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Article ; Online: Retraction Note: Neuroprotective effects of G-CSF administration in microglia-mediated reactive T cell activation in vitro.

Peng, Wei

2022 Volume 71, Issue 2, Page(s) 286

Language	English
Publishing date	2022-11-17
Publishing country	United States
Document type	Retraction of Publication
ZDB-ID	632857-x
ISSN	1559-0755 ; 0257-277X
ISSN (online)	1559-0755
ISSN	0257-277X
DOI	10.1007/s12026-022-09343-3
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Zs.A 1755: Show issues

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Article ; Online: PT-symmetric PINN for integrable nonlocal equations: Forward and inverse problems.

Peng, Wei-Qi / Chen, Yong

Chaos (Woodbury, N.Y.)

2024 Volume 34, Issue 4

Abstract: Since the PT-symmetric nonlocal equations contain the physical information of the PT-symmetric, it is very appropriate to embed the physical information of the PT-symmetric into the loss function of PINN, named PTS-PINN. For general PT-symmetric nonlocal ...

Abstract	Since the PT-symmetric nonlocal equations contain the physical information of the PT-symmetric, it is very appropriate to embed the physical information of the PT-symmetric into the loss function of PINN, named PTS-PINN. For general PT-symmetric nonlocal equations, especially those equations involving the derivation of nonlocal terms due to the existence of nonlocal terms, directly using the original PINN method to solve such nonlocal equations will face certain challenges. This problem can be solved by the PTS-PINN method, which can be illustrated in two aspects. First, we treat the nonlocal term of the equation as a new local component so that the equation is coupled at this time. In this way, we successfully avoid differentiating nonlocal terms in neural networks. On the other hand, in order to improve the accuracy, we make a second improvement, which is to embed the physical information of the PT-symmetric into the loss function. Through a series of independent numerical experiments, we evaluate the efficacy of PTS-PINN in tackling the forward and inverse problems for the nonlocal NLS equation, the nonlocal derivative NLS equation, the nonlocal (2+1)-dimensional NLS equation, and the nonlocal three-wave interaction systems. The numerical experiments demonstrate that PTS-PINN has good performance. In particular, PTS-PINN has also demonstrated an extraordinary ability to learn large space-time scale rogue waves for nonlocal equations.
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1472677-4
ISSN	1089-7682 ; 1054-1500
ISSN (online)	1089-7682
ISSN	1054-1500
DOI	10.1063/5.0197939
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Article ; Online: Trade-offs for equitable climate policy assessed.

Peng, Wei

Nature

2020 Volume 588, Issue 7837, Page(s) 225–226

MeSH term(s)	Climate ; Climate Change ; Policy
Language	English
Publishing date	2020-12-09
Publishing country	England
Document type	News ; Comment
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/d41586-020-03392-0
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Effects of cosolvent partitioning on conformational transitions and tethered chain flexibility in spherical polymer brushes.

Zhu, Peng Wei

Soft matter

2021 Volume 17, Issue 28, Page(s) 6817–6832

Abstract: In this work, based on the framework of preferential adsorption concept and analytical self-consistent field (SCF) theory, a model is proposed to investigate the reentrant transition experimentally observed from the thermoresponsive spherical brush in a ... ...

Abstract	In this work, based on the framework of preferential adsorption concept and analytical self-consistent field (SCF) theory, a model is proposed to investigate the reentrant transition experimentally observed from the thermoresponsive spherical brush in a series of aqueous alcohol solutions. The interaction between monomers is incorporated into the model. Conformational transitions of the spherical brush are quantitatively correlated to the physical parameters, including the number of adsorbed cosolvents which facilitates the solvent quality, the number of cosolvent bridges which drives the brush collapse, as well as their partition coefficients between the brush and the bulk solution. An analytical formula for the number of Kuhn segments per tethered chain is obtained based on the analytical SCF theory, which elucidates the flexibility of tethered chains in the intricate system of multicomponents involving the conformational transitions. Under the experimental conditions associated with the cosolvent-brush interaction, the variation of the monomer chemical potential with the monomer concentration indicates that the monomer distribution of the spherical brush remains continuous. The analysis based on the SFC theory also reveals that the distribution of adsorbed cosolvents is a positive parabola while the distribution of cosolvent bridges appears to be an exponential decay function, implying that the intervening space between tethered chains, rather than the number of adsorbed cosolvents, plays a crucial role in forming the cosolvent bridge. We demonstrate that the model formulated for the reentrant transition under weaker cosolvent-brush interactions provides guidelines for the one under stronger nanoparticle-brush interactions.
Language	English
Publishing date	2021-07-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2191476-X
ISSN	1744-6848 ; 1744-683X
ISSN (online)	1744-6848
ISSN	1744-683X
DOI	10.1039/d1sm00523e
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Article ; Online: The Effects of Animations and Multimedia Messages on Public Engagement in Precision Medicine: Assessment of Moderation and Mediation.

Peng, Wei / Occa, Aurora / Morgan, Susan E

Journal of health communication

2024 Volume 29, Issue 3, Page(s) 220–231

Abstract: Public participation in precision medicine (PM) research is essential to achieving effective health care but has been impeded by a lack of awareness and basic knowledge. There is a critical need for educational materials that can clearly explain PM to ... ...

Abstract	Public participation in precision medicine (PM) research is essential to achieving effective health care but has been impeded by a lack of awareness and basic knowledge. There is a critical need for educational materials that can clearly explain PM to foster involvement. This randomized controlled trial with a posttest-only control group design aims to assess the effects of educational messages delivered through animations relative to live-action videos and leaflets on intentions of involvement in PM research. Knowledge as the moderator and four mediators (engagement, vividness, trustworthiness, and cognitive value) of the intended effects were also evaluated. A total of 326 U.S. adults were sampled from Amazon Mechanical Turk. Among participants with less knowledge about PM, animations produced stronger information-seeking intentions and willingness to participate than leaflets. The effects of three message modalities were not significantly different among average and highly knowledgeable participants. Engagement and vividness mediated the effects of animations relative to two other message modalities. Trustworthiness and cognitive value mediated the effects of animations relative to live-action videos. Overall, animations can be an effective communication strategy to motivate involvement in PM but its effectiveness could decline as knowledge increases. The explanations and implications of the findings were discussed.
MeSH term(s)	Adult ; Humans ; Multimedia ; Precision Medicine ; Intention
Language	English
Publishing date	2024-02-14
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1427988-5
ISSN	1087-0415 ; 1081-0730
ISSN (online)	1087-0415
ISSN	1081-0730
DOI	10.1080/10810730.2024.2313994
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Zs.A 5899: Show issues

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Article ; Online: Enhanced matrix inference with Seq2seq models via diagonal sorting.

Peng, Wei / Wang, Yisong / Wu, Maonian

Scientific reports

2024 Volume 14, Issue 1, Page(s) 883

Abstract: The effectiveness of sequence-to-sequence (seq2seq) models in natural language processing has been well-established over time, and recent studies have extended their utility by treating mathematical computing tasks as instances of machine translation and ...

Abstract	The effectiveness of sequence-to-sequence (seq2seq) models in natural language processing has been well-established over time, and recent studies have extended their utility by treating mathematical computing tasks as instances of machine translation and achieving remarkable results. However, our exploratory experiments have revealed that the seq2seq model, when employing a generic sorting strategy, is incapable of inferring on matrices of unseen rank, resulting in suboptimal performance. This paper aims to address this limitation by focusing on the matrix-to-sequence process and proposing a novel diagonal-based sorting. The method constructs a stable ordering structure of elements for the shared leading principal submatrix sections in matrices with varying ranks. We conduct experiments involving maximal independent sets and Sudoku laws, comparing seq2seq models utilizing different sorting methods. Our findings demonstrate the advantages of the proposed diagonal-based sorting in inference, particularly when dealing with matrices of unseen ranks. By introducing and advocating for this method, we enhance the suitability of seq2seq models for investigating the laws of matrix inclusion and exploring their potential in solving matrix-related tasks.
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-50919-2
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Article ; Online: Upregulation of p300 in paclitaxel-resistant TNBC: implications for cell proliferation via the PCK1/AMPK axis.

Zhao, Peng-Wei / Cui, Jia-Xian / Wang, Xiu-Mei

The pharmacogenomics journal

2024 Volume 24, Issue 2, Page(s) 5

Abstract: Objective: To explore the role of p300 in the context of paclitaxel (PTX) resistance in triple-negative breast cancer (TNBC) cells, focusing on its interaction with the phosphoenolpyruvate carboxykinase 1 (PCK1)/adenosine monophosphate-activated protein ...

Abstract	Objective: To explore the role of p300 in the context of paclitaxel (PTX) resistance in triple-negative breast cancer (TNBC) cells, focusing on its interaction with the phosphoenolpyruvate carboxykinase 1 (PCK1)/adenosine monophosphate-activated protein kinase (AMPK) pathway. Methods: The expression of p300 and PCK1 at the messenger ribonucleic acid (mRNA) level was detected using a quantitative polymerase chain reaction. The GeneCards and GEPIA databases were used to investigate the relationship between p300 and PCK1. The MDA-MB-231/PTX cell line, known for its PTX resistance, was chosen to understand the specific role of p300 in such cells. The Lipofectamine™ 3000 reagent was used to transfer the p300 small interfering RNA and the overexpression of PCK1 plasmid into MDA-MB-231/PTX. The expression levels of p300, PCK1, 5'AMPK and phosphorylated AMPK (p-AMPK) were determined using the western blot test. Results: In TNBC cancer tissue, the expression of p300 was increased compared with TNBC paracancerous tissue (P < 0.05). In the MDA-MB-231 cell line of TNBC, the expression of p300 was lower than in the PTX-resistant TNBC cells (MDA-MB-231/PTX) (P < 0.05). The PCK1 expression was decreased in the TNBC cancer tissue compared with TNBC paracancerous tissue, and the PCK1 expression was reduced in MDA-MB-231/PTX than in MDA-MB-231 (P < 0.05) indicating that PCK1 was involved in the resistance function. Additionally, p-AMPK was decreased in MDA-MB-231/PTX compared with MDA-MB-231 (P < 0.05). The adenosine triphosphate (ATP) level was also detected and was significantly lower in MDA-MB-231/PTX than in MDA-MB-231 (P < 0.05). Additionally, cell proliferation increased significantly in MDA-MB-231/PTX at 48 and 72 h (P < 0.05) suggesting that MDA-MB-231/PTX cells obtained the resistance function which was associated with AMPK and ATP level. When p300 was inhibited, p-AMPK and ATP levels elevated in MDA-MB-231/PTX (P < 0.05). When PCK1 was suppressed, the ATP consumption rate decreased, and cell proliferation increased (P < 0.05). However, there were no changes in p300. Conclusions: In MDA-MB-231/PTX, p300 can inhibit p-AMPK and ATP levels by inhibiting PCK1 expression. Our findings suggest that targeting p300 could modulate the PCK1/AMPK axis, offering a potential therapeutic avenue for overcoming PTX resistance in TNBC.
MeSH term(s)	Humans ; Adenosine Triphosphate/therapeutic use ; AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; AMP-Activated Protein Kinases/therapeutic use ; Cell Line, Tumor ; Cell Proliferation ; Intracellular Signaling Peptides and Proteins/genetics ; Paclitaxel/pharmacology ; Paclitaxel/therapeutic use ; Phosphoenolpyruvate Carboxykinase (GTP)/genetics ; Phosphoenolpyruvate Carboxykinase (GTP)/metabolism ; Phosphoenolpyruvate Carboxykinase (GTP)/therapeutic use ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/metabolism ; Up-Regulation
Chemical Substances	Adenosine Triphosphate (8L70Q75FXE) ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Intracellular Signaling Peptides and Proteins ; Paclitaxel (P88XT4IS4D) ; PCK1 protein, human (EC 4.1.1.32) ; Phosphoenolpyruvate Carboxykinase (GTP) (EC 4.1.1.32) ; EP300 protein, human (EC 2.3.1.48)
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2106831-8
ISSN	1473-1150 ; 1470-269X
ISSN (online)	1473-1150
ISSN	1470-269X
DOI	10.1038/s41397-024-00324-3
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Article ; Online: Perforation of barium sulfate enterography in an infant: A case report.

Lu, Yixing / Mo, Lixian / Chen, Junhong / Peng, Wei

Medicine

2024 Volume 103, Issue 17, Page(s) e37926

Abstract: Rationale: Barium peritonitis is an inflammatory response that occurs when barium accidentally enters the abdominal cavity during a barium test. In extreme circumstances, it has the potential to harm various organs and even result in death.: Patient ... ...

Abstract	Rationale: Barium peritonitis is an inflammatory response that occurs when barium accidentally enters the abdominal cavity during a barium test. In extreme circumstances, it has the potential to harm various organs and even result in death. Patient concerns: A 3-month-old infant was diagnosed with multiple organ failure after severe barium peritonitis. Diagnosis: Multiple organ dysfunction is associated with barium peritonitis. Interventions: The infant underwent surgical intervention and received ventilator support, anti-infection therapy, myocardial nutrition, liver and kidney protection, rehydration, circulation stabilization, and other symptomatic supportive care. Outcomes: The patient experienced clinical death after treatment and resuscitation was unsuccessful. Lessons: Barium enema perforation complications are uncommon, but can lead to fatal injuries with a high mortality rate. This case highlights the importance of raising awareness among clinicians about the risks of gastroenterography in infants and children and actively preventing and avoiding similar serious complications. The mortality rate can be reduced by timely multidisciplinary consultation and joint management once a perforation occurs.
MeSH term(s)	Humans ; Infant ; Intestinal Perforation/etiology ; Intestinal Perforation/diagnostic imaging ; Multiple Organ Failure/etiology ; Fatal Outcome ; Peritonitis/etiology ; Male ; Barium Enema/adverse effects ; Barium Enema/methods ; Barium Sulfate/adverse effects ; Contrast Media/adverse effects
Chemical Substances	Barium Sulfate (25BB7EKE2E) ; Contrast Media
Language	English
Publishing date	2024-04-26
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037926
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Article: 生物信息学在肺动脉高压中的研究进展.

Peng, Wei / Zhang, Ze-Ying / Xiao, Yun-Bin

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

2024 Volume 26, Issue 4, Page(s) 425–431

Abstract: Pulmonary arterial hypertension (PAH) is a severe disease characterized by abnormal pulmonary vascular remodeling and increased right ventricular pressure load, posing a significant threat to patient health. While some pathological mechanisms of PAH have ...

Title translation	Research progress on bioinformatics in pulmonary arterial hypertension.
Abstract	Pulmonary arterial hypertension (PAH) is a severe disease characterized by abnormal pulmonary vascular remodeling and increased right ventricular pressure load, posing a significant threat to patient health. While some pathological mechanisms of PAH have been revealed, the deeper mechanisms of pathogenesis remain to be elucidated. In recent years, bioinformatics has provided a powerful tool for a deeper understanding of the complex mechanisms of PAH through the integration of techniques such as multi-omics analysis, artificial intelligence, and Mendelian randomization. This review focuses on the bioinformatics methods and technologies used in PAH research, summarizing their current applications in the study of disease mechanisms, diagnosis, and prognosis assessment. Additionally, it analyzes the existing challenges faced by bioinformatics and its potential applications in the clinical and basic research fields of PAH in the future.
MeSH term(s)	Humans ; Computational Biology ; Pulmonary Arterial Hypertension/genetics ; Pulmonary Arterial Hypertension/physiopathology ; Pulmonary Arterial Hypertension/etiology ; Hypertension, Pulmonary/genetics ; Hypertension, Pulmonary/physiopathology ; Hypertension, Pulmonary/etiology
Language	Chinese
Publishing date	2024-04-25
Publishing country	China
Document type	Journal Article ; Review ; English Abstract
ISSN	1008-8830
ISSN	1008-8830
DOI	10.7499/j.issn.1008-8830.2310076
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Article ; Online: Study on the controlling effect of Nanpu No. 2 Fault growth connection on buried hill evolution

Zhang Qing / Peng WeiSong

E3S Web of Conferences, Vol 352, p

2022 Volume 03028

Abstract: Nanpu fault 2 has an important control action of buried hill, in order to study the growth of Nanpu fault 2 connection process and Nanpu no. 2 the control function of buried hill through the application of slip - distance curve and slip back stripping ... ...

Abstract	Nanpu fault 2 has an important control action of buried hill, in order to study the growth of Nanpu fault 2 connection process and Nanpu no. 2 the control function of buried hill through the application of slip - distance curve and slip back stripping method to study the growth of the Nanpu fault 2 connection process, and the use of equilibrium profile to analyze its effect on the tectonic evolution of the buried hill. The results show that the Nanpu No. 2 fault is characterized by segmentalized growth, caledonian quiet structure, and widely distributed carbonate deposits. After the middle-late Caledonian uplift, the strata suffered from denudation. Strong folding occurred in The Indochinese period, and in the Himalayan Period, the Nanpu no. 2 fault was weakly active in the Shahejie sedimentary period and developed only in the north, forming the prototype of buried hill at this time. During the sedimentary period of Dongying Formation, the structure reversed slightly, which is also known as the Dongying Movement. At this time, fault no. 2 strongly extended southward, and buried-hill was formed and basically formed. The research results have certain reference value for oil and gas exploration in Nanpu sag.
Keywords	nanpu no. 2 fault ; buried hill ; fault growth ; fault connection ; Environmental sciences ; GE1-350
Subject code	550
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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