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  1. Book ; Online ; E-Book: Concepts and Models for Drug Permeability Studies

    Sarmento, Bruno / Leite Pereira, Catarina / Neves, José Das

    Cell and Tissue Based in Vitro Culture Models

    2024  

    Subject code 615.7
    Language English
    Size 1 online resource (708 pages)
    Edition 2nd ed.
    Publisher Elsevier Science & Technology
    Publishing place San Diego
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 9780443155116 ; 0443155119
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Article ; Online: Biomarkers for intervertebral disc and associated back pain: From diagnosis to disease prognosis and personalized treatment.

    Leite Pereira, Catarina / Grad, Sibylle / Gonçalves, Raquel M

    JOR spine

    2023  Volume 6, Issue 4, Page(s) e1280

    Abstract: Biomarkers are commonly recognized as objective indicators of a medical state or clinical outcome and have been widely used as clinical and diagnostic tools and surrogate endpoints in many pathological conditions. In the context of intervertebral disc ( ... ...

    Abstract Biomarkers are commonly recognized as objective indicators of a medical state or clinical outcome and have been widely used as clinical and diagnostic tools and surrogate endpoints in many pathological conditions. In the context of intervertebral disc (IVD) and associated back pain, also known as degenerative disc disease (DDD), the use of biomarkers has been poorly explored. DDD is currently diagnosed using imaging techniques and subjective pain scales, limiting an objective association between DDD and pain levels, as well as an evaluation of disease progression. There is a need for objective and reliable measurements for DDD, pain and pathology progression. DDD predictors could also help clinicians in deciding on the optimal treatment for distinct patient groups. This review addresses the current candidate biomarkers in DDD, including imaging, genetic, metabolite and protein-based parameters, both at the tissue and systemic levels, that may become a major advance in the diagnosis and prognosis of the disease, as well as in the management of therapeutic approaches to DDD.
    Language English
    Publishing date 2023-10-02
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2572-1143
    ISSN (online) 2572-1143
    DOI 10.1002/jsp2.1280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: From Threat to Opportunity: Harnessing the Invasive

    Pereira, Catarina Guerreiro / Neng, Nuno R / Custódio, Luísa

    Marine drugs

    2023  Volume 21, Issue 8

    Abstract: Carpobrotus ... ...

    Abstract Carpobrotus edulis
    MeSH term(s) Prospective Studies ; Seasons ; Antioxidants/pharmacology ; Dietary Supplements ; Plant Extracts
    Chemical Substances Antioxidants ; Plant Extracts
    Language English
    Publishing date 2023-08-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md21080436
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Seasonal and Geographic Dynamics in Bioproperties and Phytochemical Profile of

    Pereira, Catarina Guerreiro / Rodrigues, Maria João / Nawrot-Hadzik, Izabela / Matkowski, Adam / Custódio, Luísa

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 2

    Abstract: This study delved into the influence of ecological and seasonal dynamics on the synthesis of secondary metabolites in the medicinal ... ...

    Abstract This study delved into the influence of ecological and seasonal dynamics on the synthesis of secondary metabolites in the medicinal halophyte
    MeSH term(s) Antioxidants ; Plumbaginaceae ; Seasons ; Tandem Mass Spectrometry ; Lavandula ; Phytochemicals ; Polyphenols ; Anti-Inflammatory Agents
    Chemical Substances Antioxidants ; Phytochemicals ; Polyphenols ; Anti-Inflammatory Agents
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29020481
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Infectious Sacroiliitis as a Rare Postpartum Complication: A Case Report.

    Monteiro, Renata / Cabrera, Joana A / Salvador, Rui / Pereira, Catarina / Monteiro, Marta

    Cureus

    2024  Volume 16, Issue 2, Page(s) e54621

    Abstract: Infectious sacroiliitis is a rare and challenging diagnosis. Sacroiliac joint changes related to pregnancy and puerperium can predispose to this condition. However, its clinical presentation can often mimic common causes of lower back pain and delay the ... ...

    Abstract Infectious sacroiliitis is a rare and challenging diagnosis. Sacroiliac joint changes related to pregnancy and puerperium can predispose to this condition. However, its clinical presentation can often mimic common causes of lower back pain and delay the diagnosis. We report the case of a 31-year-old pregnant woman with twins who presented at 29 weeks of gestation with lower back and right buttock pain that radiated down to the thigh. Although initially interpreted as sciatica pain, the diagnosis of psoas hematoma complicated with infectious sacroiliitis was made. With this case, we aim to bring awareness to this condition in order to raise suspicion among clinicians for an earlier diagnosis.
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.54621
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mapping Health Technology Assessment Agency Approaches for Biosimilar Value Assessment: An ISPOR Special Interest Group Report.

    Barcina Lacosta, Teresa / Inotai, András / Pereira, Catarina Lopes / Barbier, Liese / Simoens, Steven

    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

    2024  Volume 27, Issue 5, Page(s) 543–551

    Abstract: Objectives: A systematic literature review undertaken by the ISPOR Biosimilar Special Interest Group highlighted that limited guidance exists on how to assess biosimilars value and on appropriate economic evaluation techniques. This study described ... ...

    Abstract Objectives: A systematic literature review undertaken by the ISPOR Biosimilar Special Interest Group highlighted that limited guidance exists on how to assess biosimilars value and on appropriate economic evaluation techniques. This study described current health technology assessment (HTA) agency approaches for biosimilar value assessment.
    Methods: Semi-structured interviews (n = 16) were carried out with HTA experts in Africa, America, Asia, Australia, and Europe to investigate current HTA practices for biosimilars. Data categorization was based on a thematic analysis approach. Findings from the qualitative data analysis were interpreted in view of relevant published literature.
    Results: Our research suggests that in systems in which frameworks for biosimilar regulatory approval are well established, HTA agencies can accept the regulators' comparability exercise, and reimbursement decisions can generally be based on price comparisons. This approach is accepted in practice and allows streamlining of biosimilars value assessment. Nevertheless, conducting HTAs for biosimilars can be relevant when (1) the originator is not reimbursed, (2) the biosimilar marketing authorization holder seeks reimbursement for indications/populations, pharmaceutical forms, methods and routes of administration that differ with respect to the originator, and (3) a price premium is sought for a biosimilar based on an added-value claim. Further, HTA agencies' role conducting class-review updates following biosimilar availability can support greater patients' access to biologics.
    Conclusions: Internationally, there are differences in how national competent authorities on pricing and reimbursement of pharmaceuticals perceive HTA's role for biosimilars. Therefore, HTA agencies are encouraged to issue clear guidance on when and how to conduct HTAs for biosimilars, and on which economic techniques to apply.
    MeSH term(s) Biosimilar Pharmaceuticals/economics ; Biosimilar Pharmaceuticals/therapeutic use ; Technology Assessment, Biomedical ; Humans ; Cost-Benefit Analysis ; Interviews as Topic
    Chemical Substances Biosimilar Pharmaceuticals
    Language English
    Publishing date 2024-05-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1471745-1
    ISSN 1524-4733 ; 1098-3015
    ISSN (online) 1524-4733
    ISSN 1098-3015
    DOI 10.1016/j.jval.2024.01.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5904: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Mimicking 3D breast tumor-stromal interactions to screen novel cancer therapeutics.

    Domingues, Mariana / Leite Pereira, Catarina / Sarmento, Bruno / Castro, Flávia

    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

    2023  Volume 190, Page(s) 106560

    Abstract: Most of the 3D breast tumor models used in drug screening studies only comprise tumor cells, keeping out other essential cell players of the tumor microenvironment. Tumor-associated macrophages and fibroblasts are frequently correlated with tumor ... ...

    Abstract Most of the 3D breast tumor models used in drug screening studies only comprise tumor cells, keeping out other essential cell players of the tumor microenvironment. Tumor-associated macrophages and fibroblasts are frequently correlated with tumor progression and therapy resistance, and targeting these cells at the tumor site has been appointed as a promising therapeutic strategy. However, the translation of new therapies to the clinic has been hampered by the absence of cellular models that more closely mimic the features of in vivo breast tumor microenvironment. Therefore, the development of innovative 3D models able to provide consistent and predictive responses about the in vivo efficacy of novel therapeutics is still an unmet preclinical need. Herein, we have established an in vitro 3D heterotypic spheroid model including MCF-7 breast tumor cells, human mammary fibroblasts and human macrophages. To establish this model, different cell densities have been combined and characterized through the evaluation of the spheroid size and metabolic activity, as well as histological and immunohistochemistry analysis of the 3D multicellular structures. The final optimized 3D model consisted in a multicellular spheroid seeded at the initial density of 5000 cells and cell ratio of 1:2:1 (MCF-7:monocytes:fibroblasts). Our model recapitulates several features of the breast tumor microenvironment, including the formation of a necrotic core, spatial organization, and extracellular matrix production. Further, it was validated as a platform for drug screening studies, using paclitaxel, a currently approved drug for breast cancer treatment, and Gefitinib, a chemotherapeutic approved for lung cancer and in preclinical evaluation for breast cancer. Generally, the impact on the cell viability of the 3D model was less evident than in 2D model, reinforcing the relevance of such complex 3D models in addressing novel treatment approaches. Overall, the use of a 3D heterotypic spheroid of breast cancer could be a valuable tool to predict the therapeutic effect of new treatments for breast cancer patients, by recapitulating key features of the breast cancer microenvironment.
    Language English
    Publishing date 2023-08-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1154366-8
    ISSN 1879-0720 ; 0928-0987
    ISSN (online) 1879-0720
    ISSN 0928-0987
    DOI 10.1016/j.ejps.2023.106560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3705: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Basal ganglia calcification: pseudohypoparathyroidism with short fourth metacarpals.

    Aires Fernandes, André / Pereira, Catarina / Almeida, Margarida / Soares, Carolina

    Practical neurology

    2023  Volume 23, Issue 3, Page(s) 249–250

    MeSH term(s) Humans ; Metacarpal Bones ; Basal Ganglia Diseases/complications ; Basal Ganglia Diseases/diagnostic imaging ; Pseudohypoparathyroidism/diagnosis ; Pseudohypoparathyroidism/diagnostic imaging ; Calcinosis/complications ; Calcinosis/diagnostic imaging ; Basal Ganglia/diagnostic imaging
    Language English
    Publishing date 2023-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2170881-2
    ISSN 1474-7766 ; 1474-7758
    ISSN (online) 1474-7766
    ISSN 1474-7758
    DOI 10.1136/pn-2022-003647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6001: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: The Role of Serratomolide-like Amino Lipids Produced by Bacteria of Genus

    Marques-Pereira, Catarina / Proença, Diogo Neves / Morais, Paula V

    Pathogens (Basel, Switzerland)

    2022  Volume 11, Issue 2

    Abstract: Bursaphelenchus ... ...

    Abstract Bursaphelenchus xylophilus
    Language English
    Publishing date 2022-02-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11020198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Advances in nanoenabled 3D matrices for cartilage repair.

    Leite Pereira, Catarina / Lamghari, Meriem / Sarmento, Bruno

    Acta biomaterialia

    2022  Volume 150, Page(s) 1–21

    Abstract: Cartilage repair strategies are evolving at a fast pace with technology development. Matrices that offer multifaceted functions and a full adaption to the cartilage defect are of pivotal interest. Current cartilage repair strategies face numerous ... ...

    Abstract Cartilage repair strategies are evolving at a fast pace with technology development. Matrices that offer multifaceted functions and a full adaption to the cartilage defect are of pivotal interest. Current cartilage repair strategies face numerous challenges, mostly related to the development of highly biomimetic materials, non-invasive injectable solutions, and adequate degradation rates. These strategies often fail due to feeble mechanical properties, the inability to sustain cell adhesion, growth, and differentiation or by underestimating other players of cartilage degeneration, such as the installed pro-inflammatory microenvironment. The integration of nanomaterials (NMs) into 3D scaffolds, hydrogels and bioinks hold great potential in the improvement of key features of materials that are currently applied in cartilage tissue engineering. NMs offer a high surface to volume ratio and their multiple applications can be explored to enhance cartilage mechanical properties, biocompatibility, cell differentiation, inflammation modulation, infection prevention and even to function as diagnostic tools or as stimuli-responsive cues in these 3D structures. In this review, we have critically reviewed the latest advances in the development of nanoenabled 3D matrices - enhanced by means of NMs - in the context of cartilage regeneration. We have provided a wide perspective of the synergistic effect of combining 3D strategies with NMs, with emphasis on the benefits brought by NMs in achieving functional and enhanced therapeutic outcomes. STATEMENT OF SIGNIFICANCE: Cartilage is one of the most challenging tissues to treat owing to its limited self-regeneration potential. Novel strategies using nanoenabled 3D matrices have emerged from the need to design more efficient solutions for cartilage repair, that take into consideration its unique mechanical properties and can direct specific cell behaviours. Here we aim to provide a comprehensive review on the synergistic effects of 3D matrices nanoenrichment in the context of cartilage regeneration, with emphasis on the heightening brought by nanomaterials in achieving functional and enhanced therapeutic outcomes. We anticipate this review to provide a wide perspective on the past years' research on the field, demonstrating the great potential of these approaches in the treatment and diagnosis of cartilage-related disorders.
    MeSH term(s) Biomimetic Materials ; Cartilage ; Hydrogels/chemistry ; Hydrogels/pharmacology ; Tissue Engineering ; Tissue Scaffolds/chemistry
    Chemical Substances Hydrogels
    Language English
    Publishing date 2022-07-25
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2022.07.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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