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  1. Article: Adipose tissue derived stem cell secretome induces motor and histological gains after complete spinal cord injury in

    Assunção-Silva, Rita C / Pinho, Andreia / Cibrão, Jorge R / Pereira, Inês M / Monteiro, Susana / Silva, Nuno A / Campos, Jonas / Rebelo, Ana L / Schlosser, Gerhard / Pinto, Luisa / Pandit, Abhay / Salgado, António J

    Journal of tissue engineering

    2024  Volume 15, Page(s) 20417314231203824

    Abstract: Mesenchymal stem cell-based therapies have been studied for spinal cord injury (SCI) treatment due to their paracrine action upon damaged tissues. MSCs neuroregenerative role may relate to the contents of their secretome in anti-inflammatory cytokines ... ...

    Abstract Mesenchymal stem cell-based therapies have been studied for spinal cord injury (SCI) treatment due to their paracrine action upon damaged tissues. MSCs neuroregenerative role may relate to the contents of their secretome in anti-inflammatory cytokines and growth-permissive factors. We propose using the secretome of MSCs isolated from the adipose tissue-adipose tissue-derived stem cells (ASCs) as a cell-free based therapy for SCI. In vivo studies were conducted in two SCI models,
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2573915-3
    ISSN 2041-7314
    ISSN 2041-7314
    DOI 10.1177/20417314231203824
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Filling the Gap: Neural Stem Cells as A Promising Therapy for Spinal Cord Injury.

    Pereira, Inês M / Marote, Ana / Salgado, António J / Silva, Nuno A

    Pharmaceuticals (Basel, Switzerland)

    2019  Volume 12, Issue 2

    Abstract: Spinal cord injury (SCI) can lead to severe motor, sensory and social impairments having a huge impact on patients' lives. The complex and time-dependent SCI pathophysiology has been hampering the development of novel and effective therapies. Current ... ...

    Abstract Spinal cord injury (SCI) can lead to severe motor, sensory and social impairments having a huge impact on patients' lives. The complex and time-dependent SCI pathophysiology has been hampering the development of novel and effective therapies. Current treatment options include surgical interventions, to stabilize and decompress the spinal cord, and rehabilitative care, without providing a cure for these patients. Novel therapies have been developed targeting different stages during trauma. Among them, cell-based therapies hold great potential for tissue regeneration after injury. Neural stem cells (NSCs), which are multipotent cells with inherent differentiation capabilities committed to the neuronal lineage, are especially relevant to promote and reestablish the damaged neuronal spinal tracts. Several studies demonstrate the regenerative effects of NSCs in SCI after transplantation by providing neurotrophic support and restoring synaptic connectivity. Therefore, human clinical trials have already been launched to assess safety in SCI patients. Here, we review NSC-based experimental studies in a SCI context and how are they currently being translated into human clinical trials.
    Language English
    Publishing date 2019-04-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph12020065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Metabolic Host Response to Intracellular Infections.

    Ferreira, Catarina M / Barbosa, Ana Margarida / Pereira, Inês M / Torrado, Egídio

    Experientia supplementum (2012)

    2018  Volume 109, Page(s) 319–350

    Abstract: The interaction between intracellular bacterial pathogens with the host immune response can result in multiple outcomes that range from asymptomatic clearance to the establishment of infection. At its core, these interactions result in multiple metabolic ...

    Abstract The interaction between intracellular bacterial pathogens with the host immune response can result in multiple outcomes that range from asymptomatic clearance to the establishment of infection. At its core, these interactions result in multiple metabolic adaptations of both the pathogen and its host cell. There is growing evidence that the host metabolic response plays a key role in the development of immune responses against the invading pathogen. However, successful intracellular pathogens have developed multiple mechanisms to circumvent the host response to thrive in the intracellular compartment. Here, we provide a brief overview on the crucial role of fundamental metabolic host responses in the generation of protective immunity to intracellular bacterial pathogens and discuss some of the mechanisms used by these pathogens to exploit the host metabolic response to their own advantage. This understanding will further our knowledge in host-pathogen interactions and may provide new insights for the development of novel therapies.
    MeSH term(s) Biochemical Phenomena ; Host-Pathogen Interactions ; Humans ; Immune System/metabolism ; Infection/metabolism
    Language English
    Publishing date 2018-12-07
    Publishing country Switzerland
    Document type Journal Article
    ISSN 1664-431X
    ISSN 1664-431X
    DOI 10.1007/978-3-319-74932-7_8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Glial cells in Parkinson´s disease: protective or deleterious?

    Domingues, Ana V / Pereira, Inês M / Vilaça-Faria, Helena / Salgado, António J / Rodrigues, Ana J / Teixeira, Fábio G

    Cellular and molecular life sciences : CMLS

    2020  Volume 77, Issue 24, Page(s) 5171–5188

    Abstract: Glial cells have been identified more than 100 years ago, and are known to play a key role in the central nervous system (CNS) function. A recent piece of evidence is emerging showing that in addition to the capacity of CNS modulation and homeostasis, ... ...

    Abstract Glial cells have been identified more than 100 years ago, and are known to play a key role in the central nervous system (CNS) function. A recent piece of evidence is emerging showing that in addition to the capacity of CNS modulation and homeostasis, glial cells are also being looked like as a promising cell source not only to study CNS pathologies initiation and progression but also to the establishment and development of new therapeutic strategies. Thus, in the present review, we will discuss the current evidence regarding glial cells' contribution to neurodegenerative diseases as Parkinson's disease, providing cellular, molecular, functional, and behavioral data supporting its active role in disease initiation, progression, and treatment. As so, considering their functional relevance, glial cells may be important to the understanding of the underlying mechanisms regarding neuronal-glial networks in neurodegeneration/regeneration processes, which may open new research opportunities for their future use as a target or treatment in human clinical trials.
    MeSH term(s) Cell- and Tissue-Based Therapy ; Central Nervous System/pathology ; Humans ; Nerve Degeneration/pathology ; Nerve Degeneration/therapy ; Neuroglia/transplantation ; Neurons/pathology ; Neurons/transplantation ; Parkinson Disease/pathology ; Parkinson Disease/therapy
    Language English
    Publishing date 2020-07-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-020-03584-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The secretome of macrophages has a differential impact on spinal cord injury recovery according to the polarization protocol.

    Lentilhas-Graça, José / Santos, Diogo J / Afonso, João / Monteiro, Andreia / Pinho, Andreia G / Mendes, Vera M / Dias, Marta S / Gomes, Eduardo D / Lima, Rui / Fernandes, Luís S / Fernandes-Amorim, Fernando / Pereira, Inês M / de Sousa, Nídia / Cibrão, Jorge R / Fernandes, Aline M / Serra, Sofia C / Rocha, Luís A / Campos, Jonas / Pinho, Tiffany S /
    Monteiro, Susana / Manadas, Bruno / Salgado, António J / Almeida, Ramiro D / Silva, Nuno A

    Frontiers in immunology

    2024  Volume 15, Page(s) 1354479

    Abstract: Introduction: The inflammatory response after spinal cord injury (SCI) is an important contributor to secondary damage. Infiltrating macrophages can acquire a spectrum of activation states, however, the microenvironment at the SCI site favors macrophage ...

    Abstract Introduction: The inflammatory response after spinal cord injury (SCI) is an important contributor to secondary damage. Infiltrating macrophages can acquire a spectrum of activation states, however, the microenvironment at the SCI site favors macrophage polarization into a pro-inflammatory phenotype, which is one of the reasons why macrophage transplantation has failed.
    Methods: In this study, we investigated the therapeutic potential of the macrophage secretome for SCI recovery. We investigated the effect of the secretome in vitro using peripheral and CNS-derived neurons and human neural stem cells. Moreover, we perform a pre-clinical trial using a SCI compression mice model and analyzed the recovery of motor, sensory and autonomic functions. Instead of transplanting the cells, we injected the paracrine factors and extracellular vesicles that they secrete, avoiding the loss of the phenotype of the transplanted cells due to local environmental cues.
    Results: We demonstrated that different macrophage phenotypes have a distinct effect on neuronal growth and survival, namely, the alternative activation with IL-10 and TGF-β1 (M(IL-10+TGF-β1)) promotes significant axonal regeneration. We also observed that systemic injection of soluble factors and extracellular vesicles derived from M(IL-10+TGF-β1) macrophages promotes significant functional recovery after compressive SCI and leads to higher survival of spinal cord neurons. Additionally, the M(IL-10+TGF-β1) secretome supported the recovery of bladder function and decreased microglial activation, astrogliosis and fibrotic scar in the spinal cord. Proteomic analysis of the M(IL-10+TGF-β1)-derived secretome identified clusters of proteins involved in axon extension, dendritic spine maintenance, cell polarity establishment, and regulation of astrocytic activation.
    Discussion: Overall, our results demonstrated that macrophages-derived soluble factors and extracellular vesicles might be a promising therapy for SCI with possible clinical applications.
    MeSH term(s) Humans ; Animals ; Mice ; Interleukin-10 ; Transforming Growth Factor beta1 ; Proteomics ; Secretome ; Spinal Cord Injuries/therapy
    Chemical Substances Interleukin-10 (130068-27-8) ; Transforming Growth Factor beta1
    Language English
    Publishing date 2024-02-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1354479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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