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Article ; Online: It's Not Just: Evaluation of a Media Campaign to Motivate Action Around Targeting of Menthol Tobacco in Black Communities.

Eggers, Matthew E / Nonnemaker, James M / Kelly, Lisa K / Ortega-Peluso, Christina / Anker, Elizabeth / Lee, Jennifer / Fajobi, OlaOluwa / Swires, Nicole B

Preventing chronic disease

2024 Volume 21, Page(s) E24

Abstract: Introduction: For more than 60 years, tobacco companies have aggressively marketed menthol tobacco products in Black communities. In 2021, New York State Department of Health-funded grantees launched a media campaign aimed toward civically engaged New ... ...

Abstract	Introduction: For more than 60 years, tobacco companies have aggressively marketed menthol tobacco products in Black communities. In 2021, New York State Department of Health-funded grantees launched a media campaign aimed toward civically engaged New York adults to educate and mobilize community action to prevent targeted marketing of menthol tobacco. This study examined audience reactions to the campaign and associations between campaign awareness and key outcomes. Methods: Following campaign implementation, we administered 2 online, cross-sectional surveys to 2,000 civically engaged New York adults to assess campaign awareness, audience reactions, and campaign-related attitudes and behaviors. We examined sociodemographic differences in audience reactions and assessed multivariate associations between campaign awareness and key outcomes. Results: Overall, 40% of respondents were aware of the campaign. Perceived advertisement (ad) effectiveness was higher among Black, Hispanic, and nonsmoking respondents and those aware of the campaign. Negative reactions to ads were higher at wave 1, among non-Hispanic White and male respondents, and among current smokers. Campaign awareness was positively associated with campaign-related beliefs. The association between campaign awareness and support for a menthol ban varied by survey wave and race, with positive associations at wave 2 and among non-Hispanic White respondents only. Among wave 2 respondents only, campaign awareness was positively associated with actions to reduce the targeting of menthol in Black communities. Conclusion: Media campaigns can play an important role in raising awareness of menthol tobacco product targeting in Black communities and building public support for local and statewide menthol restrictions that may be implemented before federal product standards are in place.
MeSH term(s)	Adult ; Humans ; Male ; Smoking ; Menthol ; Cross-Sectional Studies ; Nicotiana ; Smoking Cessation ; Tobacco Products
Chemical Substances	Menthol (1490-04-6)
Language	English
Publishing date	2024-04-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2135684-1
ISSN	1545-1151 ; 1545-1151
ISSN (online)	1545-1151
ISSN	1545-1151
DOI	10.5888/pcd21.230237
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Predicting gene expression levels from DNA sequences and post-transcriptional information with transformers.

Pipoli, Vittorio / Cappelli, Mattia / Palladini, Alessandro / Peluso, Carlo / Lovino, Marta / Ficarra, Elisa

Computer methods and programs in biomedicine

2022 Volume 225, Page(s) 107035

Abstract: Background and objectives: In the latest years, the prediction of gene expression levels has been crucial due to its potential applications in the clinics. In this context, Xpresso and others methods based on Convolutional Neural Networks and ... ...

Abstract	Background and objectives: In the latest years, the prediction of gene expression levels has been crucial due to its potential applications in the clinics. In this context, Xpresso and others methods based on Convolutional Neural Networks and Transformers were firstly proposed to this aim. However, all these methods embed data with a standard one-hot encoding algorithm, resulting in impressively sparse matrices. In addition, post-transcriptional regulation processes, which are of uttermost importance in the gene expression process, are not considered in the model. Methods: This paper presents Transformer DeepLncLoc, a novel method to predict the abundance of the mRNA (i.e., gene expression levels) by processing gene promoter sequences, managing the problem as a regression task. The model exploits a transformer-based architecture, introducing the DeepLncLoc method to perform the data embedding. Since DeepLncloc is based on word2vec algorithm, it avoids the sparse matrices problem. Results: Post-transcriptional information related to mRNA stability and transcription factors is included in the model, leading to significantly improved performances compared to the state-of-the-art works. Transformer DeepLncLoc reached 0.76 of R Conclusion: The Multi-Headed Attention mechanisms which characterizes the transformer methodology is suitable for modeling the interactions between DNA's locations, overcoming the recurrent models. Finally, the integration of the transcription factors data in the pipeline leads to impressive gains in predictive power.
MeSH term(s)	Base Sequence ; DNA/genetics ; Gene Expression ; RNA, Messenger/genetics ; Transcription Factors/genetics
Chemical Substances	RNA, Messenger ; Transcription Factors ; DNA (9007-49-2)
Language	English
Publishing date	2022-08-07
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632564-6
ISSN	1872-7565 ; 0169-2607
ISSN (online)	1872-7565
ISSN	0169-2607
DOI	10.1016/j.cmpb.2022.107035
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Article: Effectiveness of a media campaign promoting health care provider tobacco dependence treatment.

Hayes, Kim A / Brown, Elizabeth M / Nonnemaker, James / Juster, Harlan / Ortega-Peluso, Christina / Farrelly, Matthew C / Davis, Kevin

Preventive medicine reports

2023 Volume 36, Page(s) 102403

Abstract: The New York State Department of Health (NYSDOH) developed a provider-focused media campaign to encourage provision of evidence-based, clinical tobacco dependence treatment (TDT). The purpose of this study was to assess providers' awareness of the ... ...

Abstract	The New York State Department of Health (NYSDOH) developed a provider-focused media campaign to encourage provision of evidence-based, clinical tobacco dependence treatment (TDT). The purpose of this study was to assess providers' awareness of the campaign and the relationship between campaign awareness and changes in campaign-related beliefs and clinical TDT intervention. We conducted a longitudinal, mailed survey of health care providers in New York State (n = 851; AAPOR3 RR: 24.6%). We estimated descriptive statistics and used multivariable regression analyses to assess whether changes in key outcomes (campaign-related beliefs and clinical TDT) from pre- to post-campaign vary by self-reported campaign awareness. Approximately 12% of providers were aware of the campaign. In multivariable analyses, changes from pre- to post-campaign in provider beliefs that the nicotine patch and gum are very effective at helping patients quit were greater for providers aware of the campaign compared with those not aware of the campaign (For patch: OR 2.17, CI 1.06-4.45,
Language	English
Publishing date	2023-09-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2785569-7
ISSN	2211-3355
ISSN	2211-3355
DOI	10.1016/j.pmedr.2023.102403
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Article ; Online: EXERT-BC: Prospective Study of an Exercise Regimen After Treatment for Breast Cancer.

Champ, Colin E / Peluso, Chris / Carenter, David J / Rosenberg, Jared / Velasquez, Frank / Annichine, Adam / Matsko, Krista / Hyde, Parker N / Diaz, Alexander K / Beriwal, Sushil / Hilton, Christie

Sports medicine international open

2024 Volume 8, Page(s) a21930922

Abstract: ... ...

Abstract	Purpose
Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Journal Article
ISSN	2367-1890
ISSN (online)	2367-1890
DOI	10.1055/a-2193-0922
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Article ; Online: EXERT-BC: A pilot study of an exercise regimen designed to improve functional mobility, body composition, and strength after the treatment for breast cancer.

Carpenter, David J / Peluso, Chris / Hilton, Christie / Velasquez, Frank / Annichine, Adam / Matsko, Krista / Rosenberg, Jared / Diaz, Alexander K / Hyde, Parker / Beriwal, Sushil / Champ, Colin E

Cancer medicine

2024 Volume 13, Issue 5, Page(s) e7001

Abstract: Purpose: Resistance training may offer several unique advantages within breast cancer (BC) survivorship care; however, safety concerns have limited the application of high-intensity compound movements necessary to elicit optimal changes in body ... ...

Abstract	Purpose: Resistance training may offer several unique advantages within breast cancer (BC) survivorship care; however, safety concerns have limited the application of high-intensity compound movements necessary to elicit optimal changes in body composition, strength, and quality of life in this population. The EXERT-BC trial assesses the safety and feasibility of an evidence-based, dose-escalated resistance training regimen among BC survivors, with the goal of improving physical and metabolic function, mobility, muscle mass, and body composition. Methods: Participants included women with breast cancer underwent a 3-month thrice weekly exercise regimen involving dose escalation of high-intensity compound exercises. Coprimary outcomes included safety and adherence. Pre- and post-regimen assessment included body composition testing, functional mobility and balance, total load (weight × repetitions × sets) across compound exercises, and patient reported quality of life. Pairwise comparison was performed via the paired t test. Results: Fourty participants completed a 3-month exercise regimen, with a median age of 57 years (range, 27-74 years) and 73% having stage 0-2 BC. BC therapies concurrent with exercise included anti-estrogen therapy (80%), radiotherapy (30%), and non-hormonal systemic therapy (15%). No adverse events were observed aside from a single case of self-limited knee pain. Session attendance exceeded a prespecified threshold of 75%, and 98% patients reported ongoing compliance to an exercise regimen following regimen completion. Significant reductions in percent body fat (p < 0.001) and increases in percent muscle mass (p = 0.011) were observed. Significant increases in resting metabolic rate (p = 0.023), bilateral grip strength (p < 0.001), functional movement screen (p < 0.001), bilateral Y-Balance testing (p < 0.001), and Godin questionnaire scores (p < 0.001) were observed. Conclusion: A 3-month dose-escalated resistance training regimen comprising high-intensity compound movements appears safe with a high degree of adherence among breast cancer survivors, resulting in demonstrable improvements in body composition, metabolic parameters, strength increases, and patient-reported quality of life.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Middle Aged ; Body Composition ; Breast Neoplasms/therapy ; Exercise Therapy/methods ; Muscle Strength/physiology ; Pilot Projects ; Quality of Life
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Clinical Trial ; Journal Article
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.7001
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Article ; Online: Changes in Reported Secondhand Smoke Incursions and Smoking Behavior after Implementation of a Federal Smoke-Free Rule in New York State Federally Subsidized Public Housing.

Curry, Laurel E / Feld, Ashley L / Rogers, Todd / Coats, Ellen M / Nonnemaker, James / Anker, Elizabeth / Ortega-Peluso, Christina / Battles, Haven

International journal of environmental research and public health

2022 Volume 19, Issue 6

Abstract: This study assessed changes in smoking behavior and secondhand smoke (SHS) exposure after implementation of the U.S. Department of Housing and Urban Development (HUD) rule prohibiting the use of cigarettes, cigars, pipes, and waterpipes in all federally ... ...

Abstract	This study assessed changes in smoking behavior and secondhand smoke (SHS) exposure after implementation of the U.S. Department of Housing and Urban Development (HUD) rule prohibiting the use of cigarettes, cigars, pipes, and waterpipes in all federally subsidized public housing, including within residential units (apartments). Using quantitative data from a repeated cross-sectional mail survey of New York State residents of five public housing authorities (N = 761 at Wave 1, N = 649 at Wave 2), we found evidence of policy compliance (99% decrease in odds of self-reported smoking in units, OR = 0.01, p < 0.01, CI: 0.00−0.16), reduced SHS incursions (77% decrease in odds of smelling smoke within developments, OR = 0.23, p < 0.01, CI: 0.13−0.44), and lower reported smoking rates in July 2018 (9.5%, down from 16.8%), 10 months after implementation of the rule. Despite evident success, one-fifth of residents reported smelling smoke inside their apartment at least a few times per week. This study provides insights into how the policy was implemented in selected New York public housing authorities, offers evidence of policy-intended effects, and highlights challenges to consistent and impactful policy implementation.
MeSH term(s)	Cross-Sectional Studies ; Housing ; Humans ; New York/epidemiology ; Public Housing ; Smoke-Free Policy ; Smoking/epidemiology ; Tobacco Smoke Pollution/analysis
Chemical Substances	Tobacco Smoke Pollution
Language	English
Publishing date	2022-03-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19063513
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Article: Robotic approach to large tailgut cyst with malignant transformation: A case report.

Marano, Alessandra / Giuffrida, Maria Carmela / Peluso, Chiara / Testa, Valentina / Bosio, Paolo / Borghi, Felice

International journal of surgery case reports

2020 Volume 77S, Page(s) S57–S60

Abstract: Introduction: Tailgut cysts (TGC) are rare congenital retrorectal lesions deriving from vestiges of the hindgut. The risk of malignant transformation is relatively high. Thus early diagnosis and a complete removal of the mass are of paramount importance. ...

Abstract	Introduction: Tailgut cysts (TGC) are rare congenital retrorectal lesions deriving from vestiges of the hindgut. The risk of malignant transformation is relatively high. Thus early diagnosis and a complete removal of the mass are of paramount importance. We present a case of successful robotic exeresis of a large TGC adenocarcinoma. Presentation of case: A healthy 35-year-old woman was found to have a retrorectal TGC with suspected malignant transformation. The patient underwent complete robotic resection of the mass and pathology confirmed a TGC adenocarcinoma. The patient's post-operative course was unremarkable. At 24 months, the patient has not experienced any recurrence nor complained functional disorders. Discussion: The current case highlights the importance of TGC as a differential diagnosis of presacral masses, underscoring that malignant transformation can occur and may result in mortality and morbidity if radical surgery is not performed. Diagnosing TGC adenocarcinoma can be challenging because of its relatively low incidence. Biopsy is not recommended while magnetic resonance imaging (MRI) is indispensable in the evaluation of this lesion as the presence of intracystic vegetations could indicate a malignant transformation. Surgery is the mainstay of treatment and minimally invasive techniques have the potential to minimize morbidity and enhance recovery. Amongst these, the robotic approach can make the dissection of large lesions easier, reducing their manipulation and preventing nerve injuries. Conclusion: Robot-assisted resection of a TGC adenocarcinoma is safe and feasible. This approach can be particularly useful in the pelvis providing acceptable functional and oncological outcomes.
Language	English
Publishing date	2020-09-24
Publishing country	Netherlands
Document type	Case Reports
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2020.09.025
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Article ; Online: Involvement of SYCP2L and TDRD3 gene variants on ovarian reserve and reproductive outcomes: a cross-sectional study.

Rosa, Iasmim Ribeiro / Barbosa, Caio Parente / Ferrandez, Caroline Awoki / Sonoda, Bianca Del Bel / Christofolini, Denise Maria / Trevisan, Camila Martins / Laganà, Antonio Simone / Peluso, Carla / Bianco, Bianca

JBRA assisted reproduction

2023 Volume 27, Issue 3, Page(s) 428–435

Abstract: Objective: Single nucleotide variants have been implicated in the response to fertility treatment and a pharmacogenomic approach may help to customize therapy based on patient genome. We aimed to evaluate the effect, individual and combined, of SYCP2L ( ... ...

Abstract	Objective: Single nucleotide variants have been implicated in the response to fertility treatment and a pharmacogenomic approach may help to customize therapy based on patient genome. We aimed to evaluate the effect, individual and combined, of SYCP2L (rs2153157:G>A) and TDRD3 (rs4886238:G>A) variants on ovarian reserve, response to controlled ovarian stimulation (COS) and reproductive outcomes of women undergoing in vitro fertilization (IVF) treatment. Methods: This cross-sectional study included 149 normoovulatory women undergoing IVF. Genotyping was performed using the TaqMan real-time polymerase chain reaction method. Clinical parameters and reproductive outcomes were compared according to the genotypes of the variants studied. Results: Considering ovarian reserve, there were no significant differences among SYCP2L or TDRD3 genotypes in terms of FSH levels or AFC; however, AMH levels were significantly different in carriers of both variants. Regarding the SYCP2L rs2153157:G>A variant, lower AMH levels were observed in women carrying an AA genotype compared to women carrying a heterozygous genotype (p=0.01). Considering the TDRD3 rs4886238:G>A variant, women carrying an AA genotype presented higher AMH levels than carriers of GG and GA genotypes (p=0.025). Nevertheless, no difference was found regarding response to COS or reproductive outcomes. Considering the combined effect of the variants, women carrying the heterozygous genotype of both variants presented statistically increased AMH levels compared to SYCP2L rs2153157 AA genotype carriers and TDRD3 rs4886238 GG genotype carriers (p=0.042). Conclusions: Individually and combined, the SYCP2L rs2153157 and TDRD3 rs4886238 variants have an effect on AMH level.
MeSH term(s)	Female ; Humans ; Cross-Sectional Studies ; Fertility ; Fertilization in Vitro/methods ; Ovarian Reserve/genetics ; Ovulation Induction/methods ; Reproduction
Chemical Substances	Tdrd3 protein, human
Language	English
Publishing date	2023-09-12
Publishing country	Brazil
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2856226-4
ISSN	1518-0557 ; 1517-5693
ISSN (online)	1518-0557
ISSN	1517-5693
DOI	10.5935/1518-0557.20220074
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Article: Effects of

Bianco, Bianca / Loureiro, Flavia Altheman / Trevisan, Camila Martins / Peluso, Carla / Christofolini, Denise Maria / Montagna, Erik / Laganà, Antonio Simone / Barbosa, Caio Parente

Frontiers in endocrinology

2021 Volume 12, Page(s) 760616

Abstract: Background: Single nucleotide variants (SNVs) : Methods: A cross-sectional study was performed comprising 213 infertile Brazilian women with endometriosis who underwent IVF treatment. Genotyping was performed using TaqMan real-time PCR. Variables ... ...

Abstract	Background: Single nucleotide variants (SNVs) Methods: A cross-sectional study was performed comprising 213 infertile Brazilian women with endometriosis who underwent IVF treatment. Genotyping was performed using TaqMan real-time PCR. Variables were compared according to the genotypes of each variant and genetic models, and the combined effects of the SNVs were evaluated using the multifactorial dimensionality reduction method. Results: FSHB Conclusions: Variants of the
MeSH term(s)	Adult ; Alleles ; Brazil ; Cross-Sectional Studies ; Endometriosis/genetics ; Female ; Follicle Stimulating Hormone, beta Subunit/genetics ; Gene Frequency/genetics ; Genotype ; Humans ; Infertility, Female/genetics ; Polymorphism, Single Nucleotide/genetics ; Pregnancy ; Pregnancy Outcome/genetics ; Receptors, FSH/genetics ; Reproduction/genetics
Chemical Substances	Follicle Stimulating Hormone, beta Subunit ; Receptors, FSH
Language	English
Publishing date	2021-09-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2021.760616
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Article ; Online: Dentist and hygienist smoking cessation counseling and awareness of Medicaid benefits.

Brown, Elizabeth M / Hayes, Kim A / Olson, Lindsay T / Battles, Haven / Ortega-Peluso, Christina

Journal of public health dentistry

2019 Volume 79, Issue 3, Page(s) 246–252

Abstract: Objectives: Integrating smoking cessation interventions into dental care is an efficient way to intervene with smokers. This study of dentists and dental hygienists who provide dental care to Medicaid-insured patients explores awareness of Medicaid ... ...

Abstract	Objectives: Integrating smoking cessation interventions into dental care is an efficient way to intervene with smokers. This study of dentists and dental hygienists who provide dental care to Medicaid-insured patients explores awareness of Medicaid smoking cessation benefits, awareness of Quitline resources, beliefs about perceived role in providing tobacco interventions, and behaviors around clinical intervention. Methods: In 2015, we conducted a survey of dentists and hygienists who serve Medicaid patients in New York State. Results: A total of 182 dentists and 92 hygienists completed the survey. Ninety percent reported that helping patients quit smoking is part of their role, while 51.0 percent reported feeling confident in their ability to counsel a patient about quitting. Most respondents (73.4 percent) asked patients about tobacco use, 83.7 percent advised smokers to quit, and 49.1 percent assisted with quit attempts. We found that 26.7 percent were aware that dentist smoking cessation counseling is covered by Medicaid, and 15.5 percent were aware that hygienist smoking cessation counseling is covered. A total of 38.9 percent were aware of any Medicaid coverage for smoking cessation. Awareness of the Medicaid smoking cessation benefit was associated with intervention behaviors of asking and assisting. Conclusions: Most dental care providers see smoking cessation as part of their role, but few are aware of the Medicaid benefits available to help patients. Expanding coverage of and promoting Medicaid benefits for smoking cessation have the potential to increase the reach and quality of smoking cessation interventions for Medicaid-insured smokers, a population disproportionately affected by tobacco use.
MeSH term(s)	Counseling ; Dental Hygienists ; Dentist-Patient Relations ; Dentists ; Humans ; Medicaid ; Smoking Cessation ; United States
Language	English
Publishing date	2019-05-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	410719-6
ISSN	1752-7325 ; 0022-4006
ISSN (online)	1752-7325
ISSN	0022-4006
DOI	10.1111/jphd.12321
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