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Article ; Online: Metabolic, toxicological, chemical, and commercial perspectives on esterification of dietary polyphenols: a review.

Peng, Han / Shahidi, Fereidoon

Critical reviews in food science and nutrition

2023 , Page(s) 1–40

Abstract: Molecular modifications have been practiced for more than a century and nowadays they are widely applied in food, pharmaceutical, or other industries to manipulate the physicochemical, bioactivity, metabolic/catabolic, and pharmacokinetic properties. ... ...

Abstract	Molecular modifications have been practiced for more than a century and nowadays they are widely applied in food, pharmaceutical, or other industries to manipulate the physicochemical, bioactivity, metabolic/catabolic, and pharmacokinetic properties. Among various structural modifications, the esterification/
Language	English
Publishing date	2023-03-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1037504-1
ISSN	1549-7852 ; 1040-8398
ISSN (online)	1549-7852
ISSN	1040-8398
DOI	10.1080/10408398.2023.2185589
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Article ; Online: Effect of Temperature and Humidity Coupling on the Ageing Failure of Carbon Fiber Composite/Titanium Bonded Joints.

Peng, Han / Zhou, Tai / Shangguan, Linjian / Cheng, Ruixue

Polymers

2024 Volume 16, Issue 7

Abstract: Temperature and humidity coupling has a more significant effect on the failure properties of bonded joints than a single factor, and there is not enough research on this. In this paper, joints bonded with strong toughness structural adhesives are ... ...

Abstract	Temperature and humidity coupling has a more significant effect on the failure properties of bonded joints than a single factor, and there is not enough research on this. In this paper, joints bonded with strong toughness structural adhesives are selected for the experimental analysis of joints aged for 240 h, 480 h, and 720 h at temperatures of 40 °C and 60 °C and a humidity of 95% and 100%. The sequential double Fick's model was used to fit the water absorption of the joints, and the comparison yielded that the water absorption of the adhesive was in accordance with Fick's law. The quasi-static tensile tests revealed that the reduction in mechanical properties of the joints was positively correlated with the moisture content in the environment, while the competing mechanisms of post-temperature curing and hydroplasticization resulted in a slight increase in the failure strength and energy uptake of the aged joints, which is in agreement with the experimental results of the Fourier infrared spectroscopy. A combination of macroscopic failure sections and scanning electron microscope (SEM) images yielded that the failure mode of the joints changed from cohesive failure to interfacial failure with increasing ageing time. In addition, reliability analyses for the fatigue testing of joints are expected to provide guidance for the life design of bonding technology in the vehicle service temperature range.
Language	English
Publishing date	2024-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym16070952
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Article ; Online: Cancer Stem Cells in Tumours of the Central Nervous System in Children

Yi-Peng Han / Hou-Wei Lin / Hao Li

Cancers, Vol 15, Iss 12, p

A Comprehensive Review

2023 Volume 3154

Abstract: Cancer stem cells (CSCs) are a subgroup of cells found in various kinds of tumours with stem cell characteristics, such as self-renewal, induced differentiation, and tumourigenicity. The existence of CSCs is regarded as a major source of tumour ... ...

Abstract	Cancer stem cells (CSCs) are a subgroup of cells found in various kinds of tumours with stem cell characteristics, such as self-renewal, induced differentiation, and tumourigenicity. The existence of CSCs is regarded as a major source of tumour recurrence, metastasis, and resistance to conventional chemotherapy and radiation treatment. Tumours of the central nervous system (CNS) are the most common solid tumours in children, which have many different types including highly malignant embryonal tumours and midline gliomas, and low-grade gliomas with favourable prognoses. Stem cells from the CNS tumours have been largely found and reported by researchers in the last decade and their roles in tumour biology have been deeply studied. However, the cross-talk of CSCs among different CNS tumour types and their clinical impacts have been rarely discussed. This article comprehensively reviews the achievements in research on CSCs in paediatric CNS tumours. Biological functions, diagnostic values, and therapeutic perspectives are reviewed in detail. Further investigations into CSCs are warranted to improve the clinical practice in treating children with CNS tumours.
Keywords	cancer stem cells (CSCs) ; tumours of the central nervous system (CNS) ; children ; biology impact ; clinical significance ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Trajectory tracking method based on the circulation of feasible path planning.

Yi Yu / Peng Han

PLoS ONE, Vol 16, Iss 6, p e

2021 Volume 0252542

Abstract: The control method is the central point of the unmanned vehicles. As the core system to guarantee the properties of self-decision and trajectory tracking of the unmanned vehicles, a new kind of trajectory tracking method based on the circulation of ... ...

Abstract	The control method is the central point of the unmanned vehicles. As the core system to guarantee the properties of self-decision and trajectory tracking of the unmanned vehicles, a new kind of trajectory tracking method based on the circulation of feasible path planning for the unmanned vehicles are proposed in this article which considered the dynamics and kinematics characteristics of vehicles. The multi-trace-points cooperative trajectory tracking control strategy on the basis of the circulation of feasible path generation method is proposed and the lateral controller is designed for trajectory tracking. The process of feasible path generation is conducted once the tracking error exceeded. A simulation platform of the trajectory tracking simulation of unmanned vehicles is built considering the mechanical properties of system elements and the mechanical characteristics. Finally, the proposed trajectory tracking method is verified. The tracking error would be reduced to make sure the vehicles move along the pre-set virtual track.
Keywords	Medicine ; R ; Science ; Q
Subject code	629
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Effects of Acyl Chain Length on Antioxidant Efficacy of Mono- and Multi-Acylated Resveratrol: A Comparative Assessment.

Peng, Han / Shahidi, Fereidoon

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 3

Abstract: Acylated derivatives of the dietary phenolic, resveratrol, were prepared via enzymatic and chemical transesterification modification with selected vinyl fatty acids to expand the potential application of resveratrol and its acylated derivatives in ... ...

Abstract	Acylated derivatives of the dietary phenolic, resveratrol, were prepared via enzymatic and chemical transesterification modification with selected vinyl fatty acids to expand the potential application of resveratrol and its acylated derivatives in functional supplement, cosmetic/skincare, and pharmaceutical fields. The acylation was implemented using eight vinyl fatty acids with varying chain lengths (C2:0-C18:0). Eight monoesters enzymatically prepared, eight diesters and four triesters, chemically prepared, were isolated and purified and identified via MS (mass spectra) or/and NMR (nuclear magnetic resonance). The lipophilicity of resveratrol and its acylated derivatives was calculated using ALOGPS 2.1. Compared with related acylated products, resveratrol itself rendered higher antioxidant efficacy in all the antioxidant assays, namely DPPH, ABTS, FRAP, and ferrous chelation tests. Within various ester derivatives of resveratrol, short-chain fatty acid mono- and di-substituted resveratrols, especially the resveratrol monoacetate/diacetate, exhibited higher antioxidant efficacy in DPPH and ABTS assays than the rest of resveratrol derivatives, but the medium-chain monoesters of resveratrol, including caproate, caprylate, caprate, and laurate, showed a higher metal ion chelation ability compared to other acylated resveratrols. These results imply that resveratrol derivatives may be used in lipidic media as health-beneficial antioxidants.
MeSH term(s)	Acylation ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Biphenyl Compounds/chemistry ; Esterification ; Free Radicals/chemistry ; Humans ; Picrates/chemistry ; Resveratrol/analogs & derivatives ; Resveratrol/pharmacology
Chemical Substances	Antioxidants ; Biphenyl Compounds ; Free Radicals ; Picrates ; 1,1-diphenyl-2-picrylhydrazyl (DFD3H4VGDH) ; Resveratrol (Q369O8926L)
Language	English
Publishing date	2022-02-02
Publishing country	Switzerland
Document type	Comparative Study ; Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27031001
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Article ; Online: Enzymatic Synthesis and Antioxidant Activity of Mono- and Diacylated Epigallocatechin Gallate and Related By-Products.

Peng, Han / Shahidi, Fereidoon

Journal of agricultural and food chemistry

2022 Volume 70, Issue 29, Page(s) 9227–9242

Abstract: Ester derivatives of epigallocatechin gallate (EGCG) were enzymatically prepared by one-step transesterification with vinyl fatty acids consisting of varying acyl groups ranging from 2 to 18 carbon atoms (acetate, butyrate, caproate, caprylate, caprate, ... ...

Abstract	Ester derivatives of epigallocatechin gallate (EGCG) were enzymatically prepared by one-step transesterification with vinyl fatty acids consisting of varying acyl groups ranging from 2 to 18 carbon atoms (acetate, butyrate, caproate, caprylate, caprate, laurate, myristate, and stearate). The main acylation products were EGCG monoesters and diesters. However, due to the presence of trace amounts of water in the reaction medium, minor but noticeable hydrolysis of EGCG also occurred as a side reaction which required a prolonged purification process due to the formation of by-products such as gallic acid, epigallocatechin, and their esters. In this contribution, 8 EGCG monoesters, 7 EGCG diesters, and 7 gallic acid monoesters were isolated and purified, and the acylation positions were characterized. Meanwhile, several classical chemicals (DPPH, ABTS, FRAP, and Fe
MeSH term(s)	Antioxidants/chemistry ; Catechin/analogs & derivatives ; Catechin/chemistry ; Esters ; Gallic Acid ; Oxidation-Reduction ; Water
Chemical Substances	Antioxidants ; Esters ; Water (059QF0KO0R) ; Gallic Acid (632XD903SP) ; Catechin (8R1V1STN48) ; epigallocatechin gallate (BQM438CTEL)
Language	English
Publishing date	2022-07-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.2c03086
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Zs.A 1172: Show issues

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Article ; Online: Quercetin Fatty Acid Monoesters (C2:0-C18:0): Enzymatic Preparation and Antioxidant Activity.

Peng, Han / Shahidi, Fereidoon

Journal of agricultural and food chemistry

2022 Volume 70, Issue 43, Page(s) 14073–14083

Abstract: Quercetin monoesters were prepared via a one-step enzymatic transesterification. The main acylation products were eight quercetin ester derivatives, respectively, consisting of varying acyl groups ranging from 2 to 18 carbon atoms (acetate, butyrate, ... ...

Abstract	Quercetin monoesters were prepared via a one-step enzymatic transesterification. The main acylation products were eight quercetin ester derivatives, respectively, consisting of varying acyl groups ranging from 2 to 18 carbon atoms (acetate, butyrate, caproate, caprylate, caprate, laurate, myristate, and stearate). The purified quercetin esters were structurally characterized by LC-ESI-ToF and NMR HSQC. Meanwhile, several classical chemical (DPPH, ABTS, FRAP, and Fe
MeSH term(s)	Quercetin/chemistry ; Antioxidants/chemistry ; Fatty Acids/chemistry ; Esters/chemistry ; Esterification
Chemical Substances	Quercetin (9IKM0I5T1E) ; Antioxidants ; Fatty Acids ; Esters
Language	English
Publishing date	2022-10-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.2c05724
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Article: Enzymatic Synthesis and Antioxidant Activity of Mono- and Diacylated Epigallocatechin Gallate and Related By-Products

Peng, Han / Shahidi, Fereidoon

Journal of agricultural and food chemistry. 2022 July 13, v. 70, no. 29

2022

Abstract	Ester derivatives of epigallocatechin gallate (EGCG) were enzymatically prepared by one-step transesterification with vinyl fatty acids consisting of varying acyl groups ranging from 2 to 18 carbon atoms (acetate, butyrate, caproate, caprylate, caprate, laurate, myristate, and stearate). The main acylation products were EGCG monoesters and diesters. However, due to the presence of trace amounts of water in the reaction medium, minor but noticeable hydrolysis of EGCG also occurred as a side reaction which required a prolonged purification process due to the formation of by-products such as gallic acid, epigallocatechin, and their esters. In this contribution, 8 EGCG monoesters, 7 EGCG diesters, and 7 gallic acid monoesters were isolated and purified, and the acylation positions were characterized. Meanwhile, several classical chemicals (DPPH, ABTS, FRAP, and Fe²⁺ chelation assays), food (β-carotene bleaching assay), and biological (LDL and DNA oxidation assays) models were conducted to evaluate and systematically compare their antioxidant efficacy. The lipophilicity of the EGCG derivatives increased with the increasing chain length of the acyl group and led to the fluctuation of their antioxidant efficacies. Three main factors, namely, the reduction potential, the partition coefficient of solute in the solvent system, and the steric hindrance of antioxidant agent and related substrates were considered to help explain the biased antioxidant performance of EGCG derivatives upon acylation modification. The results strongly suggest that the acylated EGCGs have great potential as lipophilic alternatives to the water-soluble EGCG in lipid-based matrices.
Keywords	DNA ; acetates ; acylation ; antioxidant activity ; antioxidants ; butyrates ; carbon ; chelation ; epigallocatechin gallate ; food chemistry ; gallic acid ; hexanoic acid ; hydrolysis ; lipophilicity ; oxidation ; purification methods ; solutes ; solvents ; stearic acid ; transesterification ; water solubility
Language	English
Dates of publication	2022-0713
Size	p. 9227-9242.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.2c03086
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Building gender-specific sexually transmitted infection risk prediction models using CatBoost algorithm and NHANES data.

Hu, Mengjie / Peng, Han / Zhang, Xuan / Wang, Lefeng / Ren, Jingjing

BMC medical informatics and decision making

2024 Volume 24, Issue 1, Page(s) 24

Abstract: Background and aims: Sexually transmitted infections (STIs) are a significant global public health challenge due to their high incidence rate and potential for severe consequences when early intervention is neglected. Research shows an upward trend in ... ...

Abstract	Background and aims: Sexually transmitted infections (STIs) are a significant global public health challenge due to their high incidence rate and potential for severe consequences when early intervention is neglected. Research shows an upward trend in absolute cases and DALY numbers of STIs, with syphilis, chlamydia, trichomoniasis, and genital herpes exhibiting an increasing trend in age-standardized rate (ASR) from 2010 to 2019. Machine learning (ML) presents significant advantages in disease prediction, with several studies exploring its potential for STI prediction. The objective of this study is to build males-based and females-based STI risk prediction models based on the CatBoost algorithm using data from the National Health and Nutrition Examination Survey (NHANES) for training and validation, with sub-group analysis performed on each STI. The female sub-group also includes human papilloma virus (HPV) infection. Methods: The study utilized data from the National Health and Nutrition Examination Survey (NHANES) program to build males-based and females-based STI risk prediction models using the CatBoost algorithm. Data was collected from 12,053 participants aged 18 to 59 years old, with general demographic characteristics and sexual behavior questionnaire responses included as features. The Adaptive Synthetic Sampling Approach (ADASYN) algorithm was used to address data imbalance, and 15 machine learning algorithms were evaluated before ultimately selecting the CatBoost algorithm. The SHAP method was employed to enhance interpretability by identifying feature importance in the model's STIs risk prediction. Results: The CatBoost classifier achieved AUC values of 0.9995, 0.9948, 0.9923, and 0.9996 and 0.9769 for predicting chlamydia, genital herpes, genital warts, gonorrhea, and overall STIs infections among males. The CatBoost classifier achieved AUC values of 0.9971, 0.972, 0.9765, 1, 0.9485 and 0.8819 for predicting chlamydia, genital herpes, genital warts, gonorrhea, HPV and overall STIs infections among females. The characteristics of having sex with new partner/year, times having sex without condom/year, and the number of female vaginal sex partners/lifetime have been identified as the top three significant predictors for the overall risk of male STIs. Similarly, ever having anal sex with a man, age and the number of male vaginal sex partners/lifetime have been identified as the top three significant predictors for the overall risk of female STIs. Conclusions: This study demonstrated the effectiveness of the CatBoost classifier in predicting STI risks among both male and female populations. The SHAP algorithm revealed key predictors for each infection, highlighting consistent demographic characteristics and sexual behaviors across different STIs. These insights can guide targeted prevention strategies and interventions to alleviate the impact of STIs on public health.
MeSH term(s)	Female ; Male ; Humans ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Herpes Genitalis ; Gonorrhea ; Nutrition Surveys ; Papillomavirus Infections ; Sexually Transmitted Diseases/epidemiology ; Algorithms ; Warts
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2046490-3
ISSN	1472-6947 ; 1472-6947
ISSN (online)	1472-6947
ISSN	1472-6947
DOI	10.1186/s12911-024-02426-1
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Article ; Online: Research progress in the relationship between plasma FIB and prostate cancer

Zhang Peng, Han Conghui, Liu Dachuang

Xin yixue, Vol 54, Iss 10, Pp 708-

2023 Volume 711

Abstract: The incidence of prostate cancer （PCa） has been increased year by year， mainly occurring in elderly men. Currently， prostate-specific antigen （PSA） is still used as a marker for diagnosing PCa in clinical practice. However， the accuracy and sensitivity ... ...

Abstract	The incidence of prostate cancer （PCa） has been increased year by year， mainly occurring in elderly men. Currently， prostate-specific antigen （PSA） is still used as a marker for diagnosing PCa in clinical practice. However， the accuracy and sensitivity of PSA remain relatively low. Identifying more clinical detection parameters for assisting diagnosis becomes a research hotspot. Most of patients with malignant tumors are in a hypercoagulable state. Studies have found that plasma fibrinogen （FIB） is differentially expressed in PCa. In addition， FIB has been considered as a potential tumor-promoting factor in PCa. In this article， the discovery， biological structure， physiological function， pathological changes （inflammation and tumor） and functions of plasma FIB， especially the relationship between plasma FIB and PCa， were systematically reviewed， aiming to provide reference for relevant clinical research.
Keywords	prostate cancer\|plasma fibrinogen\|tumor-promoting factor ; Medicine ; R
Subject code	610
Language	Chinese
Publishing date	2023-10-01T00:00:00Z
Publisher	Editorial Office of Journal of New Medicine
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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