LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 141

Search options

  1. Book: Gynecologic cancers

    Pejovic, Tanja / Odunsi, Kunle

    a multidisciplinary approach to diagnosis and management

    (Current multidisciplinary oncology)

    2014  

    Author's details ed. by Kunle Odunsi ; Tanja Pejovic
    Series title Current multidisciplinary oncology
    Keywords Genital Neoplasms, Female / diagnosis ; Genital Neoplasms, Female / therapy
    Language English
    Size XIX, 299 S. : Ill., graph. Darst.
    Publisher Demos Medical
    Publishing place New York
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT017702675
    ISBN 978-1-936287-89-5 ; 1-936287-89-7
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

  2. Book ; Thesis: Cytogenetic analysis of ovarian tumors

    Pejovic, Tanja

    1991  

    Author's details av Tanja Pejovic
    Language English
    Size 141 S. : Ill., graph. Darst.
    Publishing country Sweden
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Lund, Univ., Diss., 1991
    HBZ-ID HT005001637
    Database Catalogue ZB MED Medicine, Health

    Kategorien

  3. Article ; Online: Ovarian cancer recurrence: "is the definition of platinum resistance modified by PARP inhibitors and other intervening treatments?"

    Pejovic, Tanja / Fitch, Katherine / Mills, Gordon

    Cancer drug resistance (Alhambra, Calif.)

    2022  Volume 5, Issue 2, Page(s) 451–458

    Abstract: PolyADP ribose polymerase inhibitors (PARPi) have transformed the treatment of ovarian cancer. Particularly in high-grade serous ovarian cancer (HGSOC), a disease characterized by homologous recombination deficiency (HRD), PARPi have had a rapid and ... ...

    Abstract PolyADP ribose polymerase inhibitors (PARPi) have transformed the treatment of ovarian cancer. Particularly in high-grade serous ovarian cancer (HGSOC), a disease characterized by homologous recombination deficiency (HRD), PARPi have had a rapid and profound impact on the disease course, as well as biologic and biomarker definitions of HGSOC, thereby creating a paradigm shift in the approach to treatment. In this review, we discuss the role of PARPi in the maintenance treatment of HGSOC, its effect on platinum sensitivity, and cross-resistance between platinum and PARP inhibitors.
    Language English
    Publishing date 2022-06-01
    Publishing country United States
    Document type Journal Article
    ISSN 2578-532X
    ISSN (online) 2578-532X
    DOI 10.20517/cdr.2021.138
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Immune Checkpoint and Poly(ADP-Ribose) Polymerase Inhibition for Recurrent Platinum-Resistant Ovarian and Metastatic Triple-Negative Breast Cancers.

    Odunsi, Kunle / Pejovic, Tanja

    JAMA oncology

    2019  Volume 5, Issue 8, Page(s) 1103–1105

    Language English
    Publishing date 2019-06-13
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2019.1009
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Book: Gynecologic cancers

    Odunsi, Kunle / Pejovic, Tanja

    a multidisciplinary approach to diagnosis and management

    (Current multidisciplinary oncology)

    2014  

    Author's details edited by Kunle Odunsi, Tanja Pejovic
    Series title Current multidisciplinary oncology
    MeSH term(s) Genital Neoplasms, Female/diagnosis ; Genital Neoplasms, Female/therapy
    Language English
    Size xiv, 299 pages :, illustrations
    Document type Book
    ISBN 9781936287895 ; 1936287897
    Database Catalogue of the US National Library of Medicine (NLM)

    More links

    Kategorien

  6. Article ; Online: Adnexal masses during pregnancy: diagnosis, treatment, and prognosis.

    Cathcart, Ann M / Nezhat, Farr R / Emerson, Jenna / Pejovic, Tanja / Nezhat, Ceana H / Nezhat, Camran R

    American journal of obstetrics and gynecology

    2022  Volume 228, Issue 6, Page(s) 601–612

    Abstract: Adnexal masses are identified in pregnant patients at a rate of 2 to 20 in 1000, approximately 2 to 20 times more frequently than in the age-matched general population. The most common types of adnexal masses in pregnancy requiring surgical management ... ...

    Abstract Adnexal masses are identified in pregnant patients at a rate of 2 to 20 in 1000, approximately 2 to 20 times more frequently than in the age-matched general population. The most common types of adnexal masses in pregnancy requiring surgical management are dermoid cysts (32%), endometriomas (15%), functional cysts (12%), serous cystadenomas (11%), and mucinous cystadenomas (8%). Approximately 2% of adnexal masses in pregnancy are malignant. Although most adnexal masses in pregnancy can be safely observed and approximately 70% spontaneously resolve, a minority of cases warrant surgical intervention because of symptoms, risk of torsion, or suspicion of malignancy. Ultrasound is the mainstay of evaluation of adnexal masses in pregnancy because of accuracy, safety, and availability. Several ultrasound mass scoring systems, including the Sassone, Lerner, International Ovarian Tumor Analysis Simple Rules, and International Ovarian Tumor Analysis Assessment of Different NEoplasias in the adneXa scoring systems have been validated specifically in pregnant populations. Decisions regarding expectant vs surgical management of adnexal masses in pregnancy must balance the risks of torsion or malignancy with the likelihood of spontaneous resolution and the risks of surgery. Laparoscopic surgery is preferred over open surgery when possible because of consistently demonstrated shorter hospital length of stay and less postoperative pain and some data demonstrating shorter operative time, lower blood loss, and lower risks of fetal loss, preterm birth, and low birthweight. The best practices for laparoscopic surgery during pregnancy include left lateral decubitus positioning after the first trimester of pregnancy, port placement with respect to uterine size and pathology location, insufflation pressure of less than 12 to 15 mm Hg, intraoperative maternal capnography, pre- and postoperative fetal heart rate and contraction monitoring, and appropriate mechanical and chemical thromboprophylaxes. Although planning surgery for the second trimester of pregnancy generally affords time for mass resolution while optimizing visualization with regards to uterine size and pathology location, necessary surgery should not be delayed because of gestational age. When performed at a facility with appropriate obstetrical, anesthetic, and neonatal support, adnexal surgery in pregnancy generally results in excellent outcomes for pregnant patients and fetuses.
    MeSH term(s) Pregnancy ; Female ; Humans ; Infant, Newborn ; Premature Birth ; Adnexal Diseases/diagnostic imaging ; Adnexal Diseases/surgery ; Ovarian Neoplasms/diagnostic imaging ; Ovarian Neoplasms/surgery ; Prognosis ; Pregnancy Trimester, Second ; Laparoscopy/methods ; Retrospective Studies
    Language English
    Publishing date 2022-11-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2022.11.1291
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Development and Perspectives: Multifunctional Nucleic Acid Nanomedicines for Treatment of Gynecological Cancers.

    Korzun, Tetiana / Moses, Abraham S / Diba, Parham / Sattler, Ariana L / Olson, Brennan / Taratula, Olena R / Pejovic, Tanja / Marks, Daniel L / Taratula, Oleh

    Small (Weinheim an der Bergstrasse, Germany)

    2023  , Page(s) e2301776

    Abstract: Gynecological malignancies are a significant cause of morbidity and mortality across the globe. Due to delayed presentation, gynecological cancer patients are often referred late in the disease's course, resulting in poor outcomes. A considerable number ... ...

    Abstract Gynecological malignancies are a significant cause of morbidity and mortality across the globe. Due to delayed presentation, gynecological cancer patients are often referred late in the disease's course, resulting in poor outcomes. A considerable number of patients ultimately succumb to chemotherapy-resistant disease, which reoccurs at advanced stages despite treatment interventions. Although efforts have been devoted to developing therapies that demonstrate reduced resistance to chemotherapy and enhanced toxicity profiles, current clinical outcomes remain unsatisfactory due to treatment resistance and unfavorable off-target effects. Consequently, innovative biological and nanotherapeutic approaches are imperative to strengthen and optimize the therapeutic arsenal for gynecological cancers. Advancements in nanotechnology-based therapies for gynecological malignancies offer significant advantages, including reduced toxicity, expanded drug circulation, and optimized therapeutic dosing, ultimately leading to enhanced treatment effectiveness. Recent advances in nucleic acid therapeutics using microRNA, small interfering RNA, and messenger RNA provide novel approaches for cancer therapeutics. Effective single-agent and combinatorial nucleic acid therapeutics for gynecological malignancies have the potential to transform cancer treatment by giving safer, more tailored approaches than conventional therapies. This review highlights current preclinical studies that effectively exploit these approaches for the treatment of gynecological malignant tumors and malignant ascites.
    Language English
    Publishing date 2023-07-30
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202301776
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Trends in permanent contraceptive procedural volume in the United States between 2019 and 2020.

    Cathcart, Ann M / Nezhat, Farr R / Fitch, Katherine C / Nguyen, Christine G T / Pejovic, Tanja / Harrison, Ross / Luccarelli, James

    American journal of obstetrics and gynecology

    2023  Volume 229, Issue 4, Page(s) 468–470.e5

    Language English
    Publishing date 2023-07-15
    Publishing country United States
    Document type Letter
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2023.07.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article: Endometriosis and Endometriosis-Associated Ovarian Cancer (EAOC).

    Pejovic, Tanja / Thisted, Sarah / White, Michael / Nezhat, Farr R

    Advances in experimental medicine and biology

    2020  Volume 1242, Page(s) 73–87

    Abstract: Endometriosis is a gynecologic disease that affects over 10% of women of reproductive age causing pelvic pain, dysmenorrhea, and infertility, resulting in significant disability and reduced quality of life. Very recent genetic studies have suggested that ...

    Abstract Endometriosis is a gynecologic disease that affects over 10% of women of reproductive age causing pelvic pain, dysmenorrhea, and infertility, resulting in significant disability and reduced quality of life. Very recent genetic studies have suggested that endometriosis is a clonal disease in the epithelium and its development is independent of stroma, providing new insight into the genesis of endometriosis. The endometrioid tissue lining may also react by epithelial atypical hyperplasia and even neoplasia, in a manner somehow similar to that in the uterine cavity and under the same hormonal influences.
    MeSH term(s) Endometriosis ; Female ; Humans ; Ovarian Neoplasms ; Precancerous Conditions ; Quality of Life
    Language English
    Publishing date 2020-05-13
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-38474-6_5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Drugging homologous recombination: back to the future.

    Sanford-Crane, Hannah / Pejovic, Tanja / Xiao, Xiangshu

    Future medicinal chemistry

    2018  Volume 10, Issue 11, Page(s) 1279–1281

    MeSH term(s) Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; DNA Repair/drug effects ; Drug Resistance/drug effects ; Gene Expression Regulation/drug effects ; Homologous Recombination ; Humans ; Protein Kinase Inhibitors/pharmacology ; Signal Transduction ; Ubiquitination/drug effects
    Chemical Substances Antineoplastic Agents ; Protein Kinase Inhibitors
    Language English
    Publishing date 2018-05-02
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1756-8927
    ISSN (online) 1756-8927
    DOI 10.4155/fmc-2018-0096
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top