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  1. Article ; Online: Evidence-based practice in mental health.

    Moreno-Calvete, Maria Concepcion / Uriarte-Uriarte, Jose Juan / Penas, Patricia

    Enfermeria clinica (English Edition)

    2022  Volume 32, Issue 1, Page(s) 66–67

    MeSH term(s) Attitude of Health Personnel ; Evidence-Based Practice ; Mental Health
    Language English
    Publishing date 2022-01-22
    Publishing country Spain
    Document type Letter
    ISSN 2445-1479
    ISSN (online) 2445-1479
    DOI 10.1016/j.enfcle.2021.06.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effects of a Multi-Component Psychological Intervention to Cultivate Mental Health in Older Adults.

    Sarrionandia, Sare / Gorbeña, Susana / Gómez, Ignacio / Penas, Patricia / Macía, Patricia / Iraurgi, Ioseba

    Clinical interventions in aging

    2022  Volume 17, Page(s) 1493–1502

    Abstract: Introduction: Psychological interventions to cultivate mental health in older adults are scarce and tend to focus on and use a limited number of activities.: Objective: The aim of this study was to test the effects of an intervention based on Keyes' ... ...

    Abstract Introduction: Psychological interventions to cultivate mental health in older adults are scarce and tend to focus on and use a limited number of activities.
    Objective: The aim of this study was to test the effects of an intervention based on Keyes' concept of positive mental health.
    Methods: The intervention was conducted with 24 self-selected participants, while 34 were part of the control group. Positive mental health and distress outcomes were measured at baseline and at the end of the intervention. ANCOVA analysis and effect sizes were calculated.
    Results: Results showed that the intervention increased mental health (F= 18.22, p<0.001, η
    Discussion: Despite study limitations, the intervention effectively promoted older people's well-being. Future research, should evaluate the long-term effects of the intervention with varied older adult populations.
    MeSH term(s) Aged ; Humans ; Mental Health ; Psychosocial Intervention
    Language English
    Publishing date 2022-10-11
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2364924-0
    ISSN 1178-1998 ; 1176-9092
    ISSN (online) 1178-1998
    ISSN 1176-9092
    DOI 10.2147/CIA.S376894
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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Design and evaluation of a positive intervention to cultivate mental health: preliminary findings.

    Gorbeña, Susana / Govillard, Leila / Gómez, Ignacio / Sarrionandia, Sare / Macía, Patricia / Penas, Patricia / Iraurgi, Ioseba

    Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS

    2021  Volume 34, Issue 1, Page(s) 7

    Abstract: The past two decades have witnessed a proliferation of positive psychological interventions for clinical and non-clinical populations, and recent research, including meta-analyses, is providing evidence of its effectiveness. Most interventions have ... ...

    Abstract The past two decades have witnessed a proliferation of positive psychological interventions for clinical and non-clinical populations, and recent research, including meta-analyses, is providing evidence of its effectiveness. Most interventions have focused on increasing life satisfaction, positive affect, and psychological well-being. Manualized, multi-component interventions based on a comprehensive theory are scarce. Keyes' concept of mental health and flourishing (subjective, psychological, and social well-being) is an overarching theoretical framework to guide the design of a multi-component psychological intervention to cultivate well-being and personal development. Therefore, the purpose of this study was to design a theory-driven positive intervention and to pilot test the intervention. The manual presents an 8-week group program that includes homework activities. A sample of 56 young adults completed the intervention. Participants were assessed at base line, after termination, and at a 6-month follow-up session. Standardized instruments were used to assess the dimensions of mental health proposed by Keyes. Pre- and post-test measures of subjective, psychological, and social well-being showed significant differences, as did the total mental health scores. At 6-month follow-up, differences remained in subjective and psychological well-being and in positive mental health, with smaller effect sizes. Limitations of these preliminary findings as well as future lines of research and improvements in this manualized intervention are proposed in the light of current research on positive interventions.
    Language English
    Publishing date 2021-02-24
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2038349-6
    ISSN 1678-7153 ; 0102-7972
    ISSN (online) 1678-7153
    ISSN 0102-7972
    DOI 10.1186/s41155-021-00172-1
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  4. Article ; Online: Discrepancy between experience and importance of recovery components in the symptomatic and recovery perceptions of people with severe mental disorders.

    Penas, Patricia / Uriarte, Jose-Juan / Gorbeña, Susana / Slade, Mike / Moreno-Calvete, María-Concepción / Iraurgi, Ioseba

    BMC psychiatry

    2021  Volume 21, Issue 1, Page(s) 277

    Abstract: Background: Personal recovery has become an increasingly important approach in the care of people with severe mental disorders and consequently in the orientation of mental health services. The objective of this study was to assess the personal recovery ...

    Abstract Background: Personal recovery has become an increasingly important approach in the care of people with severe mental disorders and consequently in the orientation of mental health services. The objective of this study was to assess the personal recovery process in people using mental health services, and to clarify the role of variables such as symptomatology, self-stigma, sociodemographic and treatment.
    Methods: Standardised measures of personal recovery process, clinical recovery, and internalized stigma were completed by a sample of 312 participants in a Severe Mental Disorder program.
    Results: Users valued most the recovery elements of: improving general health and wellness; having professionals who care; hope; and sense of meaning in life. Significant discrepancies between perceived experience and relative importance assigned to each of the components of the REE were observed. Regression modeling (χ
    Conclusions: An improvement in psychiatric services should be focused on recovery aspects that have the greatest discrepancy between importance and experience, in particular social roles, basic needs and hope. Personal and clinical recovery are correlated, but the relationship between them is mediated by internalized stigma, indicating the need for clinical interventions to target self-stigma.
    MeSH term(s) Humans ; Mental Disorders/therapy ; Mental Health Services ; Perception ; Self Concept ; Social Stigma
    Language English
    Publishing date 2021-05-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1471-244X
    ISSN (online) 1471-244X
    DOI 10.1186/s12888-021-03287-y
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  5. Article ; Online: The effects of an intervention to improve mental health during the COVID-19 quarantine: comparison with a COVID control group, and a pre-COVID intervention group.

    Gorbeña, Susana / Gómez, Ignacio / Govillard, Leila / Sarrionandia, Sare / Macía, Patricia / Penas, Patricia / Iraurgi, Ioseba

    Psychology & health

    2021  Volume 37, Issue 2, Page(s) 178–193

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) COVID-19 ; Control Groups ; Humans ; Mental Health ; Pandemics ; Quarantine ; SARS-CoV-2
    Language English
    Publishing date 2021-06-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 625255-2
    ISSN 1476-8321 ; 0887-0446
    ISSN (online) 1476-8321
    ISSN 0887-0446
    DOI 10.1080/08870446.2021.1936520
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2856: Show issues Location:
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  6. Article ; Online: How is evaluated mental health recovery?: A systematic review.

    Penas, Patricia / Iraurgi, Ioseba / Moreno, M Concepción / Uriarte, Jose J

    Actas espanolas de psiquiatria

    2019  Volume 47, Issue 1, Page(s) 23–32

    Abstract: There is an increasingly recognition of the concept of personal recovery in the treatment of mental illness. Recovery defined as living a fulfilling, rewarding life, even in the ongoing presence of a mental illness. Consequently, a number of different ... ...

    Abstract There is an increasingly recognition of the concept of personal recovery in the treatment of mental illness. Recovery defined as living a fulfilling, rewarding life, even in the ongoing presence of a mental illness. Consequently, a number of different instruments have been designed to assess recovery-oriented outcomes. The objective of the study was to conduct a systematic revision of the domains and the instruments used to assess personal recovery and mental health services orientation to recovery. After the systematic review, it has been carried out a selection process of the most adequate instruments taking into account different criteria of adequacy, psychometric properties and the validation to the Spanish population. In the results have been obtained 35 instruments for measuring personal recovery and 18 for assessing the orientation of recovery in mental health services. However, many of them have been dismissed for not reaching the adequacy criteria. This review makes clear the lack of consensus on the concept of recovery, as a consequence of the high number of instruments that evaluate the same concept through different domains. In addition, few instruments offer data related to the psychometric properties and only one instrument to assess personal recovery is validated to the Spanish population.
    MeSH term(s) Humans ; Mental Disorders/psychology ; Mental Disorders/rehabilitation ; Mental Disorders/therapy ; Mental Health Recovery
    Language English
    Publishing date 2019-01-01
    Publishing country Spain
    Document type Journal Article ; Systematic Review
    ZDB-ID 1480971-0
    ISSN 1578-2735 ; 1575-071X ; 1139-9287
    ISSN (online) 1578-2735
    ISSN 1575-071X ; 1139-9287
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    In stock of ZB MED Cologne/Königswinter

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  7. Article: Psychometric Adequacy of Recovery Enhancing Environment (REE) Measure: CHIME Framework as a Theory Base for a Recovery Measure.

    Penas, Patricia / Uriarte, Jose Juan / Gorbeña, Susana / Moreno-Calvete, Maria Concepcion / Ridgway, Priscilla / Iraurgi, Ioseba

    Frontiers in psychiatry

    2020  Volume 11, Page(s) 595

    Abstract: Purpose: The aim of this study was to assess to what extent the recovery elements of the Recovery Enhancing Environment (REE) instrument measured the dimensions proposed by the CHIME framework, (Connectedness, Hope and optimism about future, Identity, ... ...

    Abstract Purpose: The aim of this study was to assess to what extent the recovery elements of the Recovery Enhancing Environment (REE) instrument measured the dimensions proposed by the CHIME framework, (Connectedness, Hope and optimism about future, Identity, Meaning in life and Empowerment dimensions), so as to evaluate personal recovery in people with severe mental illness.
    Methods: Two processes were conducted. Firstly, five experts matched the elements of recovery evaluated by the REE items with the CHIME domains and subdomains. Then, the resulting structure from those experts agreement was analyzed with different confirmatory factor analyses (CFA) using responses to the recovery elements dimension of the REE of 312 mental health service users.
    Results: The percentage of agreements and the kappa coefficients were adequate taking into account the CHIME dimensions (κ = 0.57 to 0.69, total κ = 0.74); however, lower agreement was found at the subdimensions level. Some indexes of the CFA were acceptable for a second order factor analysis [
    Conclusions: Despite the subjective and complex nature of the personal recovery construct, the REE measure can be a valid instrument to verify the existing CHIME conceptual framework, since two of the models tested have resulted in adequate indexes and were also congruent with the theoretical framework and the statistical solution. Thus, REE can be used to obtain a global index of Personal Recovery dimension, and the five indicators proposed by the CHIME framework.
    Language English
    Publishing date 2020-06-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2020.00595
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  8. Article ; Online: Evidence of psychometric adequacy of the Spanish Adaptation of REE: Recovery Enhancing Environment.

    Uriarte, Jose-Juan / Penas, Patricia / Moreno-Calvete, M Concepción / Ridgway, Priscilla / Iraurgi, Ioseba

    Actas espanolas de psiquiatria

    2020  Volume 48, Issue 2, Page(s) 75–88

    Abstract: Introduction: In this study we present the process and results of the Spanish adaptation and validation of REE (Recovery Enhancing Environment), an instrument designed to assess the personal process of recovery and the recovery orientation of mental ... ...

    Abstract Introduction: In this study we present the process and results of the Spanish adaptation and validation of REE (Recovery Enhancing Environment), an instrument designed to assess the personal process of recovery and the recovery orientation of mental health services.
    Methodology: The Spanish REE version has been completed by a representative sample of the Severe Mental Disorder (SMD) program users in the Mental Health Services of Biscay (n=312).
    Results: The validity evidence of each section (importance of recovery elements, experience of recovery elements, organizational climate and recovery markers) of the REE has shown unidimensionality of the scale, with suitable indexes in the factorial analyses and Cronbach alphas greater than .90 for each dimension. Moreover, significant correlations have been found between REE and its dimensions, and with other instruments that measure severity, functionality and quality of life.
    Conclusions: The adequacy of the psychometric properties of the REE make it an interesting instrument to assess the different indicators related to the recovery model, especially if the scarcity of available instruments is taken into account.
    MeSH term(s) Female ; Humans ; Male ; Mental Disorders/therapy ; Mental Health Recovery ; Middle Aged ; Psychometrics/statistics & numerical data ; Reproducibility of Results ; Spain ; Surveys and Questionnaires/standards
    Language English
    Publishing date 2020-03-01
    Publishing country Spain
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 1480971-0
    ISSN 1578-2735 ; 1575-071X ; 1139-9287
    ISSN (online) 1578-2735
    ISSN 1575-071X ; 1139-9287
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  9. Article: High Levels of Receptor Tyrosine Kinases in CCM3-Deficient Cells Increase Their Susceptibility to Tyrosine Kinase Inhibition.

    Sartages, Miriam / Floridia, Ebel / García-Colomer, Mar / Iglesias, Cristina / Macía, Manuel / Peñas, Patricia / Couraud, Pierre-Olivier / Romero, Ignacio A / Weksler, Babette / Pombo, Celia M / Zalvide, Juan

    Biomedicines

    2020  Volume 8, Issue 12

    Abstract: Cerebral cavernous malformations (CCMs) are vascular malformations that can be the result of the deficiency of one of the CCM genes. Their only present treatment is surgical removal, which is not always possible, and an alternative pharmacological ... ...

    Abstract Cerebral cavernous malformations (CCMs) are vascular malformations that can be the result of the deficiency of one of the CCM genes. Their only present treatment is surgical removal, which is not always possible, and an alternative pharmacological strategy to eliminate them is actively sought. We have studied the effect of the lack of one of the CCM genes, CCM3, in endothelial and non-endothelial cells. By comparing protein expression in control and CCM3-silenced cells, we found that the levels of the Epidermal Growth Factor Receptor (EGFR) are higher in CCM3-deficient cells, which adds to the known upregulation of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) in these cells. Whereas VEGFR2 is upregulated at the mRNA level, EGFR has a prolonged half-life. Inhibition of EGFR family members in CCM3-deficient cells does not revert the known cellular effects of lack of CCM genes, but it induces significantly more apoptosis in CCM3-deficient cells than in control cells. We propose that the susceptibility to tyrosine kinase inhibitors of CCM3-deficient cells can be harnessed to kill the abnormal cells of these lesions and thus treat CCMs pharmacologically.
    Language English
    Publishing date 2020-12-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines8120624
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