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  1. Article: The Impact of 8 Weeks of Combined Physical Exercise Training on SIRT3 and mTOR in Lymphocytes, and on Lipid Peroxidation.

    Soares, Jorge Pinto / Cardoso, Ricardo / Almeida, Vanessa / Pereira, Ana Fátima / Silva, Amélia M / Mota, Maria Paula

    Healthcare (Basel, Switzerland)

    2024  Volume 12, Issue 3

    Abstract: The sirtuins (SIRT) protein family and the mechanistic/mammalian target of rapamycin (mTOR) are intracellular molecules that have been involved in the regulation of several biological processes, as well as in various aging-related processes. This pilot ... ...

    Abstract The sirtuins (SIRT) protein family and the mechanistic/mammalian target of rapamycin (mTOR) are intracellular molecules that have been involved in the regulation of several biological processes, as well as in various aging-related processes. This pilot study, in small scale, aimed to analyze the effects of an 8-week physical exercise program on SIRT3 and mTOR levels in lymphocytes, as well as on lipid peroxidation in middle aged and older men. A total of 9 participants aged between 56 and 73 years were enrolled in an 8-week physical exercise program comprising cardiovascular and high-intensity interval training. The program involved three sessions per week, each lasting 45-60 min, conducted on non-consecutive days. Tests were conducted before and after the experimental period (pre- and post-training). Assessments included a vertical jump, 20 m velocity, ball throwing, and an aerobic capacity test. Lipid peroxidation (MDA) was measured in plasma as an oxidative stress biomarker. Additionally, sirtuin 3 (SIRT3/β-actin) and mTOR (mTOR/β-actin) levels were measured in isolated lymphocytes extracted from venous blood. Following the exercise training period, our results demonstrated a significant improvement in aerobic capacity (pre-training: 615.4 ± 45.3 m; post-training: 687.2 ± 34.6 m; t = -2.521;
    Language English
    Publishing date 2024-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare12030350
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The Multistage 20-m Shuttle Run Test for Predicting VO2Peak in 6–9-Year-Old Children: A Comparison with VO2Peak Predictive Equations

    Brito, João Paulo / Domingos, Christophe / Pereira, Ana Fátima / Moutão, João / Oliveira, Rafael

    Biology. 2022 Sept. 16, v. 11, no. 9

    2022  

    Abstract: This study aimed (i) to verify if using and carrying a portable gas analyzer (PGA) constrained the performance of school children on the multistage 20-m shuttle run test (20mSRT), (ii) to verify which peak oxygen consumption (VO₂peak) predictive ... ...

    Abstract This study aimed (i) to verify if using and carrying a portable gas analyzer (PGA) constrained the performance of school children on the multistage 20-m shuttle run test (20mSRT), (ii) to verify which peak oxygen consumption (VO₂peak) predictive equations have greater agreement with VO₂peak values measured by direct oximetry using the 20mSRT. The study participants were 130 children ((67 boys (age 7.76 ± 0.97 years) and 63 girls (age 7.59 ± 0.91 years)), who performed two randomized trials of the 20mSRT with and without a PGA. Twenty-two predictive equations predicted the VO₂peak values through the performance of the test with and without a PGA. Without a PGA, lower values of maximal speed (MS), total laps (TL), and total time (TT) were found for girls than for boys with a PGA. Only six equations were considered to correctly predict VO₂peak. In general, higher MS, TL, and TT values were found with the use of a PGA. The predicted VO₂peak values from the 20mSRT varied significantly among the published predictive equations. Therefore, we suggest that the six equations that presented satisfactory accuracy could be practically used to examine cardiorespiratory fitness in schools and in research with large populations when direct measurement of VO₂peak is not feasible.
    Keywords Biological Sciences ; cardiorespiratory fitness ; oxygen consumption
    Language English
    Dates of publication 2022-0916
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology11091356
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: The Multistage 20-m Shuttle Run Test for Predicting VO

    Brito, João Paulo / Domingos, Christophe / Pereira, Ana Fátima / Moutão, João / Oliveira, Rafael

    Biology

    2022  Volume 11, Issue 9

    Abstract: This study aimed (i) to verify if using and carrying a portable gas analyzer (PGA) constrained the performance of school children on the multistage 20-m shuttle run test (20mSRT), (ii) to verify which peak oxygen consumption ( ... ...

    Abstract This study aimed (i) to verify if using and carrying a portable gas analyzer (PGA) constrained the performance of school children on the multistage 20-m shuttle run test (20mSRT), (ii) to verify which peak oxygen consumption (VO
    Language English
    Publishing date 2022-09-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology11091356
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Muscle tissue changes with aging.

    Pereira, Ana Fátima / Silva, António José / Matos Costa, Aldo / Monteiro, António Miguel / Bastos, Estela Maria / Cardoso Marques, Mário

    Acta medica portuguesa

    2013  Volume 26, Issue 1, Page(s) 51–55

    Abstract: Sarcopenia is characterized by a progressive generalized decrease of skeletal muscle mass, strength and function with aging. Recently, the genetic determination has been associated with muscle mass and muscle strength in elderly. These two phenotypes of ... ...

    Abstract Sarcopenia is characterized by a progressive generalized decrease of skeletal muscle mass, strength and function with aging. Recently, the genetic determination has been associated with muscle mass and muscle strength in elderly. These two phenotypes of risk are the most commonly recognized and studied for sarcopenia, with heritability ranging from 30 to 85% for muscle strength and 45-90% for muscle mass. It is well known that the development and maintenance of muscle mass in early adulthood reduces the risk of developing sarcopenia and leads to a healthy aging. For that reason it seems important to identify which genetic factors interact with aging and in particular with the musculoskeletal response to exercise in such individuals. This review is designed to summarize the most important and representative studies about the possible association between certain genetic polymorphisms and muscle phenotypes in older populations. Also we will focuses on nutrition and some concerns associated with aging, including the role that exercise can have on reducing the negative effects of this phenomenon. Some results are inconsistent between studies and more replication studies underlying sarcopenia are needed, with larger samples and with different life cycles, particularly in the type and level of physical activity throughout life. In future we believe that further progress in understanding the genetic etiology and the metabolic pathways will provide valuable information on important biological mechanisms underlying the muscle physiology. This will enable better recognition of individuals at higher risk and the ability to more adequately address this debilitating condition.
    MeSH term(s) Aging ; Humans ; Muscle, Skeletal/pathology ; Sarcopenia/etiology ; Sarcopenia/prevention & control
    Language English
    Publishing date 2013-01
    Publishing country Portugal
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 603078-6
    ISSN 1646-0758 ; 0870-399X
    ISSN (online) 1646-0758
    ISSN 0870-399X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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