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Article ; Online: Plasma concentrations of glucagon and glucagon-like peptide-1 are reduced in dogs with aminoaciduric canine hypoaminoacidemic hepatopathy syndrome versus healthy dogs: a preliminary study.

Holm, Sarah M / Peng, Seth A / Holter, Marlena M / Cummings, Bethany P / Loftus, John P

2023 Volume 84, Issue 4

Abstract: Objective: To compare plasma concentrations of glucagon and glucagon-like peptide-1 (GLP-1) between healthy dogs and dogs with aminoaciduric canine hypoaminoacidemic hepatopathy syndrome (ACHES) dogs.: Animals: Privately owned healthy (n = 5) control ...

Abstract	Objective: To compare plasma concentrations of glucagon and glucagon-like peptide-1 (GLP-1) between healthy dogs and dogs with aminoaciduric canine hypoaminoacidemic hepatopathy syndrome (ACHES) dogs. Animals: Privately owned healthy (n = 5) control (CON) and ACHES (8; including 3 with diabetes mellitus) dogs enrolled between October 2, 2019, and March 4, 2020. Procedures: This was a prospective case-control study. Fasting and 15-minute postprandial plasma glucagon total GLP-1 concentrations were measured with commercial immunoassays. Results: Dogs with ACHES had lower fasting (median, 0.5; mean difference, 3.8; 95% CI, 0.52 to 7.0 pmol/L; P = .021) and postprandial (median, 0.35; mean difference, 5.0; 95% CI, 1.8 to 8.3 pmol/L; P = .002) plasma glucagon concentrations than CON (fasting and postprandial medians, 3.5 and 4.6 pmol/L, respectively). ACHES dogs had significantly (median, 4.15; mean difference, 12.65; 95% CI, 2.0 to 16.3 pg/ml; P = .011) lower postprandial plasma GLP-1 concentrations than CON (median, 16.8 pg/ml). There was no significant difference between fasting GLP-1 levels between the 2 groups. Clinical relevance: Lower postprandial plasma GLP-1 concentrations may contribute to the propensity of diabetes mellitus in ACHES. Lower glucagon concentrations may reflect an appropriate physiologic response to hypoaminoacidemia.
MeSH term(s)	Dogs ; Animals ; Glucagon ; Glucagon-Like Peptide 1 ; Insulin ; Case-Control Studies ; Fasting ; Syndrome ; Blood Glucose ; Peptide Fragments ; Postprandial Period/physiology ; Dog Diseases
Chemical Substances	Glucagon (9007-92-5) ; Glucagon-Like Peptide 1 (89750-14-1) ; Insulin ; Blood Glucose ; Peptide Fragments
Language	English
Publishing date	2023-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	390796-x
ISSN	1943-5681 ; 0002-9645
ISSN (online)	1943-5681
ISSN	0002-9645
DOI	10.2460/ajvr.22.10.0174
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Article ; Online: Basophil responses in susceptible AKR mice upon infection with the intestinal helminth parasite Trichuris muris.

Smita, Shuchi / Webb, Lauren M / Mooney, Bridget / Früh, Simon P / Oyesola, Oyebola O / Matheson, Macy K / Peng, Seth A / Wojno, Elia D Tait

Parasite immunology

2023 Volume 45, Issue 8, Page(s) e12999

Abstract: Intestinal helminth infection promotes a Type 2 inflammatory response in resistant C57BL/6 mice that is essential for worm clearance. The study of inbred mouse strains has revealed factors that are critical for parasite resistance and delineated the role ...

Abstract	Intestinal helminth infection promotes a Type 2 inflammatory response in resistant C57BL/6 mice that is essential for worm clearance. The study of inbred mouse strains has revealed factors that are critical for parasite resistance and delineated the role of Type 1 versus Type 2 immune responses in worm clearance. In C57BL/6 mice, basophils are key innate immune cells that promote Type 2 inflammation and are programmed via the Notch signalling pathway during infection with the helminth Trichuris muris. However, how the host genetic background influences basophil responses and basophil expression of Notch receptors remains unclear. Here we use genetically susceptible inbred AKR/J mice that have a Type 1-skewed immune response during T. muris infection to investigate basophil responses in a susceptible host. Basophil population expansion occurred in AKR/J mice even in the absence of fulminant Type 2 inflammation during T. muris infection. However, basophils in AKR/J mice did not robustly upregulate expression of the Notch2 receptor in response to infection as occurred in C57BL/6 mice. Blockade of the Type 1 cytokine interferon-γ in infected AKR/J mice was not sufficient to elicit infection-induced basophil expression of the Notch2 receptor. These data suggest that the host genetic background, outside of the Type 1 skew, is important in regulating basophil responses during T. muris infection in susceptible AKR/J mice.
MeSH term(s)	Animals ; Mice ; Mice, Inbred AKR ; Trichuris ; Basophils ; Parasites ; Receptor, Notch2 ; Trichuriasis ; Mice, Inbred C57BL ; Disease Susceptibility ; Inflammation
Chemical Substances	Receptor, Notch2
Language	English
Publishing date	2023-07-06
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	424444-8
ISSN	1365-3024 ; 0141-9838
ISSN (online)	1365-3024
ISSN	0141-9838
DOI	10.1111/pim.12999
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Article: Serum Vitamin D Metabolites and CXCL10 Concentrations Associate With Survival in Dogs With Immune Mediated Disease.

Mick, Phillip J / Peng, Seth A / Loftus, John P

Frontiers in veterinary science

2019 Volume 6, Page(s) 247

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2019-07-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2019.00247
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Article ; Online: The gene regulatory basis of bystander activation in CD8

Science immunology

2024 Volume 9, Issue 92, Page(s) eadf8776

Abstract: ... ...

Abstract	CD8
MeSH term(s)	Humans ; Adult ; Mice ; Animals ; CD8-Positive T-Lymphocytes ; Immunity, Innate ; Cytokines ; T-Lymphocyte Subsets ; Antigens
Chemical Substances	Cytokines ; Antigens
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Journal Article
ISSN	2470-9468
ISSN (online)	2470-9468
DOI	10.1126/sciimmunol.adf8776
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Article ; Online: The Prostaglandin D

Oyesola, Oyebola O / Duque, Carolina / Huang, Linda C / Larson, Elisabeth M / Früh, Simon P / Webb, Lauren M / Peng, Seth A / Tait Wojno, Elia D

Journal of immunology (Baltimore, Md. : 1950)

2020 Volume 204, Issue 4, Page(s) 1001–1011

Abstract: Group 2 innate lymphoid cells (ILC2s) are rare innate immune cells that accumulate in tissues during allergy and helminth infection, performing critical effector functions that drive type 2 inflammation. ILC2s express ST2, the receptor for the cytokine ... ...

Abstract	Group 2 innate lymphoid cells (ILC2s) are rare innate immune cells that accumulate in tissues during allergy and helminth infection, performing critical effector functions that drive type 2 inflammation. ILC2s express ST2, the receptor for the cytokine IL-33, and chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2), a receptor for the bioactive lipid prostaglandin D
MeSH term(s)	Adoptive Transfer ; Animals ; Cell Movement/immunology ; Cell Proliferation ; Cells, Cultured ; Disease Models, Animal ; Female ; Humans ; Hypersensitivity/immunology ; Hypersensitivity/pathology ; Immunity, Innate ; Interleukin-33/administration & dosage ; Interleukin-33/immunology ; Lung/cytology ; Lung/immunology ; Lung/pathology ; Lymphocytes/immunology ; Lymphocytes/metabolism ; Mice ; Mice, Knockout ; Nippostrongylus/immunology ; Primary Cell Culture ; Prostaglandin D2/immunology ; Prostaglandin D2/metabolism ; Receptors, Immunologic/genetics ; Receptors, Immunologic/immunology ; Receptors, Immunologic/metabolism ; Receptors, Prostaglandin/genetics ; Receptors, Prostaglandin/immunology ; Receptors, Prostaglandin/metabolism ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/immunology ; Strongylida Infections/immunology ; Strongylida Infections/parasitology ; Strongylida Infections/pathology
Chemical Substances	Il33 protein, mouse ; Interleukin-33 ; Receptors, Immunologic ; Receptors, Prostaglandin ; Recombinant Proteins ; Prostaglandin D2 (RXY07S6CZ2) ; prostaglandin D2 receptor (XZF106QU24)
Language	English
Publishing date	2020-01-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1900745
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Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Elevated circulating Th2 but not group 2 innate lymphoid cell responses characterize canine atopic dermatitis.

Früh, Simon P / Saikia, Mridusmita / Eule, Jeremy / Mazulis, Christina A / Miller, Julia E / Cowulich, Joby M / Oyesola, Oyebola O / Webb, Lauren M / Peng, Seth A / Cubitt, Rebecca L / Danko, Charles G / Miller, William H / Tait Wojno, Elia D

Veterinary immunology and immunopathology

2020 Volume 221, Page(s) 110015

Abstract: Atopic dermatitis (AD) is an allergic skin disease that causes significant morbidity and affects multiple species. AD is highly prevalent in companion dogs, and the clinical management of the disease remains challenging. An improved understanding of the ... ...

Abstract	Atopic dermatitis (AD) is an allergic skin disease that causes significant morbidity and affects multiple species. AD is highly prevalent in companion dogs, and the clinical management of the disease remains challenging. An improved understanding of the immunologic and genetic pathways that lead to disease could inform the development of novel treatments. In allergic humans and mouse models of AD, the disease is associated with Th2 and group 2 innate lymphoid cell (ILC2) activation that drives type 2 inflammation. Type 2 inflammation also appears to be associated with AD in dogs, but gaps remain in our understanding of how key type 2-associated cell types such as canine Th2 cells and ILC2s contribute to the pathogenesis of canine AD. Here, we describe previously uncharacterized canine ILC2-like cells and Th2 cells ex vivo that produced type 2 cytokines and expressed the transcription factor Gata3. Increased circulating Th2 cells were associated with chronic canine AD. Single-cell RNA sequencing revealed a unique gene expression signature in T cells in dogs with AD. These findings underline the importance of pro-allergic Th2 cells in orchestrating AD and provide new methods and pathways that can inform the development of improved therapies.
MeSH term(s)	Animals ; Blood Cells/immunology ; Dermatitis, Atopic/immunology ; Dermatitis, Atopic/veterinary ; Dog Diseases/immunology ; Dogs ; Female ; Immunity, Innate ; Inflammation ; Lymphocytes/classification ; Lymphocytes/immunology ; Male ; Sequence Analysis, RNA ; Single-Cell Analysis ; Th2 Cells/immunology
Language	English
Publishing date	2020-01-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	754160-0
ISSN	1873-2534 ; 0165-2427
ISSN (online)	1873-2534
ISSN	0165-2427
DOI	10.1016/j.vetimm.2020.110015
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Zs.A 2177: Show issues

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Article ; Online: Developmental Origin Governs CD8

Smith, Norah L / Patel, Ravi K / Reynaldi, Arnold / Grenier, Jennifer K / Wang, Jocelyn / Watson, Neva B / Nzingha, Kito / Yee Mon, Kristel J / Peng, Seth A / Grimson, Andrew / Davenport, Miles P / Rudd, Brian D

Cell

2018 Volume 174, Issue 1, Page(s) 117–130.e14

Abstract: Heterogeneity is a hallmark feature of the adaptive immune system in vertebrates. Following infection, naive T cells differentiate into various subsets of effector and memory T cells, which help to eliminate pathogens and maintain long-term immunity. The ...

Abstract	Heterogeneity is a hallmark feature of the adaptive immune system in vertebrates. Following infection, naive T cells differentiate into various subsets of effector and memory T cells, which help to eliminate pathogens and maintain long-term immunity. The current model suggests there is a single lineage of naive T cells that give rise to different populations of effector and memory T cells depending on the type and amounts of stimulation they encounter during infection. Here, we have discovered that multiple sub-populations of cells exist in the naive CD8
MeSH term(s)	Animals ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Cell Differentiation ; Cell Line, Tumor ; Chromatin/metabolism ; Cytokines/pharmacology ; Epitopes, T-Lymphocyte/genetics ; Epitopes, T-Lymphocyte/metabolism ; Genes, Developmental ; Immunologic Memory ; Interferon-gamma/metabolism ; Killer Cells, Natural/cytology ; Killer Cells, Natural/metabolism ; Listeria monocytogenes/metabolism ; Listeria monocytogenes/pathogenicity ; Mice ; Mice, Inbred C57BL ; Principal Component Analysis ; T-Lymphocyte Subsets/cytology ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Thymus Gland/transplantation ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcriptome
Chemical Substances	Chromatin ; Cytokines ; Epitopes, T-Lymphocyte ; Transcription Factors ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2018-06-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2018.05.029
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Zs.A 1167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The Notch signaling pathway promotes basophil responses during helminth-induced type 2 inflammation.

Webb, Lauren M / Oyesola, Oyebola O / Früh, Simon P / Kamynina, Elena / Still, Katherine M / Patel, Ravi K / Peng, Seth A / Cubitt, Rebecca L / Grimson, Andrew / Grenier, Jennifer K / Harris, Tajie H / Danko, Charles G / Tait Wojno, Elia D

The Journal of experimental medicine

2019 Volume 216, Issue 6, Page(s) 1268–1279

Abstract: Type 2 inflammation drives the clearance of gastrointestinal helminth parasites, which infect over two billion people worldwide. Basophils are innate immune cells that support host-protective type 2 inflammation during murine infection with the ... ...

Abstract	Type 2 inflammation drives the clearance of gastrointestinal helminth parasites, which infect over two billion people worldwide. Basophils are innate immune cells that support host-protective type 2 inflammation during murine infection with the helminth
MeSH term(s)	Animals ; Basophils/immunology ; Cecum/parasitology ; Female ; Gene Expression Regulation ; Inflammation/complications ; Inflammation/pathology ; Interleukins/metabolism ; Male ; Mice, Inbred C57BL ; Receptors, Notch/metabolism ; Signal Transduction ; Trichuris/physiology ; Up-Regulation
Chemical Substances	Interleukins ; Receptors, Notch
Language	English
Publishing date	2019-04-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.20180131
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Article ; Online: PGD2 and CRTH2 counteract Type 2 cytokine-elicited intestinal epithelial responses during helminth infection.

Oyesola, Oyebola O / Shanahan, Michael T / Kanke, Matt / Mooney, Bridget M / Webb, Lauren M / Smita, Shuchi / Matheson, Macy K / Campioli, Pamela / Pham, Duc / Früh, Simon P / McGinty, John W / Churchill, Madeline J / Cahoon, Jordan L / Sundaravaradan, Pavithra / Flitter, Becca A / Mouli, Karthik / Nadjsombati, Marija S / Kamynina, Elena / Peng, Seth A /

Cubitt, Rebecca L / Gronert, Karsten / Lord, James D / Rauch, Isabella / von Moltke, Jakob / Sethupathy, Praveen / Tait Wojno, Elia D

The Journal of experimental medicine

2021 Volume 218, Issue 9

Abstract: Type 2 inflammation is associated with epithelial cell responses, including goblet cell hyperplasia, that promote worm expulsion during intestinal helminth infection. How these epithelial responses are regulated remains incompletely understood. Here, we ... ...

Abstract	Type 2 inflammation is associated with epithelial cell responses, including goblet cell hyperplasia, that promote worm expulsion during intestinal helminth infection. How these epithelial responses are regulated remains incompletely understood. Here, we show that mice deficient in the prostaglandin D2 (PGD2) receptor CRTH2 and mice with CRTH2 deficiency only in nonhematopoietic cells exhibited enhanced worm clearance and intestinal goblet cell hyperplasia following infection with the helminth Nippostrongylus brasiliensis. Small intestinal stem, goblet, and tuft cells expressed CRTH2. CRTH2-deficient small intestinal organoids showed enhanced budding and terminal differentiation to the goblet cell lineage. During helminth infection or in organoids, PGD2 and CRTH2 down-regulated intestinal epithelial Il13ra1 expression and reversed Type 2 cytokine-mediated suppression of epithelial cell proliferation and promotion of goblet cell accumulation. These data show that the PGD2-CRTH2 pathway negatively regulates the Type 2 cytokine-driven epithelial program, revealing a mechanism that can temper the highly inflammatory effects of the anti-helminth response.
MeSH term(s)	Animals ; Cytokines/metabolism ; Female ; Gastroenteritis/parasitology ; Gastroenteritis/pathology ; Goblet Cells/pathology ; Host-Parasite Interactions/physiology ; Intestinal Mucosa/parasitology ; Intestinal Mucosa/pathology ; Male ; Mice, Inbred C57BL ; Nippostrongylus/pathogenicity ; Organoids ; Prostaglandin D2/metabolism ; Receptors, Immunologic/genetics ; Receptors, Immunologic/metabolism ; Receptors, Prostaglandin/genetics ; Receptors, Prostaglandin/metabolism ; Strongylida Infections/parasitology ; Strongylida Infections/pathology ; Mice
Chemical Substances	Cytokines ; Receptors, Immunologic ; Receptors, Prostaglandin ; Prostaglandin D2 (RXY07S6CZ2) ; prostaglandin D2 receptor (XZF106QU24)
Language	English
Publishing date	2021-07-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.20202178
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