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  1. Article ; Online: Association of SGLT2is with respiratory and skin diseases.

    Xiao, Yu / Peng, Shanshan / Liu, Chao

    Endocrine

    2024  

    Language English
    Publishing date 2024-02-17
    Publishing country United States
    Document type Letter
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-024-03739-x
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    Zs.A 3884: Show issues Location:
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  2. Article ; Online: A dual-functional oncolytic adenovirus ZD55-aPD-L1 scFv armed with PD-L1 inhibitor potentiates its antitumor activity.

    Mei, Shengsheng / Peng, Shanshan / Vong, Eu Gene / Zhan, Jinbiao

    International immunopharmacology

    2024  Volume 128, Page(s) 111579

    Abstract: Background: Clinical data indicate that a substantial portion of cancer patients, though eligible for immune checkpoint inhibitor (ICI) therapy, cannot fully benefit from ICI monotherapy due to the poor immunogenicity of tumors and lack of tumor- ... ...

    Abstract Background: Clinical data indicate that a substantial portion of cancer patients, though eligible for immune checkpoint inhibitor (ICI) therapy, cannot fully benefit from ICI monotherapy due to the poor immunogenicity of tumors and lack of tumor-infiltrating lymphocytes within the 'cold' tumor microenvironment (TME). In addition to poor antibody penetrance into the TME, systemic delivery of ICIs is associated with immune-related adverse events (irAEs) among recipients, some of which are life-threatening. Oncolytic virotherapy is a potentially viable approach to improving the efficacy of ICI therapy because of their ability to selectively replicate and lyse tumor cells, release tumor-associated antigens (TAAs), induce inflammatory response and promote lymphocyte infiltration in tumors.
    Methods: A recombinant oncolytic adenoviruses (OAd), denoted ZD55-aPD-L1 scFv, which carried the expression cassette for anti-PD-L1 scFv was constructed by molecular cloning. Western blot and ELISA assay were performed to detect aPD-L1 scFv expression. Flow cytometry were used to analyse PD-L1 expression and count tumor cells. Co-culture assay of human peripheral blood mononuclear cells (PBMCs) with tumor cells in vitro and triple-negative breast cancer (TNBC) MDA-MB-231 tumor-bearing model in vivo were evaluated the antitumor effects of recombinant oncolytic adenoviruses ZD55-aPD-L1 scFv.
    Results: We found that cells infected with recombinant oncolytic adenovirus ZD55-aPD-L1 scFv can effectively express aPD-L1 scFv, which function similarly to its full-length anti-PD-L1 antibody. PBMCs have inherently very limited killing effect on tumor cells even with administration of anti-PD-L1 antibody as observed from our in vitro co-cultures. Treatment consisting of ZD55 alone or ZD55 combined with anti-PD-L1 antibody yielded mediocre antitumor efficacy in subsequent in vitro and in vivo investigations, but were all substantially surpassed by the synergistic antitumor effects observed with ZD55-aPD-L1 scFv treatment. We show that the concomitant direct oncolysis by the recombinant OAd and localized autocrine/paracrine interception of PD-1:PD-L1 checkpoint interaction mediated by ZD55-aPD-L1 scFv-infected cells is exceedingly superior to co-administration of ZD55 and anti-PD-L1 antibody in the human TNBC mice model.
    Conclusions: Our results provided evidence for the development of novel strategies, in this case an anti-PD-L1 scFv-armed OAd, to bolster immune responses to 'cold' tumors and to improve therapeutic responsiveness to ICIs.
    MeSH term(s) Animals ; Mice ; Humans ; Immune Checkpoint Inhibitors ; Adenoviridae ; B7-H1 Antigen ; Leukocytes, Mononuclear ; Triple Negative Breast Neoplasms ; Cell Line, Tumor ; Tumor Microenvironment
    Chemical Substances Immune Checkpoint Inhibitors ; B7-H1 Antigen
    Language English
    Publishing date 2024-01-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2024.111579
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    Zs.A 5408: Show issues Location:
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  3. Article ; Online: Prenatal and early-life exposure to traffic-related air pollution and allergic rhinitis in children: A systematic literature review.

    Liu, Lifang / Ma, Jingxuan / Peng, Shanshan / Xie, Linshen

    PloS one

    2023  Volume 18, Issue 4, Page(s) e0284625

    Abstract: Background: Traffic-related air pollution (TRAP) is hypothesised to play a role in the development of allergic rhinitis (AR). Prenatal and early-life exposure to traffic-related air pollution is considered critical for later respiratory health. However, ...

    Abstract Background: Traffic-related air pollution (TRAP) is hypothesised to play a role in the development of allergic rhinitis (AR). Prenatal and early-life exposure to traffic-related air pollution is considered critical for later respiratory health. However, we could not find any articles systematically reviewing the risk of prenatal and early-life exposure to traffic-related air pollution for allergic rhinitis in children.
    Methods: A systematic literature search of PubMed, Web of Science and Medline was conducted to identify studies focused on the association between prenatal and early-life exposure to TRAP and AR in children. Other inclusion criteria were: 1) original articles; 2) based upon prospective or retrospective studies or case-control studies; and 3) publications were restricted to English. Literature quality assessment was processed using the Newcastle-Ottawa Scale (NOS) evaluation scale. This systematic literature review has been registered on the prospero (crd.york.ac.uk/prospero) with the following registry number: CRD42022361179.
    Results: Only eight studies met the inclusion criteria. The exposure assessment indicators included PM2.5, PM2.5 absorbance, PM10, NOx, CO, and black carbon. On the whole, exposure to TRAP during pregnancy and the first year of life were positively associated with the development of AR in children.
    Conclusions: This systematic review presents supportive evidence about prenatal and early-life exposure to TRAP and the risk of AR in children.
    MeSH term(s) Pregnancy ; Female ; Humans ; Child ; Air Pollutants/toxicity ; Air Pollutants/analysis ; Air Pollution/adverse effects ; Air Pollution/analysis ; Prospective Studies ; Retrospective Studies ; Environmental Exposure/adverse effects ; Environmental Exposure/analysis ; Rhinitis, Allergic/epidemiology ; Rhinitis, Allergic/etiology ; Vitamins ; Particulate Matter/analysis
    Chemical Substances Air Pollutants ; Vitamins ; Particulate Matter
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Systematic Review ; Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0284625
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  4. Article ; Online: Hepatic veno-occlusive disease induced by Gynura segetum

    PENG Shanshan

    Journal of Clinical Hepatology, Vol 31, Iss 7, Pp 1132-

    a report of two cases

    2015  Volume 1134

    Keywords hepatic veno-occlusive disease; sedum aizoon; case reports ; Medicine (General) ; R5-920 ; Medicine ; R
    Language Chinese
    Publishing date 2015-07-01T00:00:00Z
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: A nomogram for predicting overall survival rate in patients with brain metastatic non-small cell lung cancer.

    Peng, Shanshan / Xiao, Yu / Li, Xinjun / Wu, Zhanling

    Medicine

    2022  Volume 101, Issue 38, Page(s) e30824

    Abstract: The purpose was to develop a nomogram for the prediction of the 1- and 2-year overall survival (OS) rates in patients with brain metastatic non-small cell lung cancer (BMNSCLC). Patients were collected from the Surveillance Epidemiology and End Results ... ...

    Abstract The purpose was to develop a nomogram for the prediction of the 1- and 2-year overall survival (OS) rates in patients with brain metastatic non-small cell lung cancer (BMNSCLC). Patients were collected from the Surveillance Epidemiology and End Results program (SEER) and classified into the training and validation groups. Several independent prognostic factors identified by statistical methods were incorporated to establish a predictive nomogram. The concordance index (C-index), the area under the receiver operating characteristics curve (AUC), and calibration curve were applied to estimate predictive ability of the nomogram. To compare the clinical practicability of the nomogram and TNM staging system by decision curve analysis (DCA). A total of 24,164 eligible patients were collected and assigned into the training (n = 16,916) and validation groups (n = 7248). Based on the prognostic factors, we developed a nomogram with good discriminative ability. The C-indices for training and validation group were 0.727 and 0.728. The AUCs of 1- and 2-year OS rates were both 0.8, and the calibration curves also demonstrated good performance of the nomogram. DCA illustrated that the nomogram provided clinical net benefit compared with the TNM staging system. We developed a predictive nomogram for more accurate and comprehensive prediction of OS in BMNSCLC patients, which can be a useful and convenient tool for clinicians to make proper clinical decisions, and adjust follow-up management strategies.
    MeSH term(s) Brain ; Carcinoma, Non-Small-Cell Lung/therapy ; Humans ; Lung Neoplasms ; Nomograms ; Prognosis ; SEER Program ; Survival Rate
    Language English
    Publishing date 2022-10-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000030824
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  6. Article ; Online: Liver Mass: Island-Like Sign.

    Zhong, Yandan / Peng, Shanshan / Yang, Yongfeng

    Gastroenterology

    2022  Volume 164, Issue 7, Page(s) e9–e12

    MeSH term(s) Humans ; Female ; Ovarian Neoplasms ; Digestive System Abnormalities ; Liver/diagnostic imaging
    Language English
    Publishing date 2022-12-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2022.11.039
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  7. Article ; Online: Low awareness of HPV infection and willingness of HPV vaccination among Chinese male college students in the east of China.

    Ran, Hu / Chen, Yue / Gao, Jun / Guo, Hongxiong / Peng, Shanshan

    Frontiers in public health

    2022  Volume 10, Page(s) 971707

    Abstract: Introduction: Human Papillomavirus (HPV) vaccine has proven to play a major role in preventing sexually transmitted diseases and related cancers among both men and women. However, the coverage of the HPV vaccination is still limited.: Objective: The ... ...

    Abstract Introduction: Human Papillomavirus (HPV) vaccine has proven to play a major role in preventing sexually transmitted diseases and related cancers among both men and women. However, the coverage of the HPV vaccination is still limited.
    Objective: The study aims to evaluate the awareness of HPV and HPV vaccine, as well as the willingness to take HPV vaccine, especially factors influencing vaccination willingness among male college students.
    Methods: We conducted a cross-sectional investigation among male college students from six colleges in Jiangsu, China. A structured questionnaire was used to investigate the subjects' basic information, behavior habits, cognition of the HPV vaccine, and intention for HPV vaccination. Multivariate analysis modes were used to analyze the influencing factors of vaccine awareness and willingness.
    Results: We found that among 912 participants, only 24.34% of the participants had a "good knowledge" of HPV and HPV vaccine, and 34.54% showed a "positive attitude" toward the HPV vaccine after obtaining knowledge of HPV and its vaccine. Factors such as immune persistence, side effects, pricing strategy, and participants' self-assessment of HPV infection were the main factors influencing the HPV vaccination.
    Conclusion: Strengthening health education on the HPV vaccination and finding appropriate ways to solve the problem of "vaccine hesitancy" will be effective in improving the coverage of the HPV vaccine and preventing related diseases. In addition, the lifting of restrictions on HPV vaccination for men in China may also prove useful.
    MeSH term(s) China ; Cross-Sectional Studies ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Papillomavirus Infections/drug therapy ; Papillomavirus Infections/prevention & control ; Papillomavirus Vaccines/therapeutic use ; Students ; Vaccination
    Chemical Substances Papillomavirus Vaccines
    Language English
    Publishing date 2022-09-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.971707
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  8. Article ; Online: Secretion of IL-6 and IL-8 in the senescence of bone marrow mesenchymal stem cells is regulated by autophagy via FoxO3a.

    Zheng, Yong / Wu, Shangrong / Ke, Haiqiang / Peng, Shanshan / Hu, Chengjun

    Experimental gerontology

    2022  Volume 172, Page(s) 112062

    Abstract: Bone marrow mesenchymal stem cells (BMSCs) are widely used for therapeutic applications in tissue engineering and regenerative medicine. Nevertheless, the function of BMSCs is adversely affected by senescence. Thus, understanding the molecular mechanisms ...

    Abstract Bone marrow mesenchymal stem cells (BMSCs) are widely used for therapeutic applications in tissue engineering and regenerative medicine. Nevertheless, the function of BMSCs is adversely affected by senescence. Thus, understanding the molecular mechanisms that contribute to BMSC senescence is critical for the development of BMSC-based tissue engineering and regenerative medicine. In this study, senescent BMSCs were characterized with >80 % of BMSCs stained positive for SA-β-gal, increased expressions of senescence-related genes (p16
    MeSH term(s) Autophagy/physiology ; Bone Marrow Cells/metabolism ; Cellular Senescence/physiology ; Interleukin-6/metabolism ; Interleukin-8 ; Mesenchymal Stem Cells/physiology ; Forkhead Transcription Factors
    Chemical Substances Interleukin-6 ; Interleukin-8 ; Forkhead Transcription Factors
    Language English
    Publishing date 2022-12-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 390992-x
    ISSN 1873-6815 ; 0531-5565
    ISSN (online) 1873-6815
    ISSN 0531-5565
    DOI 10.1016/j.exger.2022.112062
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 579: Show issues Location:
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  9. Article ; Online: Treatment of paradoxical eczematous eruption in psoriasis treated with secukinumab: A case report.

    Xiao, Yu / Peng, Shanshan / Li, Xiangjun / Mao, Tianyi / Fang, Muping / Hu, Youhong / Ye, Wenzheng

    Medicine

    2023  Volume 102, Issue 6, Page(s) e32844

    Abstract: Rationale: Eczematous eruption is an increasingly recognized form of drug-related eruption, typically reported in association with interleukin 17 (IL-17)A inhibitors. However, severe paradoxical eczematous eruption due to IL-17A inhibitors has been ... ...

    Abstract Rationale: Eczematous eruption is an increasingly recognized form of drug-related eruption, typically reported in association with interleukin 17 (IL-17)A inhibitors. However, severe paradoxical eczematous eruption due to IL-17A inhibitors has been rarely reported. Herein, we reported a case of a man with severe psoriasis with erythematous scaly plaques on the scalp, trunk, and arms and legs after the administration of secukinumab was initiated.
    Patient concerns: We reported a case of a 20-year-old man with severe psoriasis with erythematous scaly plaques on the scalp, trunk, and arms and legs after the administration of secukinumab was initiated. A skin biopsy was performed. It revealed spongiotic dermatitis consistent with eczematous reaction. Direct and indirect immunofluorescence assays were negative.
    Diagnoses: He was diagnosed with eczematous eruption.
    Interventions: Discontinuation of secukinumab and administration of cyclosporine and prednisone were considered.
    Outcomes: Significant improvement was observed, with no adverse events.
    Conclusion: Our case shows that eczematous eruption can paradoxically occur in patients on IL-17A inhibitors and this report is expected to increase awareness of the rising number of cutaneous eruptions related to biological agents.
    MeSH term(s) Humans ; Male ; Young Adult ; Antibodies, Monoclonal, Humanized/adverse effects ; Drug Eruptions/etiology ; Eczema/chemically induced ; Eczema/complications ; Erythema ; Exanthema/chemically induced ; Interleukin-17 ; Psoriasis/drug therapy ; Psoriasis/complications
    Chemical Substances Antibodies, Monoclonal, Humanized ; Interleukin-17 ; secukinumab (DLG4EML025)
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000032844
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  10. Article ; Online: Adipocyte-derived CCDC3 promotes tumorigenesis in epithelial ovarian cancer through the Wnt/ß-catenin signalling pathway.

    Wang, Fen / Jin, Feng / Peng, Shanshan / Li, Chen / Wang, Li / Wang, Shubin

    Biochemistry and biophysics reports

    2023  Volume 35, Page(s) 101507

    Abstract: Introduction: Epithelial ovarian cancer (EOC) is a highly aggressive disease whose unique metastatic site is the omentum. Coiled-coil domain containing 3 (CCDC3) is an adipocyte-derived secreted protein that is specifically elevated in omental adipose ... ...

    Abstract Introduction: Epithelial ovarian cancer (EOC) is a highly aggressive disease whose unique metastatic site is the omentum. Coiled-coil domain containing 3 (CCDC3) is an adipocyte-derived secreted protein that is specifically elevated in omental adipose tissue. However, its function is still unknown.
    Material and methods: Initially, a Kaplan-Meier plot was applied to evaluate the prognostic value of CCDC3 expression in patients with EOC. A bioinformatics analysis was next used to explore the biological function of CCDC3 in EOC. Western blot, quantitative real-time polymerase chain reaction, and
    Results: Overexpression of CCDC3 was associated with poor prognosis of EOC. CCDC3 interacted with multiple key signalling pathways, including the Wnt/β-catenin pathway. EOC cellular proliferation, migration, and invasion were promoted
    Conclusions: Our results support that CCDC3 promotes EOC tumorigenesis through the Wnt/β-catenin pathway and that CCDC3 may serve as a novel prognostic biomarker and therapeutic target for metastatic EOC.
    Language English
    Publishing date 2023-07-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2831046-9
    ISSN 2405-5808 ; 2405-5808
    ISSN (online) 2405-5808
    ISSN 2405-5808
    DOI 10.1016/j.bbrep.2023.101507
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