LIVIVO - Search results -

Search results

Result 1 - 10 of total 40

Search options

Article ; Online: Evaluation of the in vitro and in vivo effect of liposomal doxorubicin along with oncolytic Newcastle disease virus on 4T1 cell line

Pooya Faranoush / Alireza Jahandideh / Reza Nekouian / Pejman Mortazavi

Veterinary Medicine and Science, Vol 9, Iss 3, Pp 1426-

Animal preclinical research

2023 Volume 1437

Abstract: Abstract Background Breast cancer is one of the most common malignancies in women, with one in 20 globally. Oncolytic viruses have recently been the first step in the biological treatment of cancer, either genetically engineered or naturally occurring. ... ...

Abstract	Abstract Background Breast cancer is one of the most common malignancies in women, with one in 20 globally. Oncolytic viruses have recently been the first step in the biological treatment of cancer, either genetically engineered or naturally occurring. They increase specifically inside cancer cells and destroy them without damaging normal tissues or producing a host immune response against tumour cells or expressing transgenes. One of the most known members of this family is the Newcastle disease virus (NDV), a natural oncolytic virus that selectively induces apoptosis and DNA fragmentation in human cancer cells. Methods This study performed biochemical and molecular investigations with variable doses of NDV (32, 64, 128 HAU) and liposomal doxorubicin (9 mg/kg) on mouse triple‐negative mammary carcinoma cell line 4T1 and BALB/c models tumours for the first time. Results Real‐time quantitative PCR analysis in NDV‐treated animal tumours showed increased expression of P21, P27 and P53 genes and decreased expression of CD34, integrin Alpha 5, VEGF and VEGF‐R genes. Additional assessments in treated mouse models also showed that NDV increased ROS production, induced apoptosis, reduced tumour size and significantly improved prognosis, with no adverse effect on normal tissues. Conclusions These findings all together might indicate that NDV in combination with chemotherapy drugs could improve prognosis in cancer patients although many more conditions should be considered.
Keywords	breast cancer ; liposomal doxorubicin ; Newcastle disease virus ; oncolytic virus ; 4T1 cell line ; Veterinary medicine ; SF600-1100
Subject code	616 ; 610
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Protective effect of Descurainia sophia ethanolic extract on antioxidant enzyme levels in carbon tetrachloride induced liver damage of Wistar rats

Mahboubeh Mahlouji / Akram Eidi / Pejman Mortazavi / Shahrbanoo Oryan

Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī, Vol 17, Iss 1 (65) بهار, Pp 1-

2023 Volume 12

Abstract: Various studies have shown the anti-inflammatory and anti-oxidant effects of Descorainia sophia. The purpose of this study was to evaluate the hepatoprotective ability of Descorainia sophia ethanolic extract in liver damage induced by carbon ... ...

Abstract	Various studies have shown the anti-inflammatory and anti-oxidant effects of Descorainia sophia. The purpose of this study was to evaluate the hepatoprotective ability of Descorainia sophia ethanolic extract in liver damage induced by carbon tetrachloride in male Wistar rats. In this experimental study, 60 male Wistar rats were randomly divided into 10 groups of 6 consisting of normal control, intoxified control (intraperitoneal injection of 0.5 ml/kg of carbon tetrachloride), normal experimental (Descorainia sophia ethanolic extract at doses of 10, 50, 100 and 200 mg/kg via intragastric gavage) and intoxified experimental (intraperitoneal injection of 0.5 ml/kg of carbon tetrachloride and Descorainia sophia ethanolic extract at doses of 10, 50, 100 and 200 mg/kg via intragastric gavage). After 28 days, the levels of antioxidant enzymes viz. superoxide dismutase, catalase, glutathione peroxidase and level of malondialdehyde in liver homogenate were evaluated. Data were analyzed using one-way ANOVA and the Tukey post hoc test with statistical significance defined as p<0.05. Our results showed that administration of carbon tetrachloride significantly decreased the levels of antioxidant enzymes and increased the level of malondialdehyde in the intoxified control group in comparison to normal control group (p<0.001). Also, the administration of Descorainia sophia ethanolic extract significantly increased the levels of antioxidant enzymes and decreased the level of malondialdehyde in the liver of intoxified experimental groups in comparison with the intoxified control group (p<0.05) in a dose dependent manner. The results of the study indicated that Descorainia sophia removes free radicals and reduces oxidative stress caused by carbon tetrachloride in hepatic tissue of rats probably due to its flavonoid compounds.
Keywords	carbon tetrachloride ; descorainia sophia ; hepatoprotection ; liver toxication ; rat ; Veterinary medicine ; SF600-1100
Language	Persian
Publishing date	2023-05-01T00:00:00Z
Publisher	Islamic Azad University, Tabriz Branch
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Effects of Cold Atmospheric Plasma on Infectious Diabetic Wound Healing in Rat Models

Pouria Dehghanpisheh / Alireza Jahandideh / Ahmad Asghari / Pejman Mortazavi / Mahmood Ghorannevis

Crescent Journal of Medical and Biological Sciences, Vol 10, Iss 2, Pp 93-

2023 Volume 97

Abstract: Objectives: Patients with diabetes often suffer from chronic wounds which can occur due to the impairment of wound healing in these patients. Scientists have been trying to address this issue by using wide spectrum of antibiotics and drugs. However, ... ...

Abstract	Objectives: Patients with diabetes often suffer from chronic wounds which can occur due to the impairment of wound healing in these patients. Scientists have been trying to address this issue by using wide spectrum of antibiotics and drugs. However, overusing antibiotics in recent years has led to antibiotic resistant crisis; therefore, there is an urgent need to develop new approaches in order for controlling microbial infections in diabetic patients. This study aimed to determine if cold plasma was effective in wound healing in the infectious diabetic conditions. Material and Methods: In this experimental study, 40 adult male rats with diabetes infected with Staphylococcus aureus were included. The animals were randomly divided into two groups of 20 rats and four sub-groups (i.e., day 3rd, day 7th, day 14th, and day 21st). The rats in the treatment group were exposed to helium plasma irradiated for 3 minutes per day for 21 days. Wound healing in the samples was evaluated using five healing indexes including epithelium formation, Inflammatory cells, new vascularization, fibroblast, and collagen formation. Results: A significant difference (P<0.05) was found between the indexes in the plasma radiation group compared to the control group. The results showed that the speed of wound healing in the group treated with cold helium gas plasma was higher than that in the control group. Collagen formation was always completed faster in the helium plasma group, indicating the positive effects of helium plasma on infected diabetic wounds. Conclusions: Helium plasma was remarkable effective in healing wound and controlling infections in diabetic rats.
Keywords	cold atmospheric ; diabetes ; healing ; histopathology ; plasma ultraviolet radiation ; Medicine ; R
Subject code	630
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Aras Part Medical International Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Effect of magnesium oxide nanoparticles on varicocele-induced testicular damage in male Wistar rats

Masoumeh Tolu Ghamari / Akram Eidi / Pejman Mortazavi / Ahmad Asghari

Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī, Vol 17, Iss 1 (65) بهار, Pp 13-

2023 Volume 25

Abstract: Varicocele is a pathological dilation of the venous network of the spermatic cord and considering that magnesium oxide nanoparticles play a key role in various physiological functions, the aim of this study was to evaluate the performance of ... ...

Abstract	Varicocele is a pathological dilation of the venous network of the spermatic cord and considering that magnesium oxide nanoparticles play a key role in various physiological functions, the aim of this study was to evaluate the performance of nanoparticles on sperm characteristics affected by experimental varicocele. A total of 54 male Wistar rats were randomly divided into 9 equal groups including healthy control group (untouched animals), sham-operated group (underwent sham surgery), three healthy experimental groups (animals in these groups received magnesium oxide nanoparticles at doses of 1.25, 2.5 and 5 mg/kg respectively by gavage for 6 weeks), varicocele control group (varicocele was induced by renal vein ligation) and three experimental varicocele groups (in addition to varicocele induction, magnesium oxide nanoparticles were given at doses of 1.25, 2.5 and 5 mg/kg respectively by gavage for 6 weeks). At the end of the 6th week, the abdomen was opened and semen samples were collected from the tail of the epididymis to determine the indices of concentration, survival and motility of sperm and the data were statistically analyzed (p<0.05). The results showed that magnesium oxide nanoparticles were able to significantly increase the concentration, viability, progressive, moderate and non-progressive movements of sperm compared to the varicocele group (p<0.001) and also caused a significant decrease (p<0.001) in the number of non-moving sperms in the varicocele experimental groups. Therefore, magnesium oxide nanoparticles may possibly reduce the destructive effects of varicocele due to their antioxidant activity and be effective in its treatment by improving sperm properties during varicocele.
Keywords	magnesium oxide nanoparticles ; rat ; sperm ; testicular damage ; varicocele ; Veterinary medicine ; SF600-1100
Subject code	630
Language	Persian
Publishing date	2023-05-01T00:00:00Z
Publisher	Islamic Azad University, Tabriz Branch
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Effect of Magnesium Oxide Nanoparticles on Oxidative Stress Parameters to Treat Alzheimer\'s Disease in Adult Male Wistar Rats

Tara Aminoleslamzadeh / Akram Eidi / Pejman Mortazavi / Shahrbanoo Oryan

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, Vol 30, Iss 5, Pp 78-

2022 Volume 88

Abstract: Introduction: Many factors affect memory and learning. One of the most important ones is magnesium, which is essential for the proper functioning of our memory. Magnesium is the fourth most important cation and the second most important intracellular ... ...

Abstract	Introduction: Many factors affect memory and learning. One of the most important ones is magnesium, which is essential for the proper functioning of our memory. Magnesium is the fourth most important cation and the second most important intracellular cation after potassium in the body. Magnesium plays an important role in neurotransmission. This study aimed to examine magnesium oxide nanoparticles' effect on the parameters of oxidative stress to treat memory deficit in the rat model of Alzheimer's disease with the help of Amyloid-β. Material & Methods: In this experimental study, 54 adult male rats were divided randomly into nine groups, such as 1. Healthy control group, 2. Alzheimer's control group (rats that underwent stereotactic surgery and received 2nmol/µl of Amyloid-β by intracerebroventricular injection [ICVI]), 3. Sham group (rats that underwent stereotactic surgery and received saline as an Amyloid-β’s solvent), 4, 5, and 6. The healthy experimental groups (healthy rats receiving 2.5, 5, and 10 mg/kg body-weight doses of magnesium oxide nanoparticles by intraperitoneal injection), 7, 8, and 9. Alzheimer's experimental group (Alzheimer's rats receiving 2.5, 5, and 10 mg/kg body-weight doses of magnesium oxide nanoparticles by intraperitoneal injection). The duration of oral treatment of nanoparticles was 30 days. At the end of the treatment period (30 days), oxidative stress parameters, including superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT), and malondialdehyde (MDA) were measured in neural (brain tissue), and all data were analyzed by one-Factor ANOVA and Tukey post hoc test in SPSS software (version 21) considering a significance level of P<0.05. (Ethic code: IR.IAU.SRB.REC.1398.126) Findings: The results showed that magnesium oxide nanoparticles at 2.5, 5, and 10 mg/kg body-weight doses caused a significant reduction in malondialdehyde levels in Alzheimer's rats. Moreover, the number of antioxidant enzymes including GPX, SOD, and CAT in rats that received 2.5, 5, ...
Keywords	alzheimer's disease ; magnesium oxide nanoparticles ; oxidative stress ; rat ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	600
Language	Persian
Publishing date	2022-12-01T00:00:00Z
Publisher	Ilam University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: The Effect of Broccoli Extract in Arsenic-Induced Experimental Poisoning on the Hematological, Biochemical, and Electrophoretic Parameters of the Liver and Kidney of Rats

Mahdieh Raeeszadeh / Pouria Karimi / Nadia Khademi / Pejman Mortazavi

Evidence-Based Complementary and Alternative Medicine, Vol

2022 Volume 2022

Abstract: Heavy metals such as arsenic contribute to environmental pollution that can lead to systemic effects in various body organs. Some medicinal plants such as broccoli have been shown to reduce the harmful effects of these heavy metals. The main aim of the ... ...

Abstract	Heavy metals such as arsenic contribute to environmental pollution that can lead to systemic effects in various body organs. Some medicinal plants such as broccoli have been shown to reduce the harmful effects of these heavy metals. The main aim of the present study is to evaluate the effects of broccoli extract on liver and kidney toxicity, considering hematological and biochemical changes. The experimental study was performed in 28 days on 32 male Wistar rats classified into four groups: the control group (C), a group receiving 5 mg/kg oral arsenic (AS), a group receiving 300 mg/kg broccoli (B), and a group receiving arsenic and broccoli combination (AS + B). Finally, blood samples were taken to evaluate the hematological and biochemical parameters of the liver and kidney, as well as serum proteins’ concentration. Liver and kidney tissue were fixed and stained by H&E and used for histopathological diagnosis. The results demonstrated a significant decrease in white blood cells (WBC), red blood cells (RBC), and hemoglobin (Hb) in the AS group compared to other groups. However, in the B group, a significant increase in RBC and WBC was observed compared to the AS and C groups (P < 0.05). Moreover, RBC and WBC levels increased significantly in the AS + B group compared to the AS group (P = 0.046). However, in the AS group, aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine levels increased, while total protein, albumin, and globulin decreased. This can be a result of liver and kidney damage, which was observed in the AS group. Furthermore, the increase in the concentration of albumin and globulin in the AS + B group was higher than that in the AS group. Infiltration of inflammatory cells and necrosis of the liver and kidney tissue in the pathological evaluation of the AS group were significantly higher than other groups. There was an increase in superoxide dismutases (SOD), glutathione peroxidase (GPx), and total antioxidant capacity (TAC); however, a decrease in ...
Keywords	Other systems of medicine ; RZ201-999
Subject code	630
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: A study on the relationship between tumor size, tumor grade and lymph node involvement in canine mammary cancer

Sanaz Rismanchi / Pejman Mortazavi / Samad Muhammadnejad

Basic & Clinical Cancer Research, Vol 12, Iss

Simulation of tumor behavior in human breast cancer

2021 Volume 4

Abstract: Background: In the last two decades, canine mammary cancer has played an important role in human breast cancer research. In many cases, there are various similarities between the biological and clinical features of canine breast cancer and female breast ... ...

Abstract	Background: In the last two decades, canine mammary cancer has played an important role in human breast cancer research. In many cases, there are various similarities between the biological and clinical features of canine breast cancer and female breast cancer. Clinical studies and evaluation of prognostic parameters of canine mammary cancer can increase confidence in generalizing results for human cancers. This study was performed in the direction of comparative oncology. Methods: Clinical-pathological data from invasive type of canine mammary carcinoma were collected from clinical records and pathology reports. The parameters of age, tumor laterality, tumor size, lymph node status and tumor grade were recorded and the relationships between the parameters were evaluated using linear regression analysis. Results: 97 patients were included in the study and the mean age was 10.06 ± 2.73 years. 51% of the left mammary glands were involved and pT2 tumor size was the most common. Lymph nodes were involved in 27% of patients and 43% of tumors were grade I. Statistical analysis showed no statistical relationship between tumor size and laterality with other clinico-pathological features. However, there was a statistically significant relationship between tumor size and tumor grade and the condition of lymph nodes, so that with increasing tumor size, tumor grade increased and the likelihood of lymph node involvement increased. Conclusions: The results of this study are very similar to breast cancer in women and show that canine mammary carcinoma is a suitable model in comparative oncology research. Dogs live shorter than humans, so researchers can get the results of treatment and survival rate assessments faster in clinical trials. By observing ethical principles, dogs with breast cancer may replace phase I and II of human clinical trials in some types of cancer in the near future.
Keywords	Canine mammary carcinoma ; Tumor size ; Tumor grade ; Lymph node status ; comparative oncology ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Histomorphometric Effects of 2% Risedronate Gel on Calvarial Bone Defects in Rabbits

Shabnam Aghayan / Ahmad Asghari / Pejman Mortazavi / Shirin Marzoughi

Journal of Dentistry, Vol 22, Iss 1, Pp 14-

2021 Volume 20

Abstract: Statement of the Problem: Alveolar bone resorption associated with periodontal disease is a common finding and generally irreversible. It impairs mastication and causes esthetic problems for patients. Bisphosphonates are the most commonly used ... ...

Abstract	Statement of the Problem: Alveolar bone resorption associated with periodontal disease is a common finding and generally irreversible. It impairs mastication and causes esthetic problems for patients. Bisphosphonates are the most commonly used antiresorptive agents for bone diseases. Purpose: Considering the risk of bisphosphonate-related osteonecrosis of the jaw, this study aimed to assess the effect of 2% risedronate gel on calvarial bone defects in rabbits. Materials and Method: In this animal study, critical-size defects of 8mm were created in the calvaria of 20 New Zealand white rabbits. In group 1 (n=10), 2% risedronate gel was applied into the right side defect while the left side defect remained empty and served as control. In group 2 (n=10), placebo gel was applied into the right side defect, while the left side defect remained empty and served as control. Five rabbits in each group were sacrificed at 1month and the remaining five at 2 month, post-operatively, and tissue samples were collected for histomorphometric analysis. Histomorphometric assessments included bone fill, degree of inflammation, number of osteoblasts, number of osteoclasts, and foreign body reaction at the site. Data were statistically analysed using SPSS version 25 via the Dunn test and Kruskal-Wallis test. Results: No bone remodeling was noted in any group at 1 month. The risedronate group showed significantly higher bone fill than the other groups after 2 months (p= 0.016). At 2 months, the number of osteoblasts was significantly higher in the risedronate group (p< 0.05). The groups were not significantly different in terms of inflammation score at 1 (p= 0.31) or 2 (p=0.69) months. Foreign body reaction was not observed in any group at any time point. No osteoclast was detected in any group at any time point. Conclusion: Risedronate gel showed superior efficacy with regard to regeneration of rabbit calvarial bone defects compared to the placebo and control groups.
Keywords	bone loss ; osteoclast ; rabbit ; risedronate ; Medicine ; R ; Dentistry ; RK1-715
Subject code	616
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Shiraz University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Evaluation of Serum Alkaline Phosphatase Changes and TGF- β Expression in the Liver of Cholestatic Rats Treated with Ethanolic Extract of Plantago Ovata

Maede Rafiee / Pejman Mortazavi / Ahmad Asghari

Iranian Journal of Veterinary Medicine, Vol 15, Iss 3, Pp 358-

2021 Volume 368

Abstract: BACKGROUND: Induction of cholestasis is one of the methods of liver fibrosis which causes the development of oxidative stress, increased expression of fibrogenic markers, excessive deposition of extracellular matrix, and finally the incidence of fibrosis. ...

Abstract	BACKGROUND: Induction of cholestasis is one of the methods of liver fibrosis which causes the development of oxidative stress, increased expression of fibrogenic markers, excessive deposition of extracellular matrix, and finally the incidence of fibrosis. Plantago ovata is known as a rich source of various secondary metabolites such as phenolic compounds, flavonoids, alkaloids, trypanoids, and ascorbic acid. OBJECTIVES: the present study, the expression of TGF- β as a fibrotic marker and serum alkaline phosphatase (ALP) changes in cholestatic rats treated with P. ovata extract were evaluated. METHODS: In this study, 48 adult Wistar rats were used. The rats were randomly divided into eight groups of six animals each as follows: (1) healthy control group without bile duct ligation (BDL) surgery and treatment; (2–4) three healthy experimental plus P. ovata groups: rats without BDL, treated with P. ovata at dose levels of 100, 200, and 400 mg/kg body weight, respectively; (5) the BDL group: rats with BDL and treated with distilled water; and (6–8) the BDL plus P. ovata groups: rats with BDL and treated with P. ovata at dose levels of 100, 200, and 400 mg/kg body weight, respectively. The rats were treated with P. ovata extract for 45 consecutive days (once per day). After euthanasia and serum isolation, ALP enzyme level was measured. Moreover, the rat liver was fixed in 10% formalin buffer solution. The immunohistochemical study was performed by TGF-β antibody. Data analysis was performed using the One-way ANOVA and Kruskal-Wallis test and the Prism statistical program (p <0.0001). RESULTS: The results showed a significant increase in the serum levels of ALP enzyme and TGF-β expression in BDL group. Treatment with P. ovata extract was able to significantly improve these changes in a dose-dependent manner. CONCLUSIONS: The results of this study showed that P. ovata extract probably due to its phenolic compounds and its antioxidant effect has a protective effect on the liver and subsequently improves the increased ...
Keywords	tgf- β ; cholestatic rats ; plantago ovata ; Veterinary medicine ; SF600-1100
Subject code	630
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	University of Tehran
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Effect of Saponin on Cerebral Edema Rate in An Animal Model of Stroke

Elmira Shiri / Mohammad Reza Bigdeli / Akram Eidi / Seyed Pejman Mortazavi

Journal of Mazandaran University of Medical Sciences, Vol 32, Iss 214, Pp 43-

2022 Volume 54

Abstract: Background and purpose: Oxidative stress and neuroinflammation are the main causes of cerebral ischemia. Saponin with steroid or triterpenoid compounds with a sugar part has strong antioxidant and anti-inflammatory properties. The aim of this study was ... ...

Abstract	Background and purpose: Oxidative stress and neuroinflammation are the main causes of cerebral ischemia. Saponin with steroid or triterpenoid compounds with a sugar part has strong antioxidant and anti-inflammatory properties. The aim of this study was to evaluate the effect of saponin on cerebral edema, Bax gene expression level, and ischemic neurological defects. Materials and methods: In this experimental study, 24 male Wistar rats were divided into three groups: sham, stroke, and stroke+saponin. Rats in the stroke+saponin group received intravenous injection of saponin (3mg/kg) 30 minutes before cerebral ischemia. Each group was divided into two subgroups: brain edema (n=5) and gene expression level investigation (n=3). Cerebral ischemia was induced by middle cerebral artery occlusion model. After 24 hrs, we investigated neurological deficits resulting from ischemia (Kruskal-Wallis test), the degree of brain edema, and Bax gene expression levels in the cortex, piriform cortex-amygdala, striatum, and hippocampus (one-way ANOVA). Results: Findings indicated a significant decrease in the score of neurological defects resulting from ischemia, the amount of cerebral edema, and the level of Bax gene expression in stroke+saponin group (P<0.05). Conclusion: This study showed that saponin pretreatment in rats with ischemia-reperfusion injury can be effective in reducing the damage caused by cerebral ischemia.
Keywords	stroke ; cerebral edema ; saponin ; bax ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Mazandaran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED