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  1. Article ; Online: CBD and THC: Do They Complement Each Other Like Yin and Yang?

    Pennypacker, Sarah D / Romero-Sandoval, E Alfonso

    Pharmacotherapy

    2020  Volume 40, Issue 11, Page(s) 1152–1165

    Abstract: Increased public access to cannabis calls for a deeper understanding of cannabis's constituents and how they interact to induce clinical effects. Whereas trans- ... ...

    Abstract Increased public access to cannabis calls for a deeper understanding of cannabis's constituents and how they interact to induce clinical effects. Whereas trans-Δ
    MeSH term(s) Cannabidiol/pharmacokinetics ; Dronabinol/pharmacokinetics ; Drug Synergism ; Humans
    Chemical Substances Cannabidiol (19GBJ60SN5) ; Dronabinol (7J8897W37S)
    Language English
    Publishing date 2020-10-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 603158-4
    ISSN 1875-9114 ; 0277-0008
    ISSN (online) 1875-9114
    ISSN 0277-0008
    DOI 10.1002/phar.2469
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1738: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 585: Show issues

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  2. Article: Potency and Therapeutic THC and CBD Ratios: U.S. Cannabis Markets Overshoot.

    Pennypacker, Sarah D / Cunnane, Katharine / Cash, Mary Catherine / Romero-Sandoval, E Alfonso

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 921493

    Abstract: Background and aims: ...

    Abstract Background and aims:
    Language English
    Publishing date 2022-06-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.921493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Methods and protocols for translatable rodent models of postsurgical pain.

    Morgan, James W / Pennypacker, Sarah D / Romero-Sandoval, E Alfonso / Fonseca, Miriam M

    Methods in cell biology

    2022  Volume 168, Page(s) 249–276

    Abstract: Due to the large volume of surgeries and the subsequent incidence of postsurgical pain, it is vital that the underlying mechanisms of postsurgical pain are thoroughly understood. The intensity of acute postsurgical pain is typically dependent on the ... ...

    Abstract Due to the large volume of surgeries and the subsequent incidence of postsurgical pain, it is vital that the underlying mechanisms of postsurgical pain are thoroughly understood. The intensity of acute postsurgical pain is typically dependent on the severity of tissue damage the surgery produces, and the development of chronic pain is more frequent in major surgeries than in minor ones. It is therefore important that postsurgical pain studies are conducted with the differences between major and minor surgeries in mind. To this end, the paw incision and skin muscle incision and retraction models are the focus of this chapter as they feature aspects observed in minor and major surgeries in humans, respectively. Several elements of these models translate to humans with some limitations, as they allow for the measurement of reflexive, spontaneous, and functional pain-like behavior. For these attributes, the SMIR and paw incision surgeries are widely used in postsurgical pain research. Here we layout detailed protocols to instruct experienced as well as inexperienced researchers studying postsurgical pain in rats and mice.
    MeSH term(s) Animals ; Chronic Pain/complications ; Mice ; Pain, Postoperative/etiology ; Rats ; Rats, Sprague-Dawley ; Rodentia ; Skin
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Journal Article
    ISSN 0091-679X
    ISSN 0091-679X
    DOI 10.1016/bs.mcb.2021.12.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Association of Tetrahydrocannabinol Content and Price in Herbal Cannabis Products Offered by Dispensaries in California: A Purview of Consumers/Patients.

    Dobbins, MaryBeth / Rakkar, Mannat / Cunnane, Katharine / Pennypacker, Sarah D / Wagoner, Kimberly G / Reboussin, Beth A / Romero-Sandoval, E Alfonso

    Frontiers in public health

    2022  Volume 10, Page(s) 893009

    Abstract: Background and aims: The U.S. legal cannabis market is saturated with products containing high levels of tetrahydrocannabinol (THC), with no distinction between medical and recreational programs. This omnipresence of potent cannabis products seems to be ...

    Abstract Background and aims: The U.S. legal cannabis market is saturated with products containing high levels of tetrahydrocannabinol (THC), with no distinction between medical and recreational programs. This omnipresence of potent cannabis products seems to be driven by the recreational realm, where cannabis with the highest THC content is prized. This prevalence of highly potent cannabis is conveyed to medical programs, which places consumers (patients) at higher risk for over consumption and cannabis use disorder. Thus, understanding what factors influence the market that patients face in medical cannabis programs could shed light on the risks of legal cannabis. The supply and demand dynamic of the US for-profit cannabis market could explain the current market composition; therefore, we postulate that a financial gain could influence the perpetuation of the prevalence of high THC products in legal cannabis dispensaries. We investigate whether THC content in popular cannabis products correlates with higher prices and assess whether some attributes (type of product, chemovars, or presence of cannabidiol (CBD) affect the association of THC with price.
    Methods: We focus on the world's largest cannabis market, California. We randomly selected dispensaries across the state, screened for a web presence and product menu, determined the most prevalent product type, and collected THC and CBD concentration, price, and other product attributes.
    Results: We observed that herbal products were more common, they had THC concentrations greater than 10%, and THC concentrations positively correlated with price. This correlation existed in flower and preroll presentations, all chemovar, and independently of the level of CBD. CBD did not correlate with price; however, the presence of CBD diminished the THC and price correlation particularly in products with high THC (>15%).
    Conclusions: Overall, highly potent herbal cannabis products (>15% THC) are the majority of products offered and more expensive regardless of product type or chemovar in California dispensaries, suggesting that a financial gain contributes to the current market composition. Efforts to limit the availability of highly potent THC products and educate consumers about potential harms are needed.
    MeSH term(s) California ; Cannabidiol ; Cannabis ; Dronabinol ; Humans
    Chemical Substances Cannabidiol (19GBJ60SN5) ; Dronabinol (7J8897W37S)
    Language English
    Publishing date 2022-06-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.893009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Methods and protocols for chemotherapy-induced peripheral neuropathy (CIPN) mouse models using paclitaxel.

    Pennypacker, Sarah D / Fonseca, Miriam M / Morgan, James W / Dougherty, Patrick M / Cubillos-Ruiz, Juan R / Strowd, Roy E / Romero-Sandoval, E Alfonso

    Methods in cell biology

    2022  Volume 168, Page(s) 277–298

    Abstract: While cancer patients may have chemotherapeutics to thank for being cured of their malignancy, they are often left to suffer a disabling neuropathy induced by that same cancer treatment. This neuropathy, known as chemotherapy-induced peripheral ... ...

    Abstract While cancer patients may have chemotherapeutics to thank for being cured of their malignancy, they are often left to suffer a disabling neuropathy induced by that same cancer treatment. This neuropathy, known as chemotherapy-induced peripheral neuropathy, or CIPN, is one of the most debilitating survivorship concerns for patients, with many citing hallmark symptoms of hyperalgesia, allodynia, and numbness, and subsequently reducing their dose or even ceasing treatment altogether. Investigations into this interplay between the antineoplastic activity of chemotherapeutic agents and the preservation of peripheral nerve health are therefore crucial for the development of CIPN treatment and prevention methods. Responding to need, current literature is inundated with varying preclinical models of CIPN. This chapter thus seeks to provide a detailed and reliable methodology for the induction and assessment of CIPN in mice, using a preclinical model that is both reproducible and translatable to several aspects of the clinical phenotype. Specifically, this chapter lays out a model for intermittent low-dose paclitaxel induction of CIPN in C57BL/6J mice, and a testing of this induction via von Frey filament mechanical hypersensitivity assays, a mechanical hyposensitivity (numbness) assay, and a cold-thermal allodynia assay (acetone test). These protocols can easily be adjusted to fit the needs of individual CIPN experiments, as stated throughout the chapter.
    MeSH term(s) Animals ; Antineoplastic Agents/toxicity ; Humans ; Hyperalgesia/chemically induced ; Hyperalgesia/drug therapy ; Hyperalgesia/genetics ; Mice ; Mice, Inbred C57BL ; Paclitaxel/adverse effects ; Peripheral Nervous System Diseases/chemically induced ; Peripheral Nervous System Diseases/drug therapy
    Chemical Substances Antineoplastic Agents ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2022-01-10
    Publishing country United States
    Document type Journal Article
    ISSN 0091-679X
    ISSN 0091-679X
    DOI 10.1016/bs.mcb.2021.12.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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