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Article ; Online: Complex Case of Skull Base Osteomyelitis Secondary to Chronic Otitis Media.

Petrovic, Masa / Landsberger, Hannah G / Peng, Kevin A

2023 Volume 102, Issue 9_suppl, Page(s) 31S–34S

Abstract: We present a case of a 58-year-old male with type II diabetes managed with metformin and insulin, who presented to the clinic with left chronic otitis media, persistent drainage, a stenotic meatus, and a prior history of 3 canal wall-down mastoidectomies ...

Abstract	We present a case of a 58-year-old male with type II diabetes managed with metformin and insulin, who presented to the clinic with left chronic otitis media, persistent drainage, a stenotic meatus, and a prior history of 3 canal wall-down mastoidectomies and antibiotic therapy. A revision tympanoplasty with mastoidectomy was performed, and during the postoperative period, the patient had persistent pain and otorrhea, which were managed with opioids and several courses of antibiotic therapy. After symptoms persisted, imaging and culture ultimately led to the diagnosis of fungal skull base osteomyelitis, which was eventually treated successfully. While these complications are rare, their likelihood is increased with treatment delay and in the immunocompromised patient. Close management of immunocompromised patients, including diabetic patients, is vital in identifying complications early to aid in timely diagnosis and treatment to lead to the best possible outcome.
MeSH term(s)	Male ; Humans ; Middle Aged ; Mastoid/surgery ; Diabetes Mellitus, Type 2/complications ; Osteomyelitis/diagnosis ; Osteomyelitis/etiology ; Osteomyelitis/therapy ; Otitis Media/complications ; Otitis Media/surgery ; Anti-Bacterial Agents/therapeutic use ; Skull Base
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-07-28
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	750153-5
ISSN	1942-7522 ; 0145-5613
ISSN (online)	1942-7522
ISSN	0145-5613
DOI	10.1177/01455613231189219
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Article ; Online: Injury and protection of spiral ganglion neurons.

Duan, Beilei / Peng, Kevin A / Wang, Line

Chinese medical journal

2023 Volume 137, Issue 6, Page(s) 651–656

Abstract: Abstract: Cochlear spiral ganglion neurons (SGNs) are bipolar ganglion cells and are the first neurons in the auditory transduction pathway. They transmit complex acoustic information from hair cells to second-order sensory neurons in the cochlear ... ...

Abstract	Abstract: Cochlear spiral ganglion neurons (SGNs) are bipolar ganglion cells and are the first neurons in the auditory transduction pathway. They transmit complex acoustic information from hair cells to second-order sensory neurons in the cochlear nucleus for sound processing. Injury to SGNs causes largely irreversible hearing impairment because these neurons are highly differentiated cells and cannot regenerate, making treatment of sensorineural hearing loss (SNHL) arising from SGN injury difficult. When exposed to ototoxic drugs or damaging levels of noise or when there is loss of neurotrophic factors (NTFs), aging, and presence of other factors, SGNs can be irreversibly damaged, resulting in SNHL. It has been found that NTFs and stem cells can induce regeneration among dead spiral ganglion cells. In this paper, we summarized the present knowledge regarding injury, protection, and regeneration of SGNs.
MeSH term(s)	Humans ; Spiral Ganglion/metabolism ; Neurons ; Cochlea ; Hearing Loss, Sensorineural ; Hair Cells, Auditory/metabolism
Language	English
Publishing date	2023-07-05
Publishing country	China
Document type	Journal Article
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000002765
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Ua VI Zs.425: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Intraoperative Fluorescence With Second Window Indocyanine Green Enhances Visualization During Vestibular Schwannoma Surgery.

Peng, Kevin A / Lekovic, Gregory P

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

2021 Volume 43, Issue 2, Page(s) e259–e262

Abstract: Objective: To investigate the utility of the so-called "second window" of indocyanine green (ICG) as a near-infrared fluorescent dye for intraoperative visualization.: Patients: Three patients who underwent surgical resection of vestibular schwannoma ...

Abstract	Objective: To investigate the utility of the so-called "second window" of indocyanine green (ICG) as a near-infrared fluorescent dye for intraoperative visualization. Patients: Three patients who underwent surgical resection of vestibular schwannoma (two retrosigmoid and one middle fossa approach). Interventions: Patients underwent intravenous infusion of ICG at a mean dose of 4.8 mg/kg at a mean of 15.3 hours before surgical incision. Once tumor dissection began, near-infrared fluorescence was used alongside conventional operative microscopy to visualize tumor tissue. Main outcome measures: Ability to distinguish tumor tissue from adjacent nerves. Results: Intraoperative fluorescence allowed for enhanced visualization of the tumor-nerve plane in all patients. However, the effect varied among patients, and the effect faded with increasing surgical time. Conclusions: ICG, a well-tolerated cyanine dye, demonstrates late fluorescence hours after administration secondary to diffusion into tumor as well as normal tissues (the so-called "second window" of fluorescence). Its fluorescence in the near-infrared spectrum is a promising adjunct for enhancing visualization of tumor planes during vestibular schwannoma surgery.
MeSH term(s)	Fluorescent Dyes ; Humans ; Indocyanine Green ; Neuroma, Acoustic/diagnostic imaging ; Neuroma, Acoustic/surgery ; Optical Imaging
Chemical Substances	Fluorescent Dyes ; Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2021-11-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2036790-9
ISSN	1537-4505 ; 1531-7129
ISSN (online)	1537-4505
ISSN	1531-7129
DOI	10.1097/MAO.0000000000003400
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Zs.A 1554: Show issues

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Article ; Online: The endaural subtemporal keyhole: a novel minimally invasive approach to the middle cranial fossa.

Olszewski, Adam M / Hattar, Ellina / Curry, Steven D / Peng, Kevin A / Lekovic, Gregory P

Journal of neurosurgery

2024 , Page(s) 1–8

Abstract: Objective: The goal of this study was to evaluate the feasibility of a minimally invasive approach to the middle cranial fossa using a novel endaural keyhole.: Methods: The charts of all patients who underwent this novel minimally invasive approach ... ...

Abstract	Objective: The goal of this study was to evaluate the feasibility of a minimally invasive approach to the middle cranial fossa using a novel endaural keyhole. Methods: The charts of all patients who underwent this novel minimally invasive approach to the middle cranial fossa were retrospectively reviewed. In addition, cadaveric dissection was performed to demonstrate the feasibility of the endaural keyhole to the middle cranial fossa. Results: Six patients (5 female and 1 male; age range 47-77 years) who underwent craniotomy for CSF leak (n = 3), intracerebral hematoma evacuation (n = 2), and tumor resection (n = 1) via the endaural subtemporal approach were identified. There were no approach-related complications noted. Representative imaging from cadaveric dissection is provided with a stepwise discussion of the procedure. Conclusions: The endaural subtemporal keyhole craniotomy provides a novel approach to middle fossa skull base pathology, as well as a minimally invasive approach to intra-axial pathology of the temporal lobe and basal ganglia. Further research is needed to establish the limitations and potential complications of this novel approach.
Language	English
Publishing date	2024-05-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	3089-2
ISSN	1933-0693 ; 0022-3085
ISSN (online)	1933-0693
ISSN	0022-3085
DOI	10.3171/2024.2.JNS232068
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Article ; Online: A teenager with auricular infection secondary to piercing.

Cheng, Xiaoting / Peng, Kevin A / Chen, Bing / Shu, Yilai

BMJ (Clinical research ed.)

2023 Volume 380, Page(s) e071715

MeSH term(s)	Humans ; Adolescent ; Ear Cartilage ; Pseudomonas Infections ; Cosmetic Techniques
Language	English
Publishing date	2023-03-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj-2022-071715
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Article ; Conference proceedings: Endaural Subtemporal Approach for Middle Fossa Encephalocele and CSF Leak Repair

Peng, Kevin A. / Olszewski, Adam / Bigelow, Robin / Lekovic, Gregory P.

Journal of Neurological Surgery Part B: Skull Base

2023 Volume 84, Issue S 01

Event/congress	32nd Annual Meeting North American Skull Base Society, JW Marriott Tampa Water Street, Tampa, Florida, United States, 2023-02-17
Language	English
Publishing date	2023-02-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2654269-9
ISSN	2193-634X ; 2193-6331
ISSN (online)	2193-634X
ISSN	2193-6331
DOI	10.1055/s-0043-1762320
Database	Thieme publisher's database

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Zs.A 3425: Show issues

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Article ; Conference proceedings: Combined Condylar Approach for Skull Base Chondrosarcoma Centered at the Jugular Foramen with Extension into the Neck: Two Illustrative Cases

Olsewski, Adam M. / Avillion, Michael / Lekovic, Gregory P. / Peng, Kevin A.

Journal of Neurological Surgery Part B: Skull Base

2023 Volume 84, Issue S 01

Event/congress	32nd Annual Meeting North American Skull Base Society, JW Marriott Tampa Water Street, Tampa, Florida, United States, 2023-02-17
Language	English
Publishing date	2023-02-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2654269-9
ISSN	2193-634X ; 2193-6331
ISSN (online)	2193-634X
ISSN	2193-6331
DOI	10.1055/s-0043-1762256
Database	Thieme publisher's database

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Article ; Online: Schwartze sign.

Peng, Kevin A / House, John W

Ear, nose, & throat journal

2018 Volume 97, Issue 3, Page(s) 54

MeSH term(s)	Adult ; Hearing Loss/etiology ; Humans ; Male ; Otosclerosis/complications ; Otosclerosis/diagnostic imaging ; Otoscopy ; Tomography, X-Ray Computed
Language	English
Publishing date	2018-03-19
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	750153-5
ISSN	1942-7522 ; 0145-5613
ISSN (online)	1942-7522
ISSN	0145-5613
DOI	10.1177/014556131809700315
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Article ; Online: Identification of Perinatal Risk Factors for Auditory Neuropathy Spectrum Disorder.

West, Alisha N / Kuan, Edward C / Peng, Kevin A

The Laryngoscope

2020 Volume 131, Issue 3, Page(s) 671–674

Abstract: Objectives/hypothesis: To identify medical risk factors associated with auditory neuropathy spectrum disorder (ANSD).: Study design: Retrospective case-control study.: Methods: During a 2-year period (2013-2014) patients with newly diagnosed ANSD ... ...

Abstract	Objectives/hypothesis: To identify medical risk factors associated with auditory neuropathy spectrum disorder (ANSD). Study design: Retrospective case-control study. Methods: During a 2-year period (2013-2014) patients with newly diagnosed ANSD were identified at a tertiary care facility. Twenty-two patients (n = 22) were identified aged 0.5 to 8.1 years. There were 15 males and seven females. Sixteen had bilateral, four had left-sided, and two had right-sided ANSD. Two age-matched, side-matched, and gender-matched control groups were then collected. The first group was 22 normal-hearing children (n = 22). The second was 22 children with sensorineural hearing loss (SNHL) (n = 22) who did not meet the criteria for ANSD. The chart of each subject was reviewed for the following five-predictor variables: prematurity, low birth weight, jaundice, use of mechanical ventilation, and administration of ototoxic medications. Analysis of variance was performed to analyze the prevalence of perinatal risk factors among the three groups. Multivariate linear regression was then applied. Results: When comparing the ANSD group to both the normal-hearing and SNHL groups, the subjects with ANSD had statistically significant higher rates of prematurity, low birth weight, jaundice, and mechanical ventilation. Multiple regression analysis was performed to identify predictors of ANSD compared to each control group individually. Jaundice in the first month of life approached significance when comparing the ANSD group to the normal-hearing group, and was the only medical risk factor found to be statistically significant when comparing the ANSD group to the SNHL group. Conclusions: A history of neonatal hyperbilirubinemia was significantly more common in children with ANSD compared to children with severe SNHL. Level of evidence: 3 Laryngoscope, 131:671-674, 2021.
MeSH term(s)	Case-Control Studies ; Child ; Child, Preschool ; Female ; Hearing Loss, Central/etiology ; Hearing Loss, Sensorineural/complications ; Humans ; Hyperbilirubinemia/complications ; Infant ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Premature ; Jaundice, Neonatal/complications ; Linear Models ; Male ; Ototoxicity/complications ; Respiration, Artificial/adverse effects ; Retrospective Studies ; Risk Assessment ; Risk Factors
Language	English
Publishing date	2020-07-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.28904
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Article ; Online: Clinical characteristics in unilateral cochlear nerve canal stenosis.

Liang, Wenqi / Wang, Line / Wang, Zhenxiao / Zhao, Pengfei / Wang, Qimei / Peng, Kevin A

Ear, nose, & throat journal

2022 , Page(s) 1455613221082625

Abstract: Objective: To characterize the clinical features of patients with congenital hearing loss and unilateral cochlear nerve canal stenosis (CNCS).: Methods: A retrospective review of 12 patients with unilateral CNCS diagnosed between January 2018 and ... ...

Abstract	Objective: To characterize the clinical features of patients with congenital hearing loss and unilateral cochlear nerve canal stenosis (CNCS). Methods: A retrospective review of 12 patients with unilateral CNCS diagnosed between January 2018 and December 2019 at a tertiary referral hospital was performed. Results: Of the 12 patients identified, there were 6 males and 6 females. All patients presented with hearing loss, with no other chief complaints. Two patients had accessory auricles. Eleven patients had a severe to profound sensorineural hearing loss on the affected side, while 1 patient had an isolated high-frequency hearing loss. Nine patients demonstrated atresia of the cochlear nerve canal (CNC), while three patients had a stenotic, but patent, CNC. Conclusion: Prompt radiologic diagnosis of patients with unilateral CNCS is important for patient counseling and appropriate rehabilitation.
Language	English
Publishing date	2022-06-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	750153-5
ISSN	1942-7522 ; 0145-5613
ISSN (online)	1942-7522
ISSN	0145-5613
DOI	10.1177/01455613221082625
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