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  1. Article ; Online: Late onset corneal haze after corneal cross-linking for progressive keratoconus.

    Peponis, Vasilios / Kontomichos, Loukas / Chatziralli, Irini / Kontadakis, George / Parikakis, Efstratios

    American journal of ophthalmology case reports

    2019  Volume 14, Page(s) 64–66

    Abstract: Purpose: To present the case of a patient that underwent corneal crosslinking for progressive keratoconus and 18 months later revealed clinically significant corneal stromal haze.: Observations: A 20-year-old male presented with progressive visual ... ...

    Abstract Purpose: To present the case of a patient that underwent corneal crosslinking for progressive keratoconus and 18 months later revealed clinically significant corneal stromal haze.
    Observations: A 20-year-old male presented with progressive visual loss OU for the past few years. His corrected distance visual acuity (CDVA) OD was 20/30 (-2.75 -1.75 @55) and OS 20/30 (-0.50 -1.75@110). Corneal topography revealed keratoconus OU and the patient underwent corneal crosslinking according to the Dresden Protocol. The postoperative regimen included combined tobramycin and dexamethasone qid along with lubrication until epithelium healed and then fluorometholone qid with weekly tapering. At 3 months postoperatively, his topography was stable and his corrected distance visual acuity (CDVA) was 20/25 OU. On slit lamp examination, only clinically insignificant stromal haze was observed. At 18 months postoperatively, the patient reported vision deterioration. On examination his CDVA was 20/25 in right eye, and 20/40 in his left eye. Deep stromal haze was revealed in his central cornea, more dense in his left eye. Corneal topography was stable and the CDVA loss was attributed to the notable deep stromal haze. The patient was treated with dexamethasone qid with biweekly tapering. 18 months after corneal crosslinking, the patient demonstrated clinically significant stromal haze, most prominent OS. He was treated with dexamethasone qid. One month later his CDVA OS gradually improved to 20/25, and stromal haze was still noted but less dense.
    Conclusions and importance: Late-onset deep corneal haze is a possible complication of corneal crosslinking in keratoconic patients.
    Language English
    Publishing date 2019-02-26
    Publishing country United States
    Document type Case Reports
    ISSN 2451-9936
    ISSN (online) 2451-9936
    DOI 10.1016/j.ajoc.2019.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Patterns of macular edema in patients with uveitis: qualitative and quantitative assessment using optical coherence tomography.

    Markomichelakis, Nikos N / Halkiadakis, Ioannis / Pantelia, Eugenia / Peponis, Vasilios / Patelis, Andreas / Theodossiadis, Panagiotis / Theodossiadis, George

    Ophthalmology

    2004  Volume 111, Issue 5, Page(s) 946–953

    Abstract: Purpose: To describe the morphologic characteristics of uveitic macular edema by the use of optical coherence tomography (OCT) and to investigate the correlation between tomographic features and visual acuity (VA).: Design: Cross-sectional study.: ... ...

    Abstract Purpose: To describe the morphologic characteristics of uveitic macular edema by the use of optical coherence tomography (OCT) and to investigate the correlation between tomographic features and visual acuity (VA).
    Design: Cross-sectional study.
    Participants: Seventy consecutive patients with uveitis in a university-based practice with a clinical diagnosis of macular edema in at least one eye. Inclusion criteria were: (1) verification of macular edema by OCT, (2) adequate media clarity for fundus visualization, and (3) absence of coexisting ocular disease limiting visual potential.
    Methods: Complete ophthalmic examination: best-corrected Snellen VA, slit-lamp examination, fundus biomicroscopy, indirect ophthalmoscopy, and OCT. Fluorescein angiography was performed in selected cases.
    Main outcome measures: Best-corrected Snellen VA and tomographic features of the macula, including macular thickness measurement and correlation of macular thickness with VA.
    Results: Eighty-four eyes of 60 patients met the inclusion criteria. The mean VA (Snellen test) was 20/36. There were 3 patterns of macular edema: diffuse macular edema (DME), cystoid macular edema (CME), and serous retinal detachment (RD). Serous retinal detachment was detected in 17 eyes (20.2%). Patients were classified into the following groups: DME (46 eyes, 54.8%), CME (21 eyes, 25%), DME and RD (5 eyes, 5.9%), CME and RD (12 eyes, 14.3%). Epiretinal membrane was detected by OCT in 34 eyes (40.5%). Eight eyes (9.5%) demonstrated vitreomacular traction. The mean retinal thickness at the central fovea was 333+/-171 microm (mean +/- standard deviation). Macular edema was located mainly in the outer retinal layers. Eyes with CME had significantly greater retinal thickness measurements than eyes with DME (P<0.001). Multivariate analysis revealed that VA was negatively correlated with increased macular thickness, presence of CME, and RD (P<0.05).
    Conclusions: Optical coherence tomography demonstrated 3 patterns of macular edema in patients with uveitis: DME, CME, and RD. Epiretinal membrane coexisted in a significant percentage of patients. In patients with uveitis with clear media, the morphologic features of macular edema and macular thickness correlated with VA.
    MeSH term(s) Adolescent ; Adult ; Aged ; Child ; Cross-Sectional Studies ; Diagnostic Techniques, Ophthalmological ; Female ; Fluorescein Angiography ; Humans ; Macular Edema/complications ; Macular Edema/diagnosis ; Male ; Middle Aged ; Tomography, Optical Coherence/methods ; Uveitis/complications ; Uveitis/diagnosis ; Visual Acuity
    Language English
    Publishing date 2004-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2003.08.037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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