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Article ; Online: Mechanisms of Prostate Cancer Cells Survival and Their Therapeutic Targeting.

Pejčić, Tomislav / Todorović, Zoran / Đurašević, Siniša / Popović, Lazar

International journal of molecular sciences

2023 Volume 24, Issue 3

Abstract: Prostate cancer (PCa) is today the second most common cancer in the world, with almost 400,000 deaths annually. Multiple factors are involved in the etiology of PCa, such as older age, genetic mutations, ethnicity, diet, or inflammation. Modern treatment ...

Abstract	Prostate cancer (PCa) is today the second most common cancer in the world, with almost 400,000 deaths annually. Multiple factors are involved in the etiology of PCa, such as older age, genetic mutations, ethnicity, diet, or inflammation. Modern treatment of PCa involves radical surgical treatment or radiation therapy in the stages when the tumor is limited to the prostate. When metastases develop, the standard procedure is androgen deprivation therapy, which aims to reduce the level of circulating testosterone, which is achieved by surgical or medical castration. However, when the level of testosterone decreases to the castration level, the tumor cells adapt to the new conditions through different mechanisms, which enable their unhindered growth and survival, despite the therapy. New knowledge about the biology of the so-called of castration-resistant PCa and the way it adapts to therapy will enable the development of new drugs, whose goal is to prolong the survival of patients with this stage of the disease, which will be discussed in this review.
MeSH term(s)	Male ; Humans ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms, Castration-Resistant/pathology ; Androgen Antagonists/therapeutic use ; Testosterone/therapeutic use ; Prostate/pathology ; Orchiectomy ; Receptors, Androgen/genetics
Chemical Substances	Androgen Antagonists ; Testosterone (3XMK78S47O) ; Receptors, Androgen
Language	English
Publishing date	2023-02-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24032939
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Alteration of Lipid Metabolism in Prostate Cancer: Multifaceted Oncologic Implications.

Zeković, Milica / Bumbaširević, Uros / Živković, Marko / Pejčić, Tomislav

International journal of molecular sciences

2023 Volume 24, Issue 2

Abstract: Cancer is increasingly recognized as an extraordinarily heterogeneous disease featuring an intricate mutational landscape and vast intra- and intertumor variability on both genetic and phenotypic levels. Prostate cancer (PCa) is the second most prevalent ...

Abstract	Cancer is increasingly recognized as an extraordinarily heterogeneous disease featuring an intricate mutational landscape and vast intra- and intertumor variability on both genetic and phenotypic levels. Prostate cancer (PCa) is the second most prevalent malignant disease among men worldwide. A single metabolic program cannot epitomize the perplexing reprogramming of tumor metabolism needed to sustain the stemness of neoplastic cells and their prominent energy-consuming functional properties, such as intensive proliferation, uncontrolled growth, migration, and invasion. In cancerous tissue, lipids provide the structural integrity of biological membranes, supply energy, influence the regulation of redox homeostasis, contribute to plasticity, angiogenesis and microenvironment reshaping, mediate the modulation of the inflammatory response, and operate as signaling messengers, i.e., lipid mediators affecting myriad processes relevant for the development of the neoplasia. Comprehensive elucidation of the lipid metabolism alterations in PCa, the underlying regulatory mechanisms, and their implications in tumorigenesis and the progression of the disease are gaining growing research interest in the contemporary urologic oncology. Delineation of the unique metabolic signature of the PCa featuring major aberrant pathways including de novo lipogenesis, lipid uptake, storage and compositional reprogramming may provide novel, exciting, and promising avenues for improving diagnosis, risk stratification, and clinical management of such a complex and heterogeneous pathology.
MeSH term(s)	Male ; Humans ; Lipid Metabolism/genetics ; Prostatic Neoplasms/metabolism ; Lipogenesis ; Oxidation-Reduction ; Lipids ; Tumor Microenvironment
Chemical Substances	Lipids
Language	English
Publishing date	2023-01-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24021391
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Article ; Online: The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer

Pejčić, Tomislav / Zeković, Milica / Bumbaširević, Uroš / Kalaba, Milica / Vovk, Irena / Bensa, Maja / Popović, Lazar / Tešić, Živoslav

Antioxidants. 2023 Feb. 03, v. 12, no. 2

2023

Abstract: This narrative review summarizes epidemiological studies on breast cancer and prostate cancer with an overview of their global incidence distribution to investigate the relationship between these diseases and diet. The biological properties, mechanisms ... ...

Abstract	This narrative review summarizes epidemiological studies on breast cancer and prostate cancer with an overview of their global incidence distribution to investigate the relationship between these diseases and diet. The biological properties, mechanisms of action, and available data supporting the potential role of isoflavones in the prevention of breast cancer and prostate cancer are discussed. Studies evaluating the effects of isoflavones in tissue cultures of normal and malignant breast and prostate cells, as well as the current body of research regarding the effects of isoflavones attained through multiple modifications of cellular molecular signaling pathways and control of oxidative stress, are summarized. Furthermore, this review compiles literature sources reporting on the following: (1) levels of estrogen in breast and prostate tissue; (2) levels of isoflavones in the normal and malignant tissue of these organs in European and Asian populations; (3) average concentrations of isoflavones in the secretion of these organs (milk and semen). Finally, particular emphasis is placed on studies investigating the effect of isoflavones on tissues via estrogen receptors (ER).
Keywords	breast neoplasms ; breasts ; diet ; estrogens ; isoflavones ; milk ; oxidative stress ; prostatic neoplasms ; secretion ; semen
Language	English
Dates of publication	2023-0203
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12020368
Database	NAL-Catalogue (AGRICOLA)

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Article: The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer.

Pejčić, Tomislav / Zeković, Milica / Bumbaširević, Uroš / Kalaba, Milica / Vovk, Irena / Bensa, Maja / Popović, Lazar / Tešić, Živoslav

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 2

Abstract	This narrative review summarizes epidemiological studies on breast cancer and prostate cancer with an overview of their global incidence distribution to investigate the relationship between these diseases and diet. The biological properties, mechanisms of action, and available data supporting the potential role of isoflavones in the prevention of breast cancer and prostate cancer are discussed. Studies evaluating the effects of isoflavones in tissue cultures of normal and malignant breast and prostate cells, as well as the current body of research regarding the effects of isoflavones attained through multiple modifications of cellular molecular signaling pathways and control of oxidative stress, are summarized. Furthermore, this review compiles literature sources reporting on the following: (1) levels of estrogen in breast and prostate tissue; (2) levels of isoflavones in the normal and malignant tissue of these organs in European and Asian populations; (3) average concentrations of isoflavones in the secretion of these organs (milk and semen). Finally, particular emphasis is placed on studies investigating the effect of isoflavones on tissues via estrogen receptors (ER).
Language	English
Publishing date	2023-02-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12020368
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Article: Comprehensive Evaluation of Quality of Life in Penile Cancer Patients following Surgical Treatment.

Jovanović, Darko / Aćimović, Miodrag / Pejčić, Tomislav / Milojević, Bogomir / Čegar, Bojan / Zeković, Milica / Lisičić, Nikola / Džamić, Zoran / Marić, Gorica

Healthcare (Basel, Switzerland)

2023 Volume 11, Issue 23

Abstract: Background: Penile cancer (PC) is a highly aggressive disease, with a significant tendency for lymphatic spreading and subsequent development of distant metastases. The mutilating nature of PC surgical treatment has profound implications on the patient' ... ...

Abstract	Background: Penile cancer (PC) is a highly aggressive disease, with a significant tendency for lymphatic spreading and subsequent development of distant metastases. The mutilating nature of PC surgical treatment has profound implications on the patient's body integrity and self-image, sexual life and intimacy, voiding and mental health. The aim of our study was to comprehensively evaluate PC patients' post-treatment quality of life (QoL), sexual activity, self-esteem, fatigue and fear of disease recurrence. (2) Methods: A cross-sectional study was conducted at the Clinic of Urology, University Clinical Centre of Serbia, and included 31 PC patients. Data were collected by means of a questionnaire. (3) Results: The average score on the Global health status scale was 67.2 out of 100 (ranging from 16.7 to 100), and the SD was 22.5. Hierarchical linear regression analysis showed that demographic characteristics, Hospital Anxiety and Depression scale (HADS) anxiety and depression scores, total Multidimensional Fatigue Inventory, Fear of cancer recurrence and Rosenberg scores and erectile function score explained a total of 78.2% of the variance in the global health status/QoL scale of PC patients. (4) Conclusions: Efforts should be made not only to increase the survival of PC patients after surgical treatment but also to enable the best possible level of QoL in the post-operative period.
Language	English
Publishing date	2023-12-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11233091
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Article: Polyphenols as Possible Agents for Pancreatic Diseases.

Gašić, Uroš / Ćirić, Ivanka / Pejčić, Tomislav / Radenković, Dejan / Djordjević, Vladimir / Radulović, Siniša / Tešić, Živoslav

Antioxidants (Basel, Switzerland)

2020 Volume 9, Issue 6

Abstract: Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in ... ...

Abstract	Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in combination with other cytostatic agents such as cisplatin (Cis), 5-fluorouracil (5-FU), irinotecan, capecitabine, or oxaliplatin (Oxa) is used in conventional therapy. Outgoing literature provides data on the use of polyphenols, biologically active compounds, in the treatment of pancreatic cancer and the prevention of acute pancreatitis. Therefore, the first part of this review gives a brief overview of the state of pancreatic disease as well as the procedures for its treatment. The second part provides a detailed overview of the research regarding the anticancer effects of both pure polyphenols and their plant extracts. The results regarding the antiproliferative, antimetastatic, as well as inhibitory effects of polyphenols against PC cell lines as well as the prevention of acute pancreatitis are presented in detail. Finally, particular emphasis is given to the polyphenolic profiles of apples, berries, cherries, sour cherries, and grapes, given the fact that these fruits are rich in polyphenols and anthocyanins. Polyphenolic profiles, the content of individual polyphenols, and their relationships are discussed. Based on this, significant data can be obtained regarding the amount of fruit that should be consumed daily to achieve a therapeutic effect.
Language	English
Publishing date	2020-06-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox9060547
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Article: Usage of GreenLight HPS 180-W laser vaporisation for treatment of benign prostatic hyperplasia.

Jovanović, M / Džamić, Z / Aćimović, M / Kajmaković, B / Pejčić, T

Acta chirurgica Iugoslavica

2014 Volume 61, Issue 1, Page(s) 57–61

Abstract: Introduction: Laser therapy has gained increasing acceptance as a relatively less invasive treatment for lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). From the early procedure of interstitial laser coagulation through to ...

Abstract	Introduction: Laser therapy has gained increasing acceptance as a relatively less invasive treatment for lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). From the early procedure of interstitial laser coagulation through to the use of holmium laser enucleation of the prostate, there has been an expanding body of evidence on the efficacy of such procedures. One of the newer lasers is the Green Light HPS 180 W laser. Studies with this GreenLight laser (GLL) (American Medical Systems, Inc, Minnetonka, MN, USA) showing results as good as those of transurethral resection of the prostate (TURP). In this paper, the efficacy of the new GLL 180-W versus the gold standard TURP in patients with LUTS due to BPH was tested in a prospective clinical trial. Objective: To compare results of Green light laser (GLL) evaporisation of the prostatae and transurethral resection of the prostate (TURP) for treatment of BPH. MATERIJALS AND METHODS: A total of 62 patients with BPH were randomly assigned to two equal groups: TURP or GLL. Results: Both groups were compared regarding all relevant preoperative, operative, and postoperative parameters. Functional results in terms of improvement of International Prostate Symptom Score (IPSS), maximum flow rate (Qmax), and postvoid residual (PVR) urine were assessed at 1, 3, 6 and 12 mo. A total of 62 patients completed 12 mo of follow-up in the TURP and GLL groups, respectively. Baseline characteristics were comparable. Mean operative time was significantly shorter for TURP. Compared to preoperative values, there was significant reduction in hemoglobin levels at the end of TURP only. A significant difference in favor of GLL was achieved regarding the duration of catheterization and hospital stay. In the GLL, no major intraoperative complications were recorded and none of the patients required blood transfusion. Among TURP patients, 6 required transfusion, 1 developed TUR syndrome, and capsule perforation was observed in 5 patients. There was dramatic improvement in Qmax, IPSS, and GLL compared with preoperative values and the degree of improvement was comparable in both groups at all time points of follow-up. Four TURP patients and one GLL patients developed bladder neck contracture treated by bladder neck incision; none in either group experienced urethral stricture or urinary incontinence. Conclusions: Compared to transurethral resection of the prostate, GreenLight HPS 180-W laser photoselective vaporization of the prostate is safe and effective in the treatment of patients suffering from lower urinary tract symptoms due to benign prostatic hyperplasia.
MeSH term(s)	Aged ; Comparative Effectiveness Research ; Humans ; Laser Therapy/adverse effects ; Laser Therapy/instrumentation ; Laser Therapy/methods ; Lasers/utilization ; Length of Stay ; Lower Urinary Tract Symptoms/etiology ; Lower Urinary Tract Symptoms/psychology ; Lower Urinary Tract Symptoms/therapy ; Male ; Middle Aged ; Postoperative Complications/surgery ; Prospective Studies ; Prostate/pathology ; Prostatic Hyperplasia/complications ; Prostatic Hyperplasia/diagnosis ; Prostatic Hyperplasia/therapy ; Quality of Life ; Transurethral Resection of Prostate/adverse effects ; Transurethral Resection of Prostate/methods ; Treatment Outcome ; Urinary Bladder Neck Obstruction/etiology ; Urinary Bladder Neck Obstruction/surgery
Language	English
Publishing date	2014
Publishing country	Serbia
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial
ZDB-ID	428721-6
ISSN	0354-950X ; 0001-5474
ISSN	0354-950X ; 0001-5474
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Article: Trans-Obturator-Tape (T.O.T.) "outside-in" approach in surgical treatment of female stress urinary incontinence.

Jovanović, M / Džamić, Z / Aćimović, M / Kajmaković, B / Pejčić, T

Acta chirurgica Iugoslavica

2014 Volume 61, Issue 1, Page(s) 69–72

Abstract: Objective: The aim of the study was to analyzed the efficacy and safety of a minimally invasive surgical procedure using the Trans- Obturator-Tape with "outside-in" approach for treatment female stress urinary incontinence.: Patients and methods: 171 ...

Abstract	Objective: The aim of the study was to analyzed the efficacy and safety of a minimally invasive surgical procedure using the Trans- Obturator-Tape with "outside-in" approach for treatment female stress urinary incontinence. Patients and methods: 171 women with stress urinary incontinence (SUI) associated with urethral hypermobility, underwent the T.O.T. procedure (March 2010 to January 2014). 27 patients were previously operated for incontinence. Mean age was 59 years (37-80). 6 patients were having mixed incontinence, and 51 had SUI with urgencies. A non-elastic, polypropylene tape was placed under the mid-urethra. The surgical placement technique utilises a trans-obturator percutaneous approach. All patients underwent post-operative clinical examination, cough-stress test (full bladder), uroflowmetry, and post-voiding residual assessment. Results: Mean follow-up was 22 months (4-45). At 12 months follow-up 91,2% of the patients were completely cured. The overall peri-operative complication rate was 6.4% with no vascular, nerve or bowel injury. 5 patients (2.9%) had post-operative urinary retention. Conclusion: The present study confirms the results obtained by the instigator of the technique, E. Delorme, and allows us to consider T.O.T. as an effective and safe technique for the treatment of female stress urinary incontinence.
MeSH term(s)	Female ; Humans ; Middle Aged ; Minimally Invasive Surgical Procedures/methods ; Polypropylenes/therapeutic use ; Postoperative Complications/therapy ; Suburethral Slings ; Treatment Outcome ; Urinary Incontinence, Stress/surgery ; Urinary Retention/etiology ; Urinary Retention/therapy ; Urologic Surgical Procedures/adverse effects ; Urologic Surgical Procedures/instrumentation ; Urologic Surgical Procedures/methods
Chemical Substances	Polypropylenes
Language	English
Publishing date	2014
Publishing country	Serbia
Document type	Journal Article
ZDB-ID	428721-6
ISSN	0354-950X ; 0001-5474
ISSN	0354-950X ; 0001-5474
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Article ; Online: The Polyphenols as Potential Agents in Prevention and Therapy of Prostate Diseases.

Pejčić, Tomislav / Tosti, Tomislav / Džamić, Zoran / Gašić, Uroš / Vuksanović, Aleksandar / Dolićanin, Zana / Tešić, Živoslav

Molecules (Basel, Switzerland)

2019 Volume 24, Issue 21

Abstract: In recent years, the progress of science and medicine greatly has influenced human life span and health. However, lifestyle habits, like physical activity, smoking cessation, moderate alcohol consumption, diet, and maintaining a normal body weight ... ...

Abstract	In recent years, the progress of science and medicine greatly has influenced human life span and health. However, lifestyle habits, like physical activity, smoking cessation, moderate alcohol consumption, diet, and maintaining a normal body weight represent measures that greatly reduce the risk of various diseases. The type of diet is very important for disease development. Numerous epidemiological clinical data confirm that longevity is linked to predominantly plant-based diets and it is related to a long life; whereas the western diet, rich in red meat and fats, increases the risk of oxidative stress and thus the risk of developing various diseases and pre-aging. This review is focused on the bioavailability of polyphenols and the use of polyphenols for the prevention of prostate diseases. Special focus in this paper is placed on the isoflavonoids and flavan-3-ols, subgroups of polyphenols, and their protective effects against the development of prostate diseases.
MeSH term(s)	Flavonoids/therapeutic use ; Humans ; Isoflavones/therapeutic use ; Male ; Polyphenols/therapeutic use ; Prostatic Diseases/drug therapy ; Prostatic Diseases/prevention & control
Chemical Substances	Flavonoids ; Isoflavones ; Polyphenols ; flavan-3-ol (35HDD3NRIE)
Language	English
Publishing date	2019-11-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules24213982
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Article: The case of the diverticular bladder tumor treated with diverticulectomy.

Pejcić, T / Dzamić, Z / Dimitrijević, V / Aćimović, M / Hadzi-Djokić, J

Acta chirurgica Iugoslavica

2014 Volume 60, Issue 1, Page(s) 91–93

Abstract: Introduction: The majority of diverticular bladder tumors (DBT) are urothelial. Due to the lack of the muscular layer in the diverticulum, the progression of these tumors is easier than in the bladder wall.: Case report: The case of invasive DBT with ...

Abstract	Introduction: The majority of diverticular bladder tumors (DBT) are urothelial. Due to the lack of the muscular layer in the diverticulum, the progression of these tumors is easier than in the bladder wall. Case report: The case of invasive DBT with painless hematuria is presented. The patient was treated with diverticulectomy. Conclusion: Unifocal Stage-T3 DBTs can be successfully treated with diverticulectomy.
MeSH term(s)	Aged ; Carcinoma, Transitional Cell/pathology ; Carcinoma, Transitional Cell/surgery ; Diverticulum/pathology ; Diverticulum/surgery ; Hematuria/etiology ; Humans ; Male ; Neoplasm Invasiveness ; Urinary Bladder Neoplasms/pathology ; Urinary Bladder Neoplasms/surgery
Language	English
Publishing date	2014-03-25
Publishing country	Serbia
Document type	Case Reports ; Journal Article
ZDB-ID	428721-6
ISSN	0354-950X ; 0001-5474
ISSN	0354-950X ; 0001-5474
DOI	10.2298/aci1301091p
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