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  1. Article ; Online: Obesity Survival Paradox in the Critically Ill.

    Pepper, Dominique J

    Critical care medicine

    2017  Volume 45, Issue 8, Page(s) e872

    MeSH term(s) Body Mass Index ; Critical Illness ; Enteral Nutrition ; Humans ; Obesity
    Language English
    Publishing date 2017-07-31
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000002474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Adipose Tissue Measurements in Patients With Sepsis.

    Pepper, Dominique J

    Critical care medicine

    2017  Volume 45, Issue 3, Page(s) e331

    MeSH term(s) Adipose Tissue ; Humans ; Sepsis
    Language English
    Publishing date 2017-02-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000002195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The authors reply.

    Pepper, Dominique J / Kadri, Sameer S

    Critical care medicine

    2019  Volume 47, Issue 9, Page(s) e790–e791

    MeSH term(s) Death ; Humans ; Obesity ; Retrospective Studies ; Sepsis
    Language English
    Publishing date 2019-08-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000003875
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  4. Article ; Online: Goal-directed resuscitation in septic shock.

    Pepper, Dominique J

    The New England journal of medicine

    2015  Volume 372, Issue 2, Page(s) 190

    MeSH term(s) Female ; Fluid Therapy ; Humans ; Male ; Shock, Septic/therapy ; Vasoconstrictor Agents/therapeutic use
    Chemical Substances Vasoconstrictor Agents
    Language English
    Publishing date 2015-01-08
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1413936#SA3
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  5. Article ; Online: Treatment for hospitalized patients with severe community-acquired pneumonia.

    Pepper, Dominique J

    JAMA

    2015  Volume 313, Issue 21, Page(s) 2184

    MeSH term(s) Anti-Inflammatory Agents/therapeutic use ; Cytokines/blood ; Female ; Humans ; Male ; Methylprednisolone/therapeutic use ; Pneumonia/drug therapy
    Chemical Substances Anti-Inflammatory Agents ; Cytokines ; Methylprednisolone (X4W7ZR7023)
    Language English
    Publishing date 2015-06-02
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2015.4774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Evidence Underpinning the Centers for Medicare & Medicaid Services' Severe Sepsis and Septic Shock Management Bundle (SEP-1).

    Pepper, Dominique J / Natanson, Charles / Eichacker, Peter Q

    Annals of internal medicine

    2018  Volume 168, Issue 8, Page(s) 610–612

    MeSH term(s) Centers for Medicare and Medicaid Services, U.S. ; Humans ; Medicaid ; Medicare ; Sepsis ; Shock, Septic ; United States
    Language English
    Publishing date 2018-03-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L18-0140
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  7. Article: Top Ten Facts You Need to Know about the Treatment of Venous Thromboembolism.

    Pepper, Dominique J / Brewer, J Michael

    Journal of the Mississippi State Medical Association

    2015  Volume 56, Issue 8, Page(s) 252–253

    MeSH term(s) Humans ; Venous Thromboembolism/therapy
    Language English
    Publishing date 2015-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604042-1
    ISSN 0026-6396
    ISSN 0026-6396
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  8. Article ; Online: Mechanical Ventilation in Acute Respiratory Distress Syndrome. Insights into Opening the Lung and Driving Pressure.

    Chatterjee, Souvik / Pepper, Dominique J / Galiatsatos, Panagis / Seam, Nitin

    American journal of respiratory and critical care medicine

    2018  Volume 198, Issue 1, Page(s) 117–119

    MeSH term(s) Dyspnea ; Humans ; Lung ; Positive-Pressure Respiration ; Respiration, Artificial ; Respiratory Distress Syndrome, Adult
    Language English
    Publishing date 2018-04-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201711-2342RR
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  9. Article ; Online: Antibiotic- and Fluid-Focused Bundles Potentially Improve Sepsis Management, but High-Quality Evidence Is Lacking for the Specificity Required in the Centers for Medicare and Medicaid Service's Sepsis Bundle (SEP-1).

    Pepper, Dominique J / Sun, Junfeng / Cui, Xizhong / Welsh, Judith / Natanson, Charles / Eichacker, Peter Q

    Critical care medicine

    2019  Volume 47, Issue 10, Page(s) 1290–1300

    Abstract: Objective: To address three controversial components in the Centers for Medicare and Medicaid Service's sepsis bundle for performance measure (SEP-1): antibiotics within 3 hours, a 30 mL/kg fluid infusion for all hypotensive patients, and repeat lactate ...

    Abstract Objective: To address three controversial components in the Centers for Medicare and Medicaid Service's sepsis bundle for performance measure (SEP-1): antibiotics within 3 hours, a 30 mL/kg fluid infusion for all hypotensive patients, and repeat lactate measurements within 6 hours if initially elevated. We hypothesized that antibiotic- and fluid-focused bundles like SEP-1 would probably show benefit, but evidence supporting specific antibiotic timing, fluid dosing, or serial lactate requirements would not be concordant. Therefore, we performed a meta-analysis of studies of sepsis bundles like SEP-1.
    Data sources: PubMed, Embase, ClinicalTrials.gov through March 15, 2018.
    Study selection: Studies comparing survival in septic adults receiving versus not receiving antibiotic- and fluid-focused bundles.
    Data extraction: Two investigators (D.J.P., P.Q.E.).
    Data synthesis: Seventeen observational studies (11,303 controls and 4,977 bundle subjects) met inclusion criteria. Bundles were associated with increased odds ratios of survival (odds ratio [95% CI]) in 15 studies with substantial heterogeneity (I = 61%; p < 0.01). Survival benefits were consistent in the five largest (1,697-12,486 patients per study) (1.20 [1.11-1.30]; I = 0%) and six medium-sized studies (167-1,029) (2.03 [1.52-2.71]; I = 8%) but not the six smallest (64-137) (1.25 [0.42-3.66]; I = 57%). Bundles were associated with similarly increased survival benefits whether requiring antibiotics within 1 hour (n = 7 studies) versus 3 hours (n = 8) versus no specified time (n = 2); or 30 mL/kg fluid (n = 7) versus another volume (≥ 2 L, n = 1; ≥ 20 mL/kg, n = 2; 1.5-2 L or 500 mL, n = 1 each; none specified, n = 4) (p = 0.19 for each comparison). In the only study employing serial lactate measurements, survival was not increased versus others. No study had a low risk of bias or assessed potential adverse bundle effects.
    Conclusions: Available studies support the notion that antibiotic- and fluid-focused sepsis bundles like SEP-1 improve survival but do not demonstrate the superiority of any specific antibiotic time or fluid volume or of serial lactate measurements. Until strong reproducible evidence demonstrates the safety and benefit of any fixed requirement for these interventions, the present findings support the revision of SEP-1 to allow flexibility in treatment according to physician judgment.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Fluid Therapy ; Humans ; Medicaid ; Medicare ; Patient Care Bundles ; Quality Indicators, Health Care ; Sepsis/therapy ; United States
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2019-11-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Systematic Review
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000003892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Body-mass index and all-cause mortality.

    Pepper, Dominique J / Sun, Junfeng / Suffredini, Anthony F / Kadri, Sameer

    Lancet (London, England)

    2017  Volume 389, Issue 10086, Page(s) 2284

    MeSH term(s) Body Mass Index ; Humans ; Mortality ; Obesity ; Proportional Hazards Models
    Language English
    Publishing date 2017--10
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(17)31436-8
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