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Book ; Online ; E-Book: Children's health and the peril of climate change

Perera, Frederica P.

2022

Author's details	Frederica P. Perera
Keywords	Electronic books ; Child Health ; Climate Change ; Fossil Fuels / adverse effects
Language	English
Size	1 Online-Ressource (ix, 236 Seiten), Illustrationen, Diagramme
Publisher	Oxford University Press
Publishing place	New York, NY
Publishing country	United States
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT021702282
ISBN	978-0-19-758818-5 ; 978-0-19-758817-8 ; 9780197588161 ; 0-19-758818-2 ; 0-19-758817-4 ; 0197588166
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Health implications of the West Virginia v Environmental Protection Agency US Supreme Court decision.

Kizer, Kenneth W / Perera, Frederica P / Nadeau, Kari C

The Lancet. Planetary health

2022 Volume 6, Issue 11, Page(s) e847–e848

MeSH term(s)	Supreme Court Decisions ; United States ; United States Environmental Protection Agency ; West Virginia ; Public Health ; Greenhouse Gases ; Power Plants ; Greenhouse Effect
Chemical Substances	Greenhouse Gases
Language	English
Publishing date	2022-10-27
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2542-5196
ISSN (online)	2542-5196
DOI	10.1016/S2542-5196(22)00249-2
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Article ; Online: Multiple Threats to Child Health from Fossil Fuel Combustion: Impacts of Air Pollution and Climate Change.

Perera, Frederica P

Environmental health perspectives

2016 Volume 125, Issue 2, Page(s) 141–148

Abstract: Background: Approaches to estimating and addressing the risk to children from fossil fuel combustion have been fragmented, tending to focus either on the toxic air emissions or on climate change. Yet developing children, and especially poor children, ... ...

Abstract	Background: Approaches to estimating and addressing the risk to children from fossil fuel combustion have been fragmented, tending to focus either on the toxic air emissions or on climate change. Yet developing children, and especially poor children, now bear a disproportionate burden of disease from both environmental pollution and climate change due to fossil fuel combustion. Objective: This commentary summarizes the robust scientific evidence regarding the multiple current and projected health impacts of fossil fuel combustion on the young to make the case for a holistic, child-centered energy and climate policy that addresses the full array of physical and psychosocial stressors resulting from fossil fuel pollution. Discussion: The data summarized here show that by sharply reducing our dependence on fossil fuels we would achieve highly significant health and economic benefits for our children and their future. These benefits would occur immediately and also play out over the life course and potentially across generations. Conclusion: Going beyond the powerful scientific and economic arguments for urgent action to reduce the burning of fossil fuels is the strong moral imperative to protect our most vulnerable populations. Citation: Perera FP. 2017. Multiple threats to child health from fossil fuel combustion: impacts of air pollution and climate change. Environ Health Perspect 125:141-148; http://dx.doi.org/10.1289/EHP299.
MeSH term(s)	Air Pollutants/analysis ; Air Pollution/statistics & numerical data ; Child Health/statistics & numerical data ; Environmental Exposure/statistics & numerical data ; Humans
Chemical Substances	Air Pollutants
Language	English
Publishing date	2016-06-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	195189-0
ISSN	1552-9924 ; 0091-6765 ; 1078-0475
ISSN (online)	1552-9924
ISSN	0091-6765 ; 1078-0475
DOI	10.1289/EHP299
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Article ; Online: Understanding the Role of Persistent Organic Pollutants and Stress in the Association between Proximity to the World Trade Center Disaster and Birth Outcomes.

Spratlen, Miranda J / Perera, Frederica P / Sjodin, Andreas / Wang, Yuyan / Herbstman, Julie B / Trasande, Leonardo

International journal of environmental research and public health

2022 Volume 19, Issue 4

Abstract: Fetal growth is affected by exposure to both prenatal stress and environmental contaminants. The attacks on the World Trade Center (WTC) resulted in exposure to chemicals and psychological stress amongst New York City residents. We measured prenatal ... ...

Abstract	Fetal growth is affected by exposure to both prenatal stress and environmental contaminants. The attacks on the World Trade Center (WTC) resulted in exposure to chemicals and psychological stress amongst New York City residents. We measured prenatal maternal stress and exposure to persistent organic pollutants (polybrominated diphenyl ethers, polychlorinated biphenyls, and polychlorinated dibenzo-p-dioxins (PCDDs)) in 108 participants from a Columbia University WTC birth cohort. Principal component (PC) analyses were conducted to characterize the mixture of exposure to the three groups of chemicals. We evaluated the associations between geographical exposures (proximity to the WTC disaster) and both chemical exposures (PCs) and stress (demoralization). We then evaluated the effect these exposures (PCs and stress) had on previously reported associations between geographical WTC exposure and birth outcomes (birth weight and birth length) in this study population to understand their individual roles in the observed associations. Geographical exposure via proximity to the WTC was associated with the PC reflecting higher PCDD exposure (PC3) (β = 0.60, 95% CI: 0.03, 1.18 for living/working within 2 miles of the WTC; and β = 0.73, 95% CI = 0.08, 1.38 for living within 2 miles of WTC). Previously reported reductions in birth weight and length associated with WTC proximity (β = -215.2, 95% CI: -416.2, -14.3 and β = -1.47, 95% CI: -2.6, -0.34, respectively) were attenuated and no longer significant for birth weight (β = -156.4, 95% CI: -358.2, 45.4) after adjusting for PC3, suggesting that PCDDs may act as partial mediators in this previously observed association. The results of this study can help focus future research on the long-term health effects of these prenatally exposed populations.
MeSH term(s)	Disasters ; Female ; Humans ; New York City/epidemiology ; Persistent Organic Pollutants ; Polychlorinated Biphenyls/analysis ; Polychlorinated Dibenzodioxins/analysis ; Pregnancy ; September 11 Terrorist Attacks
Chemical Substances	Polychlorinated Dibenzodioxins ; Polychlorinated Biphenyls (DFC2HB4I0K)
Language	English
Publishing date	2022-02-11
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19042008
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Article ; Online: Characteristics of peak exposure to black carbon pollution in school, commute and home environments among school children in an urban community

Jung, Kyung Hwa / Goodwin, Kathleen E. / Ross, James M. / Cai, Jing / Chillrud, Steven N. / Perzanowski, Matthew / Perera, Frederica P. / Miller, Rachel L. / Lovinsky-Desir, Stephanie

Environmental Pollution. 2023 Feb., v. 319 p.120991-

2023

Abstract: Although real-time personal exposure monitoring devices have the ability to capture a wealth of data regarding fluctuations in pollutant levels, only a few studies have defined ‘peaks’ in black carbon (BC) exposure utilizing high-resolution data. ... ...

Abstract	Although real-time personal exposure monitoring devices have the ability to capture a wealth of data regarding fluctuations in pollutant levels, only a few studies have defined ‘peaks’ in black carbon (BC) exposure utilizing high-resolution data. Furthermore, studies to assess and characterize various features of peak exposure are very limited especially among children. A better understanding of characteristics of BC peak exposure would improve our understanding of health risks associated with BC. By capturing personal BC exposure at 5-min intervals using a real-time monitor during 24-hr monitoring periods among children in New York City (NYC), we defined ‘peak characteristics’ in 4 different ways across three major microenvironments (school vs. commute vs. home): 1) mean concentrations of BC across the 3 microenvironments, 2) ‘peak duration’ or time spent above the peak threshold (i.e., ≥1.5 μg/m³), 3) ‘peak intensity’ or the rate of exposure, defined as time spent above the threshold within each microenvironment divided by the total time spent in the microenvironment and 4) a novel metric of ‘peak variability’, defined as frequency of peaks (i.e., data points with +50% and −50% changes compared to the preceding and the subsequent data points), divided by the total time spent in the microenvironment. While peak duration was greatest at home, the intensity of peak exposure was greatest during commute hours, despite the short time spent in commute (p < 0.05). Peak variability was highest during commute, yet lowest in home environments (p < 0.05), particularly during non-sleeping hours. Children residing in a high-density urban setting spent on average, 5.4 hr per day above our peak threshold (≥1.5 μg/m³) in their everyday environments. Policies that limit children's exposure during high traffic periods and improved efforts to increase the number of vehicles using clean air technology could reduce the intensity of peaks and peak variability in children's BC exposure.
Keywords	air ; carbon ; pollutants ; pollution ; traffic ; New York ; Real-time personal monitoring ; Black carbon peak exposure ; Peak characteristics ; Commute ; Microenvironments ; Air pollution
Language	English
Dates of publication	2023-02
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2022.120991
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Socioeconomic Status at Birth and Breast Tissue Composition in Adolescence and Adulthood.

Kehm, Rebecca D / Lilge, Lothar / Walter, E Jane / White, Melissa / Herbstman, Julie B / Perera, Frederica P / Miller, Rachel L / Terry, Mary Beth / Tehranifar, Parisa

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

2024 Volume 32, Issue 10, Page(s) 1294–1301

Abstract: Background: Socioeconomic status (SES) at birth is associated with breast cancer risk. Whether this association is driven by changes in breast tissue composition (BTC) prior to adulthood remains unclear.: Methods: We used multivariable linear ... ...

Abstract	Background: Socioeconomic status (SES) at birth is associated with breast cancer risk. Whether this association is driven by changes in breast tissue composition (BTC) prior to adulthood remains unclear. Methods: We used multivariable linear regression models to examine whether SES at birth is associated with BTC in adolescence and adulthood using data from a New York City cohort of daughters (n = 165, 11-20 years) and mothers (n = 160, 29-55 years). We used maternal-reported data on daughters' household income and maternal education at birth, analyzed individually and in combination (SES index). Women also reported their own mothers' education at birth. We used optical spectroscopy to evaluate BTC measures that positively (water content, collagen content, optical index) and negatively (lipid content) correlate with mammographic breast density, a recognized breast cancer risk factor. Results: Being in the highest versus lowest category of the SES index was associated with lower lipid content [βadjusted (βadj) = -0.80; 95% confidence interval (CI), -1.30 to -0.31] and higher collagen content (βadj = 0.54; 95% CI, 0.09-0.99) in adolescence. In women with a body mass index (BMI) <30 kg/m2, higher maternal education at birth (≥ vs. < high school degree) was associated with lower lipid content (βadj = -0.57; 95% CI, -0.97 to -0.17), higher water content (βadj = 0.70; 95% CI, 0.26-1.14), and higher optical index (βadj = 0.53; 95% CI, 0.10-0.95). Conclusions: This study supports that SES at birth is associated with BTC in adolescence and adulthood, although the latter association may depend on adult BMI. Impact: Further research is needed to identify the socially patterned early life factors influencing BTC.
MeSH term(s)	Adult ; Infant, Newborn ; Humans ; Female ; Adolescent ; Social Class ; Breast ; Breast Neoplasms ; Breast Density ; Body Mass Index ; Lipids ; Socioeconomic Factors
Chemical Substances	Lipids
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1153420-5
ISSN	1538-7755 ; 1055-9965
ISSN (online)	1538-7755
ISSN	1055-9965
DOI	10.1158/1055-9965.EPI-23-0444
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Article ; Online: Combined and sequential exposure to prenatal second hand smoke and postnatal maternal distress is associated with cingulo-opercular global efficiency and attention problems in school-age children.

Greenwood, Paige B / DeSerisy, Mariah / Koe, Emily / Rodriguez, Elizabeth / Salas, Leilani / Perera, Frederica P / Herbstman, Julie / Pagliaccio, David / Margolis, Amy E

Neurotoxicology and teratology

2024 Volume 102, Page(s) 107338

Abstract: Background: Prenatal exposure to secondhand (environmental) tobacco smoke (SHS) is associated with adverse neurodevelopmental outcomes, including altered functional activation of cognitive control brain circuitry and increased attention problems in ... ...

Abstract	Background: Prenatal exposure to secondhand (environmental) tobacco smoke (SHS) is associated with adverse neurodevelopmental outcomes, including altered functional activation of cognitive control brain circuitry and increased attention problems in children. Exposure to SHS is more common among Black youth who are also disproportionately exposed to socioeconomic disadvantage and concomitant maternal distress. We examine the combined effects of exposure to prenatal SHS and postnatal maternal distress on the global efficiency (GE) of the brain's cingulo-opercular (CO) and fronto-parietal control (FP) networks in childhood, as well as associated attention problems. Methods: Thirty-two children of non-smoking mothers followed in a prospective longitudinal birth cohort at the Columbia Center for Children's Environmental Health (CCCEH) completed magnetic resonance imaging (MRI) at ages 7-9 years old. GE scores were extracted from general connectivity data collected while children completed the Simon Spatial Incompatibility functional magnetic resonance imaging (fMRI) task. Prenatal SHS was measured using maternal urinary cotinine from the third trimester; postnatal maternal distress was assessed at child age 5 using the Psychiatric Epidemiology Research Interview (PERI-D). The Child Behavior Checklist (CBCL) measured Attention and Attention Deficit Hyperactivity Disorder (ADHD) problems at ages 7-9. Linear regressions examined the interaction between prenatal SHS and postnatal maternal distress on the GE of the CO or FP networks, as well as associations between exposure-related network alterations and attention problems. All models controlled for age, sex, maternal education at prenatal visit, race/ethnicity, global brain correlation, and mean head motion. Results: The prenatal SHS by postnatal maternal distress interaction term associated with the GE of the CO network (β = 0.673, B Conclusions: These preliminary findings suggest that sequential prenatal SHS exposure and postnatal maternal distress could alter the efficiency of the CO network and increase risk for downstream attention problems and ADHD. These findings are consistent with prior studies showing that prenatal SHS exposure is associated with altered function of brain regions that support cognitive control and with ADHD problems. Our model also identifies postnatal maternal distress as a significant moderator of this association. These data highlight the combined neurotoxic effects of exposure to prenatal SHS and postnatal maternal distress. Critically, such exposures are disproportionately distributed among youth from minoritized groups, pointing to potential pathways to known mental health disparities.
MeSH term(s)	Child ; Female ; Pregnancy ; Adolescent ; Humans ; Child, Preschool ; Tobacco Smoke Pollution/adverse effects ; Prospective Studies ; Attention Deficit Disorder with Hyperactivity/etiology ; Attention Deficit Disorder with Hyperactivity/psychology ; Mothers ; Cotinine ; Prenatal Exposure Delayed Effects/chemically induced
Chemical Substances	Tobacco Smoke Pollution ; Cotinine (K5161X06LL)
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	639165-5
ISSN	1872-9738 ; 0892-0362
ISSN (online)	1872-9738
ISSN	0892-0362
DOI	10.1016/j.ntt.2024.107338
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Article ; Online: Rhinorrhea and watery eyes in infancy and risk of attention-deficit hyperactivity disorder in school-age children.

Perzanowski, Matthew S / Rauh, Virginia / Ramphal, Bruce / Acosta, Luis / Hoepner, Lori / Rundle, Andrew G / Perera, Frederica P / Herbstman, Julie / Miller, Rachel L / Margolis, Amy E

Developmental psychobiology

2024 Volume 66, Issue 5, Page(s) e22497

Abstract: Increased parasympathetic nervous system (PNS) activity is associated with attention-deficit/hyperactivity disorder (ADHD) inattentive symptoms, but not hyperactive-impulsive symptoms, and may contribute to inattentive subtype etiology. Guided by prior ... ...

Abstract	Increased parasympathetic nervous system (PNS) activity is associated with attention-deficit/hyperactivity disorder (ADHD) inattentive symptoms, but not hyperactive-impulsive symptoms, and may contribute to inattentive subtype etiology. Guided by prior work linking infant rhinorrhea and watery eyes without a cold (RWWC) to PNS dysregulation, we examined associations between infant RWWC and childhood ADHD symptoms in a longitudinal cohort of Black and Latinx children living in the context of economic disadvantage (N = 301 youth: 158 females, 143 males). Infant RWWC predicted higher inattentive (relative risk [RR] 2.16, p < .001) but not hyperactive-impulsive (RR 1.53, p = .065) ADHD symptoms (DuPaul scale), administered to caregivers at child age 8-14 years. Stratified analyses revealed that these associations were present in females but not males, who were three times more likely to have higher ADHD current total symptoms if they had infant RWWC than if they did not. Additionally, associations between RWWC and inattention symptoms were observed only in females. RWWC may thus serve as a novel risk marker of ADHD inattentive-type symptoms, especially for females.
MeSH term(s)	Humans ; Attention Deficit Disorder with Hyperactivity ; Male ; Female ; Child ; Adolescent ; Infant ; Longitudinal Studies ; Sex Factors ; Parasympathetic Nervous System/physiopathology ; Hispanic or Latino
Language	English
Publishing date	2024-04-30
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	4107-5
ISSN	1098-2302 ; 0012-1630
ISSN (online)	1098-2302
ISSN	0012-1630
DOI	10.1002/dev.22497
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Article ; Online: Cancer: the big questions to address in coming years.

Perera, Frederica P

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

2011 Volume 20, Issue 4, Page(s) 571–573

MeSH term(s)	Humans ; Molecular Epidemiology/trends ; Neoplasms/epidemiology ; Neoplasms/genetics ; Neoplasms/prevention & control
Language	English
Publishing date	2011-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1153420-5
ISSN	1538-7755 ; 1055-9965
ISSN (online)	1538-7755
ISSN	1055-9965
DOI	10.1158/1055-9965.EPI-11-0184
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Article ; Online: Clean fleets, different streets: evaluating the effect of New York City's clean bus program on changes to estimated ambient air pollution.

Lovasi, Gina S / Treat, Christian A / Fry, Dustin / Shah, Isha / Clougherty, Jane E / Berberian, Alique / Perera, Frederica P / Kioumourtzoglou, Marianthi-Anna

Journal of exposure science & environmental epidemiology

2022 Volume 33, Issue 3, Page(s) 332–338

Abstract: Background: Motor vehicles, including public transit buses, are a major source of air pollution in New York City (NYC) and worldwide. To address this problem, governments and transit agencies have implemented policies to introduce cleaner vehicles into ... ...

Abstract	Background: Motor vehicles, including public transit buses, are a major source of air pollution in New York City (NYC) and worldwide. To address this problem, governments and transit agencies have implemented policies to introduce cleaner vehicles into transit fleets. Beginning in 2000, the Metropolitan Transit Agency began deploying compressed natural gas, hybrid electric, and low-sulfur diesel buses to reduce urban air pollution. Objective: We hypothesized that bus fleet changes incorporating cleaner vehicles would have detectable effects on air pollution concentrations between 2009 and 2014, as measured by the New York City Community Air Survey (NYCCAS). Methods: Depot- and route-specific information allowed identification of areas with larger or smaller changes in the proportion of distance traveled by clean buses. Data were assembled for 9670 300 m × 300 m grid cell areas with annual concentration estimates for nitrogen oxide (NO), nitrogen dioxide (NO Results: While concentrations of all three pollutants declined between 2009 and 2014 even in the 39.7% of cells without bus service, the decline in concentrations of NO and NO Significance: These results provide evidence that the NYC clean bus program impacted concentrations of air pollution, particularly in reductions of NO Impact statement: Urban air pollution from diesel-burning buses is an important health exposure. The New York Metropolitan Transit Agency has worked to deploy cleaner buses into their fleet, but the impact of this policy has not been evaluated. Successful reductions in air pollution are critical for public health.
MeSH term(s)	Humans ; Air Pollutants/analysis ; Vehicle Emissions/analysis ; Nitrogen Dioxide ; New York City ; Air Pollution/analysis ; Motor Vehicles ; Nitrogen Oxides ; Nitric Oxide ; Particulate Matter/analysis
Chemical Substances	Air Pollutants ; Vehicle Emissions ; Nitrogen Dioxide (S7G510RUBH) ; Nitrogen Oxides ; Nitric Oxide (31C4KY9ESH) ; Particulate Matter
Language	English
Publishing date	2022-07-20
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2218551-3
ISSN	1559-064X ; 1559-0631
ISSN (online)	1559-064X
ISSN	1559-0631
DOI	10.1038/s41370-022-00454-5
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