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Book ; Online: Performance of a fast timing micro-pattern gaseous detector for future collider experiments

Pellecchia, Antonello / Verwilligen, Piet

2021

Abstract: The fast timing MPGD is a micro-pattern gaseous detector conceived for achieving sub-nanosecond time resolution while maintaining the ability to instrument large areas in high-rate environments; applications of such technology are perspected in high- ... ...

Abstract	The fast timing MPGD is a micro-pattern gaseous detector conceived for achieving sub-nanosecond time resolution while maintaining the ability to instrument large areas in high-rate environments; applications of such technology are perspected in high-energy physics experiments at future colliders and medical diagnostics with time-of-flight methods. This work shows the systematic studies carried on an FTM prototype on the performance of GEM foils coated with resistive DLC films, whose development is essential for the FTM operation. The resistive foil performance has been tested with several gas mixtures and compared with the results obtained on conductive foils. The results show that the performance of the FTM is presently limited by the technology of manufacturing of DLC-coated GEM foils, with high gains reachable exclusively in isobuthane-based mixtures.
Keywords	Physics - Instrumentation and Detectors ; High Energy Physics - Experiment
Subject code	621
Publishing date	2021-07-20
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Recovery ability of lowshore sessile assemblages in a highly contaminated post-industrial area.

Pellecchia, Antonella / Fernández, Tomás Vega / Franzitta, Giulio / Bertocci, Iacopo

Marine environmental research

2019 Volume 153, Page(s) 104829

Abstract: The inheritance of environmental contamination left by abandoned industrial plants is widespread globally. Here we compared the patterns of recovery of lowshore algal and invertebrate assemblages between the post-industrial site of Bagnoli-Coroglio and ... ...

Abstract	The inheritance of environmental contamination left by abandoned industrial plants is widespread globally. Here we compared the patterns of recovery of lowshore algal and invertebrate assemblages between the post-industrial site of Bagnoli-Coroglio and four reference sites distributed along the coast in the Gulf of Naples, southern Tyrrhenian Sea. The structure of whole assemblages, richness of taxa and abundance of individual taxa were followed during one year since an event of experimental disturbance consisting in the removal of all erect organisms from the rocky substrate. Our main findings suggest that the examined benthic assemblages recovered effectively and quickly after a pulse disturbance and, contrarily to initial expectations, that this ability was comparable between the post-industrial site and the reference sites. This result is discussed in terms of several plausible processes and mechanisms, including the general capability of intertidal organisms to recover from physical disturbance, the potential high level of environmental stress affecting the reference sites too, the chance that the most intense impacts of contamination remained restricted to the sediments of the post-industrial site without propagating to adjacent rocky habitats, and the large natural variability of reference sites that may have masked weak effects of the historical contamination. Irrespective of the actual causes, we emphasize the need for including natural variability of the examined system in any future restoration interventions, to guarantee representation of the range of variation of target organisms and of their underlying processes, and to avoid confounding the intended post-industrial impact with the effects of other natural and anthropogenic processes.
Language	English
Publishing date	2019-10-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1502505-6
ISSN	1879-0291 ; 0141-1136
ISSN (online)	1879-0291
ISSN	0141-1136
DOI	10.1016/j.marenvres.2019.104829
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Article ; Online: Recovery ability of lowshore sessile assemblages in a highly contaminated post-industrial area

Pellecchia, Antonella / Fernández, Tomás Vega / Franzitta, Giulio / Bertocci, Iacopo

Marine environmental research. 2020 Jan., v. 153, p. 104829

2020 , Page(s) 104829

Abstract	The inheritance of environmental contamination left by abandoned industrial plants is widespread globally. Here we compared the patterns of recovery of lowshore algal and invertebrate assemblages between the post-industrial site of Bagnoli-Coroglio and four reference sites distributed along the coast in the Gulf of Naples, southern Tyrrhenian Sea. The structure of whole assemblages, richness of taxa and abundance of individual taxa were followed during one year since an event of experimental disturbance consisting in the removal of all erect organisms from the rocky substrate. Our main findings suggest that the examined benthic assemblages recovered effectively and quickly after a pulse disturbance and, contrarily to initial expectations, that this ability was comparable between the post-industrial site and the reference sites. This result is discussed in terms of several plausible processes and mechanisms, including the general capability of intertidal organisms to recover from physical disturbance, the potential high level of environmental stress affecting the reference sites too, the chance that the most intense impacts of contamination remained restricted to the sediments of the post-industrial site without propagating to adjacent rocky habitats, and the large natural variability of reference sites that may have masked weak effects of the historical contamination. Irrespective of the actual causes, we emphasize the need for including natural variability of the examined system in any future restoration interventions, to guarantee representation of the range of variation of target organisms and of their underlying processes, and to avoid confounding the intended post-industrial impact with the effects of other natural and anthropogenic processes.
Keywords	Anthropogenic disturbance ; Breakwater ; Brownfield ; Environmental impact ; Mediterranean sea ; Rocky intertidal ; Temporal variability
Language	English
Dates of publication	2020-01
Size	p. 104829
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	1502505-6
ISSN	1879-0291 ; 0141-1136
ISSN (online)	1879-0291
ISSN	0141-1136
DOI	10.1016/j.marenvres.2019.104829
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Article ; Online: Using endoscopic ultrasound-guided fine needle aspiration to diagnose mediastinal cryptococcosis.

Rahimi, E / Behin, D / Pellecchia, A

Endoscopy

2011 Volume 43 Suppl 2 UCTN, Page(s) E304–5

MeSH term(s)	Adult ; Aspergillosis/diagnosis ; Biopsy, Fine-Needle ; Cryptococcosis/diagnostic imaging ; Cryptococcosis/microbiology ; Cryptococcosis/pathology ; Cryptococcus neoformans ; Female ; Humans ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/microbiology ; Lymph Nodes/pathology ; Mediastinum ; Ultrasonography, Interventional
Language	English
Publishing date	2011
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/s-0030-1256616
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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: [No title information]

Pellecchia, Alessandra / Certain, Agnès / Mohammed, Roland / Damien, Carole / Kada, Nicolas / Tirard Fleury, Véronique / Gross, Olivia / de la Tribonnière, Xavier

Sante publique (Vandoeuvre-les-Nancy, France)

2021 Volume 31, Issue 5, Page(s) 683–692

Abstract: Purpose of research: The purpose of this research was to promote the involvement and intervention of patient-partners (PPs) in collective sessions of therapeutic patient education (TPE), including training and support for the implementation of these ... ...

Title translation	Formation et conditions facilitant l’intégration de patients dans la coanimation de séances collectives d’éducation thérapeutique.
Abstract	Purpose of research: The purpose of this research was to promote the involvement and intervention of patient-partners (PPs) in collective sessions of therapeutic patient education (TPE), including training and support for the implementation of these sessions, in co-facilitation with a health professional (HP). Therefore, the matter was to co-construct a training model, to experiment with its implementation and to define favorable conditions for this collaboration. Methods: Collaborative research oriented by the design, led by a steering committee representative of different categories of stakeholders, which has been spread over 2 years, in Paris area and Montpellier, in 4 phases: 1/ exploration (bibliographic review and investigation); 2/ recruitment of PPs affected by different pathologies; 3/ implementation and evaluation of PPs training in inter-pathology; 4/ implementation and evaluation of co-facilitated group sessions. Results: 35 patients solicited, 24 (69%) included. Of these, 22 (92%) completed the training entirely; 17 sessions were conducted in co-facilitation (15 planned) for 151 patients (150 expected). Satisfaction rates for PPs, HPs and patient beneficiaries were very high. Conclusions: This research validated a training model for patient-partners in therapeutic education and identified some conditions that could facilitate their integration into TPE programs.
Language	French
Publishing date	2021-07-11
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	1465524-x
ISSN	2104-3841 ; 0995-3914
ISSN (online)	2104-3841
ISSN	0995-3914
DOI	10.3917/spub.195.0683
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Article: Physical Functional Impairment and the Risk of Incident Mild Cognitive Impairment in an Observational Study of World Trade Center Responders.

Pellecchia, Alison / Kritikos, Minos / Guralnik, Jack / Ahuvia, Isaac / Santiago-Michels, Stephanie / Carr, Melissa / Kotov, Roman / Bromet, Evelyn J / Clouston, Sean A P / Luft, Benjamin J

Neurology. Clinical practice

2022 Volume 12, Issue 6, Page(s) e162–e171

Abstract: Background and objectives: Posttraumatic stress disorder (PTSD) has been linked to increased risk of cognitive dysfunction and physical functional impairment (PFI). The objective of this prospective cohort study was to examine whether PFI was associated ...

Abstract	Background and objectives: Posttraumatic stress disorder (PTSD) has been linked to increased risk of cognitive dysfunction and physical functional impairment (PFI). The objective of this prospective cohort study was to examine whether PFI was associated with increased risk of incident mild cognitive impairment (MCI) among World Trade Center (WTC) responders with PTSD. We hypothesized that responders with PTSD would have an elevated risk of incident MCI and that PFI would mediate this increase. Methods: We examined responder participants in the WTC Aging Study whose baseline physical assessments were completed by May 2016-April 2017 and were followed up at least once before December 2019. Those without complete demographic, medical, or behavioral data were excluded. PFI was assessed using measures of upper body strength (maximal handgrip strength [HGS]) and lower extremity physical functioning (Short Physical Performance Battery). PTSD was rated using a diagnostic interview and symptom checklist; MCI and dementia were assessed using the Montreal Cognitive Assessment and diagnosed using the National Institute on Aging-Alzheimer's Association criteria. Group differences and longitudinal comparisons were examined. Cox proportional hazards models were evaluated from time to incident MCI and conversion to dementia. A mediation analysis examined whether PFI mediated associations between PTSD and MCI. Results: Within the sample of 2,687 WTC responders, 324 (12.06%, 95% CI = [10.83-13.29]) had lower extremity PFI. Responders with lower extremity PFI were older, had lower education and higher body mass, and were at a higher risk of pulmonary embolisms and PTSD. Responders with lower extremity PFI demonstrated lower baseline cognition and had increased hazards of MCI (multivariable-adjusted hazards ratio [aHR] = 1.55 [95% CI 1.21-1.98]); those with MCI converted to dementia more rapidly than those without PFI (2.73 [1.38-5.39] Discussion: WTC responders with PFI demonstrated worse cognitive and behavioral outcomes, and PFI played an intermediary role in the relationship between PTSD and incident MCI, suggesting that PFI may be an early indicator of MCI in responders with PTSD. Regular monitoring of PFI should be considered among PTSD populations.
Language	English
Publishing date	2022-12-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2645818-4
ISSN	2163-0933 ; 2163-0402
ISSN (online)	2163-0933
ISSN	2163-0402
DOI	10.1212/CPJ.0000000000200089
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Article ; Online: ETV4 promotes late development of prostatic intraepithelial neoplasia and cell proliferation through direct and p53-mediated downregulation of p21.

Cosi, Irene / Pellecchia, Annamaria / De Lorenzo, Emanuele / Torre, Eugenio / Sica, Michela / Nesi, Gabriella / Notaro, Rosario / De Angioletti, Maria

Journal of hematology & oncology

2020 Volume 13, Issue 1, Page(s) 112

Abstract: Background: ETV4 is one of the ETS proteins overexpressed in prostate cancer (PC) as a result of recurrent chromosomal translocations. In human prostate cell lines, ETV4 promotes migration, invasion, and proliferation; however, its role in PC has been ... ...

Abstract	Background: ETV4 is one of the ETS proteins overexpressed in prostate cancer (PC) as a result of recurrent chromosomal translocations. In human prostate cell lines, ETV4 promotes migration, invasion, and proliferation; however, its role in PC has been unclear. In this study, we have explored the effects of ETV4 expression in the prostate in a novel transgenic mouse model. Methods: We have created a mouse model with prostate-specific expression of ETV4 (ETV4 mice). By histochemical and molecular analysis, we have investigated in these engineered mice the expression of p21, p27, and p53. The implications of our in vivo findings have been further investigated in human cells lines by chromatin-immunoprecipitation (ChIP) and luciferase assays. Results: ETV4 mice, from two independent transgenic lines, have increased cell proliferation in their prostate and two-thirds of them, by the age of 10 months, developed mouse prostatic intraepithelial neoplasia (mPIN). In these mice, cdkn1a and its p21 protein product were reduced compared to controls; p27 protein was also reduced. By ChIP assay in human prostate cell lines, we show that ETV4 binds to a specific site (-704/-696 bp upstream of the transcription start) in the CDKN1A promoter that was proven, by luciferase assay, to be functionally competent. ETV4 further controls CDKN1A expression by downregulating p53 protein: this reduction of p53 was confirmed in vivo in ETV4 mice. Conclusions: ETV4 overexpression results in the development of mPIN but not in progression to cancer. ETV4 increases prostate cell proliferation through multiple mechanisms, including downregulation of CDKN1A and its p21 protein product: this in turn is mediated through direct binding of ETV4 to the CDKN1A promoter and through the ETV4-mediated decrease of p53. This multi-faceted role of ETV4 in prostate cancer makes it a potential target for novel therapeutic approaches that could be explored in this ETV4 transgenic model.
MeSH term(s)	Androgen-Binding Protein/genetics ; Animals ; Cell Division ; Cell Line, Tumor ; Cell Transformation, Neoplastic/genetics ; Cyclin-Dependent Kinase Inhibitor p21/biosynthesis ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinase Inhibitor p27/biosynthesis ; Cyclin-Dependent Kinase Inhibitor p27/genetics ; Down-Regulation ; Gene Expression Regulation, Neoplastic ; HEK293 Cells ; Humans ; Male ; Matrix Metalloproteinases/biosynthesis ; Matrix Metalloproteinases/genetics ; Mice ; Mice, Transgenic ; Neoplasm Proteins/physiology ; Oncogene Proteins, Fusion/physiology ; Promoter Regions, Genetic/genetics ; Prostate/metabolism ; Prostatic Intraepithelial Neoplasia/genetics ; Prostatic Intraepithelial Neoplasia/metabolism ; Prostatic Intraepithelial Neoplasia/pathology ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Protein Binding ; Rats ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Tumor Suppressor Protein p53/physiology
Chemical Substances	Androgen-Binding Protein ; CDKN1A protein, human ; Cdkn1a protein, mouse ; Cdkn1b protein, mouse ; Cyclin-Dependent Kinase Inhibitor p21 ; Neoplasm Proteins ; Oncogene Proteins, Fusion ; Recombinant Fusion Proteins ; TMPRSS2-ETV4 fusion protein, human ; Trp53 protein, mouse ; Tumor Suppressor Protein p53 ; probasin ; Cyclin-Dependent Kinase Inhibitor p27 (147604-94-2) ; Matrix Metalloproteinases (EC 3.4.24.-)
Language	English
Publishing date	2020-08-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2429631-4
ISSN	1756-8722 ; 1756-8722
ISSN (online)	1756-8722
ISSN	1756-8722
DOI	10.1186/s13045-020-00943-w
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Article: Formation et conditions facilitant l’intégration de patients dans la coanimation de séances collectives d’éducation thérapeutique.

Pellecchia, Alessandra / Certain, Agnès / Mohammed, Roland / Damien, Carole / Kada, Nicolas / Tirard Fleury, Véronique / Gross, Olivia / de la Tribonnière, Xavier

Sante publique (Vandoeuvre-les-Nancy, France)

2020 Volume 31, Issue 5, Page(s) 683–692

Title translation	Training and conditions improving the integration of patients in the co-facilitation of collective sessions of therapeutic education.
Abstract	Purpose of research: The purpose of this research was to promote the involvement and intervention of patient-partners (PPs) in collective sessions of therapeutic patient education (TPE), including training and support for the implementation of these sessions, in co-facilitation with a health professional (HP). Therefore, the matter was to co-construct a training model, to experiment with its implementation and to define favorable conditions for this collaboration. Methods: Collaborative research oriented by the design, led by a steering committee representative of different categories of stakeholders, which has been spread over 2 years, in Paris area and Montpellier, in 4 phases: 1/ exploration (bibliographic review and investigation); 2/ recruitment of PPs affected by different pathologies; 3/ implementation and evaluation of PPs training in inter-pathology; 4/ implementation and evaluation of co-facilitated group sessions. Results: 35 patients solicited, 24 (69%) included. Of these, 22 (92%) completed the training entirely; 17 sessions were conducted in co-facilitation (15 planned) for 151 patients (150 expected). Satisfaction rates for PPs, HPs and patient beneficiaries were very high. Conclusions: This research validated a training model for patient-partners in therapeutic education and identified some conditions that could facilitate their integration into TPE programs.
MeSH term(s)	Humans ; Paris ; Patient Education as Topic/organization & administration ; Patient Participation/statistics & numerical data ; Physician-Patient Relations
Language	French
Publishing date	2020-05-06
Publishing country	France
Document type	Journal Article
ZDB-ID	1465524-x
ISSN	2104-3841 ; 0995-3914
ISSN (online)	2104-3841
ISSN	0995-3914
DOI	10.3917/spub.195.0683
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Article ; Online: Complement-mediated oxidative damage of red cells impairs response to eculizumab in a G6PD-deficient patient with PNH.

Sica, Michela / Pellecchia, Annamaria / De Angioletti, Maria / Caocci, Giovanni / Nannelli, Caterina / La Nasa, Giorgio / Luzzatto, Lucio / Notaro, Rosario

Blood

2020 Volume 136, Issue 26, Page(s) 3082–3085

MeSH term(s)	Adult ; Antibodies, Monoclonal, Humanized/administration & dosage ; Antibodies, Monoclonal, Humanized/adverse effects ; Complement System Proteins/metabolism ; Erythrocytes/metabolism ; Erythrocytes/pathology ; Female ; Glucosephosphate Dehydrogenase Deficiency/drug therapy ; Glucosephosphate Dehydrogenase Deficiency/genetics ; Glucosephosphate Dehydrogenase Deficiency/metabolism ; Hemoglobinuria, Paroxysmal/drug therapy ; Hemoglobinuria, Paroxysmal/metabolism ; Hemoglobinuria, Paroxysmal/pathology ; Humans ; Oxidative Stress/drug effects
Chemical Substances	Antibodies, Monoclonal, Humanized ; Complement System Proteins (9007-36-7) ; eculizumab (A3ULP0F556)
Language	English
Publishing date	2020-09-11
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2020007780
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Uh III Zs.140: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 364: Show issues

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Article: Assessment of Alzheimer's Disease Imaging Biomarkers in World Trade Center Responders with Cognitive Impairment at Midlife.

Kritikos, Minos / Franceschi, Ana M / Vaska, Paul / Clouston, Sean A P / Huang, Chuan / Salerno, Michael / Deri, Yael / Tang, Cheuk / Pellecchia, Alison / Santiago-Michels, Stephanie / Sano, Mary / Bromet, Evelyn J / Lucchini, Roberto G / Gandy, Sam / Luft, Benjamin J

World journal of nuclear medicine

2022 Volume 21, Issue 4, Page(s) 267–275

Abstract: ... ...

Abstract	Purpose
Language	English
Publishing date	2022-09-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2911903-0
ISSN	1607-3312 ; 1450-1147
ISSN (online)	1607-3312
ISSN	1450-1147
DOI	10.1055/s-0042-1750013
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