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Article ; Online: Development of a Core Outcome Set for the Benefits and Adverse Events of Acute Heart Failure in Clinical Trials of Traditional Chinese Medicine and Western Medicine

Ruijin Qiu / Songjie Han / Xuxu Wei / Changming Zhong / Min Li / Jiayuan Hu / Pengqian Wang / Chen Zhao / Jing Chen / Hongcai Shang

Frontiers in Medicine, Vol

A Study Protocol

2021 Volume 8

Abstract: Aims: To identify a minimum set of efficacy and adverse events for patients with acute heart failure (AHF) among different stakeholders in clinical trials of traditional Chinese medicine and Western medicine.Methods and Analysis: First, we will develop a ...

Abstract	Aims: To identify a minimum set of efficacy and adverse events for patients with acute heart failure (AHF) among different stakeholders in clinical trials of traditional Chinese medicine and Western medicine.Methods and Analysis: First, we will develop a preliminary long list of outcomes that includes efficacy and adverse events/reactions via three steps: (i) systematic reviews of efficacy and safety outcomes for clinical trials of AHF; (ii) drugs included in the National Medical Insurance Catalog, the National Essential Medicines Catalog, and the WHO Essential Medicines List will be collected and safety outcomes extracted from the package inserts; and (iii) patients' or caregivers' semi-structured interviews will be carried out to add new viewpoints to the list. Second, after merging outcomes and grouping them under different outcome domains, questionnaires for health professionals and patients will be separately developed. Further, two rounds of Delphi survey for health professionals and a survey for patients and the public will be carried out. Third, different stakeholders will discuss and determine the final core outcome set (COS) for AHF in a consensus meeting.Ethics and Dissemination: The entire project has been approved by the Ethics Committee of the main institution. After the final COS is developed, it will be published and discussed widely in conferences.Clinical Trial Registration: This study is registered with the Core Outcome Measures in Effectiveness Trials database as study 1566 (available at: https://www.cometinitiative.org/Studies/Details/1566).
Keywords	acute heart failure ; core outcome set ; integrative medicine ; methodology ; safety and efficacy ; study protocol ; Medicine (General) ; R5-920
Subject code	020
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Experimental Study on NO x Reduction in Oxy-fuel Combustion Using Synthetic Coals with Pyridinic or Pyrrolic Nitrogen

Chang’an Wang / Pengqian Wang / Lin Zhao / Yongbo Du / Defu Che

Applied Sciences, Vol 8, Iss 12, p

2018 Volume 2499

Abstract: Oxy-fuel combustion technology can capture carbon dioxide (CO 2 ) in the large-scale and greatly lower nitrogen oxides (NO x ) emission in coal-fired power plants. However, the influence of inherent minerals on NO x reduction still remains unclear and ... ...

Abstract	Oxy-fuel combustion technology can capture carbon dioxide (CO 2 ) in the large-scale and greatly lower nitrogen oxides (NO x ) emission in coal-fired power plants. However, the influence of inherent minerals on NO x reduction still remains unclear and the impact of oxy-fuel combustion on the transformation of different nitrogen functional groups has yet to be fully understood. The present work aims to obtain a further understanding of the NO x reduction during oxy-fuel combustion using synthetic coals with pyrrolic or pyridinic nitrogen. Compared to pyridinic nitrogen, more of the pyrrolic nitrogen in synthetic coal was converted to NO x . The conversion ratio of nitric oxide (NO) first increased significantly with the rising oxygen content and then trended to an asymptotically constant as the oxygen (O 2 ) content varied between 10⁻50%. The nitrogen dioxide (NO 2 ) formation was roughly proportional to the oxygen content. The NO 2 conversion was increased with particle size but the case of NO showed a non-monotonic variation. The catalytic effects of sodium carbonate (Na 2 CO 3 ), calcium carbonate (CaCO 3 ), and ferric oxide (Fe 2 O 3 ) on the transformation of pyridinic nitrogen to NO were independent of the combustion atmosphere, while the alteration from air to the oxy-fuel combustion led to a change of mineral catalytic effect on the oxidation of pyrrolic nitrogen within the coal matrix.
Keywords	oxy-fuel combustion ; NO x reduction ; pyridinic nitrogen ; pyrrolic nitrogen ; synthetic coal ; mineral effect ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	290
Language	English
Publishing date	2018-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Numerical Investigation on Co-firing Characteristics of Semi-Coke and Lean Coal in a 600 MW Supercritical Wall-Fired Boiler

Chang’an Wang / Qinqin Feng / Qiang Lv / Lin Zhao / Yongbo Du / Pengqian Wang / Jingwen Zhang / Defu Che

Applied Sciences, Vol 9, Iss 5, p

2019 Volume 889

Abstract: Semi-coke is one of the principal by-products of coal pyrolysis and gasification, which features the disadvantages of ignition difficulty, low burnout rate, and high nitrogen oxides (NOx) emission during combustion process. Co-firing semi-coke with coal ... ...

Abstract	Semi-coke is one of the principal by-products of coal pyrolysis and gasification, which features the disadvantages of ignition difficulty, low burnout rate, and high nitrogen oxides (NOx) emission during combustion process. Co-firing semi-coke with coal is a potential approach to achieve clean and efficient utilization of such low-volatile fuel. In this paper, the co-firing performance of semi-coke and lean coal in a 600 MW supercritical wall-fired boiler was numerically investigated which has been seldom done previously. The influences of semi-coke blending ratio, injection position of semi-coke, excess air ratio in the main combustion zone, the co-firing method, and over fire air (OFA) arrangement on the combustion efficiency and NOx generation characteristics of the utility boiler were extensively analyzed. The simulation results indicated that as the blending ratio of semi-coke increased, the NOx emission at furnace outlet decreased. The blending methods (in-furnace versus out-furnace) had certain impacts on the NOx emission and carbon content in fly ash, while the in-furnace blending method showed more flexibility in co-firing adjustment. The injection of semi-coke from the upper burners could significantly abate NOx emission at the furnace outlet, but also brought about the rise of carbon content in fly ash and the increase of outlet temperature. Compared with the condition that semi-coke and lean coal were injected from different burners, the burnout ratio of the blend premixed outside the furnace was higher at the same blending ratio of semi-coke. With the excess air ratio in the main combustion zone increased, NOx concentration at the furnace outlet was increased. The excess air ratio of 0.75 in the main combustion zone was recommended for co-firing 45% semi-coke with lean coal. The operational performance of the boiler co-firing semi-coke was greatly affected by the arrangement of OFA as well. The amount of NOx generated from the supercritical wall-fired boiler could be reduced with an increase of the ...
Keywords	semi-coke ; supercritical wall-fired boiler ; combustion efficiency ; NOx emission ; co-combustion ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	670
Language	English
Publishing date	2019-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The effects of red yeast rice dietary supplement on blood pressure, lipid profile, and C-reactive protein in hypertension: A systematic review

Xiong, Xingjiang / Pengqian Wang / Shengjie Li / Xiaoke Li / Yuqing Zhang

Critical reviews in food science and nutrition. 2017 June 13, v. 57, no. 9

2017

Abstract: Interest is increasing regarding the potential health effects of red yeast rice (RYR) consumption, which is described as a ânatural statinâ in China. This review aims to evaluate the efficacy of RYR on blood pressure (BP), lipid profile, and C- ... ...

Abstract	Interest is increasing regarding the potential health effects of red yeast rice (RYR) consumption, which is described as a ânatural statinâ in China. This review aims to evaluate the efficacy of RYR on blood pressure (BP), lipid profile, and C-reactive protein (CRP) in treating hypertension. Seven electronic databases including the Cochrane Central Register of Controlled Trials, EMBASE, PubMed, the Chinese National Knowledge Infrastructure (CNKI), the Chinese Scientific Journal Database (VIP), the Chinese Biomedical Literature Database (CBM), and the Wanfang database were searched. To investigate the role of RYR for hypertension, randomized controlled trials for the use of RYR either as monotherapy or in combination with conventional medicine versus placebo, no intervention, or conventional medicine for hypertension were identified. A total of 21 trials containing 4558 patients were analyzed, the majority of which had low methodological quality. âRYR plus conventional therapyâ exhibited significant lowering effects on serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and CRP but exhibited no significant effect on systolic BP, diastolic BP, triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) compared with âplacebo plus conventional therapy.â âRYR plus conventional therapyâ showed significant lowering effects on systolic BP, TC, LDL-C, and CRP but no effect on diastolic BP, TG, and HDL-C compared with âplacebo plus conventional therapy.â No significant difference in BP and lipid profile between âRYR plus conventional therapyâ and âstatins plus conventional therapyâ was observed. âRYR plus statinsâ appeared to be more effective in lowering BP, TC, TG, and LDL-C but without a significant difference in HDL-C compared to statins. No serious adverse events were reported. The results of this meta-analysis suggested some supportive but limited evidence regarding RYR for hypertension. Further rigorously designed trials are warranted before RYR could be recommended to hypertensive patients.
Keywords	blood pressure ; blood serum ; C-reactive protein ; databases ; high density lipoprotein cholesterol ; hypertension ; lipid composition ; low density lipoprotein cholesterol ; medicine ; meta-analysis ; patients ; placebos ; red yeast rice ; systematic review ; therapeutics ; triacylglycerols ; China
Language	English
Dates of publication	2017-0613
Size	p. 1831-1851.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	1037504-1
ISSN	1549-7852 ; 1040-8398
ISSN (online)	1549-7852
ISSN	1040-8398
DOI	10.1080/10408398.2015.1018987
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Gene Expression Profiling Confirms the Dosage-Dependent Additive Neuroprotective Effects of Jasminoidin in a Mouse Model of Ischemia-Reperfusion Injury

Haixia Li / Jingtao Wang / Pengqian Wang / Yingying Zhang / Jun Liu / Yanan Yu / Bing Li / Zhong Wang

BioMed Research International, Vol

2018 Volume 2018

Abstract: Recent evidence demonstrates that a double dose of Jasminoidin (2·JA) is more effective than Jasminoidin (JA) in cerebral ischemia therapy, but its dosage-effect mechanisms are unclear. In this study, the software GeneGo MetaCore was used to perform ... ...

Abstract	Recent evidence demonstrates that a double dose of Jasminoidin (2·JA) is more effective than Jasminoidin (JA) in cerebral ischemia therapy, but its dosage-effect mechanisms are unclear. In this study, the software GeneGo MetaCore was used to perform pathway analysis of the differentially expressed genes obtained in microarrays of mice belonging to four groups (Sham, Vehicle, JA, and 2·JA), aiming to elucidate differences in JA and 2·JA’s dose-dependent pharmacological mechanism from a system’s perspective. The top 10 enriched pathways in the 2·JA condition were mainly involved in neuroprotection (70% of the pathways), apoptosis and survival (40%), and anti-inflammation (20%), while JA induced pathways were mainly involved in apoptosis and survival (60%), anti-inflammation (20%), and lipid metabolism (20%). Regarding shared pathways and processes, 3, 1, and 3 pathways overlapped between the Vehicle and JA, Vehicle and 2·JA, and JA and 2·JA conditions, respectively; for the top ten overlapped processes these numbers were 3, 0, and 4, respectively. The common pathways and processes in the 2·JA condition included differentially expressed genes significantly different from those in JA. Seven representative pathways were only activated by 2·JA, such as Gamma-Secretase regulation of neuronal cell development. Process network comparison indicated that significant nodes, such as alpha-MSH, ACTH, PKR1, and WNT, were involved in the pharmacological mechanism of 2·JA. Function distribution was different between JA and 2·JA groups, indicating a dosage additive mechanism in cerebral ischemia treatment. Such systemic approach based on whole-genome multiple pathways and networks may provide an effective and alternative approach to identify alterations underlining dosage-dependent therapeutic benefits of pharmacological compounds on complex disease processes.
Keywords	Medicine ; R
Subject code	570
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Efficacy and safety of Chinese herbal medicine Xiao Yao San in hypertension: a systematic review and meta-analysis

Xiong, Xingjiang / Fuyong Chu / Hu You / Kelei Su / Lian Duan / Pengqian Wang / Shengjie Li / Wei Liu / Xiaoke Li / Yanwei Xing

Phytomedicine. 2019 Jan. 26,

2019

Abstract: Xiao Yao San (XYS) is thought to be beneficial for the treatment of hypertension in China.A systematic review and meta-analysis was performed to evaluate the efficacy and safety of XYS in hypertension.A comprehensive literature search was conducted in 7 ... ...

Abstract	Xiao Yao San (XYS) is thought to be beneficial for the treatment of hypertension in China.A systematic review and meta-analysis was performed to evaluate the efficacy and safety of XYS in hypertension.A comprehensive literature search was conducted in 7 electronic databases for randomized controlled trials from their inception until January 7, 2019.Methodological quality was assessed independently using the Cochrane Handbook for Systematic Reviews of Interventions.A total of 17 trials including 1460 hypertensive patients met the selection criteria. Pooled analysis favored XYS plus antihypertensive drugs on blood pressure (BP), Hamilton anxiety scale, self-rating anxiety scale, self-rating depression scale, 9-item patient health questionnaire scale, total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, homocysteine, and C-reactive protein. No significant difference between XYS plus antihypertensive drugs and antihypertensive drugs on major cardiovascular and cerebrovascular events was identified. XYS was well tolerated in the treatment of hypertension.XYS adjuvant to antihypertensive drugs maybe beneficial for hypertensive patients in lowering BP, improving depression, regulating blood lipids, and inhibiting inflammation. However, the efficacy and safety of XYS are still uncertain due to methodological shortcomings. More long-term, randomized, double-blinded clinical trials are needed in future studies.
Keywords	adjuvants ; antihypertensive agents ; anxiety ; blood lipids ; blood pressure ; C-reactive protein ; databases ; herbal medicines ; high density lipoprotein cholesterol ; homocysteine ; hypertension ; inflammation ; low density lipoprotein cholesterol ; meta-analysis ; patients ; questionnaires ; randomized clinical trials ; systematic review ; triacylglycerols
Language	English
Dates of publication	2019-0126
Size	p. 152849.
Publishing place	Elsevier GmbH
Document type	Article
Note	Pre-press version
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2019.152849
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Trends in the Treatment of Hypertension from the Perspective of Traditional Chinese Medicine

Xingjiang Xiong / Xiaochen Yang / Wei Liu / Fuyong Chu / Pengqian Wang / Jie Wang

Evidence-Based Complementary and Alternative Medicine, Vol

2013 Volume 2013

Abstract: Hypertension is a major public-health issue. Much consensus has been reached in the treatment, and considerable progress has been made in the field of antihypertensive drugs. However, the standard-reaching rate of blood pressure is far from satisfaction. ...

Abstract	Hypertension is a major public-health issue. Much consensus has been reached in the treatment, and considerable progress has been made in the field of antihypertensive drugs. However, the standard-reaching rate of blood pressure is far from satisfaction. Considering these data and the seriousness of the effects of hypertension on the individual and society as a whole, both economically and socially, physicians must look for more effective and alternative ways to achieve the target blood pressure. Could treatment of hypertension be improved by insights from traditional Chinese medicine? As one of the most important parts in complementary and alternative therapies, TCM is regularly advocated for lowering elevated blood pressure. Due to the different understanding of the pathogenesis of hypertension between ancient and modern times, new understanding and treatment of hypertension need to be reexplored. Aiming to improve the efficacy of Chinese herbal medicine in treating hypertension, the basis of treatment is explored through systematically analyzing the literature available in both English and Chinese search engines. This paper systematically reviews the trends in emerging therapeutic strategies for hypertension from the perspective of traditional Chinese medicine.
Keywords	Other systems of medicine ; RZ201-999
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chinese Patent Medicine Liu Wei Di Huang Wan Combined with Antihypertensive Drugs, a New Integrative Medicine Therapy, for the Treatment of Essential Hypertension

Jie Wang / Kuiwu Yao / Xiaochen Yang / Wei Liu / Bo Feng / Jizheng Ma / Xinliang Du / Pengqian Wang / Xingjiang Xiong

Evidence-Based Complementary and Alternative Medicine, Vol

A Systematic Review of Randomized Controlled Trials

2012 Volume 2012

Abstract: Objectives. To assess the beneficial and adverse effects of Liu Wei Di Huang Wan (LWDHW), combined with antihypertensive drugs, for essential hypertension. Methods. Five major electronic databases were searched up to August 2012 to retrieve any potential ...

Abstract	Objectives. To assess the beneficial and adverse effects of Liu Wei Di Huang Wan (LWDHW), combined with antihypertensive drugs, for essential hypertension. Methods. Five major electronic databases were searched up to August 2012 to retrieve any potential randomized controlled trials designed to evaluate the clinical effectiveness of LWDHW combined with antihypertensive drugs for essential hypertension reported in any language, with main outcome measures as blood pressure. The quality of the included studies was assessed with the Jadad scale and a customized standard quality assessment scale. Results. 6 randomized trials were included. The methodological quality of the trials was evaluated as generally low. The pooled results showed that LWDHW combined with antihypertensive drugs was more effective in blood pressure and the scale for TCM syndrome and symptom differentiation scores compared with antihypertensive drugs alone. Most of the trials did not report adverse events, and the safety is still uncertain. Conclusions. LWDHW combined with antihypertensive drugs appears to be effective in improving blood pressure and symptoms in patients with essential hypertension. However, the evidence remains weak due to the poor methodological quality of the included studies.
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Banxia Baizhu Tianma Decoction for Essential Hypertension

Xingjiang Xiong / Xiaochen Yang / Wei Liu / Bo Feng / Jizheng Ma / Xinliang Du / Pengqian Wang / Fuyong Chu / Jun Li / Jie Wang

Evidence-Based Complementary and Alternative Medicine, Vol

A Systematic Review of Randomized Controlled Trials

2012 Volume 2012

Abstract: Objectives. To assess the current clinical evidence of Banxia Baizhu Tianma Decoction (BBTD) for essential hypertension (EH). Search Strategy. Electronic databases were searched until July 2012. Inclusion Criteria. We included randomized clinical trials ... ...

Abstract	Objectives. To assess the current clinical evidence of Banxia Baizhu Tianma Decoction (BBTD) for essential hypertension (EH). Search Strategy. Electronic databases were searched until July 2012. Inclusion Criteria. We included randomized clinical trials testing BBTD against placebo, antihypertensive drugs, or combined with antihypertensive drugs against antihypertensive drugs. Data Extraction and Analyses. Study selection, data extraction, quality assessment, and data analyses were conducted according to Cochrane standards. Results. 16 randomized trials were included. Methodological quality of the included trials was evaluated as generally low. 2 trials compared prescriptions based on BBTD using alone with antihypertensive drugs. Meta-analysis showed no significant effect of modified BBTD compared with captopril in systolic blood pressure (MD: −0.75 (−5.77, 4.27); P=0.77) and diastolic blood pressure (MD: −0.75 (−2.89, 1.39); P=0.49). 14 trials compared the combination of BBTD or modified BBTD plus antihypertensive drugs with antihypertensive drugs. Meta-analysis showed there are significant beneficial effect on systolic blood pressure in the combination group compare to the antihypertensive drugs (MD: −4.33 (−8.44, −0.22); P=0.04). The safety of BBTD is uncertain. Conclusions. There is encouraging evidence of BBTD for lowering SBP, but evidence remains weak. Rigorously designed trials are warranted to confirm these results.
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Zhen Gan Xi Feng Decoction, a Traditional Chinese Herbal Formula, for the Treatment of Essential Hypertension

Xingjiang Xiong / Xiaochen Yang / Bo Feng / Wei Liu / Lian Duan / Ao Gao / Haixia Li / Jizheng Ma / Xinliang Du / Nan Li / Pengqian Wang / Kelei Su / Fuyong Chu / Guohao Zhang / Xiaoke Li / Jie Wang

Evidence-Based Complementary and Alternative Medicine, Vol

A Systematic Review of Randomized Controlled Trials

2013 Volume 2013

Abstract: Objectives. To assess the clinical effectiveness and adverse effects of Zhen Gan Xi Feng Decoction (ZGXFD) for essential hypertension (EH). Methods. Five major electronic databases were searched up to August 2012 to retrieve any potential randomized ... ...

Abstract	Objectives. To assess the clinical effectiveness and adverse effects of Zhen Gan Xi Feng Decoction (ZGXFD) for essential hypertension (EH). Methods. Five major electronic databases were searched up to August 2012 to retrieve any potential randomized controlled trials designed to evaluate the clinical effectiveness of ZGXFD for EH reported in any language, with main outcome measure as blood pressure (BP). Results. Six randomized trials were included. Methodological quality of the trials was evaluated as generally low. Four trials compared prescriptions based on ZGXFD with antihypertensive drugs. Meta-analysis showed that ZGXFD was more effective in BP control and TCM syndrome and symptom differentiation (TCM-SSD) scores than antihypertensive drugs. Two trials compared the combination of modified ZGXFD plus antihypertensive drugs with antihypertensive drugs. Meta-analysis showed that there is significant beneficial effect on TCM-SSD scores. However, no significant effect on BP was found. The safety of ZGXFD is still uncertain. Conclusions. ZGXFD appears to be effective in improving blood pressure and hypertension-related symptoms for EH. However, the evidence remains weak due to poor methodological quality of the included studies. More rigorous trials are warranted to support their clinical use.
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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