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Article ; Online: Ferroptosis-mediated immune responses in cancer.

Qi, Desheng / Peng, Milin

2023 Volume 14, Page(s) 1188365

Abstract: Cell death is a universal biological process in almost every physiological and pathological condition, including development, degeneration, inflammation, and cancer. In addition to apoptosis, increasing numbers of cell death types have been discovered in ...

Abstract	Cell death is a universal biological process in almost every physiological and pathological condition, including development, degeneration, inflammation, and cancer. In addition to apoptosis, increasing numbers of cell death types have been discovered in recent years. The biological significance of cell death has long been a subject of interest and exploration and meaningful discoveries continue to be made. Ferroptosis is a newfound form of programmed cell death and has been implicated intensively in various pathological conditions and cancer therapy. A few studies show that ferroptosis has the direct capacity to kill cancer cells and has a potential antitumor effect. As the rising role of immune cells function in the tumor microenvironment (TME), ferroptosis may have additional impact on the immune cells, though this remains unclear. In this study we focus on the ferroptosis molecular network and the ferroptosis-mediated immune response, mainly in the TME, and put forward novel insights and directions for cancer research in the near future.
MeSH term(s)	Humans ; Ferroptosis ; Apoptosis ; Neoplasms ; Cell Death ; Inflammation ; Tumor Microenvironment
Language	English
Publishing date	2023-05-30
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1188365
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The mode and timing of administrating nutritional treatment of critically ill elderly patients in intensive care units: a multicenter prospective study.

Chen, Wei / Peng, Milin / Ye, Zhiwen / Ai, Yuhang / Liu, Zhiyong

Frontiers in medicine

2024 Volume 11, Page(s) 1321599

Abstract: Introduction: Critically ill patients are more susceptible to malnutrition due to their severe illness. Moreover, elderly patients who are critically ill lack specific nutrition recommendations, with nutritional care in the intensive care units (ICUs) ... ...

Abstract	Introduction: Critically ill patients are more susceptible to malnutrition due to their severe illness. Moreover, elderly patients who are critically ill lack specific nutrition recommendations, with nutritional care in the intensive care units (ICUs) deplorable for the elderly. This study aims to investigate nutrition treatment and its correlation to mortality in elderly patients who are critically ill in intensive care units. Method: A multiple-center prospective cohort study was conducted in China from 128 intensive care units (ICUs). A total of 1,238 elderly patients were included in the study from 26 April 2017. We analyzed the nutrition characteristics of elderly patients who are critically ill, including initiated timing, route, ways of enteral nutrition (EN), and feeding complications, including the adverse aspects of feeding, acute gastrointestinal injury (AGI), and feeding interruption. Multivariate logistic regression analysis was used to screen out the impact of nutrition treatment on a 28-day survival prognosis of elderly patients in the ICU. Result: A total of 1,238 patients with a median age of 76 (IQR 70-83) were enrolled in the study. The Sequential Organ Failure (SOFA) median score was 7 (interquartile range: IQR 5-10) and the median Acute Physiology and Chronic Health Evaluation (APACHE) II was 21 (IQR 16-25). The all-cause mortality score was 11.6%. The percentage of nutritional treatment initiated 24 h after ICU admission was 58%, with an EN of 34.2% and a parenteral nutrition (PN) of 16.0% in elderly patients who are critically ill. Patients who had gastrointestinal dysfunction with AGI stage from 2 to 4 were 25.2%. Compared to the survivors' group, the non-survivors group had a lower ratio of EN delivery (57% vs. 71%; Conclusion: This multi-center prospective study describes clinical characteristics, the mode and timing of nutrition treatment, frequency of AGI, and adverse effects of nutrition in elderly ICU patients. According to this survey, ICU patients with early PN delivery, older age, faster respiratory rate, and higher lactate level may experience poor prognosis.
Language	English
Publishing date	2024-02-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2024.1321599
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Article ; Online: Development of a nomogram model for the early prediction of sepsis-associated acute kidney injury in critically ill patients.

Peng, Milin / Deng, Fuxing / Qi, Desheng

Scientific reports

2023 Volume 13, Issue 1, Page(s) 15200

Abstract: Sepsis-associated acute kidney injury is a common complication of sepsis, but it is difficult to predict sepsis-associated acute kidney injury. In this retrospective observational study, adult septic patients were recruited from the MIMIC-III database as ...

Abstract	Sepsis-associated acute kidney injury is a common complication of sepsis, but it is difficult to predict sepsis-associated acute kidney injury. In this retrospective observational study, adult septic patients were recruited from the MIMIC-III database as the training cohort (n = 4764) and from Xiangya Hospital (n = 1568) and Zhang's database as validation cohorts. We identified eleven predictors with seven independent risk predictors of sepsis-associated acute kidney injury [fluid input_day1 ≥ 3390 ml (HR hazard ratio 1.42), fluid input_day2 ≥ 2734 ml (HR 1.64), platelet_min_day5 ≤ 224.2 × 10
MeSH term(s)	Adult ; Humans ; Critical Illness ; Nomograms ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology ; Sepsis/complications ; Blood Platelets
Language	English
Publishing date	2023-09-14
Publishing country	England
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-41965-x
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Article ; Online: Early Hemoglobin Status as a Predictor of Long-Term Mortality for Sepsis Patients in Intensive Care Units.

Qi, Desheng / Peng, Milin

Shock (Augusta, Ga.)

2021 Volume 55, Issue 2, Page(s) 215–223

Abstract: Objectives: It is still not clear what influences hemoglobin has on the outcomes of patients with sepsis. The intention of this research is to investigate the impact of early hemoglobin levels on clinical outcomes for sepsis.: Methods: In this single- ...

Abstract	Objectives: It is still not clear what influences hemoglobin has on the outcomes of patients with sepsis. The intention of this research is to investigate the impact of early hemoglobin levels on clinical outcomes for sepsis. Methods: In this single-center, cohort study, each patient was put into one of four groups dependent on hemoglobin levels of 70 g/L, 80 g/L, or 90 g/L in the first 48 h of being admitted to intensive care unit (ICU). Adjustments for baseline/confounding factors were made using the multiple Cox regression model. Results: In all, 235 septic patients were examined in this research. The non-survivors exhibited significantly higher levels for early hemoglobin status at or below 80 g/L (33.7% vs. 19.4%, P = 0.016) than survivors. Survival curve demonstrated that septic patients with early hemoglobin levels at or below 80 g/L survived at significantly lower rates than those with hemoglobin above 80 g/L. Multivariate Cox analysis demonstrated that levels of 1-year mortality rose as early hemoglobin levels fell in the first 48 h after ICU admission, with relative risks for 80 g/L to 90 g/L, 70 g/L to 80 g/L, and at or below 70 g/L being respectively 1.11 (95% CI: 0.654-1.882), 1.742 (95% CI: 0.969-3.133), 1.981 (95% CI: 1.124-3.492) times higher than those for hemoglobin levels above 90 g/L. Conclusions: Hemoglobin levels at or below 80 g/L in the first 48 h after ICU admission are an alternative indicator for predicting long-term mortality of sepsis. Awareness should be encouraged of the importance of targeting early hemoglobin levels when treating sepsis to improve prognosis.
MeSH term(s)	Adult ; Aged ; Cohort Studies ; Female ; Hemoglobins/analysis ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Sepsis/blood ; Sepsis/mortality ; Time Factors
Chemical Substances	Hemoglobins
Language	English
Publishing date	2021-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1185432-7
ISSN	1540-0514 ; 1073-2322
ISSN (online)	1540-0514
ISSN	1073-2322
DOI	10.1097/SHK.0000000000001612
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Article ; Online: HCV非结构蛋白5A对HIV长末端重复序列影响的初步探讨

PENG Milin

Journal of Clinical Hepatology, Vol 30, Iss 2, Pp 136-

2014 Volume 140

Abstract: ObjectiveTo investigate the effect of nonstructural protein 5A (NS5A) encoded by the human hepatitis C virus (HCV) RNA genome on human immunodeficiency virus (HIV) long terminal repeat (LTR) and to provide an experimental basis for the study on the ... ...

Abstract	ObjectiveTo investigate the effect of nonstructural protein 5A (NS5A) encoded by the human hepatitis C virus (HCV) RNA genome on human immunodeficiency virus (HIV) long terminal repeat (LTR) and to provide an experimental basis for the study on the effect of HCV on HIV. MethodsHepatocellular carcinoma Huh7 cells were divided into blank group, control group, and experimental group to be transfected with plasmid pGL3-LTR-Luc (containing luciferase reporter gene driven by the LTR promoter), plasmid pRc/CMV plus plasmid pGL3-LTR-Luc, and plasmid pCNS5A (containing HCV NS5A gene) plus plasmid pGL3-LTR-Luc, respectively; Huh7 cells were collected 48 h later. The protein and mRNA expression levels of HCV NS5A were measured by immunocytochemistry, Western blot, and RT-PCR. The relative luciferase activity was measured to evaluate the HIV LTR activity and the effect of HCV NS5A on HIV LTR. The activity values were expressed as mean±SD, and Levene′s test of homogeneity of variance was used; comparison between all groups was made by one-way analysis of variance (ANOVA), and comparison between two groups was made by least significant difference (LSD) test. ResultsThe mRNA and protein expression of HCV NS5A was detected in the cytoplasm of Huh7 cells in experimental group. The one-way ANOVA showed that there were significant differences in LTR luciferase activity between the three groups (F=7.876, P=0002). The LSD test showed that the experimental group had a significantly higher relative luciferase activity than the blank group and control group (22476±4471 vs 15887±3039, P=0.002; 22476±4471 vs 16321±4162, P=0.008). ConclusionHuh7 cells can be transfected with the HCV NS5A expression plasmid (pCNS5A). HCV NS5A can activate HIV LTR, which suggests that HCV NS5A may be one of the molecular mechanisms of HCV promoting HIV replication.
Keywords	hepacivirus; HIV; viral nonstructural proteins; HIV long terminal repeat ; Medicine (General) ; R5-920 ; Medicine ; R
Subject code	570
Language	Chinese
Publishing date	2014-02-01T00:00:00Z
Document type	Article ; Online
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Article: [Clinical analysis of sepsis with extensively drug resistant Gram-negative bacteria in intensive care unit treated with polymyxin B-based combination therapy].

Zhao, Shuangping / Yan, Liting / Wang, Chixiang / Peng, Milin

Zhonghua wei zhong bing ji jiu yi xue

2020 Volume 32, Issue 2, Page(s) 150–154

Abstract: Objective: To investigate the clinical efficacy and safety of polymyxin B in the treatment of sepsis caused by extensively-drug resistant (XDR) Gram-negative bacteria.: Methods: A retrospective analysis of 39 septic patients with XDR Gram-negative ... ...

Abstract	Objective: To investigate the clinical efficacy and safety of polymyxin B in the treatment of sepsis caused by extensively-drug resistant (XDR) Gram-negative bacteria. Methods: A retrospective analysis of 39 septic patients with XDR Gram-negative bacterial infection treated with polymyxin B in the department of critical care medicine of Xiangya Hospital of Central South University from June 2018 to September 2019 were enrolled. The clinical characteristics, bacterial culture, the sensitivity antibacterial drugs, types and courses of antibiotics, biochemical indexes, and acute physiology and chronic health evaluation II (APACHE II) before and after polymyxin B treatment were collected, to assess microbial clearance and efficacy, drug related adverse effects, and 28-day mortality in septic patients with XDR. Results: Of the 39 septic patients with XDR, 32 (82.1%) were male, with the mean age of (53.6±12.6) years old. The main infection site was pulmonary infection (51.2%), and the treatment courses of polymyxin B were ≥ 5 days. A total of 66 pathogenic bacteria were detected from 39 patients. Among them, with the high estrate of detecting Acinetobacter baumannii of 51.5% (34/66). After treatment with polymyxin B, the results showed that the clearance rate of microorganisms was 65.2% (43/66), the overall effective rate was 59.0% (23/39), and the 28-day all-cause mortality was 41.0% (16/39). There were no significant differences in clinical efficacy and microbial clearance among patients with different treatment groups of polymyxin B [< 10 days, 10-15 days, and > 15 days groups: effective rates were 56.5% (13/23), 54.5% (6/11), 80.0% (4/5), χ Conclusions: Polymyxin B can be used as an effective treatment option for patients with severe infection of XDR Gram-negative bacteria.
MeSH term(s)	Adult ; Aged ; Anti-Bacterial Agents ; Drug Contamination ; Female ; Gram-Negative Bacteria ; Humans ; Intensive Care Units ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Polymyxin B/therapeutic use ; Retrospective Studies ; Sepsis
Chemical Substances	Anti-Bacterial Agents ; Polymyxin B (J2VZ07J96K)
Language	Chinese
Publishing date	2020-04-10
Publishing country	China
Document type	Journal Article
ISSN	2095-4352
ISSN	2095-4352
DOI	10.3760/cma.j.cn121430-20200108-00028
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Article: Care for Critical Ill Patients With COVID-19: Establishment of a Temporary Intensive Care Unit in an Isolated Hospital.

Peng, Milin / Qian, Zhaoxin / Zhang, Lina

Frontiers in medicine

2020 Volume 7, Page(s) 519

Abstract: The current global spread of COVID-19, a highly contagious disease, has challenged healthcare systems, and placed immense burdens on medical staff globally. With a sharp increase in the number of newly confirmed cases and the rapid progression of the ... ...

Abstract	The current global spread of COVID-19, a highly contagious disease, has challenged healthcare systems, and placed immense burdens on medical staff globally. With a sharp increase in the number of newly confirmed cases and the rapid progression of the disease into a critically ill state, overstretched critical care units have had to contend with a shortage of beds, specialist personnel, and medical resources. Temporary intensive care units (ICUs) were therefore set up in isolated hospitals to provide the required standardized care for all severe cases. The current paper describes the authors' experience of setting up and managing such an ICU in Wuhan, Hubei Province, China, from the identification of critically ill COVID-19 patients through to the arranging and equipping of the unit, providing training and protection for staff, and standardizing all aspects of care.
Keywords	covid19
Language	English
Publishing date	2020-08-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2020.00519
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Article: The Hyperbilirubinemia and Potential Predictors Influence on Long-Term Outcomes in Sepsis: A Population-Based Propensity Score-Matched Study.

Peng, Milin / Deng, Fuxing / Qi, Desheng / Hu, Zhonghua / Zhang, Lina

Frontiers in medicine

2021 Volume 8, Page(s) 713917

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2021-09-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2021.713917
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Article ; Online: Response to Comment on 'Meta-Analysis of Early Enteral Nutrition Provided Within 24 Hours of Admission on Clinical Outcomes in Acute Pancreatitis'.

Qi, Desheng / Yu, Bo / Huang, Jia / Peng, Milin

JPEN. Journal of parenteral and enteral nutrition

2018 Volume 42, Issue 7, Page(s) 1111

MeSH term(s)	Acute Disease ; Enteral Nutrition ; Hospitalization ; Humans ; Pancreatitis
Language	English
Publishing date	2018-05-30
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	800861-9
ISSN	1941-2444 ; 0148-6071
ISSN (online)	1941-2444
ISSN	0148-6071
DOI	10.1002/jpen.1182
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Article ; Online: Meta-Analysis of Early Enteral Nutrition Provided Within 24 Hours of Admission on Clinical Outcomes in Acute Pancreatitis.

Qi, Desheng / Yu, Bo / Huang, Jia / Peng, Milin

JPEN. Journal of parenteral and enteral nutrition

2018 Volume 42, Issue 7, Page(s) 1139–1147

Abstract: Background: Enteral nutrition (EN) is more beneficial than parenteral nutrition (PN) in reducing organ failure, infectious complications, and mortality of acute pancreatitis (AP), but its timing is controversial. We attempted to evaluate the safety and ... ...

Abstract	Background: Enteral nutrition (EN) is more beneficial than parenteral nutrition (PN) in reducing organ failure, infectious complications, and mortality of acute pancreatitis (AP), but its timing is controversial. We attempted to evaluate the safety and clinical outcomes of early EN within 24 hours of admission in patients with AP, especially in predicted severe or severe acute pancreatitis (SAP). Methods: We searched PubMed, EMBASE Databases, Web of Science, and the Cochrane Library for relevant articles before June 2016 using RevMan 5.2 software. Results: Eight studies containing 727 patients with AP were analyzed in the meta-analysis. Comparing early EN to late EN or total parental nutrition in AP, the odds ratios (OR) were 0.56 (95% CI 0.23 -1.34) for the risk of mortality, 0.40 (95% CI 0.20-0.79) for multiple organ failure, 0.57 (95% CI 0.23-1.42) for infectious complications, 0.45 (95% CI 0.17-1.21) for adverse events, and 0.83 (95% CI 0.59-1.18) for pancreatic-related infections. Furthermore, subgroup analysis for early EN in predicted severe or SAP showed a significant reduction in multiple organ failure (OR 0.30; 95% CI 0.09-0.96) and pancreatic-related infections (OR 0.51, 95% CI 0.29-0.88). Early EN provided no benefits for mild to moderate AP. Conclusion: Early EN within 24 hours of admission is safe and provides benefits for predicted severe or SAP, but not for mild to moderate pancreatitis.
MeSH term(s)	Acute Disease ; Adolescent ; Adult ; Enteral Nutrition/methods ; Hospitalization ; Humans ; Nutritional Status ; Pancreatitis/mortality ; Pancreatitis/therapy ; Parenteral Nutrition/methods ; Severity of Illness Index
Language	English
Publishing date	2018-01-26
Publishing country	United States
Document type	Journal Article ; Meta-Analysis
ZDB-ID	800861-9
ISSN	1941-2444 ; 0148-6071
ISSN (online)	1941-2444
ISSN	0148-6071
DOI	10.1002/jpen.1139
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