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  1. Article ; Online: The Dismal History of Cancer Treatment and Ongoing Racial Disparities.

    Peker Barclift, Deniz

    Laboratory medicine

    2023  Volume 54, Issue 3, Page(s) 248–249

    MeSH term(s) Humans ; Black or African American ; Neoplasms/epidemiology ; Neoplasms/ethnology ; Neoplasms/therapy ; United States/epidemiology ; White ; Healthcare Disparities/ethnology ; Healthcare Disparities/history ; Healthcare Disparities/statistics & numerical data
    Language English
    Publishing date 2023-04-20
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 391758-7
    ISSN 1943-7730 ; 0007-5027
    ISSN (online) 1943-7730
    ISSN 0007-5027
    DOI 10.1093/labmed/lmad031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Molecular Genetic Profile of Myelofibrosis: Implications in the Diagnosis, Prognosis, and Treatment Advancements.

    Verma, Tanvi / Papadantonakis, Nikolaos / Peker Barclift, Deniz / Zhang, Linsheng

    Cancers

    2024  Volume 16, Issue 3

    Abstract: Myelofibrosis (MF) is an essential element of primary myelofibrosis, whereas secondary MF may develop in the advanced stages of other myeloid neoplasms, especially polycythemia vera and essential thrombocythemia. Over the last two decades, advances in ... ...

    Abstract Myelofibrosis (MF) is an essential element of primary myelofibrosis, whereas secondary MF may develop in the advanced stages of other myeloid neoplasms, especially polycythemia vera and essential thrombocythemia. Over the last two decades, advances in molecular diagnostic techniques, particularly the integration of next-generation sequencing in clinical laboratories, have revolutionized the diagnosis, classification, and clinical decision making of myelofibrosis. Driver mutations involving
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16030514
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Measurable (Minimal) Residual Disease in Myelodysplastic Neoplasms (MDS): Current State and Perspectives.

    Zhang, Linsheng / Deeb, George / Deeb, Kristin K / Vale, Colin / Peker Barclift, Deniz / Papadantonakis, Nikolaos

    Cancers

    2024  Volume 16, Issue 8

    Abstract: Myelodysplastic Neoplasms (MDS) have been traditionally studied through the assessment of blood counts, cytogenetics, and morphology. In recent years, the introduction of molecular assays has improved our ability to diagnose MDS. The role of Measurable ( ... ...

    Abstract Myelodysplastic Neoplasms (MDS) have been traditionally studied through the assessment of blood counts, cytogenetics, and morphology. In recent years, the introduction of molecular assays has improved our ability to diagnose MDS. The role of Measurable (minimal) Residual Disease (MRD) in MDS is evolving, and molecular and flow cytometry techniques have been used in several studies. In this review, we will highlight the evolving concept of MRD in MDS, outline the various techniques utilized, and provide an overview of the studies reporting MRD and the correlation with outcomes.
    Language English
    Publishing date 2024-04-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16081503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Hantavirus Disease and COVID-19.

    Joyce, Allison K / Oliver, Tarrah T / Kofman, Aaron D / Talker, Donna L / Safaeian, Shahrokh / Peker Barclift, Deniz / Perricone, Adam J / D'Andrea, Shawn M / Whitesell, Amy N / Yazzie, Del / Guarner, Jeannette / Saleki, Mozafar / Ingall, Glynnis B / Choi, Mary J / Antone-Nez, Ramona

    American journal of clinical pathology

    2022  Volume 157, Issue 3, Page(s) 470–475

    Abstract: Objectives: Navajo Nation is disproportionately affected by hantavirus cardiopulmonary syndrome (HCPS), a severe respiratory disease that can quickly progress to respiratory failure and cardiogenic shock. The initial signs and symptoms of HCPS are ... ...

    Abstract Objectives: Navajo Nation is disproportionately affected by hantavirus cardiopulmonary syndrome (HCPS), a severe respiratory disease that can quickly progress to respiratory failure and cardiogenic shock. The initial signs and symptoms of HCPS are indistinguishable from coronavirus disease 2019 (COVID-19). However, this distinction is critical, as the disease course differs greatly, with most patients with COVID-19 experiencing mild to moderate illness. We set out to determine if the evaluation of peripheral blood smears for five hematopathologic criteria previously identified as hallmarks of hantavirus infection, or "the hantavirus 5-point screen," could distinguish between COVID-19 and HCPS.
    Methods: The hantavirus 5-point screen was performed on peripheral blood smears from 139 patients positive for COVID-19 seeking treatment from Tséhootsooí Medical Center and two Emory University hospitals.
    Results: Of these 139 individuals, 136 (98%) received a score of 3/5 or below, indicating low suspicion for HCPS. While thrombocytopenia, one of the key signs of HCPS, was seen in the patients with COVID-19, it was generally mild and remained stable on repeat specimens collected 12 to 24 hours later.
    Conclusions: Given these findings, the 5-point screen remains a useful rapid screening tool for potential HCPS cases and may be useful to distinguish early HCPS from COVID-19 in HCPS endemic regions.
    MeSH term(s) COVID-19 ; Hantavirus ; Hantavirus Infections/diagnosis ; Hantavirus Pulmonary Syndrome/diagnosis ; Hantavirus Pulmonary Syndrome/epidemiology ; Hantavirus Pulmonary Syndrome/pathology ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2022-03-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1093/ajcp/aqab155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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