Article ; Online: β-Adrenergic Receptor Stimulates L-Type Calcium Current in Adult Smooth Muscle Cells
Journal of Vascular Research - Incorporating 'International Journal of Microcirculation'
1991 Volume 28, Issue 1-3, Page(s) 154–158
Abstract: The hormonal regulation of L-type calcium current was investigated in freshly isolated tracheal smooth muscle cells using the whole-cell configuration of the patch-clamp technique. Isoproterenol stimulated the L-type calcium current 2.6-fold through β- ... ...
Abstract | The hormonal regulation of L-type calcium current was investigated in freshly isolated tracheal smooth muscle cells using the whole-cell configuration of the patch-clamp technique. Isoproterenol stimulated the L-type calcium current 2.6-fold through β-adrenoceptors. Dialysis of these cells with cyclic AMP, cyclic AMP analogues or the catalytic sub-unit of cyclic AMP kinase had no effect on basal or isoproterenol-stimulated calcium current. The calcium current was stimulated and inhibited by dialysis of the cells with GTP=γS and GDPβS, respectively. Evidently, in some smooth muscle cells the β-adrenoceptor couples directly to L-type calcium channels via a G protein. |
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Keywords | Smooth muscle calcium channel ; β-Adrenergic receptor ; Regulation of calcium channels ; Receptor ion channel coupling |
Language | English |
Publisher | S. Karger AG |
Publishing place | Basel |
Publishing country | Switzerland |
Document type | Article ; Online |
ZDB-ID | 1105259-4 |
ISSN | 1423-0135 ; 1018-1172 ; 1018-1172 |
ISSN (online) | 1423-0135 |
ISSN | 1018-1172 |
DOI | 10.1159/000158855 |
Database | Karger publisher's database |
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