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  1. Article ; Online: Therapeutic targeting of eukaryotic initiation factor (eIF) 4E.

    Pelletier, Jerry / Sonenberg, Nahum

    Biochemical Society transactions

    2023  Volume 51, Issue 1, Page(s) 113–124

    Abstract: Fundamental studies unraveled the role of eukaryotic initiation factor (eIF) 4E in mRNA translation and its control. Under physiological conditions, regulation of translation by eIF4E is essential to cellular homeostasis. Under stress, gene flow ... ...

    Abstract Fundamental studies unraveled the role of eukaryotic initiation factor (eIF) 4E in mRNA translation and its control. Under physiological conditions, regulation of translation by eIF4E is essential to cellular homeostasis. Under stress, gene flow information is parsed by eIF4E to support adaptive mechanisms that favor cell survival. Dysregulated eIF4E activity fuels tumor formation and progression and modulates response to therapy. Thus, there has been heightened interest in understanding eIF4E function in controlling gene expression as well as developing strategies to block its activity to treat disease.
    MeSH term(s) Humans ; Eukaryotic Initiation Factor-4E/genetics ; Eukaryotic Initiation Factor-4E/metabolism ; Peptide Initiation Factors/genetics ; Peptide Initiation Factors/metabolism ; Neoplasms ; Phosphorylation
    Chemical Substances Eukaryotic Initiation Factor-4E ; Peptide Initiation Factors
    Language English
    Publishing date 2023-02-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 184237-7
    ISSN 1470-8752 ; 0300-5127
    ISSN (online) 1470-8752
    ISSN 0300-5127
    DOI 10.1042/BST20220285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 944: Show issues Location:
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  2. Article: Est-il toujours utile de faire une ponction lombaire lors d'une suspicion de sclérose en plaques? Non.

    Pelletier, J

    Revue neurologique

    2015  Volume 171, Issue 8-9, Page(s) 607–610

    Abstract: In the absence of a specific test for the diagnosis of multiple sclerosis (MS), cerebrospinal fluid analysis (CSF) remains discussed. There are robust evidences which demonstrated that an early diagnosis of MS must be done, due to the availability of ... ...

    Title translation Is it always useful to perform lumbar puncture for the diagnosis of multiple sclerosis? No.
    Abstract In the absence of a specific test for the diagnosis of multiple sclerosis (MS), cerebrospinal fluid analysis (CSF) remains discussed. There are robust evidences which demonstrated that an early diagnosis of MS must be done, due to the availability of disease-modifying drugs that could influence the natural history of the disease. However, several arguments can be put forward to assert that CSF analysis is not useful for the diagnosis of MS and thus should not be realized in a systematic way. First, MRI remains the most sensitive and specific marker to validate dissemination in space and in time and CSF analysis is not recommended by the 2010 McDonald criteria. The second argument is related to the low sensitivity and specificity of abnormalities detected in CSF analysis to confirm the diagnosis of MS. Moreover, there is currently no evidence that the presence of oligoclonal bands could represent a surrogate marker on an individual prognostic way. Furthermore, lumbar puncture could be traumatic, may entail some infrequent risks and represents unnecessary expense. Thus, there are strong reasons to not recommend systematic CSF examination to diagnose MS.
    MeSH term(s) Biomarkers ; Diagnosis, Differential ; Early Diagnosis ; Humans ; Magnetic Resonance Imaging ; Multiple Sclerosis/cerebrospinal fluid ; Multiple Sclerosis/diagnosis ; Multiple Sclerosis/pathology ; Nervous System Diseases/diagnosis ; Neurologic Examination ; Oligoclonal Bands/cerebrospinal fluid ; Prognosis ; Risk Assessment ; Sensitivity and Specificity ; Spinal Puncture/adverse effects ; Spinal Puncture/economics ; Spinal Puncture/utilization ; Unnecessary Procedures/adverse effects ; Unnecessary Procedures/economics ; Unnecessary Procedures/utilization
    Chemical Substances Biomarkers ; Oligoclonal Bands
    Language French
    Publishing date 2015-09
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 4593-7
    ISSN 2213-0004 ; 0035-3787
    ISSN (online) 2213-0004
    ISSN 0035-3787
    DOI 10.1016/j.neurol.2015.05.006
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    Ui II Zs.45: Show issues Location:
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  3. Article ; Online: Acute aortic occlusion: A narrative review for emergency clinicians.

    Pelletier, Jessica / Koyfman, Alex / Long, Brit

    The American journal of emergency medicine

    2024  Volume 79, Page(s) 192–197

    Abstract: Introduction: Acute aortic occlusion (AAO) is a rare but serious condition associated with significant morbidity and mortality.: Objective: This review provides an emergency medicine focused evaluation of AAO, including presentation, assessment, and ... ...

    Abstract Introduction: Acute aortic occlusion (AAO) is a rare but serious condition associated with significant morbidity and mortality.
    Objective: This review provides an emergency medicine focused evaluation of AAO, including presentation, assessment, and emergency department (ED) management based on current evidence.
    Discussion: AAO refers to obstruction of blood flow through the aorta due to either thrombosis or embolism. This condition primarily affects older adults ages 60-70 with cardiovascular comorbidities and most commonly presents with signs and symptoms of acute limb ischemia, though the gastrointestinal tract, kidneys, and spinal cord may be affected. The first line imaging modality includes computed tomography angiography of the chest, abdomen, and pelvis. ED resuscitative management consists of avoiding extremes of blood pressure or heart rate, maintaining normal oxygen saturation and euvolemic status, anticoagulation with heparin, and pain control. Emergent consultation with the vascular surgery specialist is recommended to establish a plan for restoration of perfusion to ischemic tissues via endovascular or open techniques. High rates of baseline comorbidities present in the affected population as well as ischemic and reperfusion injuries place AAO patients at high risk for complications in an immediate and delayed fashion after surgical management.
    Conclusions: An understanding of AAO can assist emergency clinicians in diagnosing and managing this rare but devastating disease.
    MeSH term(s) Humans ; Aged ; Vascular Surgical Procedures/adverse effects ; Thrombosis/etiology ; Embolism/complications ; Arterial Occlusive Diseases/diagnosis ; Arterial Occlusive Diseases/therapy ; Arterial Occlusive Diseases/etiology ; Aortic Diseases/diagnosis ; Aortic Diseases/therapy ; Aorta, Abdominal/surgery ; Ischemia/diagnosis ; Ischemia/etiology ; Ischemia/therapy
    Language English
    Publishing date 2024-02-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2024.02.033
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    Zs.A 2005: Show issues Location:
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  4. Article ; Online: Troubles cognitifs dans la sclérose en plaques : fréquents et précoces

    Pelletier, Jean

    La Revue du praticien

    2018  Volume 66, Issue 1, Page(s) 42–43

    Title translation Cognitive impairment in multiple sclerosis: Frequent and early
    MeSH term(s) Cognition Disorders/etiology ; Cognitive Dysfunction/etiology ; Humans ; Multiple Sclerosis/complications
    Language French
    Publishing date 2018-12-03
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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  5. Book ; Online: Should Crime Scene Photos Ever Be Deleted?

    Pelletier, Jonathan

    Faculty Publications and Presentations

    2020  

    Abstract: There are two general opposing positions regarding deleting photographs of a crime scene. In a recent laboratory update (internet based because of COVID-19), the Virginia Department of Forensic Science raised an issue that warrants discussion: “DFS ... ...

    Abstract There are two general opposing positions regarding deleting photographs of a crime scene. In a recent laboratory update (internet based because of COVID-19), the Virginia Department of Forensic Science raised an issue that warrants discussion: “DFS position - Best (and most transparent) practice - any image captured in the course of processing a crime [scene] should be retained, no matter the quality or the intent (or lack thereof, such as an accidental shutter depress [sic])” [1]. With conventional film, this was never an issue. There was no option to delete an image. With digital images, however, the option exists and should be considered when establishing good policy and procedure.
    Keywords Other Social and Behavioral Sciences ; Political Science ; Public Affairs ; Public Policy and Public Administration ; covid19
    Publishing date 2020-01-01T08:00:00Z
    Publisher Scholars Crossing
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: The Need for Living Guidelines in a Learning Health System.

    Horvat, Christopher M / Dave, Amanda / Tarchichi, Tony / Pelletier, Jonathan

    Hospital pediatrics

    2024  Volume 14, Issue 4, Page(s) e215–e218

    MeSH term(s) Learning Health System
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article
    ISSN 2154-1671
    ISSN (online) 2154-1671
    DOI 10.1542/hpeds.2023-007442
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  7. Article ; Online: GLP-1 agonists: A review for emergency clinicians.

    Long, Brit / Pelletier, Jessica / Koyfman, Alex / Bridwell, Rachel E

    The American journal of emergency medicine

    2024  Volume 78, Page(s) 89–94

    Abstract: Introduction: Glucagon-like peptide 1 (GLP-1) based therapies, including GLP-1 agonists, are currently in use for treatment of diabetes and obesity. However, several complications may occur with their use.: Objective: This narrative review provides a ...

    Abstract Introduction: Glucagon-like peptide 1 (GLP-1) based therapies, including GLP-1 agonists, are currently in use for treatment of diabetes and obesity. However, several complications may occur with their use.
    Objective: This narrative review provides a focused evaluation of GLP-1 agonist therapy and associated complications for emergency clinicians.
    Discussion: GLP-1 agonists potentiate insulin release and reduce gastric emptying and food intake. These agents have demonstrated significant improvements in glucose control in diabetics and weight loss in obese patients. The two most common agents include subcutaneous semaglutide (Ozempic, approved for type 2 diabetes, and Wegovy, approved for weight loss) and liraglutide (Saxenda, approved for weight loss, and Victoza, approved for type 2 diabetes), though an oral formulation of semaglutide is available (Rybelsus). While these drugs are associated with improved long-term outcomes, there are a variety of associated adverse events. The most common include gastrointestinal (GI) adverse events such as nausea, vomiting, diarrhea, and abdominal pain. Pancreatitis and biliary disease may also occur. Hypersensitivity including injection site reactions have been associated with use, with reports of anaphylaxis and other rashes. Renal adverse events are most commonly associated with severe GI losses. Hypoglycemia may occur when these agents are used with sulfonylureas or insulin. There is also an increased risk of diabetic retinopathy. Due to the current shortage and expense of these medications, many patients have attempted to obtain these medications from non-licensed and unregulated agents, which may be associated with increased risk of serious complications.
    Conclusions: An understanding of the indications for GLP-1 agonist use and associated adverse events can assist emergency clinicians.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Hypoglycemic Agents/adverse effects ; Glucagon-Like Peptide 1/therapeutic use ; Obesity ; Weight Loss ; Insulin/therapeutic use
    Chemical Substances Hypoglycemic Agents ; Glucagon-Like Peptide 1 (89750-14-1) ; Insulin
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2024.01.010
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    Zs.A 2005: Show issues Location:
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  8. Article ; Online: In response: Considerations regarding compounding pharmacies and GLP-1 agonists.

    Long, Brit / Pelletier, Jessica / Koyfman, Alex / Bridwell, Rachel E

    The American journal of emergency medicine

    2024  

    Language English
    Publishing date 2024-04-06
    Publishing country United States
    Document type Letter
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2024.03.037
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  9. Article: Novel Academic Tabletop 2022 (NAT22): A Dynamic Dice-Based Emergency Medicine Education Tool.

    Heilmann, Adam / Pelletier, Jessica / Murray, Collyn / Croft, Alexander

    Cureus

    2023  Volume 15, Issue 11, Page(s) e49498

    Abstract: Gamification is an effective teaching tool that improves engagement and knowledge retention. Tabletop role-playing games are dynamic games that use random chance and foster player/leader partnership. To date, there are no teaching tools that mimic ... ...

    Abstract Gamification is an effective teaching tool that improves engagement and knowledge retention. Tabletop role-playing games are dynamic games that use random chance and foster player/leader partnership. To date, there are no teaching tools that mimic dynamic or unpredictable patient presentations. This style of game may work well as a tool for medical education in a simulation-based modality. In this report, we document the rules, materials, and training required to reproduce a hybrid game created to combine facets of simulation and tabletop role-playing games (TRPGs) to create a dynamic medical education tool. After testing the game for flaws and fluidity of gameplay, we plan to collect data evaluating emergency medicine residents' enjoyability and knowledge retention. In this article, we describe a novel TRPG simulation hybrid game that we hypothesize will improve learner enjoyability/engagement and have similar educational benefits to standard medical education.
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.49498
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  10. Article: Magnetic resonance imaging assessments for knee segmentation and their use in combination with machine/deep learning as predictors of early osteoarthritis diagnosis and prognosis.

    Martel-Pelletier, Johanne / Paiement, Patrice / Pelletier, Jean-Pierre

    Therapeutic advances in musculoskeletal disease

    2023  Volume 15, Page(s) 1759720X231165560

    Abstract: Knee osteoarthritis (OA) is a prevalent and disabling disease that can develop over decades. This disease is heterogeneous and involves structural changes in the whole joint, encompassing multiple tissue types. Detecting OA before the onset of ... ...

    Abstract Knee osteoarthritis (OA) is a prevalent and disabling disease that can develop over decades. This disease is heterogeneous and involves structural changes in the whole joint, encompassing multiple tissue types. Detecting OA before the onset of irreversible changes is crucial for early management, and this could be achieved by allowing knee tissue visualization and quantifying their changes over time. Although some imaging modalities are available for knee structure assessment, magnetic resonance imaging (MRI) is preferred. This narrative review looks at existing literature, first on MRI-developed approaches for evaluating knee articular tissues, and second on prediction using machine/deep-learning-based methodologies and MRI as input or outcome for early OA diagnosis and prognosis. A substantial number of MRI methodologies have been developed to assess several knee tissues in a semi-quantitative and quantitative fashion using manual, semi-automated and fully automated systems. This dynamic field has grown substantially since the advent of machine/deep learning. Another active area is predictive modelling using machine/deep-learning methodologies enabling robust early OA diagnosis/prognosis. Moreover, incorporating MRI markers as input/outcome in such predictive models is important for a more accurate OA structural diagnosis/prognosis. The main limitation of their usage is the ability to move them in rheumatology practice. In conclusion, MRI knee tissue determination and quantification provide early indicators for individuals at high risk of developing this disease or for patient prognosis. Such assessment of knee tissues, combined with the development of models/tools from machine/deep learning using, in addition to other parameters, MRI markers for early diagnosis/prognosis, will maximize opportunities for individualized risk assessment for use in clinical practice permitting precision medicine. Future efforts should be made to integrate such prediction models into open access, allowing early disease management to prevent or delay the OA outcome.
    Language English
    Publishing date 2023-04-28
    Publishing country England
    Document type Address ; Journal Article ; Review
    ZDB-ID 2516075-8
    ISSN 1759-7218 ; 1759-720X
    ISSN (online) 1759-7218
    ISSN 1759-720X
    DOI 10.1177/1759720X231165560
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