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  1. Article: The Incidence of Rectal Neuroendocrine Tumors Is Increasing in Younger Adults in the US, 2001-2020.

    Abboud, Yazan / Pendyala, Navya / Le, Alexander / Mittal, Anmol / Alsakarneh, Saqr / Jaber, Fouad / Hajifathalian, Kaveh

    Cancers

    2023  Volume 15, Issue 21

    Abstract: Prior non-comparative data showed increasing incidence of rectal neuroendocrine tumors (RNET) in the US. We aimed to evaluate age-specific RNET incidence rates and time-trends in demographic- and tumor-specific populations. The RNET age-adjusted ... ...

    Abstract Prior non-comparative data showed increasing incidence of rectal neuroendocrine tumors (RNET) in the US. We aimed to evaluate age-specific RNET incidence rates and time-trends in demographic- and tumor-specific populations. The RNET age-adjusted incidence rates were calculated from the United States Cancer Statistics (USCS) database between 2001 and 2020. The population was stratified by age into older (≥55 years) and younger adults (<55 years), as well as by sex and race. The tumors were categorized by their stage at diagnosis into early and late. The annual percentage change (APC) and average APC (AAPC) were estimated using joinpoint regression and Monte Carlo permutation analysis. Pairwise comparison assessed for parallelism and coincidence. There were 59,846 patients diagnosed with RNET between 2001 and 2020 (50.3% women). Overall, the RNET incidence rates during this period were increasing in younger but not older adults (AAPC = 3.12 vs. -1.10; AAPC difference = 4.22,
    Language English
    Publishing date 2023-11-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15215286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Temporal Changes in Functional and Structural Neuronal Activities in Auditory System in Non-Severe Blast-Induced Tinnitus.

    Shao, Ningning / Skotak, Maciej / Pendyala, Navya / Rodriguez, Jose / Ravula, Arun Reddy / Pang, Kevin / Perumal, Venkatesan / Rao, Kakulavarapu V Rama / Chandra, Namas

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 9

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Animals ; Tinnitus/etiology ; Reflex, Startle ; Deafness ; Anxiety ; Anxiety Disorders
    Language English
    Publishing date 2023-09-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59091683
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Association Between Modified Frailty Index and Postoperative Outcomes of Tracheostomies.

    Chinta, Sree / Haleem, Afash / Sibala, Dhiraj R / Kumar, Keshav D / Pendyala, Navya / Aftab, Owais M / Choudhry, Hannaan S / Hegazin, Michael / Eloy, Jean Anderson

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2024  Volume 170, Issue 5, Page(s) 1307–1313

    Abstract: Objective: The 5-item modified frailty index (mFI-5) has been used to stratify patients based on the risk of postoperative complications in several surgical procedures but has not yet been done in tracheostomies. This study investigates the association ... ...

    Abstract Objective: The 5-item modified frailty index (mFI-5) has been used to stratify patients based on the risk of postoperative complications in several surgical procedures but has not yet been done in tracheostomies. This study investigates the association between the mFI-5 score and tracheostomy complications.
    Study design: Retrospective database review.
    Setting: United States hospitals.
    Methods: The National Surgical Quality Improvement Program database was queried for tracheostomy patients between 2005 and 2018. The mFI-5 was calculated for each patient by assigning 1 point for each of the following comorbidities: diabetes mellitus, hypertension, congestive heart failure, chronic obstructive pulmonary disease, and functionally dependent health status. Univariate and multivariable analyses were conducted to determine associations between the mFI-5 score and postoperative complications.
    Results: A total of 4438 patients undergoing tracheostomies were queried and stratified into the following groups: mFI = 0 (N = 1741 [39.2%], mFI = 1 (N = 1720 [38.8%]), mFI = 2 (N = 726 [16.4%]), and mFI of 3 or higher (N = 251 [5.7%]). Univariate analysis showed that patients with higher mFI-5 scores had a greater proportion of smoking, dyspnea, obesity, steroid use, emergency cases, complications, reoperations, and mortality (P < .001). Multivariable analyses found associations between mFI-5 score and any complication (odds ratio [OR]: 1.49, 95% confidence interval [CI]: 1.03-2.16, P = .035), mortality (OR: 2.32, 95% CI: 1.15-4.68, P = .019), and any medical complication (OR: 2.75, 95% CI: 1.88-4.02, P < .001).
    Conclusion: This study suggests an association between the mFI-5 score and postoperative complications in tracheostomies. mFI-5 score can be used to stratify tracheostomy patients by operative risk.
    MeSH term(s) Humans ; Tracheostomy ; Male ; Female ; Postoperative Complications/epidemiology ; Retrospective Studies ; Aged ; Frailty/complications ; Middle Aged ; United States/epidemiology ; Risk Assessment ; Risk Factors ; Databases, Factual
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1002/ohn.667
    Database MEDical Literature Analysis and Retrieval System OnLINE

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