (84.9%) and specificity (93.2%) but had low sensitivity (41.3%) and moderate agreement (Kappa = 0.41; p < 0.001) compared to the definition of the physical frailty phenotype. The adjusted logistic regression model showed that the patients with frailty assessed by the FRAIL scale had a greater chance of mortality than the non-frail patients (OR: 6.8; CI95%:1.477-31.513; p = 0.014).
    Conclusion: Physical frailty phenotype identifies more patients as having pre-frailty and frailty in non-dialysis dependent patients as compared to the FRAIL scale. However, the FRAIL scale is a simple bedside tool that can be useful for screening for frailty and whose results were associated with mortality.
    Language English
    Publishing date 2024-03-26
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-024-01900-3
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    Zs.A 3369: Show issues Location:
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  5. Article ; Online: Phase angle is inversely associated with lipid peroxidation in hemodialysis patients.

    Rodrigues, Hellen Christina Neves / Saraiva, Stéfany Oliveira / Freitas, Ana Tereza Vaz de Souza / Peixoto, Maria do Rosário Gondim / Costa, Nara Aline

    Journal of nephrology

    2022  Volume 36, Issue 6, Page(s) 1723–1725

    MeSH term(s) Humans ; Lipid Peroxidation ; Renal Dialysis/adverse effects ; Antioxidants ; Oxidative Stress ; Superoxide Dismutase/metabolism ; Glutathione Peroxidase
    Chemical Substances Antioxidants ; Superoxide Dismutase (EC 1.15.1.1) ; Glutathione Peroxidase (EC 1.11.1.9)
    Language English
    Publishing date 2022-12-21
    Publishing country Italy
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-022-01544-1
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    Zs.A 3369: Show issues Location:
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  6. Article: Low hand grip strength is associated with worse functional capacity and higher inflammation in people receiving maintenance hemodialysis

    Lopes, Lorena Cristina Curado / Gonzalez, Maria Cristina / Avesani, Carla Maria / Prado, Carla M. / Peixoto, Maria do Rosário Gondim / Mota, João Felipe

    Nutrition. 2022 Jan., v. 93

    2022  

    Abstract: To evaluate the associations of hand grip strength (HGS) with body composition, functional capacity, muscle quality, and inflammatory markers in people receiving maintenance hemodialysis.This is a cross-sectional study in people receiving maintenance ... ...

    Abstract To evaluate the associations of hand grip strength (HGS) with body composition, functional capacity, muscle quality, and inflammatory markers in people receiving maintenance hemodialysis.This is a cross-sectional study in people receiving maintenance hemodialysis. HGS was measured by hydraulic dynamometer on the upper limb without fistula. Participants were stratified into low or adequate HGS, based on population-specific cutoff points. Body composition was assessed by dual-energy X-ray absorptiometry, and functional capacity by the Short Physical Performance Battery and timed up-and-go tests. In addition, serum creatinine, interleukin-6 (IL-6), IL-10, tumor necrosis factor-α, and ultra-sensitive C-reactive protein (us-CRP) were measured before the dialysis session.A total of 67 participants (41.8% women, 58.2% male; ages 54.1 ± 11.7 y) were included. Those with low HGS had worse functional capacity than those with adequate HGS (timed up-and-go test, 10.7 ± 1.0 versus 8.5 ± 0.8 sec, respectively; P < 0.001). IL-6 and us-CRP were higher in those with low HGS than their counterparts (IL-6: 2.7 ± 0.3 versus 1.9 pg/mL, P = 0.03; us-CRP: 14.8 ± 3.0 versus 4.7 ± 1.9 mg/L, P = 0.03). Multiple linear regression analysis showed that appendicular lean mass, us-CRP, age, sex, and seven-point subjective global assessment score were associated with HGS.Participants with low HGS showed higher inflammation and lower functional capacity. In addition to muscle mass, inflammation and nutritional status also affect HGS.<END ABSTRACT>
    Keywords C-reactive protein ; blood serum ; body composition ; creatinine ; cross-sectional studies ; dialysis ; dual-energy X-ray absorptiometry ; exercise test ; fistula ; hand strength ; hemodialysis ; inflammation ; interleukin-10 ; interleukin-6 ; males ; muscle tissues ; muscles ; necrosis ; neoplasms ; nutritional status ; regression analysis
    Language English
    Dates of publication 2022-01
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2021.111469
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  7. Article ; Online: Transcultural adaptation of the Thirst Distress Scale (TDS) into Brazilian Portuguese and an analysis of the psychometric properties of the scale for patients on hemodialysis.

    Sugizaki, Clara Sandra de Araujo / Braga, Clarice Carneiro / Freitas, Ana Tereza Vaz de Souza / Peixoto, Maria do Rosário Gondim

    Jornal brasileiro de nefrologia

    2020  Volume 42, Issue 2, Page(s) 153–162

    Abstract: Objective: To produce a transcultural adaptation of the Thirst Distress Scale (TDS) into Brazilian Portuguese and analyze the scale's psychometric properties for patients on hemodialysis (HD).: Methods: The original scale was translated, back ... ...

    Abstract Objective: To produce a transcultural adaptation of the Thirst Distress Scale (TDS) into Brazilian Portuguese and analyze the scale's psychometric properties for patients on hemodialysis (HD).
    Methods: The original scale was translated, back translated, and discussed with psychometric assessment experts. The final version was tested with 126 patients on HD and retested with 70 individuals from the original patient population. Cronbach's alpha was used to measure the scale's internal consistency. Reliability of thirst intensity evaluated via the visual analogue scale (VAS) was tested with Kappa statistic and the Bland-Altman plot. Reproducibility was assessed based on the intraclass correlation coefficient (ICC).
    Results: The wording of three items and the verb tenses of six had to be adjusted in the final version of the Brazilian Portuguese TDS. Comprehension of the scale by patients on HD was good, the scale's internal consistency was satisfactory (0.84; p<0.001), agreement with a visual analogue scale (VAS) was moderate (kappa=0.44; p<0.001), and reproducibility neared perfection (ICC=0.87; p<0.001).
    Conclusion: Our results showed that the Brazilian Portuguese version of the scale might be used reliably. The Brazilian Portuguese version of the TDS is a practical, affordable, accessible and well-accepted tool that has a lot to offer for the management of patients with HD.
    MeSH term(s) Adult ; Aged ; Anxiety/psychology ; Brazil/epidemiology ; Cross-Cultural Comparison ; Cross-Sectional Studies ; Female ; Humans ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/etiology ; Kidney Failure, Chronic/therapy ; Language ; Male ; Middle Aged ; Psychometrics/methods ; Renal Dialysis/adverse effects ; Renal Dialysis/psychology ; Reproducibility of Results ; Surveys and Questionnaires ; Thirst/classification ; Thirst/physiology ; Time Factors ; Translations ; Visual Analog Scale
    Language Portuguese
    Publishing date 2020-04-21
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2057873-8
    ISSN 2175-8239 ; 2175-8239
    ISSN (online) 2175-8239
    ISSN 2175-8239
    DOI 10.1590/2175-8239-JBN-2019-0151
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  8. Article ; Online: Low hand grip strength is associated with worse functional capacity and higher inflammation in people receiving maintenance hemodialysis.

    Lopes, Lorena Cristina Curado / Gonzalez, Maria Cristina / Avesani, Carla Maria / Prado, Carla M / Peixoto, Maria do Rosário Gondim / Mota, João Felipe

    Nutrition (Burbank, Los Angeles County, Calif.)

    2021  Volume 93, Page(s) 111469

    Abstract: Objectives: To evaluate the associations of hand grip strength (HGS) with body composition, functional capacity, muscle quality, and inflammatory markers in people receiving maintenance hemodialysis.: Methods: This is a cross-sectional study in ... ...

    Abstract Objectives: To evaluate the associations of hand grip strength (HGS) with body composition, functional capacity, muscle quality, and inflammatory markers in people receiving maintenance hemodialysis.
    Methods: This is a cross-sectional study in people receiving maintenance hemodialysis. HGS was measured by hydraulic dynamometer on the upper limb without fistula. Participants were stratified into low or adequate HGS, based on population-specific cutoff points. Body composition was assessed by dual-energy X-ray absorptiometry, and functional capacity by the Short Physical Performance Battery and timed up-and-go tests. In addition, serum creatinine, interleukin-6 (IL-6), IL-10, tumor necrosis factor-α, and ultra-sensitive C-reactive protein (us-CRP) were measured before the dialysis session.
    Results: A total of 67 participants (41.8% women, 58.2% male; ages 54.1 ± 11.7 y) were included. Those with low HGS had worse functional capacity than those with adequate HGS (timed up-and-go test, 10.7 ± 1.0 versus 8.5 ± 0.8 sec, respectively; P < 0.001). IL-6 and us-CRP were higher in those with low HGS than their counterparts (IL-6: 2.7 ± 0.3 versus 1.9 pg/mL, P = 0.03; us-CRP: 14.8 ± 3.0 versus 4.7 ± 1.9 mg/L, P = 0.03). Multiple linear regression analysis showed that appendicular lean mass, us-CRP, age, sex, and seven-point subjective global assessment score were associated with HGS.
    Conclusions: Participants with low HGS showed higher inflammation and lower functional capacity. In addition to muscle mass, inflammation and nutritional status also affect HGS.<END ABSTRACT>.
    MeSH term(s) Absorptiometry, Photon ; Adult ; Aged ; Cross-Sectional Studies ; Female ; Hand Strength ; Humans ; Inflammation ; Male ; Middle Aged ; Renal Dialysis
    Language English
    Publishing date 2021-08-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2021.111469
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  9. Article ; Online: Turmeric supplementation with piperine is more effective than turmeric alone in attenuating oxidative stress and inflammation in hemodialysis patients: A randomized, double-blind clinical trial.

    Freitas E Silva-Santana, Nayara Cristina / Rodrigues, Hellen Christina Neves / Pereira Martins, Tatiane Fagundes / Braga, Clarice Carneiro / Silva, Marina Alves Coelho / Carlos da Cunha, Luiz / de Souza Freitas, Ana Tereza Vaz / Costa, Nara Aline / Peixoto, Maria do Rosário Gondim

    Free radical biology & medicine

    2022  Volume 193, Issue Pt 2, Page(s) 648–655

    Abstract: Purpose: Turmeric has renop rotective effects that can act to reduce oxidative stress and inflammation in hemodialysis (HD) patients. Piperine has been indicated as a bioavailability enhancer of turmeric and consequently of its biological effects. ... ...

    Abstract Purpose: Turmeric has renop rotective effects that can act to reduce oxidative stress and inflammation in hemodialysis (HD) patients. Piperine has been indicated as a bioavailability enhancer of turmeric and consequently of its biological effects. However, data on the efficacy of the turmeric/piperine combination in HD patients are limited. We aimed to verify whether turmeric supplementation in combination with piperine has a superior effect to turmeric alone in increasing antioxidant capacity and reducing oxidative stress and inflammation in HD patients.
    Methods: This randomized, double-blind clinical trial was conducted in HD patients (age 20-75 years). Patients were supplemented with turmeric (3 g/day) or turmeric/piperine (3 g turmeric + 2 mg piperine/day) for 12 weeks. Malondialdehyde (MDA), antioxidant enzymes catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), high-sensitivity C-reactive protein (hs-CRP), and ferritin were evaluated at baseline and the end of the study.
    Results: There was a reduction in the MDA and ferritin levels in the turmeric/piperine group and in the comparison between groups at the end of the study [MDA: -0.08(-0.14/0.01) nmol/mL versus -0.003(-0.10/0.26) nmol/mL, p = 0.003; ferritin: -193.80 ± 157.29 mg/mL versus 51.99 ± 293.25 mg/mL, p = 0.018]. In addition, GPx activity reduced in the turmeric group (p = 0.029). No changes were observed for CAT, GR, and hs-CRP.
    Conclusion: Turmeric plus piperine was superior to turmeric alone in decreasing MDA and ferritin levels. The use of a combination of turmeric and piperine as a dietary intervention may be beneficial for modulating the status oxidative and inflammation in HD patients.
    Brazilian registry of clinical trials number: RBR-2t5zpd; Registration Date: May 2, 2018.
    MeSH term(s) Curcuma/metabolism ; Antioxidants/therapeutic use ; Antioxidants/metabolism ; C-Reactive Protein/metabolism ; Oxidative Stress ; Inflammation/drug therapy ; Renal Dialysis/adverse effects ; Dietary Supplements ; Ferritins/metabolism ; Double-Blind Method
    Chemical Substances piperine (U71XL721QK) ; Antioxidants ; C-Reactive Protein (9007-41-4) ; Ferritins (9007-73-2)
    Language English
    Publishing date 2022-11-09
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2022.11.008
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    Zs.A 2109: Show issues Location:
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  10. Article ; Online: Antioxidant and anti-inflammatory response to curcumin supplementation in hemodialysis patients: A randomized, double-blind, placebo-controlled clinical trial.

    Rodrigues, Hellen Christina Neves / Martins, Tatiane Fagundes Pereira / Santana, Nayara Cristina Freitas E Silva / Braga, Clarice Carneiro / Silva, Marina Alves Coelho / Cunha, Luiz Carlos da / Sugizaki, Clara Sandra de Araújo / Freitas, Ana Tereza Vaz de Souza / Costa, Nara Aline / Peixoto, Maria do Rosário Gondim

    Clinical nutrition ESPEN

    2021  Volume 44, Page(s) 136–142

    Abstract: Background and objectives: Hemodialysis (HD) patients are vulnerable to malnutrition and cardiovascular complications due to many factors, including oxidative stress and inflammation. Curcumin supplementation is associated with attenuation of ... ...

    Abstract Background and objectives: Hemodialysis (HD) patients are vulnerable to malnutrition and cardiovascular complications due to many factors, including oxidative stress and inflammation. Curcumin supplementation is associated with attenuation of proinflammatory cytokines and increased activity of antioxidant enzymes, but its effects in HD patients are unknown. This study aimed to evaluate the effect of curcumin supplementation on oxidative stress and inflammation in HD patients.
    Methods: This randomized, double-blind, placebo-controlled trial enrolled 43 HD patients and divided them into two groups: supplemented with curcumin (1 g/day) or placebo (corn starch) for 12 weeks. Demographic information and blood samples were taken at the start and the end of the study to determine serum malondialdehyde (MDA) concentrations, antioxidant enzyme activity, and high-sensitivity C-reactive protein (hs-CRP).
    Results: The curcumin group showed a significant increase in catalase activity [Δ = 1.13 ± 2.87 versus Δ = -1.08 ± 2.68; p = 0.048] and preserved glutathione peroxidase activity [Δ = -4.23 ± 11.50 versus Δ = -14.44 ± 13.96; p < 0.01] compared with the placebo group. However, no significant changes were found in MDA concentrations, glutathione reductase activity, and hs-CRP concentrations after the intervention.
    Conclusion: Curcumin supplementation for 12 weeks had potential effects on antioxidant response, but it was not enough to reduce oxidative stress markers and inflammation in HD patients. This trial was registered at EnsaiosClínicos.gov.br under registration number RBR-2t5zpd.
    MeSH term(s) Anti-Inflammatory Agents ; Antioxidants ; Curcumin ; Dietary Supplements ; Humans ; Renal Dialysis
    Chemical Substances Anti-Inflammatory Agents ; Antioxidants ; Curcumin (IT942ZTH98)
    Language English
    Publishing date 2021-06-24
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ISSN 2405-4577
    ISSN (online) 2405-4577
    DOI 10.1016/j.clnesp.2021.06.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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