LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 2 of total 2

Search options

  1. Article ; Online: Modulation of the Aryl Hydrocarbon Receptor Signaling Pathway Impacts on Junín Virus Replication.

    Pelaez, Miguel Angel / Torti, María Florencia / Alvarez De Lauro, Aaron Ezequiel / Marquez, Agostina Belén / Giovannoni, Federico / Damonte, Elsa Beatriz / García, Cybele Carina

    Viruses

    2023  Volume 15, Issue 2

    Abstract: Junín virus (JUNV), a member of the ... ...

    Abstract Junín virus (JUNV), a member of the family
    MeSH term(s) Animals ; Humans ; Arenaviridae ; Argentina ; Junin virus ; Mammals ; Receptors, Aryl Hydrocarbon/genetics ; Signal Transduction ; Virus Replication
    Chemical Substances Receptors, Aryl Hydrocarbon
    Language English
    Publishing date 2023-01-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15020369
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Effects of the Natural Flavonoid Quercetin on Arenavirus Junín Infection.

    Alvarez De Lauro, Aaron Ezequiel / Pelaez, Miguel Angel / Marquez, Agostina Belén / Wagner, Mariel Selene / Scolaro, Luis Alberto / García, Cybele Carina / Damonte, Elsa Beatriz / Sepúlveda, Claudia Soledad

    Viruses

    2023  Volume 15, Issue 8

    Abstract: There is no specific chemotherapy approved for the treatment of pathogenic arenaviruses that cause severe hemorrhagic fever (HF) in the population of endemic regions in America and Africa. The present study reports the effects of the natural flavonoid ... ...

    Abstract There is no specific chemotherapy approved for the treatment of pathogenic arenaviruses that cause severe hemorrhagic fever (HF) in the population of endemic regions in America and Africa. The present study reports the effects of the natural flavonoid quercetin (QUER) on the infection of A549 and Vero cells with Junín virus (JUNV), agent of the Argentine HF. By infectivity assays, a very effective dose-dependent reduction of JUNV multiplication was shown by cell pretreatment at 2-6 h prior to the infection at non-cytotoxic concentrations, with 50% effective concentration values in the range of 6.1-7.5 µg/mL. QUER was also active by post-infection treatment but with minor efficacy. Mechanistic studies indicated that QUER mainly affected the early steps of virus adsorption and internalization in the multiplication cycle of JUNV. Treatment with QUER blocked the phosphorylation of Akt without changes in the total protein expression, detected by Western blot, and the consequent perturbation of the PI3K/Akt pathway was also associated with the fluorescence redistribution from membrane to cytoplasm of TfR1, the cell receptor recognized by JUNV. Then, it appears that the cellular antiviral state, induced by QUER treatment, leads to the prevention of JUNV entry into the cell.
    MeSH term(s) Chlorocebus aethiops ; Animals ; Quercetin/pharmacology ; Flavonoids ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt ; Vero Cells ; Arenaviridae Infections ; Arenavirus
    Chemical Substances Quercetin (9IKM0I5T1E) ; Flavonoids ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2023-08-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15081741
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top