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  1. Article ; Online: Bone pattern changes in post liver transplant patients using bisphosphonates.

    Bueno, Marcus Vinícius / Munhoz, Luciana / Ortega, Karem L / Peres, Maria Paula Siqueira de Melo / Franco, Juliana Bertoldi

    Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry

    2024  

    Abstract: Objective: To identify radiographic findings suggestive of drug-induced osteonecrosis and evaluate radiomorphometric patterns indicative of changes in bone mineral density in individuals transplanted for liver disorders using bisphosphonates.: Study ... ...

    Abstract Objective: To identify radiographic findings suggestive of drug-induced osteonecrosis and evaluate radiomorphometric patterns indicative of changes in bone mineral density in individuals transplanted for liver disorders using bisphosphonates.
    Study design: The study group included panoramic x-rays of liver transplant patients who are being monitored and who present a clinical status of osteoporosis and use bisphosphonates. The control group was made up of liver transplant patients who did not have osteoporosis. On panoramic radiographs, mental index (MI) and mandibular cortical index (MCI) and the presence of radiographic anomalies suggestive of osteonecrosis were evaluated.
    Results: There were significant statistical results when comparing the groups in relation to the decrease in bone mineral density (BMD) with MCI-C3 (p = 0.036), however, there were none in relation to MI (p = 0.14). There were no valid statistical results when relating MCI (p = 0.94) and MI (p = 0.66) with reduced BMD and use of bisphosphonates.
    Conclusion: Liver transplant individuals using bisphosphonates present greater radiographic signs of bone sclerosis suggestive of a greater propensity to develop osteonecrosis of the jaw and an increased risk of presenting changes suggestive of reduced bone mineral density on panoramic radiographs when compared to liver transplant individuals not using bisphosphonates.
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604118-8
    ISSN 1754-4505 ; 0275-1879
    ISSN (online) 1754-4505
    ISSN 0275-1879
    DOI 10.1111/scd.12992
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  2. Article ; Online: Is there a superiority between arthrocentesis and stabilizing occlusal splint for the treatment of anterior disc displacement with reduction and intermittent block and anterior disc displacement without reduction in TMJ? Randomized clinical trial.

    Corrêa-Silva, Matheus / de Carvalho, Tayná Mendes Inácio / Zambon, Camila Eduarda / Peres, Maria Paula Siqueira de Melo / Machado, Gustavo Grothe

    Oral surgery, oral medicine, oral pathology and oral radiology

    2024  

    Abstract: Introduction: Anterior displacement of the temporomandibular joint (TMJ) disc is a disorder in which the articular disc is dislocated from its correct position relative to the mandibular condyle and mandibular fossa. Traditionally, the initial treatment ...

    Abstract Introduction: Anterior displacement of the temporomandibular joint (TMJ) disc is a disorder in which the articular disc is dislocated from its correct position relative to the mandibular condyle and mandibular fossa. Traditionally, the initial treatment of disc displacements involves various conservative measures, including the use of a stabilizing interocclusal splint. However, in cases where there is associated limited mouth opening, as in the case of anterior disc displacement with reduction and intermittent block (ADDwRIB), and anterior disc displacement without reduction (ADDw/oR), arthrocentesis has been suggested as another modality of initial treatment due to its faster effect in preventing disease progression to a more advanced stage, as well as reducing the chances of pain chronification and central sensitization.
    Objectives: This study aimed to analyze whether there is a preponderance in efficacy between treatments with a stabilizing interocclusal splint or arthrocentesis in these patients.
    Methods: A randomized, prospective, longitudinal clinical trial was conducted. The sample was obtained by convenience, between June 2021 and January 2023. Twenty-four patients with diagnoses of ADDwRIB and ADDw/oR were included. The diagnosis and clinical evaluations followed the DC/TMD criteria, and TMJ MRI was performed. Patients were randomly allocated to 2 treatment groups. Group 1 (n = 13): stabilizing interocclusal splint. Group 2 (n = 11): arthrocentesis. Patients were evaluated after 1, 2, 3, and 6 months for clinical parameters of pain, functionality, and psychosocial status.
    Results: Both treatments were effective in reducing pain levels, with no statistically significant differences. Group 1 showed significantly greater mouth-opening levels compared to Group 2 (P = .041).
    Conclusion: Both groups showed significant improvements in various parameters evaluated throughout the study, indicating they are equally effective in pain control and most functional and quality of life parameters. However, the stabilizing interocclusal splint treatment was superior in restoring mouth opening.
    Language English
    Publishing date 2024-04-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2650843-6
    ISSN 2212-4411 ; 2212-4403
    ISSN (online) 2212-4411
    ISSN 2212-4403
    DOI 10.1016/j.oooo.2024.04.001
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  3. Article ; Online: Synovial chondromatosis of the temporomandibular joint-clinical, surgical, and imaging findings of a Milgram stage III case series.

    Machado, Gustavo Grothe / Zambon, Camila Eduarda / de Lima, José Manuel da Silva / Paiva, Gustavo Luiz Alkmin / Martins, Victor Adriano de Oliveira / Peres, Maria Paula Siqueira de Melo

    Oral surgery, oral medicine, oral pathology and oral radiology

    2022  Volume 135, Issue 5, Page(s) e94–e101

    Abstract: Synovial chondromatosis of the temporomandibular joint (TMJ) is a rare disease characterized by cartilaginous metaplasia of the mesenchymal remnants of the synovial membrane with formation of loose cartilaginous nodules. It is prevalent in middle-aged ... ...

    Abstract Synovial chondromatosis of the temporomandibular joint (TMJ) is a rare disease characterized by cartilaginous metaplasia of the mesenchymal remnants of the synovial membrane with formation of loose cartilaginous nodules. It is prevalent in middle-aged women and the main clinical characteristics are swelling, pain, and limited jaw movements. Diagnosis is difficult, especially in the early stages, because the signs and symptoms are like other TMJ diseases such as internal derangements and tumors. Imaging exams are fundamental in differential diagnosis for detection of synovitis and free cartilaginous bodies. Magnetic resonance imaging with a gadolinium contrast would be of particular interest for this purpose. Treatment involves the removal of the cartilaginous nodules and synovectomy. It can be performed by arthroscopy or arthrotomy depending on the size of the lesion, the number of corpuscles, and the need for auxiliary surgical procedures. Final diagnosis is anatomopathologic. Postoperative follow-up is necessary due to the risk of recurrence.
    MeSH term(s) Middle Aged ; Humans ; Female ; Chondromatosis, Synovial/diagnostic imaging ; Chondromatosis, Synovial/surgery ; Chondromatosis, Synovial/pathology ; Tomography, X-Ray Computed ; Temporomandibular Joint/pathology ; Temporomandibular Joint Disorders/diagnostic imaging ; Temporomandibular Joint Disorders/surgery ; Temporomandibular Joint Disorders/pathology ; Synovial Membrane ; Magnetic Resonance Imaging
    Language English
    Publishing date 2022-09-15
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2650843-6
    ISSN 2212-4411 ; 2212-4403
    ISSN (online) 2212-4411
    ISSN 2212-4403
    DOI 10.1016/j.oooo.2022.09.005
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  4. Article ; Online: Fanconi anemia and hematopoietic stem cell transplant as risk factors for oral squamous cell carcinoma: A case report with a 12-year follow-up.

    Macedo, Larissa Fernanda Dos Santos Lima / Domaneschi, Carina / Miguita Luiz, Lucyene / Peres, Maria Paula Siqueira de Melo / Franco, Juliana Bertoldi

    Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry

    2021  Volume 42, Issue 3, Page(s) 299–303

    Abstract: Fanconi anemia is a rare disorder resulting from defects in genes responsible for DNA damage responses. It is characterized by congenital anomalies, aplastic anemia, and a predisposition to cancer. Currently, hematopoietic stem cell transplant (HSCT) is ... ...

    Abstract Fanconi anemia is a rare disorder resulting from defects in genes responsible for DNA damage responses. It is characterized by congenital anomalies, aplastic anemia, and a predisposition to cancer. Currently, hematopoietic stem cell transplant (HSCT) is the only curative treatment available for bone marrow failure; however, HSCT increases oral squamous cell carcinoma (OSCC) risk. Here we report the case of a patient diagnosed with Fanconi anemia in childhood who was treated with HSCT and later diagnosed with multiple OSCCs during a 12-year follow-up. Despite multiple surgical interventions and radiotherapy regimens, the patient`s health deteriorated. Management of individuals with Fanconi anemia is challenging and must be provided by a multidisciplinary healthcare team to ensure better staging, treatment planning, and coordination.
    MeSH term(s) Carcinoma, Squamous Cell/therapy ; Fanconi Anemia/complications ; Fanconi Anemia/therapy ; Follow-Up Studies ; Head and Neck Neoplasms ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Mouth Neoplasms/therapy ; Risk Factors ; Squamous Cell Carcinoma of Head and Neck/complications
    Language English
    Publishing date 2021-11-04
    Publishing country United States
    Document type Case Reports
    ZDB-ID 604118-8
    ISSN 1754-4505 ; 0275-1879
    ISSN (online) 1754-4505
    ISSN 0275-1879
    DOI 10.1111/scd.12668
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  5. Article ; Online: Photodynamic therapy in the treatment of oral lesions caused by paracoccidiomycosis.

    Santos, Danila Silvana de Alexandria / Galvão, Gustavo Souza / Ribas, Priscila Fernandes / Peres, Maria Paula Siqueira de Melo / Franco, Juliana Bertoldi

    Photodiagnosis and photodynamic therapy

    2021  Volume 37, Page(s) 102648

    Abstract: Paracoccidioidomycosis (PCM) is an endemic disease caused by the dimorphic fungus Paracocdioides brasiliensis and Paracoccidioides lutzii. Oral ulcers are usually the first clinical signs of the disease. As it is a systemic fungal disease, local ... ...

    Abstract Paracoccidioidomycosis (PCM) is an endemic disease caused by the dimorphic fungus Paracocdioides brasiliensis and Paracoccidioides lutzii. Oral ulcers are usually the first clinical signs of the disease. As it is a systemic fungal disease, local treatments are considered complementary, such as photodynamic therapy (aPDT). We present a patient with ulcerated lesions in the oral cavity of about 6 months duration. The pain complaint in the oropharynx led to a reduction in food acceptance and a weight loss of around 40 kg. He underwent biopsy of the lip lesion, and the histopathological report described yeast with multiple buds compatible with PMC. Our team opted for treatment with aPDT sessions. Two sessions were carried out in the ward and six in the ICU, showing satisfactory results in the remission of ulcerated lesions associated with PCM as well as the painful symptoms in the oral cavity. Also, the patient underwent Amphotericin B and Sulfamethoxazole-trimethoprim. We believe that the association of aPDT with pharmacological therapy possibly accelerated the repair process of oral lesions, as well as providing fungal lesion decontamination, improving progressively the healing of oral lesions.
    MeSH term(s) Humans ; Male ; Oral Ulcer/drug therapy ; Paracoccidioidomycosis/drug therapy ; Photochemotherapy/methods
    Language English
    Publishing date 2021-11-22
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/j.pdpdt.2021.102648
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  6. Article ; Online: Assessment of mandibular cortical index in patients with hepatic cirrhosis: A case-control study.

    Tenório, Jefferson Rocha / Bueno, Marcus Vinícius / Franco, Juliana Bertoldi / Peres, Maria Paula Siqueira de Melo / Moratto, Beatriz Mota Nunes / Munhoz, Luciana / Arita, Emiko Saito / Ortega, Karem L

    Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry

    2022  Volume 43, Issue 2, Page(s) 119–124

    Abstract: Aims: To assess the presence of alterations suggestive of reduced bone mineral density (BMD) by using mandibular cortical index (MCI) in panoramic radiographs of cirrhotic individuals and to evaluate their relationship with other characteristics of ... ...

    Abstract Aims: To assess the presence of alterations suggestive of reduced bone mineral density (BMD) by using mandibular cortical index (MCI) in panoramic radiographs of cirrhotic individuals and to evaluate their relationship with other characteristics of hepatic cirrhosis (HC).
    Methods and results: This is an observational case-control study assessing the medical records of 165 cirrhotic patients matched by sex and age with healthy individuals. MELD (model of end stage liver disease) score, etiology, complications, comorbidities, and serum levels of vitamin D were collected. MCI was used to obtain BMD. Binary logistic regression was used to test associations and the risk estimates were expressed in odds ratio. Most of the sample consisted of men (73.93%) with median age of 56 years old. In the study group, the mean value of MELD was 16.5 and hepatitis C was the main etiology of HC (33.9%). Cirrhotic individuals are 3.99 times more likely to present alterations suggestive of reduced BMD (p < .01). There was no statistical significance in the association of MCI with levels of vitamin D, comorbidities, etiology or cirrhosis complications.
    Conclusions: MCI suggestive of reduced BMD is more likely to be identified in panoramic radiographs of cirrhotic individuals than of healthy ones.
    MeSH term(s) Male ; Humans ; Middle Aged ; Bone Density ; Case-Control Studies ; Liver Cirrhosis/complications ; Liver Cirrhosis/pathology ; Vitamin D ; Mandible ; Radiography, Panoramic
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2022-06-16
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 604118-8
    ISSN 1754-4505 ; 0275-1879
    ISSN (online) 1754-4505
    ISSN 0275-1879
    DOI 10.1111/scd.12747
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  7. Article ; Online: Assessment of laboratory tests and intraoperative bleeding in patients with liver cirrhosis undergoing tooth extractions.

    Franco, Juliana Bertoldi / Andrade, Natália Silva / Bueno, Marcus Vinicius Rodrigues da Silva / Peres, Maria Paula Siqueira de Melo / Medina, Janaina B / Tenório, Jefferson da Rocha / Rech, Bruna de Oliveira / Ortega, Karem L

    Oral surgery, oral medicine, oral pathology and oral radiology

    2021  Volume 133, Issue 2, Page(s) 148–155

    Abstract: Objectives: The objective of this study was to quantify intraoperative bleeding in patients with cirrhosis and correlate it with clinical characteristics and laboratory coagulation tests.: Study design: A case-control study was carried out with 74 ... ...

    Abstract Objectives: The objective of this study was to quantify intraoperative bleeding in patients with cirrhosis and correlate it with clinical characteristics and laboratory coagulation tests.
    Study design: A case-control study was carried out with 74 patients with cirrhosis who were submitted to preoperative coagulation tests (complete blood count, platelet count, prothrombin time/international normalized ratio, thrombin time, activated partial thrombin time, platelet aggregation, fibrinogen, protein C, protein S, antithrombin, and von Willebrand factor level and activity). The levels of nitrogen compounds that can affect the platelet function were determined in saliva and blood by using automated enzymatic-colorimetric assays.
    Results: Patients with cirrhosis had changes in almost all coagulation tests. The average volumes of intraoperative bleeding and blood lost per minute in the study group (5.36 mL/min and 0.19 mL/min, respectively) were greater than those in the control group (3.05 mL/min and 0.11 mL/min, respectively; P < .05). In the control group, ascites (P = .012) and presence of periapical lesion (0.034) were positively correlated with bleeding (mL/min). With regard to coagulation tests and nitrogen compounds, only a positively moderate correlation with the platelet aggregation test was observed.
    Conclusions: No patients had hemorrhagic events and it was not possible to correlate a greater amount of bleeding with coagulation tests or nitrogen compounds in the study group.
    MeSH term(s) Case-Control Studies ; Hemostasis ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/surgery ; Tooth Extraction
    Language English
    Publishing date 2021-05-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2650843-6
    ISSN 2212-4411 ; 2212-4403
    ISSN (online) 2212-4411
    ISSN 2212-4403
    DOI 10.1016/j.oooo.2021.05.010
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  8. Article ; Online: Analgesic and adjuvant anesthetic effect of submucosal tramadol after mandibular third molar surgery.

    Ceccheti, Marcelo Minharro / Negrato, Giovana Vigário / Peres, Maria Paula Siqueira de Melo / Deboni, Maria Cristina Zindel / Naclério-Homem, Maria da Graça

    Oral surgery, oral medicine, oral pathology and oral radiology

    2014  Volume 117, Issue 3, Page(s) e249–54

    Abstract: Objective: The aim of this study was to assess analgesic and adjuvant anesthetic effects of submucosal tramadol after third molar extraction.: Study design: In this double-blind, split-mouth, placebo-controlled, single-dose, crossover investigation, ... ...

    Abstract Objective: The aim of this study was to assess analgesic and adjuvant anesthetic effects of submucosal tramadol after third molar extraction.
    Study design: In this double-blind, split-mouth, placebo-controlled, single-dose, crossover investigation, 52 patients underwent mandibular third molar extraction under local anesthesia. Surgical side was randomly assigned to submucosal 2 mL 100 mg tramadol injection (group T) or normal saline solution (group P) immediately after surgery. Anesthetic blockade duration, time of intake and amount of analgesic rescue drug, and postoperative pain intensity were recorded immediately after anesthesia cessation and 4, 8, 24, 48, and 72 hours after surgery. Data were submitted to analysis of variance and Wilcoxon tests.
    Results: Anesthetic blockade duration between groups was similar. Group T took significantly less rescue drug after 72 hours (P = .008). Time elapsed before first intake of rescue drug was longer (P = .006), and pain intensity was significantly lower (P = .001) in group T.
    Conclusions: Submucosal tramadol injection after oral surgery improved postoperative analgesia, but did not extend anesthetic action duration.
    MeSH term(s) Adjuvants, Anesthesia/administration & dosage ; Adjuvants, Anesthesia/therapeutic use ; Adolescent ; Adult ; Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/therapeutic use ; Anesthesia, Local/methods ; Cross-Over Studies ; Double-Blind Method ; Female ; Humans ; Injections ; Male ; Mandible/surgery ; Molar, Third/surgery ; Pain Measurement ; Pain, Postoperative/prevention & control ; Placebos ; Prospective Studies ; Tooth Extraction ; Tramadol/administration & dosage ; Tramadol/therapeutic use
    Chemical Substances Adjuvants, Anesthesia ; Analgesics, Opioid ; Placebos ; Tramadol (39J1LGJ30J)
    Language English
    Publishing date 2014-03
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2650843-6
    ISSN 2212-4411 ; 2212-4403
    ISSN (online) 2212-4411
    ISSN 2212-4403
    DOI 10.1016/j.oooo.2012.05.015
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  9. Article ; Online: Efficacy of low-level laser therapy and aluminum hydroxide in patients with chemotherapy and radiotherapy-induced oral mucositis.

    Lima, Aline Gouvêa de / Antequera, Reynaldo / Peres, Maria Paula Siqueira de Melo / Snitcosky, Igor Moysés Longo / Federico, Miriam Hatsue Honda / Villar, Rosângela Correa

    Brazilian dental journal

    2010  Volume 21, Issue 3, Page(s) 186–192

    Abstract: This study evaluated the efficacy of low-level laser therapy (LLLT) and aluminum hydroxide (AH) in the prevention of oral mucositis (OM). A prospective, comparative and non-randomized study was conducted with 25 patients with head and neck cancer ... ...

    Abstract This study evaluated the efficacy of low-level laser therapy (LLLT) and aluminum hydroxide (AH) in the prevention of oral mucositis (OM). A prospective, comparative and non-randomized study was conducted with 25 patients with head and neck cancer subjected to radiotherapy (RT) or radiochemotherapy (RCT). Twelve patients received LLLT (830 nm, 15 mW, 12 J/cm²) daily from the 1st day until the end of RT before each sessions during 5 consecutive days, and the other 13 patients received AH 310 mg/5 mL, 4 times/day, also throughout the duration of RT, including weekends. OM was measured using an oral toxicity scale (OTS) and pain was measured using the visual analogue scale (VAS). EORTC questionnaires were administered to the evaluate impact of OM on quality of life. The LLLT group showed lower mean OTS and VAS scores during the course of RT. A significant difference was observed in pain evaluation in the 13th RT session (p=0.036). In both groups, no interruption of RT was needed. The prophylactic use of both treatments proposed in this study seems to reduce the incidence of severe OM lesions. However, the LLLT was more effective in delaying the appearance of severe OM.
    MeSH term(s) Aluminum Hydroxide/administration & dosage ; Combined Modality Therapy ; Head and Neck Neoplasms/complications ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/radiotherapy ; Humans ; Low-Level Light Therapy/methods ; Mouthwashes/therapeutic use ; Prospective Studies ; Radiation Injuries/etiology ; Radiation Injuries/radiotherapy ; Radiotherapy/adverse effects ; Stomatitis/etiology ; Stomatitis/prevention & control ; Treatment Outcome
    Chemical Substances Mouthwashes ; Aluminum Hydroxide (5QB0T2IUN0)
    Language English
    Publishing date 2010-08-27
    Publishing country Brazil
    Document type Comparative Study ; Controlled Clinical Trial ; Journal Article
    ZDB-ID 1089484-6
    ISSN 1806-4760 ; 0103-6440
    ISSN (online) 1806-4760
    ISSN 0103-6440
    DOI 10.1590/s0103-64402010000300002
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  10. Article: A prospective study of dentoalveolar trauma at the Hospital das Clínicas, São Paulo University Medical School.

    Rezende, Fernanda Mendes do Carmo / Gaujac, Cristiano / Rocha, André Caroli / Peres, Maria Paula Siqueira de Melo

    Clinics (Sao Paulo, Brazil)

    2006  Volume 62, Issue 2, Page(s) 133–138

    Abstract: Purpose: This prospective study evaluated the profile of patients with dentoalveolar trauma assisted at the emergency room of the Oral and Maxillofacial Trauma and Surgery Service at the Hospital das Clínicas, São Paulo University Medical School (Brazil) ...

    Abstract Purpose: This prospective study evaluated the profile of patients with dentoalveolar trauma assisted at the emergency room of the Oral and Maxillofacial Trauma and Surgery Service at the Hospital das Clínicas, São Paulo University Medical School (Brazil).
    Methods: A prospective study by a questionnaire applied during the first attendance of those patients, in a period of eight months.
    Results: The collected data were statistically analyzed. It was observed that 4.7% of the patients that sought treatment at the Service had sustained dentoalveolar trauma and among these 74% were male. The most affected individuals were children aged 0 to 5 years and fall was the most prevalent etiologic factor. Avulsion and coronal/crown-root fractures were the most common types of dentoalveolar traumatic injures. As the age increases, the most common etiologic factors are traffic accidents and physical assault.
    Conclusion: The incidence of dentoalveolar trauma decreased with age and the main etiologic factors in adult patients were traffic accidents and physical assault.
    MeSH term(s) Adolescent ; Adult ; Alveolar Process/injuries ; Brazil/epidemiology ; Child ; Child, Preschool ; Emergency Medical Services/statistics & numerical data ; Female ; Humans ; Incidence ; Infant ; Male ; Maxillofacial Injuries/diagnosis ; Maxillofacial Injuries/epidemiology ; Middle Aged ; Prospective Studies ; Statistics, Nonparametric ; Tooth Injuries/diagnosis ; Tooth Injuries/epidemiology ; Trauma Severity Indices
    Language English
    Publishing date 2006-06-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2182801-5
    ISSN 1807-5932
    ISSN 1807-5932
    DOI 10.1590/s1807-59322007000200007
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