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  1. AU="Pennell, Evan N"
  2. AU="Kai Yang"
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  1. Article ; Online: Temporal changes in blood oxidative stress biomarkers across the menstrual cycle and with oral contraceptive use in active women.

    Quinn, Karlee M / Cox, Amanda J / Roberts, Llion / Pennell, Evan N / McKeating, Daniel R / Fisher, Joshua J / Perkins, Anthony V / Minahan, Clare

    European journal of applied physiology

    2021  Volume 121, Issue 9, Page(s) 2607–2620

    Abstract: Purpose: To examine the temporal changes in blood oxidative stress biomarkers in recreationally-trained women that were naturally-cycling (WomenNC) or using oral contraceptives (WomenOC) across one month.: Methods: Blood samples were acquired at ... ...

    Abstract Purpose: To examine the temporal changes in blood oxidative stress biomarkers in recreationally-trained women that were naturally-cycling (WomenNC) or using oral contraceptives (WomenOC) across one month.
    Methods: Blood samples were acquired at three timepoints of the menstrual cycle (1: early-follicular, 2: late-follicular and 3: mid-luteal) and oral contraceptive packet (1: InactiveOC, 2: Mid-activeOC and 3: Late-activeOC) for determination of estradiol, progesterone, oxidative stress, C-reactive protein (CRP) and other cardiometabolic biomarkers in plasma and serum.
    Results: There was a Group by Time effect on estradiol (p < 0.001, partial η
    Conclusion: These findings demonstrate that WomenOC not only have higher oxidative stress and CRP than WomenNC, but also a transient increase across one month of habitual oral contraceptive use. Since changes in oxidative stress and CRP often relate to training stress and recovery, these outcomes may have implications to workload monitoring practices in female athletes.
    MeSH term(s) Adult ; Biomarkers/blood ; Contraceptives, Oral/pharmacology ; Female ; Humans ; Menstrual Cycle/blood ; Menstrual Cycle/physiology ; Oxidative Stress/drug effects ; Oxidative Stress/physiology ; Time Factors ; Young Adult
    Chemical Substances Biomarkers ; Contraceptives, Oral
    Language English
    Publishing date 2021-06-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124793-1
    ISSN 1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
    ISSN (online) 1439-6327 ; 1432-1025
    ISSN 0301-5548 ; 1439-6319
    DOI 10.1007/s00421-021-04734-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.195: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Blood oxidative stress biomarkers in women: influence of oral contraception, exercise, and N-acetylcysteine.

    Quinn, Karlee M / Roberts, Llion / Cox, Amanda J / Borg, David N / Pennell, Evan N / McKeating, Daniel R / Fisher, Joshua J / Perkins, Anthony V / Minahan, Clare

    European journal of applied physiology

    2022  Volume 122, Issue 8, Page(s) 1949–1964

    Abstract: Purpose: To compare physiological responses to submaximal cycling and sprint cycling performance in women using oral contraceptives (WomenOC) and naturally cycling women (WomenNC) and to determine whether N-acetylcysteine (NAC) supplementation mediates ... ...

    Abstract Purpose: To compare physiological responses to submaximal cycling and sprint cycling performance in women using oral contraceptives (WomenOC) and naturally cycling women (WomenNC) and to determine whether N-acetylcysteine (NAC) supplementation mediates these responses.
    Methods: Twenty recreationally trained women completed five exercise trials (i.e., an incremental cycling test, a familiarisation trial, a baseline performance trial and two double-blind crossover intervention trials). During the intervention trials participants supplemented with NAC or a placebo 1 h before exercise. Cardiopulmonary parameters and blood biochemistry were assessed during 40 min of fixed-intensity cycling at 105% of gas-exchange threshold and after 1-km cycling time-trial.
    Results: WomenOC had higher ventilation (β [95% CI] = 0.07 L·min
    Conclusions: Blood biomarkers relating to oxidative stress and inflammation are elevated in WomenOC during exercise. There may be an increased strain on the endogenous antioxidant system during exercise, since NAC supplementation in WomenOC did not dampen the exercise-induced increase in malondialdehyde. Future investigations should explore the impact of elevated oxidative stress on exercise adaptations or recovery from exercise in WomenOC.
    MeSH term(s) Acetylcysteine/pharmacology ; Biomarkers ; Contraception ; Contraceptives, Oral/pharmacology ; Cross-Over Studies ; Double-Blind Method ; Female ; Humans ; Malondialdehyde ; Oxidative Stress
    Chemical Substances Biomarkers ; Contraceptives, Oral ; Malondialdehyde (4Y8F71G49Q) ; Acetylcysteine (WYQ7N0BPYC)
    Language English
    Publishing date 2022-06-08
    Publishing country Germany
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 124793-1
    ISSN 1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
    ISSN (online) 1439-6327 ; 1432-1025
    ISSN 0301-5548 ; 1439-6319
    DOI 10.1007/s00421-022-04964-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.195: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Mitochondrial isolation, cryopreservation and preliminary biochemical characterisation from placental cytotrophoblast and syncytiotrophoblast.

    Fisher, JoshuaJ / McKeating, DanielR / Pennell, EvanN / Cuffe, JamesS / Holland, OliviaJ / Perkins, AnthonyV

    Placenta

    2019  Volume 82, Page(s) 1–4

    MeSH term(s) Adenosine Triphosphate/metabolism ; Cryopreservation ; Female ; Flow Cytometry ; Humans ; Membrane Potential, Mitochondrial/physiology ; Microscopy, Electron, Transmission ; Mitochondria/metabolism ; Mitochondria/ultrastructure ; Placenta/metabolism ; Placenta/ultrastructure ; Pregnancy ; Trophoblasts/metabolism ; Trophoblasts/ultrastructure
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2019-05-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 603951-0
    ISSN 1532-3102 ; 0143-4004
    ISSN (online) 1532-3102
    ISSN 0143-4004
    DOI 10.1016/j.placenta.2019.05.004
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1578: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Biliverdin and bilirubin sulfonate inhibit monosodium urate induced sterile inflammation in the rat.

    Shiels, Ryan G / Hewage, Wenu / Pennell, Evan N / Vidimce, Josif / Grant, Gary / Pearson, Andrew G / Wagner, Karl-Heinz / Morgan, Michael / Bulmer, Andrew C

    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

    2020  Volume 155, Page(s) 105546

    Abstract: Background: Biliverdin, a by-product of haem catabolism, possesses potent endogenous antioxidant and anti-inflammatory properties. Bilirubin-C10-sulfonate (BRS), an active metabolite formed after enteral administration of BV in the rat, also possess ... ...

    Abstract Background: Biliverdin, a by-product of haem catabolism, possesses potent endogenous antioxidant and anti-inflammatory properties. Bilirubin-C10-sulfonate (BRS), an active metabolite formed after enteral administration of BV in the rat, also possess antioxidant properties. Therefore, we investigated the anti-inflammatory and antioxidant activity of BV and BRS in an in vivo model of monosodium urate induced sterile inflammation.
    Methods: Subcutaneous air pouches were created on the dorsal flanks of Wistar rats (10-12 weeks of age). Prior to stimulation of the 6-day old pouch with monosodium urate (25 mg), groups were pre-treated with intraperitoneal BRS (27 mg/kg) and BV (27 mg/kg). Total and differential leukocyte counts were determined in pouch fluid aspirate at 1, 6, 12, 24 and 48 h after monosodium urate stimulation. Biliverdin (BV), BRS and unconjugated bilirubin (UCB) concentrations in the serum and pouch fluid were quantified using liquid chromatography-mass spectrometry. Pouch fluid cytokine concentrations (IL-1β, IL-1α, TNF-α, IL-17A, IL-12, GM-CSF, IL-33, IFN-γ, IL-18, IL-10, MCP-1, CXCL-1 and IL-6) were assessed after 6 h. In addition, 24 h protein carbonyl and chloramine concentrations were assessed in pouch fluid using ELISA and spectrophotometry, respectively.
    Results: BRS and BV significantly (p < 0.05) inhibited leukocyte (total, neutrophil and macrophage) infiltration into the pouch fluid from 6 to 48 h. For example, after 6 h neutrophil counts decreased following BRS (0.32 ± 0.11 × 10
    Conclusions: This study is the first to elucidate anti-inflammatory activity of BRS and the efficacy of BV administration in a model of gouty inflammation. Reduced leukocyte infiltration and cytokine production in response to sterile inflammation further support the importance of these molecules in physiology and their therapeutic potential in sterile inflammation.
    MeSH term(s) Animals ; Bilirubin ; Biliverdine ; Inflammation/chemically induced ; Inflammation/drug therapy ; Rats ; Rats, Wistar ; Uric Acid
    Chemical Substances Uric Acid (268B43MJ25) ; Biliverdine (O9MIA842K9) ; Bilirubin (RFM9X3LJ49)
    Language English
    Publishing date 2020-09-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1154366-8
    ISSN 1879-0720 ; 0928-0987
    ISSN (online) 1879-0720
    ISSN 0928-0987
    DOI 10.1016/j.ejps.2020.105546
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3705: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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