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  1. Article: Minimally Invasive Treatment of Stress Urinary Incontinence in Women: A Prospective Comparative Analysis between Bulking Agent and Single-Incision Sling.

    Campanella, Lorenzo / Gabrielli, Gianluca / Chiodo, Erika / Stefanachi, Vitaliana / Pennacchini, Ermelinda / Grilli, Debora / Grossi, Giovanni / Cignini, Pietro / Morciano, Andrea / Zullo, Marzio Angelo / Palazzetti, Pierluigi / Rappa, Carlo / Calcagno, Marco / Spina, Vincenzo / Cervigni, Mauro / Schiavi, Michele Carlo

    Healthcare (Basel, Switzerland)

    2024  Volume 12, Issue 7

    Abstract: Introduction: The study aims to compare the efficacy and safety of bulking agents and single-incision slings in the treatment of urinary incontinence in 159 patients during a 29-month follow-up period.: Material and methods: Of the 159 patients ... ...

    Abstract Introduction: The study aims to compare the efficacy and safety of bulking agents and single-incision slings in the treatment of urinary incontinence in 159 patients during a 29-month follow-up period.
    Material and methods: Of the 159 patients suffering from stress urinary incontinence, 64 were treated with bulking agents (PAHG Bulkamid
    Results: The bulking agents showed high efficacy and safety during the 29-month follow-up. Post-operative complications were recorded in both groups, with only two significant differences. The Bulkamid group experienced no pain, while 10.8% of the ALTIS group experienced groin pain and 5% experienced de novo urgency. Furthermore, patients treated with bulking agents experienced reduced nicturia (0.78 vs. 0.92 in patients treated with single-incision slings.). In both groups, we noticed a significant improvement in QoL (quality of life), with a halved ICIQ-UI-SF (International Consultation on Incontinence Questionnaire-Urine Incontinence-Short Form) score which was completed to assess the impact of urine symptoms. After 24 months of therapy, the Bulkamid group saw a decrease from 14.58 ± 5.11 at baseline to 5.67 ± 1.90 (
    Conclusions: In terms of efficacy and safety, bulking agents had notable results over the 29-month follow-up period. Furthermore, the patients treated with bulking agents reported a lower incidence of postoperative complications and a no discernible difference in terms of quality of life and sexual activity compared to the ones treated with single-incision slings. Bulking agents can be considered a very reliable therapeutic option based on accurate patient selection.
    Language English
    Publishing date 2024-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare12070751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Distinguishing hypertension from hypertrophic cardiomyopathy as a cause of left ventricular hypertrophy.

    Pennacchini, Ermelinda / Musumeci, Maria Beatrice / Fierro, Stefano / Francia, Pietro / Autore, Camillo

    Journal of clinical hypertension (Greenwich, Conn.)

    2015  Volume 17, Issue 3, Page(s) 239–241

    MeSH term(s) Antihypertensive Agents/therapeutic use ; Cardiomyopathy, Hypertrophic/complications ; Cardiomyopathy, Hypertrophic/diagnosis ; Diagnosis, Differential ; Echocardiography ; Electrocardiography ; Humans ; Hypertension/complications ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertrophy, Left Ventricular/etiology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Treatment Outcome
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2015-01-13
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 2077222-1
    ISSN 1751-7176 ; 1524-6175
    ISSN (online) 1751-7176
    ISSN 1524-6175
    DOI 10.1111/jch.12481
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5723: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Electrocardiographic evolution in patients with hypertrophic cardiomyopathy who develop a left ventricular apical aneurysm.

    Pennacchini, Ermelinda / Musumeci, Maria Beatrice / Conte, Maria Rosa / Stöllberger, Claudia / Formisano, Francesco / Bongioanni, Sergio / Francia, Pietro / Volpe, Massimo / Autore, Camillo

    Journal of electrocardiology

    2015  Volume 48, Issue 5, Page(s) 818–825

    Abstract: Introduction: Hypertrophic cardiomyopathy (HCM) patients with apical aneurysm have a largely unfavourable clinical course, and are often unrecognised because echocardiography is limited in the assessment of the left ventricular (LV) apex. The aim of ... ...

    Abstract Introduction: Hypertrophic cardiomyopathy (HCM) patients with apical aneurysm have a largely unfavourable clinical course, and are often unrecognised because echocardiography is limited in the assessment of the left ventricular (LV) apex. The aim of this study is the identification of electrocardiographic (ECG) abnormalities associated with the development of apical aneurysm in HCM patients.
    Materials and methods: Electrocardiographic features were assessed in 14 HCM patients who had a good-quality baseline ECG recorded before and after the diagnosis of apical aneurysm.
    Results: During follow-up (8.8±7.5years), the following ECG changes were observed: increase in QRS-complex duration (87±12ms to 118±34ms, p=0.006), QRS-complex fragmentation, decrease in QRS-complex amplitude (SV1+RV5-6, from 41±18mm to 26±11mm, p=0.015), ST-segment elevation in V4-V6 (J-point in V5, from -0.9±1.3mm to +0.7±1.3, p=0.003), positivisation of negative T waves in V3-V6 (T-wave depth in V5, from -3.4±6.6 to +3.1±4.1, p=0.005).
    Conclusions: HCM patients who develop LV apical aneurysm exhibit distinctive ECG changes along with apical remodelling. Suggestive ECGs should lead the physician to study LV apex by nonstandard echocardiographic views, and perform MRI.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Cardiomyopathy, Hypertrophic/complications ; Cardiomyopathy, Hypertrophic/diagnosis ; Disease Progression ; Electrocardiography/methods ; Female ; Follow-Up Studies ; Heart Aneurysm/diagnosis ; Heart Aneurysm/etiology ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Reproducibility of Results ; Sensitivity and Specificity ; Ventricular Dysfunction, Left/diagnosis ; Ventricular Dysfunction, Left/etiology
    Language English
    Publishing date 2015-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410286-1
    ISSN 1532-8430 ; 0022-0736
    ISSN (online) 1532-8430
    ISSN 0022-0736
    DOI 10.1016/j.jelectrocard.2015.06.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 701: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: A Next-Generation Sequencing Approach to Identify Gene Mutations in Early- and Late-Onset Hypertrophic Cardiomyopathy Patients of an Italian Cohort.

    Rubattu, Speranza / Bozzao, Cristina / Pennacchini, Ermelinda / Pagannone, Erika / Musumeci, Beatrice Maria / Piane, Maria / Germani, Aldo / Savio, Camilla / Francia, Pietro / Volpe, Massimo / Autore, Camillo / Chessa, Luciana

    International journal of molecular sciences

    2016  Volume 17, Issue 8

    Abstract: Sequencing of sarcomere protein genes in patients fulfilling the clinical diagnostic criteria for hypertrophic cardiomyopathy (HCM) identifies a disease-causing mutation in 35% to 60% of cases. Age at diagnosis and family history may increase the yield ... ...

    Abstract Sequencing of sarcomere protein genes in patients fulfilling the clinical diagnostic criteria for hypertrophic cardiomyopathy (HCM) identifies a disease-causing mutation in 35% to 60% of cases. Age at diagnosis and family history may increase the yield of mutations screening. In order to assess whether Next-Generation Sequencing (NGS) may fulfil the molecular diagnostic needs in HCM, we included 17 HCM-related genes in a sequencing panel run on PGM IonTorrent. We selected 70 HCM patients, 35 with early (≤25 years) and 35 with late (≥65 years) diagnosis of disease onset. All samples had a 98.6% average of target regions, with coverage higher than 20× (mean coverage 620×). We identified 41 different mutations (seven of them novel) in nine genes: MYBPC3 (17/41 = 41%); MYH7 (10/41 = 24%); TNNT2, CAV3 and MYH6 (3/41 = 7.5% each); TNNI3 (2/41 = 5%); GLA, MYL2, and MYL3 (1/41=2.5% each). Mutation detection rate was 30/35 (85.7%) in early-onset and 8/35 (22.9%) in late-onset HCM patients, respectively (p < 0.0001). The overall detection rate for patients with positive family history was 84%, and 90.5% in patients with early disease onset. In our study NGS revealed higher mutations yield in patients with early onset and with a family history of HCM. Appropriate patient selection can increase the yield of genetic testing and make diagnostic testing cost-effective.
    MeSH term(s) Adult ; Age of Onset ; Aged ; Biomarkers/analysis ; Cardiomyopathy, Hypertrophic/diagnosis ; Cardiomyopathy, Hypertrophic/epidemiology ; Cardiomyopathy, Hypertrophic/genetics ; Cohort Studies ; Female ; Genetic Testing ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Italy/epidemiology ; Male ; Middle Aged ; Mutation/genetics
    Chemical Substances Biomarkers
    Language English
    Publishing date 2016-07-30
    Publishing country Switzerland
    Document type Comparative Study ; Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms17081239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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