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  1. AU="Pereira, Duane G"
  2. AU="Cristofaro, Rosa Carmela"
  3. AU="Wan, Xiaolin"
  4. AU="Renfu, Chen"
  5. AU="Pisani, Antonio Rosario"
  6. AU=Zhang Yue-Miao AU=Zhang Yue-Miao
  7. AU="Chen, Z P"
  8. AU="Pinzón-Navarro, Beatriz Adriana"
  9. AU="Dong, Chuan-Ding"
  10. AU="Gomes, Rafael"
  11. AU="Goncin, Una"
  12. AU="Chen, Yan-Nan"
  13. AU="Revuelta, Belen"
  14. AU="Parmar, Dharati"
  15. AU="Herrera-Mateo, Sergio"
  16. AU="Fejes, I"
  17. AU="Zhang, Zhuhua"
  18. AU="Taillé, C"
  19. AU="San Martín, Juan Víctor"
  20. AU=Sun Yi AU=Sun Yi
  21. AU="Wu, Changping"
  22. AU="Polette, Myriam"
  23. AU="Ian D. Hickson"
  24. AU="Raasch, Siegfried"
  25. AU="Liu, Miao-Miao"
  26. AU="Beschastnov, V V"
  27. AU="Mehdi Benamar"
  28. AU="Manzoor, Jaida"

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  1. Artikel: Insight into the Inter-Organ Crosstalk and Prognostic Role of Liver-Derived MicroRNAs in Metabolic Disease Progression.

    Goncalves, Bruno de Souza / Meadows, Avery / Pereira, Duane G / Puri, Raghav / Pillai, Sneha S

    Biomedicines

    2023  Band 11, Heft 6

    Abstract: Dysfunctional hepatic metabolism has been linked to numerous diseases, including non-alcoholic fatty liver disease, the most common chronic liver disorder worldwide, which can progress to hepatic fibrosis, and is closely associated with insulin ... ...

    Abstract Dysfunctional hepatic metabolism has been linked to numerous diseases, including non-alcoholic fatty liver disease, the most common chronic liver disorder worldwide, which can progress to hepatic fibrosis, and is closely associated with insulin resistance and cardiovascular diseases. In addition, the liver secretes a wide array of metabolites, biomolecules, and microRNAs (miRNAs) and many of these secreted factors exert significant effects on metabolic processes both in the liver and in peripheral tissues. In this review, we summarize the involvement of liver-derived miRNAs in biological processes with an emphasis on delineating the communication between the liver and other tissues associated with metabolic disease progression. Furthermore, the review identifies the primary molecular targets by which miRNAs act. These consolidated findings from numerous studies provide insight into the underlying mechanism of various metabolic disease progression and suggest the possibility of using circulatory miRNAs as prognostic predictors and therapeutic targets for improving clinical intervention strategies.
    Sprache Englisch
    Erscheinungsdatum 2023-05-31
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11061597
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Biomarker panel for early screening of trastuzumab -induced cardiotoxicity among breast cancer patients in west virginia.

    Pillai, Sneha S / Pereira, Duane G / Bonsu, Gloria / Chaudhry, Hibba / Puri, Nitin / Lakhani, Hari Vishal / Tirona, Maria Tria / Sodhi, Komal / Thompson, Ellen

    Frontiers in pharmacology

    2022  Band 13, Seite(n) 953178

    Abstract: Cardiotoxicity is a well-known pathophysiological consequence in breast cancer patients receiving trastuzumab. Trastuzumab related cardiotoxicity typically results in an overall decline in cardiac function, primarily characterized by reduction in left ... ...

    Abstract Cardiotoxicity is a well-known pathophysiological consequence in breast cancer patients receiving trastuzumab. Trastuzumab related cardiotoxicity typically results in an overall decline in cardiac function, primarily characterized by reduction in left ventricular ejection fraction (LVEF) and development of symptoms associated with heart failure. Current strategies for the monitoring of cardiac function, during trastuzumab therapy, includes serial echocardiography, which is cost ineffective as well as offers limited specificity, while offering limited potential in monitoring early onset of cardiotoxicity. However, biomarkers have been shown to be aberrant prior to any detectable functional or clinical deficit in cardiac function. Hence, this study aims to develop a panel of novel biomarkers and circulating miRNAs for the early screening of trastuzumab induced cardiotoxicity. Patients with clinical diagnosis of invasive ductal carcinoma were enrolled in the study, with blood specimen collected and echocardiography performed prior to trastuzumab therapy initiation at baseline, 3- and 6-months post trastuzumab therapy. Following 6-months of trastuzumab therapy, about 18% of the subjects developed cardiotoxicity, as defined by reduction in LVEF. Our results showed significant upregulation of biomarkers and circulating miRNAs, specific to cardiac injury and remodeling, at 3- and 6-months post trastuzumab therapy. These biomarkers and circulating miRNAs significantly correlated with the cardiac injury specific markers, troponin I and T. The findings in the present study demonstrates the translational applicability of the proposed biomarker panel in early preclinical diagnosis of trastuzumab induced cardiotoxicity, further allowing management of cardiac function decline and improved health outcomes for breast cancer patients.
    Sprache Englisch
    Erscheinungsdatum 2022-08-12
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.953178
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Cognitive dysfunction associated with COVID-19: Prognostic role of circulating biomarkers and microRNAs.

    Alvarez, Marissa / Trent, Erick / Goncalves, Bruno De Souza / Pereira, Duane G / Puri, Raghav / Frazier, Nicolas Anthony / Sodhi, Komal / Pillai, Sneha S

    Frontiers in aging neuroscience

    2022  Band 14, Seite(n) 1020092

    Abstract: COVID-19 is renowned as a multi-organ disease having subacute and long-term effects with a broad spectrum of clinical manifestations. The evolving scientific and clinical evidence demonstrates that the frequency of cognitive impairment after COVID-19 is ... ...

    Abstract COVID-19 is renowned as a multi-organ disease having subacute and long-term effects with a broad spectrum of clinical manifestations. The evolving scientific and clinical evidence demonstrates that the frequency of cognitive impairment after COVID-19 is high and it is crucial to explore more clinical research and implement proper diagnostic and treatment strategies. Several central nervous system complications have been reported as comorbidities of COVID-19. The changes in cognitive function associated with neurodegenerative diseases develop slowly over time and are only diagnosed at an already advanced stage of molecular pathology. Hence, understanding the common links between COVID-19 and neurodegenerative diseases will broaden our knowledge and help in strategizing prognostic and therapeutic approaches. The present review focuses on the diverse neurodegenerative changes associated with COVID-19 and will highlight the importance of major circulating biomarkers and microRNAs (miRNAs) associated with the disease progression and severity. The literature analysis showed that major proteins associated with central nervous system function, such as Glial fibrillary acidic protein, neurofilament light chain, p-tau 181, Ubiquitin C-terminal hydrolase L1, S100 calcium-binding protein B, Neuron-specific enolase and various inflammatory cytokines, were significantly altered in COVID-19 patients. Furthermore, among various miRNAs that are having pivotal roles in various neurodegenerative diseases, miR-146a, miR-155, Let-7b, miR-31, miR-16 and miR-21 have shown significant dysregulation in COVID-19 patients. Thus the review consolidates the important findings from the numerous studies to unravel the underlying mechanism of neurological sequelae in COVID-19 and the possible association of circulatory biomarkers, which may serve as prognostic predictors and therapeutic targets in future research.
    Sprache Englisch
    Erscheinungsdatum 2022-10-04
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2022.1020092
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Contribution of adipocyte Na/K-ATPase α1/CD36 signaling induced exosome secretion in response to oxidized LDL.

    Pillai, Sneha S / Pereira, Duane G / Zhang, Jue / Huang, Wenxin / Beg, Mirza Ahmar / Knaack, Darcy A / de Souza Goncalves, Bruno / Sahoo, Daisy / Silverstein, Roy L / Shapiro, Joseph I / Sodhi, Komal / Chen, Yiliang

    Frontiers in cardiovascular medicine

    2023  Band 10, Seite(n) 1046495

    Abstract: Introduction: Adipose tissue constantly secretes adipokines and extracellular vesicles including exosomes to crosstalk with distinct tissues and organs for whole-body homeostasis. However, dysfunctional adipose tissue under chronic inflammatory ... ...

    Abstract Introduction: Adipose tissue constantly secretes adipokines and extracellular vesicles including exosomes to crosstalk with distinct tissues and organs for whole-body homeostasis. However, dysfunctional adipose tissue under chronic inflammatory conditions such as obesity, atherosclerosis, and diabetes shows pro-inflammatory phenotypes accompanied by oxidative stress and abnormal secretion. Nevertheless, molecular mechanisms of how adipocytes are stimulated to secrete exosomes under those conditions remain poorly understood.
    Methods: Mouse and human
    Results and discussion: In this work, we report that CD36, a scavenger receptor for oxidized LDL, formed a signaling complex with another membrane signal transducer Na/K-ATPase in adipocytes. The atherogenic oxidized LDL induced a pro-inflammatory response in
    Sprache Englisch
    Erscheinungsdatum 2023-04-27
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1046495
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: A Review of miRNAs as Biomarkers and Effect of Dietary Modulation in Obesity Associated Cognitive Decline and Neurodegenerative Disorders.

    Perdoncin, Maddie / Konrad, Alec / Wyner, Joshua R / Lohana, Samir / Pillai, Sneha S / Pereira, Duane G / Lakhani, Hari Vishal / Sodhi, Komal

    Frontiers in molecular neuroscience

    2021  Band 14, Seite(n) 756499

    Abstract: There has been a progressive increase in the prevalence of obesity and its comorbidities such as type 2 diabetes and cardiovascular diseases worldwide. Recent studies have suggested that the crosstalk between adipose tissue and central nervous system ( ... ...

    Abstract There has been a progressive increase in the prevalence of obesity and its comorbidities such as type 2 diabetes and cardiovascular diseases worldwide. Recent studies have suggested that the crosstalk between adipose tissue and central nervous system (CNS), through cellular mediators and signaling pathways, may causally link obesity with cognitive decline and give rise to neurodegenerative disorders. Several mechanisms have been proposed in obesity, including inflammation, oxidative stress, insulin resistance, altered lipid and cholesterol homeostasis, which may result in neuroinflammation, altered brain insulin signaling, amyloid-beta (Aβ) deposition and neuronal cell death. Since obesity is associated with functional and morphological alterations in the adipose tissues, the resulting peripheral immune response augments the development and progression of cognitive decline and increases susceptibility of neurodegenerative disorders, such as Alzheimer's Disease (AD) and Parkinson's Disease (PD). Studies have also elucidated an important role of high fat diet in the exacerbation of these clinical conditions. However, the underlying factors that propel and sustain this obesity associated cognitive decline and neurodegeneration, remains highly elusive. Moreover, the mechanisms linking these phenomena are not well-understood. The cumulative line of evidence have demonstrated an important role of microRNAs (miRNAs), a class of small non-coding RNAs that regulate gene expression and transcriptional changes, as biomarkers of pathophysiological conditions. Despite the lack of utility in current clinical practices, miRNAs have been shown to be highly specific and sensitive to the clinical condition being studied. Based on these observations, this review aims to assess the role of several miRNAs and aim to elucidate underlying mechanisms that link obesity with cognitive decline and neurodegenerative disorders. Furthermore, this review will also provide evidence for the effect of dietary modulation which can potentially ameliorate cognitive decline and neurodegenerative diseases associated with obesity.
    Sprache Englisch
    Erscheinungsdatum 2021-10-07
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2021.756499
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Involvement of Src signaling in the synergistic effect between cisplatin and digoxin on cancer cell viability.

    Pereira, Duane G / Salgado, Mariana A R / Rocha, Sayonarah C / Santos, Hérica L / Villar, José A F P / Contreras, Rubén G / Fontes, Carlos F L / Barbosa, Leandro A / Cortes, Vanessa F

    Journal of cellular biochemistry

    2017  Band 119, Heft 4, Seite(n) 3352–3362

    Abstract: Cisplatin and other platinum-containing drugs have played a crucial role in anticancer treatments for over 30 years. However, treatment with cisplatin may cause serious side effects, such as myelosuppression, nausea, ototoxicity, nephrotoxicity, and cell ...

    Abstract Cisplatin and other platinum-containing drugs have played a crucial role in anticancer treatments for over 30 years. However, treatment with cisplatin may cause serious side effects, such as myelosuppression, nausea, ototoxicity, nephrotoxicity, and cell resistance processes. In addition, cardiotonic steroids, particularly digoxin, have recently been suggested to exert potent anticancer effects. Therefore, it is possible that the combined treatment of HeLa cells with cisplatin and digoxin can ameliorate the cytotoxic effects and decrease the side effects of cisplatin. In this study, we demonstrated that the interaction between cisplatin and digoxin had a synergistic effect on cervical cancer cells and a significantly positive cytotoxic and antiproliferative effect on this cell line compared to the control and single cisplatin treatments. Although a decrease in the Na,K-ATPase α1 subunit expression was observed in total extracts, its expression remains unchanged in the membrane, as does the Na,K-ATPase activity. The antiproliferative effect of the synergistic treatment appears to depend on Src kinase activation, indicating the possible involvement of the Scr-EGFR-ERK1/2 pathway in the antitumor effect. The inhibition of ERK1/2 provoked the same synergism with 1 μM cisplatin as that observed with 1 nM digoxin plus 1 μM cisplatin but not with 1 nM digoxin. Pretreatment with PP2 during combined treatment abolished the synergistic effect on the antiproliferative activity. Cisplatin and digoxin are already used in the clinical setting; therefore, this study opens possibilities for future clinical trials of combined treatments to improve treatment outcomes with a lower incidence of toxicity and side effects.
    Mesh-Begriff(e) Antineoplastic Agents/pharmacology ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cisplatin/pharmacology ; Digoxin/pharmacology ; Drug Synergism ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; HeLa Cells ; Humans ; Phosphorylation/drug effects ; Proto-Oncogene Proteins pp60(c-src)/metabolism ; Signal Transduction/drug effects ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/metabolism
    Chemische Substanzen Antineoplastic Agents ; Digoxin (73K4184T59) ; Proto-Oncogene Proteins pp60(c-src) (EC 2.7.10.2) ; Cisplatin (Q20Q21Q62J)
    Sprache Englisch
    Erscheinungsdatum 2017-12-29
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 392402-6
    ISSN 1097-4644 ; 0730-2312
    ISSN (online) 1097-4644
    ISSN 0730-2312
    DOI 10.1002/jcb.26499
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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