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  1. AU="Percy, Matthew G"
  2. AU="Duc Thuan Nguyen"
  3. AU="Loftsson, Thorsteinn"
  4. AU="Chagumaira, Christopher"
  5. AU="Kaka, Anjum"
  6. AU="Langlois, Mélanie"
  7. AU="Bae, Byoung-Il"
  8. AU=Galili Gad
  9. AU="Diringer, Benoit"
  10. AU="Courtois, Elodie A"
  11. AU="Peters, Kristen N"
  12. AU="Gonçalves, Manuel A F V"
  13. AU="Blaskovic, Sanja"
  14. AU="Vuong, Paton"
  15. AU="de Brito, Wagner Izidoro"
  16. AU="Erin Salo"
  17. AU="Reddy, B V Subba"
  18. AU="Puhlhofer, G."
  19. AU="da Silva, Fabiana Erica Vilanova"
  20. AU="Chang Pingan"
  21. AU="John Gurnell"
  22. AU="Tang, Hon-Yin"
  23. AU="Klassen, Ben"
  24. AU=Kohsaka Shinji
  25. AU="Wenxin He"
  26. AU="He, Lin"
  27. AU="Murace, Celeste Ambra"
  28. AU="Vanini, Sven"
  29. AU=Spernovasilis Nikolaos
  30. AU="Sgouropoulou, Cleo"
  31. AU="Shyamprasad, K" AU="Shyamprasad, K"
  32. AU=Tsuda Hiroyuki
  33. AU="Arpan Bera"
  34. AU="Bilqis, Hazia Hanifa"
  35. AU=Callander Emily J
  36. AU=Oster C
  37. AU="El Aouad, Rajae"
  38. AU="Li, Han-Xu"
  39. AU="Eichhorn, Thomas"
  40. AU=Bramwell Byrom
  41. AU="Purmessur, Rushmi"
  42. AU="Fan, Chunfang"
  43. AU="Chang, Chao-Wen"
  44. AU="BENDICH, A"
  45. AU="Battista, Brad"
  46. AU="Xiong, Bing"
  47. AU="Alexandra Griffith"
  48. AU="Kawamura, Junpei"
  49. AU="Lyons, Karen M"
  50. AU="Biemans, Barbara"

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  1. Artikel ; Online: Discovery of genes required for lipoteichoic acid glycosylation predicts two distinct mechanisms for wall teichoic acid glycosylation.

    Rismondo, Jeanine / Percy, Matthew G / Gründling, Angelika

    The Journal of biological chemistry

    2018  Band 293, Heft 9, Seite(n) 3293–3306

    Abstract: The bacterial cell wall is an important and highly complex structure that is essential for bacterial growth because it protects bacteria from cell lysis and environmental insults. A typical Gram-positive bacterial cell wall is composed of peptidoglycan ... ...

    Abstract The bacterial cell wall is an important and highly complex structure that is essential for bacterial growth because it protects bacteria from cell lysis and environmental insults. A typical Gram-positive bacterial cell wall is composed of peptidoglycan and the secondary cell wall polymers, wall teichoic acid (WTA) and lipoteichoic acid (LTA). In many Gram-positive bacteria, LTA is a polyglycerol-phosphate chain that is decorated with d-alanine and sugar residues. However, the function of and proteins responsible for the glycosylation of LTA are either unknown or not well-characterized. Here, using bioinformatics, genetic, and NMR spectroscopy approaches, we found that the
    Mesh-Begriff(e) Bacillus subtilis/cytology ; Bacillus subtilis/metabolism ; Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Cell Wall/metabolism ; Conserved Sequence ; Glycosylation ; Lipopolysaccharides/metabolism ; Listeria monocytogenes/cytology ; Listeria monocytogenes/metabolism ; Teichoic Acids/metabolism
    Chemische Substanzen Bacterial Proteins ; Lipopolysaccharides ; Teichoic Acids ; lipoteichoic acid (56411-57-5)
    Sprache Englisch
    Erscheinungsdatum 2018-01-17
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.RA117.001614
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Lipoteichoic acid synthesis and function in gram-positive bacteria.

    Percy, Matthew G / Gründling, Angelika

    Annual review of microbiology

    2014  Band 68, Seite(n) 81–100

    Abstract: Lipoteichoic acid (LTA) is an important cell wall polymer found in gram-positive bacteria. Although the exact role of LTA is unknown, mutants display significant growth and physiological defects. Additionally, modification of the LTA backbone structure ... ...

    Abstract Lipoteichoic acid (LTA) is an important cell wall polymer found in gram-positive bacteria. Although the exact role of LTA is unknown, mutants display significant growth and physiological defects. Additionally, modification of the LTA backbone structure can provide protection against cationic antimicrobial peptides. This review provides an overview of the different LTA types and their chemical structures and synthesis pathways. The occurrence and mechanisms of LTA modifications with D-alanyl, glycosyl, and phosphocholine residues will be discussed along with their functions. Similarities between the production of type I LTA and osmoregulated periplasmic glucans in gram-negative bacteria are highlighted, indicating that LTA should perhaps be compared to these polymers rather than lipopolysaccharide, as is presently the case. Lastly, current efforts to use LTAs as vaccine candidates, synthesis proteins as novel antimicrobial targets, and LTA mutant strains as improved probiotics are highlighted.
    Mesh-Begriff(e) Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Biosynthetic Pathways ; Cell Wall/genetics ; Cell Wall/metabolism ; Gram-Positive Bacteria/chemistry ; Gram-Positive Bacteria/genetics ; Gram-Positive Bacteria/metabolism ; Lipopolysaccharides/biosynthesis ; Lipopolysaccharides/chemistry ; Molecular Structure ; Teichoic Acids/biosynthesis ; Teichoic Acids/chemistry
    Chemische Substanzen Bacterial Proteins ; Lipopolysaccharides ; Teichoic Acids ; lipoteichoic acid (56411-57-5)
    Sprache Englisch
    Erscheinungsdatum 2014-05-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 207931-8
    ISSN 1545-3251 ; 0066-4227
    ISSN (online) 1545-3251
    ISSN 0066-4227
    DOI 10.1146/annurev-micro-091213-112949
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Identification of a Lipoteichoic Acid Glycosyltransferase Enzyme Reveals that GW-Domain-Containing Proteins Can Be Retained in the Cell Wall of Listeria monocytogenes in the Absence of Lipoteichoic Acid or Its Modifications.

    Percy, Matthew G / Karinou, Eleni / Webb, Alexander J / Gründling, Angelika

    Journal of bacteriology

    2016  Band 198, Heft 15, Seite(n) 2029–2042

    Abstract: Unlabelled: Listeria monocytogenes is a foodborne Gram-positive bacterial pathogen, and many of its virulence factors are either secreted proteins or proteins covalently or noncovalently attached to the cell wall. Previous work has indicated that ... ...

    Abstract Unlabelled: Listeria monocytogenes is a foodborne Gram-positive bacterial pathogen, and many of its virulence factors are either secreted proteins or proteins covalently or noncovalently attached to the cell wall. Previous work has indicated that noncovalently attached proteins with GW (glycine-tryptophan) domains are retained in the cell wall by binding to the cell wall polymer lipoteichoic acid (LTA). LTA is a glycerol phosphate polymer, which is modified in L. monocytogenes with galactose and d-alanine residues. We identified Lmo0933 as the cytoplasmic glycosyltransferase required for the LTA glycosylation process and renamed the protein GtlA, for glycosyltransferase LTA A Using L. monocytogenes mutants lacking galactose or d-alanine modifications or the complete LTA polymer, we show that GW domain proteins are retained within the cell wall, indicating that other cell wall polymers are involved in the retention of GW domain proteins. Further experiments revealed peptidoglycan as the binding receptor as a purified GW domain fusion protein can bind to L. monocytogenes cells lacking wall teichoic acid (WTA) as well as purified peptidoglycan derived from a wild-type or WTA-negative strain. With this, we not only identify the first enzyme involved in the LTA glycosylation process, but we also provide new insight into the binding mechanism of noncovalently attached cell wall proteins.
    Importance: Over the past 20 years, a large number of bacterial genome sequences have become available. Computational approaches are used for the genome annotation and identification of genes and encoded proteins. However, the function of many proteins is still unknown and often cannot be predicted bioinformatically. Here, we show that the previously uncharacterized Listeria monocytogenes gene lmo0933 likely codes for a glycosyltransferase required for the decoration of the cell wall polymer lipoteichoic acid (LTA) with galactose residues. Using L. monocytogenes mutants lacking LTA modifications or the complete polymer, we show that specific cell wall proteins, often associated with virulence, are retained within the cell wall, indicating that additional cell wall polymers are involved in their retention.
    Mesh-Begriff(e) Cell Wall/chemistry ; Cell Wall/physiology ; Gene Expression Regulation, Bacterial/physiology ; Gene Expression Regulation, Enzymologic/physiology ; Glycosyltransferases/genetics ; Glycosyltransferases/metabolism ; Lipopolysaccharides/genetics ; Lipopolysaccharides/metabolism ; Listeria monocytogenes/genetics ; Listeria monocytogenes/metabolism ; Protein Domains ; Teichoic Acids/genetics ; Teichoic Acids/metabolism
    Chemische Substanzen Lipopolysaccharides ; Teichoic Acids ; lipoteichoic acid (56411-57-5) ; Glycosyltransferases (EC 2.4.-)
    Sprache Englisch
    Erscheinungsdatum 2016-07-13
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/JB.00116-16
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Structural and mechanistic insight into the Listeria monocytogenes two-enzyme lipoteichoic acid synthesis system.

    Campeotto, Ivan / Percy, Matthew G / MacDonald, James T / Förster, Andreas / Freemont, Paul S / Gründling, Angelika

    The Journal of biological chemistry

    2014  Band 289, Heft 41, Seite(n) 28054–28069

    Abstract: Lipoteichoic acid (LTA) is an important cell wall component required for proper cell growth in many Gram-positive bacteria. In Listeria monocytogenes, two enzymes are required for the synthesis of this polyglycerolphosphate polymer. The LTA primase LtaP( ... ...

    Abstract Lipoteichoic acid (LTA) is an important cell wall component required for proper cell growth in many Gram-positive bacteria. In Listeria monocytogenes, two enzymes are required for the synthesis of this polyglycerolphosphate polymer. The LTA primase LtaP(Lm) initiates LTA synthesis by transferring the first glycerolphosphate (GroP) subunit onto the glycolipid anchor and the LTA synthase LtaS(Lm) extends the polymer by the repeated addition of GroP subunits to the tip of the growing chain. Here, we present the crystal structures of the enzymatic domains of LtaP(Lm) and LtaS(Lm). Although the enzymes share the same fold, substantial differences in the cavity of the catalytic site and surface charge distribution contribute to enzyme specialization. The eLtaS(Lm) structure was also determined in complex with GroP revealing a second GroP binding site. Mutational analysis confirmed an essential function for this binding site and allowed us to propose a model for the binding of the growing chain.
    Mesh-Begriff(e) Amino Acid Sequence ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Catalytic Domain ; Cell Wall/chemistry ; Cell Wall/enzymology ; Crystallography, X-Ray ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Glycerophosphates/chemistry ; Glycerophosphates/metabolism ; Lipopolysaccharides/biosynthesis ; Listeria monocytogenes/chemistry ; Listeria monocytogenes/classification ; Listeria monocytogenes/enzymology ; Models, Molecular ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; Phylogeny ; Protein Binding ; Protein Folding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Static Electricity ; Teichoic Acids/biosynthesis
    Chemische Substanzen Bacterial Proteins ; Glycerophosphates ; Lipopolysaccharides ; Recombinant Proteins ; Teichoic Acids ; lipoteichoic acid (56411-57-5)
    Sprache Englisch
    Erscheinungsdatum 2014-08-15
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.M114.590570
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Do medical students studying in the United Kingdom have an adequate factual knowledge of basic life support?

    Willmore, Robert D / Veljanoski, Damjan / Ozdes, Feray / Stephens, Bethan / Mooney, James / Crumley, Seamus G / Doshi, Arpan / Davies, Philippa / Badhrinarayanan, Shreya / Day, Emily / Tattam, Kristian / Wilson, April / Crang, Nathan / Green, Lorna / Mounsey, Craig A / Fu, Howell / Williams, Joseph / D'souza, Michelle S / Sebastian, Dhanya /
    Mcgiveron, Liam A / Percy, Matthew G / Cohen, James / John, Imogen J / Lethbridge, Alice / Watkins, Imogen / Amin, Omar / Qamar, Mubasher A / Hanrahan, John Gerrard / Cramond-Wong, Emily

    World journal of emergency medicine

    2019  Band 10, Heft 2, Seite(n) 75–80

    Abstract: Background: Healthcare professionals have a duty to maintain basic life support (BLS) skills. This study aims to evaluate medical students' factual knowledge of BLS and the training they receive.: Methods: A cross-sectional, closed-response ... ...

    Abstract Background: Healthcare professionals have a duty to maintain basic life support (BLS) skills. This study aims to evaluate medical students' factual knowledge of BLS and the training they receive.
    Methods: A cross-sectional, closed-response questionnaire was distributed to the first- and fourth-year students studying at institutions in the United Kingdom. The paper questionnaire sought to quantify respondent's previous BLS training, factual knowledge of the BLS algorithm using five multiple choice questions (MCQs), and valuate their desire for further BLS training. Students received 1 point for each correctly identified answer to the 5 MCQ's.
    Results: A total of 3,732 complete responses were received from 21 medical schools. Eighty percent (
    Conclusion: Factual knowledge of BLS is poor among medical students in the UK. There is a disparity in standards of knowledge across institutions and respondents indicating that they would like more training.
    Sprache Englisch
    Erscheinungsdatum 2019-02-22
    Erscheinungsland China
    Dokumenttyp Journal Article
    ZDB-ID 2753264-1
    ISSN 1920-8642
    ISSN 1920-8642
    DOI 10.5847/wjem.j.1920-8642.2019.02.002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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