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  1. Article ; Online: Dual checkpoint T(h1)eamwork makes the anti-cancer dream work.

    Dietl, Alisa / Ralser, Anna / Pelka, Karin

    Immunity

    2024  Volume 57, Issue 3, Page(s) 406–408

    Abstract: Combined anti-PD-L1+anti-CTLA-4 therapy has shown benefits over anti-PD-L1 monotherapy as a neoadjuvant treatment in head and neck cancer. In this issue of Immunity, Franken et al. report that ... ...

    Abstract Combined anti-PD-L1+anti-CTLA-4 therapy has shown benefits over anti-PD-L1 monotherapy as a neoadjuvant treatment in head and neck cancer. In this issue of Immunity, Franken et al. report that CD4
    MeSH term(s) Humans ; CTLA-4 Antigen ; Head and Neck Neoplasms ; Combined Modality Therapy ; B7-H1 Antigen
    Chemical Substances CTLA-4 Antigen ; B7-H1 Antigen
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2024.02.015
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4227: Show issues Location:
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    Zs.MG 69: Show issues

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  2. Article ; Online: Listening in on Multicellular Communication in Human Tissue Immunology.

    Albers, Julian J / Pelka, Karin

    Frontiers in immunology

    2022  Volume 13, Page(s) 884185

    Abstract: Immune responses in human tissues rely on the concerted action of different cell types. Inter-cellular communication shapes both the function of the multicellular interaction networks and the fate of the individual cells that comprise them. With the ... ...

    Abstract Immune responses in human tissues rely on the concerted action of different cell types. Inter-cellular communication shapes both the function of the multicellular interaction networks and the fate of the individual cells that comprise them. With the advent of new methods to profile and experimentally perturb primary human tissues, we are now in a position to systematically identify and mechanistically dissect these cell-cell interactions and their modulators. Here, we introduce the concept of multicellular hubs, functional modules of immune responses in tissues. We outline a roadmap to discover multicellular hubs in human tissues and discuss how emerging technologies may further accelerate progress in this field.
    MeSH term(s) Cell Communication ; Communication ; Humans
    Language English
    Publishing date 2022-05-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.884185
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  3. Article ; Online: Emerging Concepts in Innate Immunity.

    Pelka, Karin / De Nardo, Dominic

    Methods in molecular biology (Clifton, N.J.)

    2017  Volume 1714, Page(s) 1–18

    Abstract: This review introduces recent concepts in innate immunity highlighting some of the latest exciting findings. These include: the discovery of the initiator of pyroptosis, Gasdermin D, and mechanisms of inflammatory caspases in innate immune signaling; the ...

    Abstract This review introduces recent concepts in innate immunity highlighting some of the latest exciting findings. These include: the discovery of the initiator of pyroptosis, Gasdermin D, and mechanisms of inflammatory caspases in innate immune signaling; the formation of oligomeric signalosomes downstream of innate immune receptors; mechanisms that shape innate immune responses, such as cellular homeostasis, cell metabolism, and pathogen viability; rapid methods of cell-to-cell communication; the interplay between the host and its microbiome and the concept of innate immunological memory. Furthermore, we discuss open questions and illustrate how technological advances, such as CRISPR/Cas9, may provide important answers for outstanding questions in the field of innate immunity.
    MeSH term(s) Animals ; CRISPR-Cas Systems ; Cell Communication ; Humans ; Immunity, Innate ; Inflammation/metabolism ; Neoplasm Proteins/immunology
    Chemical Substances GSDMD protein, human ; Neoplasm Proteins
    Language English
    Publishing date 2017-11-27
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-7519-8_1
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  4. Article ; Online: Heavy Metal Enlightens Tumor Immunity.

    Chen, Jonathan H / Pelka, Karin / Hacohen, Nir

    Cell

    2017  Volume 169, Issue 4, Page(s) 567–569

    Abstract: A deep understanding of the immune landscape in human cancer is essential for guiding the development of immunotherapy to benefit more patients with long-lasting efficacy. Now, two studies from Lavin et al. and Chevrier et al. employ mass cytometry to ... ...

    Abstract A deep understanding of the immune landscape in human cancer is essential for guiding the development of immunotherapy to benefit more patients with long-lasting efficacy. Now, two studies from Lavin et al. and Chevrier et al. employ mass cytometry to study immune infiltrates in lung adenocarcinoma and clear cell renal cell carcinoma, respectively.
    MeSH term(s) Carcinoma, Renal Cell/immunology ; Humans ; Immunotherapy ; Metals, Heavy
    Chemical Substances Metals, Heavy
    Language English
    Publishing date 2017-05-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2017.04.017
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    Zs.A 1167: Show issues Location:
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  5. Article ; Online: Mitochondrial single-cell ATAC-seq for high-throughput multi-omic detection of mitochondrial genotypes and chromatin accessibility.

    Lareau, Caleb A / Liu, Vincent / Muus, Christoph / Praktiknjo, Samantha D / Nitsch, Lena / Kautz, Pauline / Sandor, Katalin / Yin, Yajie / Gutierrez, Jacob C / Pelka, Karin / Satpathy, Ansuman T / Regev, Aviv / Sankaran, Vijay G / Ludwig, Leif S

    Nature protocols

    2023  Volume 18, Issue 5, Page(s) 1416–1440

    Abstract: Natural sequence variation within mitochondrial DNA (mtDNA) contributes to human phenotypes and may serve as natural genetic markers in human cells for clonal and lineage tracing. We recently developed a single-cell multi-omic approach, called ' ... ...

    Abstract Natural sequence variation within mitochondrial DNA (mtDNA) contributes to human phenotypes and may serve as natural genetic markers in human cells for clonal and lineage tracing. We recently developed a single-cell multi-omic approach, called 'mitochondrial single-cell assay for transposase-accessible chromatin with sequencing' (mtscATAC-seq), enabling concomitant high-throughput mtDNA genotyping and accessible chromatin profiling. Specifically, our technique allows the mitochondrial genome-wide inference of mtDNA variant heteroplasmy along with information on cell state and accessible chromatin variation in individual cells. Leveraging somatic mtDNA mutations, our method further enables inference of clonal relationships among native ex vivo-derived human cells not amenable to genetic engineering-based clonal tracing approaches. Here, we provide a step-by-step protocol for the use of mtscATAC-seq, including various cell-processing and flow cytometry workflows, by using primary hematopoietic cells, subsequent single-cell genomic library preparation and sequencing that collectively take ~3-4 days to complete. We discuss experimental and computational data quality control metrics and considerations for the extension to other mammalian tissues. Overall, mtscATAC-seq provides a broadly applicable platform to map clonal relationships between cells in human tissues, investigate fundamental aspects of mitochondrial genetics and enable additional modes of multi-omic discovery.
    MeSH term(s) Animals ; Humans ; Chromatin/genetics ; Chromatin Immunoprecipitation Sequencing ; Multiomics ; Sequence Analysis, DNA/methods ; High-Throughput Nucleotide Sequencing/methods ; DNA, Mitochondrial/genetics ; Genotype ; Mammals/genetics
    Chemical Substances Chromatin ; DNA, Mitochondrial
    Language English
    Publishing date 2023-02-15
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2244966-8
    ISSN 1750-2799 ; 1754-2189
    ISSN (online) 1750-2799
    ISSN 1754-2189
    DOI 10.1038/s41596-022-00795-3
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  6. Article: Heavy Metal Enlightens Tumor Immunity

    Chen, Jonathan H / Pelka, Karin / Hacohen, Nir

    Cell. 2017 May 04, v. 169

    2017  

    Abstract: A deep understanding of the immune landscape in human cancer is essential for guiding the development of immunotherapy to benefit more patients with long-lasting efficacy. Now, two studies from Lavin et al. and Chevrier et al. employ mass cytometry to ... ...

    Abstract A deep understanding of the immune landscape in human cancer is essential for guiding the development of immunotherapy to benefit more patients with long-lasting efficacy. Now, two studies from Lavin et al. and Chevrier et al. employ mass cytometry to study immune infiltrates in lung adenocarcinoma and clear cell renal cell carcinoma, respectively.
    Keywords heavy metals ; humans ; immunity ; immunotherapy ; patients ; renal cell carcinoma
    Language English
    Dates of publication 2017-0504
    Size p. 567-569.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2017.04.017
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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    Z 93: Show issues

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  7. Article ; Online: IRF5, IRF8, and IRF7 in human pDCs - the good, the bad, and the insignificant?

    Pelka, Karin / Latz, Eicke

    European journal of immunology

    2013  Volume 43, Issue 7, Page(s) 1693–1697

    Abstract: Interferon (IFN) regulatory factors (IRFs) are transcription factors with versatile functions in the regulation of innate and adaptive immune responses. In the current issue of the European Journal of Immunology, Steinhagen et al. [Eur. J. Immunol. 2013. ...

    Abstract Interferon (IFN) regulatory factors (IRFs) are transcription factors with versatile functions in the regulation of innate and adaptive immune responses. In the current issue of the European Journal of Immunology, Steinhagen et al. [Eur. J. Immunol. 2013. 43: 1896-1906] investigate the regulation of IFN-β and IL-6 induction in human plasmacytoid DCs stimulated with CpG DNA. Using RNA interference studies, the authors identify critical roles for IRF5 and IRF8 as positive and negative regulators, respectively. In contrast, knockdown of IRF7 had no significant effect on IFN-β or IL-6 gene induction. In this Commentary, these findings are discussed in the context of the published literature and recent data regarding IRF5 and IRF8 as susceptibility genes for autoimmunity.
    MeSH term(s) Dendritic Cells/immunology ; Humans ; Interferon Regulatory Factors/immunology ; Interferon-beta/biosynthesis ; Interleukin-6/biosynthesis ; NF-kappa B p50 Subunit/immunology
    Chemical Substances IRF5 protein, human ; Interferon Regulatory Factors ; Interleukin-6 ; NF-kappa B p50 Subunit ; Interferon-beta (77238-31-4)
    Language English
    Publishing date 2013-07
    Publishing country Germany
    Document type Comment ; Journal Article
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.201343739
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 489: Show issues Location:
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    Zs.MG 85: Show issues

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  8. Article ; Online: Nucleic acid-sensing TLRs and autoimmunity: novel insights from structural and cell biology.

    Pelka, Karin / Shibata, Takuma / Miyake, Kensuke / Latz, Eicke

    Immunological reviews

    2016  Volume 269, Issue 1, Page(s) 60–75

    Abstract: Invasion of pathogenic microorganisms or tissue damage activates innate immune signaling receptors that sample subcellular locations for foreign molecular structures, altered host molecules, or signs of compartment breaches. Upon engagement of innate ... ...

    Abstract Invasion of pathogenic microorganisms or tissue damage activates innate immune signaling receptors that sample subcellular locations for foreign molecular structures, altered host molecules, or signs of compartment breaches. Upon engagement of innate immune receptors an acute but transient inflammatory response is initiated, aimed at the clearance of pathogens and cellular debris. Among the molecules that are sensed are nucleic acids, which activate several members of the transmembrane Toll-like receptor (TLR) family. Inappropriate recognition of nucleic acids by TLRs can cause inflammatory pathologies and autoimmunity. Here, we review the mechanisms involved in triggering nucleic acid-sensing TLRs and indicate checkpoints that restrict their activation to endolysosomal compartments. These mechanisms are crucial to sample the content of endosomes for nucleic acids in the context of infection or tissue damage, yet prevent accidental activation by host nucleic acids under physiological conditions. Decoding the molecular mechanisms that regulate nucleic acid recognition by TLRs is central to understand pathologies linked to unrestricted nucleic acid sensing and to develop novel therapeutic strategies.
    MeSH term(s) Animals ; Autoimmunity ; Homeostasis ; Host-Pathogen Interactions ; Humans ; Immunity, Innate ; Inflammation ; Nucleic Acids/immunology ; Signal Transduction ; Toll-Like Receptors/metabolism
    Chemical Substances Nucleic Acids ; Toll-Like Receptors
    Language English
    Publishing date 2016-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.12375
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  9. Article ; Online: Synergistic activation of Toll-like receptor 8 by two RNA degradation products.

    Geyer, Matthias / Pelka, Karin / Latz, Eicke

    Nature structural & molecular biology

    2015  Volume 22, Issue 2, Page(s) 99–101

    MeSH term(s) Animals ; Humans ; RNA/chemistry ; RNA/metabolism ; Toll-Like Receptor 8/chemistry ; Toll-Like Receptor 8/metabolism
    Chemical Substances TLR8 protein, human ; Toll-Like Receptor 8 ; RNA (63231-63-0)
    Language English
    Publishing date 2015-02
    Publishing country United States
    Document type Comment ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126708-X
    ISSN 1545-9985 ; 1545-9993
    ISSN (online) 1545-9985
    ISSN 1545-9993
    DOI 10.1038/nsmb.2967
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    Zs.A 4101: Show issues Location:
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    Zs.MG 56: Show issues

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  10. Article ; Online: Getting closer to the dirty little secret.

    Pelka, Karin / Latz, Eicke

    Immunity

    2011  Volume 34, Issue 4, Page(s) 455–458

    Abstract: The molecular mechanism behind alum adjuvanticity is probably the oldest secret of immunology. In this issue of Immunity, Kuroda et al. (2011) and Kool et al. (2011) identify NLRP3 inflammasome-independent signaling to be crucial for the Th2 cell ... ...

    Abstract The molecular mechanism behind alum adjuvanticity is probably the oldest secret of immunology. In this issue of Immunity, Kuroda et al. (2011) and Kool et al. (2011) identify NLRP3 inflammasome-independent signaling to be crucial for the Th2 cell response induced by aluminum salts.
    Language English
    Publishing date 2011-03-25
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2011.04.003
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